CAPITOL MEDICAL CENTER COLLEGES, INC.

College of Medical Technology

HISTOPATHOLOGY
COMPREHENSIVE EXAM

NAME:___________________________________DATE:________________
INSTRUCTIONS: Select the correct answer for each of the following questions. Mark only one
answer for each item by shading the circle corresponding to the letter of your choice on the
answer sheet provided. STRICTLY NO ERASURES ALLOWED.

1. RA 5527 was approved on

A. June 21, 1969
B. August 31, 1970
C. June 28, 1974
D. June 11, 1978

2. RA 8981 was approved on

A. Dec 5, 2000
B. Feb 13,1998
C. May 5, 1994
D. June 16, 1956

3. Organ Donation Act is

A. RA 7170
B. RA 7710
C. RA 7701
D. RA 7107

4. RA 6138 was approved on

A. Aug 31, 1970
B. June 28, 1974
C. June 11, 1979
D. June 31, 1970

5. PD498 was approved on

A. Aug 31, 1970
B. June 28, 1974
C. June 11, 1979
D. June 31, 1970

6. What organ is usually removed in patients in the late course of polycythemia vera?
A. Adrenal gland
B. Spleen
C. Lungs
D. Pancreas

7. To preserve the morphologic and chemical integrity of the cell in a life-like manner is one of
the objectives during
A. Fixation
B. Decalcification
C. Dehydration
D. Impregnation
8.Which is the most commonly used clearing agent?
A. Toluene
B. Cellosolve
C. Xylene
D. Chloroform
9. Which description of location is best to describe nearest to the point of origin?
A. Distal
B. Proximal
C. Caudal
D. Anterior

10. Which description of location is best to describe the back of the body?
A. Vertebral
B . Anterior
C. Posterior
D. Dorsal

11. Cytoplasmic stain serves as a counterstain for epithelial section

a. Prussian blue c. aniline blue
b. Celestin blue d. night blue

12. Main constituents of feugen’s and schiff’s reagent

a. Acid fuchsin c. conc. HCl
b. Basic fuchsin d. picric acid

13. Most common stain for blood in wbc differentiation

a. Crystal violet c. methylene blue
b. Malachite green d. giemsa stain

14. A more appropriate cointerstain for ascaris eggs and bacterial spores
a. Malachite green c. eosin
b. Methyl green d. carmine

15. An excellent stain for elastic fibers and dermatological studies

a. Bismarck brown c. orcein

16. Mercuric chloride pigment may be removed from tissue by

A. an iodine-sodium thiosulfate sequence
B. washing in running water for 1 to 24 hours
C. washing in 50-70% alcohol
D. the alcoholic dehydration step in processing

17. When preparing Helly solution, formalin should be added

A. when other ingredients are combined
B. before adding mercuric chloride
C. when ready to use
D. 24 hours before use

18. For optimum staining results, Bouin or Zenker’s fixation is recommended for:
A. Wilder reticulum technique
B. Most trichrome stain
C. Weigert elastic tissue stain
D. Any silver stain

19. A fixative which will produce a diffuse brownish pigment is

A. Bouin solution
B. Carnoy solution
C. Zenker solution
D. Alcohol

20. When fat is preserved, the fixative of choice is

A. Formalin
B. Zenker solution
C. Carnoy solution
D. Bouin solution
21. Blood banks are inspected
A. twice a year
B. every year
C. every two years
D. every three years

22. Clinical laboratory is inspected

A. twice a year
B. every year
C. every two years
D. every three years

23. License/accreditation for a drug testing confirmatory laboratory is vaid for a period
A. 6 months
B. 1 year
C. two years
D. 3 years

24. License/ accreditation for a drug testing screening laboratory is valid for a period of
A. 6 months
B. 1 year
C. two years
D. 3 years
E. 5 years

25. The commisioners of PRC is to be appointed by the President of the Philippines for a term
of
A. 3 years
B. 5 years
C. 7 years
D. 9 years

26. A permanent change in the DNA is called:

A. mutation
B. heteroyzgosity
C. polymorphism
D. pleiomorphism

27. Humans have _________ pairs of autosomes.

A. 12
B. 20
C. 22
D. 23

28. Which gene single inheritance defect is included in newborn screening?

A. Phenylketonuria
B. Agammaglobulinemia
C. Thalassemia
D. Adrenal congenital hypoplasia

29. Blood between and along the laminar planes of the arterial media with concomitant
formation of a blood-filled channel within the aortic wall is termed as:
A. aneurysm
B. hematoma
C. dissection
D. vasculitis
30. The most important form of ischemic heart disease in which the duration and severity of loss
of tissue perfusion is sufficient to cause death and coagulative necrosis to the organ is:
A. Myocardial infarction
B. Angina pectoris
C. Myocardial ischemia
D. Myocarditis

31. Iron hematoxylin solution except

a. Wigert’s c. either
b. Heidenhain’s d. neither

32. Ferric ammonium sulfate is a mordant used to obtain

a. Harris c. heidenhain’s
b. Weigert’s D. cole’s

33. Most valuable stain used as counterstain for routine tissue processing
a. Neutral red c. safranin
b. Eosin Y d. malachite green

34. An example of stain having the oxazin as its chromophore

a. Cresyl fast violet c. congo red
b. Basic fuchsin d. eosin

35. Carboxyl groups on the benzene ring of stain function as

a. Chromophore c. auxochrome
b. Dye modifier d. none of the above

36. The primary purpose of fixation is

A. preservation of carbohydrates
B. coagulation of lipids
C. removal of tissue fluids
D. stabilization of proteins

37. Baker calcium formalin fixative

A. is recommended for central nervous system tissue
B. is recommended for the preservation of phospholipids
C. has a pH of approximately 7.5
D. enhances the growth of phospholipids in mycelial forms

38. Ethanol is useful as a fixative because it

A. rapidly dehydrates the tissue
B. increases tissue basophilia
C. stabilizes red cell membrane
D. preserves glycogen very well

39. Absolute ethanol is a poor choice for the fixation of

A. glycogen
B. pigments
C. fats and lipids
D. blood films and smears

40. Acetone is recommended for the fixation of

A. pheochromocytoma
B. fluorescent antibody techniques
C. muscle enzyme hictochemistry
D. brain tissue for the diagnosis of rabies
41. The board of Med Tech is composed of
A. 2 pathologists & 2 med techs
B. 1 pathologist & 2 med techs
C. 1 pathologist & 1 med tech
D. 1 pathologist & 1 med tech & 1 lab technician

42. According to the Blood Bank Law which of the following is not an acceptable
Anticoagulant if liquid plasma or FFP is to be prepared from whole blood?
A. ACD
B. CPD
C. CPD-A1
D. Heparin

43. Inexcusable failure to surrender a suspended or revoked COR within the required
period shall be punishable with
A. a fine of Php 5000
B. Imprisonment fro 6 months to 2 years
C. Perpetual disqualification from the practice of Medical Technology
D. A or B

44. Blood units which have been proved contaminated with blood transfusion
Transmissible diseases should be disposed within
A. 12 hours
B. 24 hours
C. 48 hours
D. 72 hours

45. A person registered wuth the Board to assist a medical technologist and/or
pathologist in the practice of medical technology as defined in PD498 is
A. phlebotomist
B. medical laboratory technician
C. laboratory aide
D. any of the above

46. The lining epithelium of the renal calyces, ureters & urinary bladder is
A. transitional
B. simple columnar
C. simple squamous
D. stratified columnar

47. The lining epithelium of the sweat and salivary glands are composed of
A. simple squamous
B. simple columnar
C. simple cuboidal
D. myoepithelial cells

48. The lens system of the microscope include the following except
A. objectives
B. focal length
C. nosepiece
D. condenser
E. All are parts of the lens system

49. What is the total magnification when the low power objective is used in focusing?
(eyepiece = 10x)
A. 100x
B. 400x
C. 1000x
D. 4000x
50. A skin tag projecting outside from the skin is a/an ____________ type of growth.
A. endophytic
B. papillary
C. cystic
D. exophytic

51. Substance responsible for the retaining property of stain

a. Chromophore c. benzene ring
b. Chromogen d. auxochrome

52. A fixative, decalcifying agent, tissue softener and a dye as well

a. Picric acid c. formic acid
b. Osmic acid d. nitric acid

53. A valuable basic nuclear stain used for diagnosis of diphtheria

a. Neutral red c. methylene blue
b. Janus green d. crystal violet

54. This is a property of tissue to be stained with fat or oil soluble dyes, regardless of the type of
dye used;
a. Lysochromicity c. lipophilia
b. Sudanophilia d. lipo-positivity

55. Widely used hematoxylin stain for staining sec chromosomes and exfoliative cytology
a. Ehrlich’s c. mayer’s
b. Iron d. harris

56. All of the following below are information should be submitted in applying application in
establishing a clinical laboratory as a basic license requirement in A.O 201 series 1973 except:
a. name of the establishment c. Scope and nature of work
b. Tax clearance d. Name, citizenship and domicile of the employees

57. In section 6 of A. O 201 series 1973 who is permitted to manage, establish and supervise a
clinical
laboratory?
a. A licensed Physician c. Either
b. A Licensed Medical Technologist d. Neither

58. In A. O 274 series 1976 Internship program should include the following except:
a. Methods and procedure to be taught c. Subjective evaluation of performance
b. Time schedule d. Principles of the methods

59. In A.O. 49-B series 1988, section 10 Quality Control Test, who is authorized to conduct such
QC test as a criteria for the renewal of license?
a. BRL Director c. Either
b. DOH Secretary d. Neither

60. According to A.O. 19-A series 1998, A RMT is designated as a cytoscreeners which shall be
trained on
the following competencies except:
a. Preparation of technical acceptable smears
b. Understand the Principle of PAP’S staining
c. Correlation of normal/abnormal smears with client history
d. Preparation of concise and acceptable standards of reporting

61. Which of the following is not a duty of the board of medical technology?
1. administer oaths
2. issue, suspend, and revoke certificate of registration
3. look into conditions affecting the practice of medical technology in the
Phils
4. to prescribe the qualifications and training of medical technologist as to special
field of the profession
 A. 1,2,3,4
B. 3 and 4
C. 3 only
D. none of the above
62. All of the following are functions of the council of medical technology education, except:
A. to require all medtech schools to submit an annual report
B. to inspect when necessary, the different medtech schools
C. formulate and recommend approval of refresher course
D. administer oaths

63. All of the following are functions of the Professional Regulatory Board, according to RA 8981
except for
A. to regulate the practice of the profession
B. to monitor the conditions affecting the practice of the profession or occupation under
their respective jurisdictions
C. to hear and investigate cases arising from violations of their respective laws
and the rules and regulations promulgated thereunder and their code ethics
D.to authorize any officer of the commission to administer oaths

64. The skin developed from the progenitor cells of the primitive
A. Ectoderm
B. Endoderm
C. Hematopoietic
D. Mesoderm

65. The thyroid developed from the progenitor stem cells of the primitive
A. Ectoderm
B. Endoderm
C. Hematopoietic
D. Mesoderm

66. Condition in inflammation when the extravascular fluid has an increase protein
concentration, cellular debris and specific gravity greater than 1.020.
A. Edema
B. Pus
C. Transudate
D. Exudate

67. An irreversible adaptive response exhibited during DNA repair and embryogenesis designed
to eliminate unwanted cells.
A. Pathologic calcification
B. Apoptosis
C. Necrosis
D. DNA methylation

68. Formaldehyde is a/an __________ substance that may induce tumor.

A. sensitizer
B. oxidizer
C. carcinogen
D. dehydrator
E. reducer

69. Which among the following types of hones give the best result
a. Begium yellow c. fine carborundun
b. Arkansa d. none of the above

70. Large blocks of paraffin embedded tissues are cut using

a. Sliding microtome c. rocking microtome
b. Rotary microtome d. freezing microtome

71. Routine tissue sectioning can be obtained by using

a. Rotary microtome c. ultrathin microscopre
 b. Sliding microtome d. freezing microtome
72. This microtome is used for unfixed, unfrozen specimen sectioning for enzyme
demonstration
a. Freezing microtome c. rocking rotary microtome
b. Cryostat d. vibrotome

73. Microtome type suitable for fluorescent antibody staining technique

a. Rotary microtome c. cold microtome
b. Rocking microtome d. sliding microtome

74. Mayer’s egg albumin contains the following except

a. Egg white c. glycerin
b. Sodium chloride d. thymol

75. Cell component which is chemically acidophillic upon staining reaction except
a. Nucleus c. mitochondria
b. Cytoplasm d. golgi bodies
76. These are jet black pigments in lung sections and bronchial glands of chronic smokers
a. Carbon c. lead
b. Iron d. A and C

77. Which of the following is not a member of council according to pd 498?

a. member of the BMT
b. director of private education
c. director of BRL
d. director of higher education

78. Which of the following is not an amendment for RA 5527?

a. PD 498 c. RA 6138
b. PD 1534 d. RA 4688

79. Required working space for facilities that offers a service on microbiology?
a. 10 sq m c. 50 sq.m
b. 20 sq. m d. 60 sq. m

80. a laboratory in a government hospital designed to provide special function and service foe
specific disease area.
A. NRL C. BHFS
B. BRL D. EQAP

81. According to AO 27, what is the another discipline that was included in anatomic
patholopgy?
a. therapeutic drug monitoring
b. molecular pathology
c. forensic pathology
d. molecular biology

82. A laboratory that does not form of any other institution

a. government c. institution based
b. private d. free standing

83. A laboratory wherein it is owned, established, and operated by individual, or corporation

a. government c. hospital based
b. private d. non hospital based

84. Mobile clinical laboratory can operate within ____ km from the main laboratory
 a. 1000 km c. 100 km
b. 10 km d. 1 km

85. Infiltrating agent which does not usually need any dehydration and clearing process
A. ester wax c. polyethylene glycols
b. carbowax d. either B or c

86. Specimens which are hard and dense may be more appropriately impregnated through
a. Paraffin c. gelatin
b. Celloidin d. carbowax

87. Water soluble waxes except

a. Gelatin c. polyethylene glycols
b. Carbowax d. none of the above

88. Most preferred type pf impregnation for frozen tissue sections

a. Celloidin c. gelatin
b. Paraffin d. ester wax

89. An adjustable type of embedding mold

a. Peel away c. leuckharts
b. Paper boats d. tissue tek

90. Recommended appearance of a perfectly trimmed block

a. Foursided prism c. either
b. Truncated pyramid d. neither

91. Plane- concave knives are recommended for cutting

a. Paraffin section c. frozen section
b. Celloidin sections d. either A or B

92. A mature cystic teratoma is

A. benign tumor
B. malignant tumor
C. borderline tumor
D. epithelial tumor

93. A dermoid cyst is a

A. benign tumor
B. malignant tumor
C. borderline tumor
D. skin tumor
94. A yolk sac tumor from a female patient is termed
A. Mucinous carcinoma
B. Seminoma
C. Dysgerminoma
D. Endodermal sinus tumor
95. A yolk sac tumor from a male patient is termed
A. Mucinous carcinoma
B. Seminoma
C. Dysgerminoma
D. Endodermal sinus tumor
96. Glandular organs secrete ___________ which differentiate them from epithelial organs.
A. hormones
B. antibodies
C. mucin
D. serous fluid
97 . The addition of thymol crystals to staining solutions used for demonstrating microorganisms
serves to
A. maintain neutral pH
B. facilitate greater reagent penetration
C. inhibit mold growth
 D. adhere tissue sections to microscope slides

98. The periodic acid Schiff procedure for fungi works on the underlying principle of the
A. argyrophilic nature of fungi
B. argentophilic nature of fungi
C. oxidation of carbohydrates fungal walls
D. affinity of ketone groups for Schiff reagent
99. The oxidizer in the Gridley silver impregnation procedure procedure for reticulin fibers is
A. potassium permanganate
B. chromic acid
C. periodic acid
D. phosphomolybdic acid

100. Which of the following is an example of a metachromatic stain?

A. Congo red
B. Schiff
C. Toluidine blue
D. Giemsa