Buffer Pack M348

Conforms to Regulation (EC) No. 1907/2006 (REACH), Annex II, as amended by Regulation (EU) No.
453/2010 -
United Kingdom (UK)
SAFETY DATA SHEET

M348 Buffer Pack MSDS no. : 01410308
SECTION 1: Identification of the substance/mixture and of the company/

undertaking
1.1 Product identifier
Product name : M348 Buffer Pack
Product code : 01410308, 104227, 10309757
Product description : Not available.
1.2 Relevant identified uses of the substance or mixture and uses advised against
Not applicable.
1.3 Company/undertaking identification
Manufactured/supplied : Siemens Healthcare Diagnostics Limited

Sir William Siemens Square
Newton House
Camberley
Frimley
Surrey
GU16 8QD
UK
Phone: +44 (0) 1276 696000

Fax: +44 (0)1276 696133
e-mail address of person : [email protected]
responsible for this SDS
1.4 Emergency telephone : Poison Control:

number In England and Wales:
NHS Direct – 0845 4647 or 111
In Scotland: NHS 24 – 08454 24 24 24
In the Republic of Ireland: 01 809 2166
CHEMTREC: 0870-8200418 (UK only)

00 + 1 + 703-527-3887 (UK & Ireland)
(International calls to the United Kingdom)
Date of issue/Date of revision : 1/15/2016. Date of previous issue : 5/5/2015. Version : 1.02 1/19
Conforms to Regulation (EC) No. 1907/2006 (REACH), Annex II - United Kingdom (UK)
M348 Buffer Pack
SECTION 1: Identification of the substance/mixture and of the company/

undertaking
SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Product definition : M348 7.382 Calibration Standard Mixture
M348 6.838 Slope Standard Mixture
Classification according to Regulation (EC) No. 1272/2008 [CLP/GHS]
M348 6.838 Slope Standard
SKIN SENSITIZATION Category 1
M348 7.382 Calibration Standard The product is not classified as
hazardous according to Regulation (EC)
1272/2008 as amended.
M348 6.838 Slope Standard The product is classified as hazardous
according to Regulation (EC) 1272/2008
as amended.
Ingredients of unknown : M348 7.382 Calibration Standard
toxicity M348 6.838 Slope Standard
Ingredients of unknown : M348 7.382 Calibration Standard
ecotoxicity M348 6.838 Slope Standard
Classification according to Directive 1999/45/EC [DPD]
M348 7.382 Calibration Standard The product is not classified as
dangerous according to Directive
1999/45/EC and its amendments.
M348 6.838 Slope Standard The product is classified as dangerous
according to Directive 1999/45/EC and
its amendments.
Classification : M348 7.382 Calibration Standard Not classified.
M348 6.838 Slope Standard R43
Physical/chemical : M348 7.382 Calibration Standard Not applicable.
hazards M348 6.838 Slope Standard Not applicable.
Human health hazards : M348 7.382 Calibration Standard Not applicable.
M348 6.838 Slope Standard May cause sensitisation by skin contact.
Environmental hazards : M348 7.382 Calibration Standard Not applicable.
M348 6.838 Slope Standard Not applicable.
See Section 16 for the full text of the R phrases or H statements declared above.
See Section 11 for more detailed information on health effects and symptoms.
2.2 Label elements

Hazard pictograms :
Signal word : M348 7.382 Calibration Standard No signal word.

M348 6.838 Slope Standard Warning
Hazard statements : M348 7.382 Calibration Standard No known significant effects or critical
hazards.
M348 6.838 Slope Standard H317 - May cause an allergic skin
reaction.
Precautionary statements
M348 Buffer Pack
SECTION 2: Hazards identification

Prevention : M348 7.382 Calibration Standard Not applicable.
M348 6.838 Slope Standard P272 - Contaminated work clothing
should not be allowed out of the
workplace.
P280 - Wear protective gloves/protective
clothing/eye protection/face protection.
Response : M348 7.382 Calibration Standard Not applicable.
M348 6.838 Slope Standard P302 + P352 - IF ON SKIN: Wash with
plenty of soap and water.
P333 + P313 - If skin irritation or rash
occurs: Get medical attention.
Storage : M348 7.382 Calibration Standard Not applicable.
Disposal : M348 7.382 Calibration Standard Not applicable.
M348 6.838 Slope Standard P501 - Dispose of contents and
container in accordance with all local,
regional, and national regulations.
:
Hazardous ingredients : M348 6.838 Slope Standard
5-chloro-2-methyl-3(2h)-isothiazolone
mixt. with 2-methyl-3(2h)-isothiazolone
Supplemental label : M348 7.382 Calibration Standard Contains reaction mass of:
elements 5-chloro-2-methyl-4-isothiazolin-3-one
[EC no. 247-500-7] and 2-methyl-2H-
isothiazol-3-one [EC no. 220-239-6] (3:1).
May produce an allergic reaction. Safety
data sheet available on request.
Annex XVII - Restrictions : M348 7.382 Calibration Standard Not applicable.
on the manufacture, M348 6.838 Slope Standard Not applicable.
placing on the market and
use of certain dangerous
substances, mixtures and
articles
2.3 Other hazards
Other hazards which do : M348 7.382 Calibration Standard None known.

not result in classification M348 6.838 Slope Standard None known.
Additional information : Not available.
Not available.
SECTION 3: Composition/information on ingredients

Substance/mixture : M348 7.382 Calibration Standard Mixture
M348 6.838 Slope Standard Mixture
M348 Buffer Pack
SECTION 3: Composition/information on ingredients

Classification
Product/ingredient Identifiers % 67/548/EEC Regulation (EC) No. Type
name 1272/2008 [CLP]
M348 7.382
Calibration Standard
4-morpholinopropanesulphonic EC: 214-478-5 >=1, <5 Not classified. Skin Irrit. 2, H315 [1]
acid CAS: 1132-61-2 Eye Irrit. 2, H319
STOT SE 3, H335
M348 6.838 Slope

Standard
4-morpholinopropanesulphonic EC: 214-478-5 >=1, <5 Not classified. Skin Irrit. 2, H315 [1]
acid CAS: 1132-61-2 Eye Irrit. 2, H319
STOT SE 3, H335
reaction mass of: CAS: 55965-84-9 >=0. T; R23/24/25 Acute Tox. 3, H301 [1]
5-chloro-2-methyl-4-isothiazolin-3-one
Index: 613-167-00-5 0015, C; R34 Acute Tox. 3, H311
[EC no. 247-500-7] <0.06 R43 Acute Tox. 3, H331
and 2-methyl-2H- N; R50/53 Skin Corr. 1B, H314
isothiazol-3-one [EC Skin Sens. 1, H317
no. 220-239-6] (3:1) Aquatic Acute 1, H400
Aquatic Chronic 1, H410
See Section 16 for See Section 16 for the
the full text of the R- full text of the H
phrases declared statements declared
above. above.
There are no additional ingredients present which, within the current knowledge of the supplier and in the
concentrations applicable, are classified as hazardous to health or the environment, are PBTs or vPvBs or have been
assigned a workplace exposure limit and hence require reporting in this section.
Type
[1] Substance classified with a health or environmental hazard
[2] Substance with a workplace exposure limit
[3] Substance meets the criteria for PBT according to Regulation (EC) No. 1907/2006, Annex XIII
[4] Substance meets the criteria for vPvB according to Regulation (EC) No. 1907/2006, Annex XIII
[5] Substance of equivalent concern
Occupational exposure limits, if available, are listed in Section 8.
SECTION 4: First aid measures

4.1 Description of first aid measures
Eye contact : M348 7.382 Calibration Standard Immediately flush eyes with plenty of
water, occasionally lifting the upper and
lower eyelids. Check for and remove
any contact lenses. Get medical
attention if irritation occurs.
M348 6.838 Slope Standard Immediately flush eyes with plenty of
water, occasionally lifting the upper and
lower eyelids. Check for and remove
any contact lenses. Continue to rinse
for at least 10 minutes. Get medical
attention if irritation occurs.
Inhalation : M348 7.382 Calibration Standard Remove victim to fresh air and keep at
rest in a position comfortable for
breathing. Get medical attention if
symptoms occur. In case of inhalation
of decomposition products in a fire,
symptoms may be delayed. The
exposed person may need to be kept
M348 Buffer Pack

under medical surveillance for 48 hours.
M348 6.838 Slope Standard Remove victim to fresh air and keep at
rest in a position comfortable for
breathing. If not breathing, if breathing
is irregular or if respiratory arrest occurs,
provide artificial respiration or oxygen by
trained personnel. It may be dangerous
to the person providing aid to give
mouth-to-mouth resuscitation. Get
medical attention if adverse health
effects persist or are severe. If
unconscious, place in recovery position
and get medical attention immediately.
Maintain an open airway. Loosen tight
clothing such as a collar, tie, belt or
waistband. In case of inhalation of
decomposition products in a fire,
symptoms may be delayed. The
exposed person may need to be kept
under medical surveillance for 48 hours.
Skin contact : M348 7.382 Calibration Standard Flush contaminated skin with plenty of
water. Remove contaminated clothing
and shoes. Get medical attention if
symptoms occur.
M348 6.838 Slope Standard Wash with plenty of soap and water.
Remove contaminated clothing and
shoes. Wash contaminated clothing
thoroughly with water before removing it,
or wear gloves. Continue to rinse for at
least 10 minutes. Get medical attention.
In the event of any complaints or
symptoms, avoid further exposure.
Wash clothing before reuse. Clean
shoes thoroughly before reuse.
Ingestion : M348 7.382 Calibration Standard Wash out mouth with water. Remove
victim to fresh air and keep at rest in a
position comfortable for breathing. If
material has been swallowed and the
exposed person is conscious, give small
quantities of water to drink. Do not
induce vomiting unless directed to do so
by medical personnel. Get medical
attention if symptoms occur.
M348 6.838 Slope Standard Wash out mouth with water. Remove
dentures if any. Remove victim to fresh
air and keep at rest in a position
comfortable for breathing. If material
has been swallowed and the exposed
person is conscious, give small
quantities of water to drink. Stop if the
exposed person feels sick as vomiting
may be dangerous. Do not induce
vomiting unless directed to do so by
medical personnel. If vomiting occurs,
the head should be kept low so that
vomit does not enter the lungs. Get
medical attention if adverse health
effects persist or are severe. Never give
anything by mouth to an unconscious
person. If unconscious, place in
M348 Buffer Pack

recovery position and get medical
attention immediately. Maintain an open
airway. Loosen tight clothing such as a
collar, tie, belt or waistband.
Protection of first-aiders : M348 7.382 Calibration Standard No action shall be taken involving any
personal risk or without suitable training.
M348 6.838 Slope Standard No action shall be taken involving any
personal risk or without suitable training.
It may be dangerous to the person
providing aid to give mouth-to-mouth
resuscitation. Wash contaminated
clothing thoroughly with water before
removing it, or wear gloves.
4.2 Most important symptoms and effects, both acute and delayed
Potential acute health effects
Eye contact : M348 7.382 Calibration Standard No known significant effects or critical
hazards.
M348 6.838 Slope Standard No known significant effects or critical
hazards.
Inhalation : M348 7.382 Calibration Standard Exposure to decomposition products
may cause a health hazard. Serious
effects may be delayed following
exposure.
M348 6.838 Slope Standard Exposure to decomposition products
exposure.
Skin contact : M348 7.382 Calibration Standard No known significant effects or critical
hazards.
M348 6.838 Slope Standard May cause an allergic skin reaction.
Ingestion : M348 7.382 Calibration Standard No known significant effects or critical
hazards.
hazards.
Over-exposure signs/symptoms
Eye contact : M348 7.382 Calibration Standard No specific data.
M348 6.838 Slope Standard No specific data.
Inhalation : M348 7.382 Calibration Standard No specific data.
Skin contact : M348 7.382 Calibration Standard No specific data.
M348 6.838 Slope Standard Adverse symptoms may include the
following:
irritation
redness
Ingestion : M348 7.382 Calibration Standard No specific data.
4.3 Indication of any immediate medical attention and special treatment needed
Notes to physician : M348 7.382 Calibration Standard In case of inhalation of decomposition
products in a fire, symptoms may be
delayed. The exposed person may need
to be kept under medical surveillance for
48 hours.
M348 6.838 Slope Standard In case of inhalation of decomposition
products in a fire, symptoms may be
M348 Buffer Pack

delayed. The exposed person may need
to be kept under medical surveillance for
48 hours.
Specific treatments : M348 7.382 Calibration Standard No specific treatment.
M348 6.838 Slope Standard No specific treatment.
SECTION 5: Firefighting measures

5.1 Extinguishing media
Suitable extinguishing : Use dry chemical, CO₂, water spray (fog) or foam.
media
Unsuitable extinguishing : None known.
media
5.2 Special hazards arising from the substance or mixture

Hazards from the : In a fire or if heated, a pressure increase will occur and the container may burst.
substance or mixture
Hazardous thermal : Decomposition products may include the following materials:
decomposition products carbon dioxide
carbon monoxide
nitrogen oxides
sulfur oxides
5.3 Advice for firefighters

Special protective actions : Promptly isolate the scene by removing all persons from the vicinity of the incident if
for fire-fighters there is a fire. No action shall be taken involving any personal risk or without
suitable training.
Special protective : Fire-fighters should wear appropriate protective equipment and self-contained
equipment for fire-fighters breathing apparatus (SCBA) with a full face-piece operated in positive pressure
mode. Clothing for fire-fighters (including helmets, protective boots and gloves)
conforming to European standard EN 469 will provide a basic level of protection for
chemical incidents.
SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
For non-emergency : No action shall be taken involving any personal risk or without suitable training.
personnel Evacuate surrounding areas. Keep unnecessary and unprotected personnel from
entering. Do not touch or walk through spilt material. Avoid breathing vapour or
mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is
inadequate. Put on appropriate personal protective equipment.
For emergency responders : If specialised clothing is required to deal with the spillage, take note of any
information in Section 8 on suitable and unsuitable materials. See also the
information in "For non-emergency personnel".
6.2 Environmental : Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains
precautions and sewers. Inform the relevant authorities if the product has caused environmental
pollution (sewers, waterways, soil or air).
6.3 Methods and materials for containment and cleaning up

Small spill : Stop leak if without risk. Move containers from spill area. Dilute with water and mop
up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry
material and place in an appropriate waste disposal container. Dispose of via a
licensed waste disposal contractor.
M348 Buffer Pack
SECTION 6: Accidental release measures

Large spill : Stop leak if without risk. Move containers from spill area. Approach the release
from upwind. Prevent entry into sewers, water courses, basements or confined
areas. Wash spillages into an effluent treatment plant or proceed as follows.
Contain and collect spillage with non-combustible, absorbent material e.g. sand,
earth, vermiculite or diatomaceous earth and place in container for disposal
according to local regulations. Dispose of via a licensed waste disposal contractor.
Contaminated absorbent material may pose the same hazard as the spilt product.
6.4 Reference to other : See Section 1 for emergency contact information.

sections See Section 8 for information on appropriate personal protective equipment.
See Section 13 for additional waste treatment information.
SECTION 7: Handling and storage

The information in this section contains generic advice and guidance. The list of Identified Uses in Section 1 should be
consulted for any available use-specific information provided in the Exposure Scenario(s).
7.1 Precautions for safe handling
Protective measures : Put on appropriate personal protective equipment (see Section 8). Persons with a
history of skin sensitization problems should not be employed in any process in
which this product is used. Do not get in eyes or on skin or clothing. Do not ingest.
Avoid breathing vapour or mist. Keep in the original container or an approved
alternative made from a compatible material, kept tightly closed when not in use.
Empty containers retain product residue and can be hazardous. Do not reuse
container.
Advice on general : Eating, drinking and smoking should be prohibited in areas where this material is
occupational hygiene handled, stored and processed. Workers should wash hands and face before
eating, drinking and smoking. Remove contaminated clothing and protective
equipment before entering eating areas. See also Section 8 for additional
information on hygiene measures.
7.2 Conditions for safe storage, including any incompatibilities

Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and
well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly
closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright
to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental
contamination.
Seveso II Directive - Reporting thresholds (in tonnes)
Named substances
Name Notification and MAPP Safety report threshold
threshold
M348 7.382 Calibration Standard
formaldehyde Concentration >= 90% 5 50

formaldehyde Concentration >= 90% 5 50
7.3 Specific end use(s)

Recommendations : Not available.
Industrial sector specific : Not available.
solutions
M348 Buffer Pack
SECTION 8: Exposure controls/personal protection

The information in this section contains generic advice and guidance. Information is provided based on typical
anticipated uses of the product. Additional measures might be required for bulk handling or other uses that could
significantly increase worker or exposure or environmental releases.
8.1 Control parameters
Occupational exposure limits
No exposure limit value known.
Recommended monitoring : If this product contains ingredients with exposure limits, personal, workplace
procedures atmosphere or biological monitoring may be required to determine the effectiveness
of the ventilation or other control measures and/or the necessity to use respiratory
protective equipment. Reference should be made to monitoring standards, such as
the following: European Standard EN 689 (Workplace atmospheres - Guidance for
the assessment of exposure by inhalation to chemical agents for comparison with
limit values and measurement strategy) European Standard EN 14042 (Workplace
atmospheres - Guide for the application and use of procedures for the assessment
of exposure to chemical and biological agents) European Standard EN 482
(Workplace atmospheres - General requirements for the performance of procedures
for the measurement of chemical agents) Reference to national guidance
documents for methods for the determination of hazardous substances will also be
required.
DNELs/DMELs
No DNELs/DMELs available.
PNECs
No PNECs available
8.2 Exposure controls

Appropriate engineering : Good general ventilation should be sufficient to control worker exposure to airborne
controls contaminants.
Individual protection measures
Hygiene measures : Wash hands, forearms and face thoroughly after handling chemical products,
before eating, smoking and using the lavatory and at the end of the working period.
Appropriate techniques should be used to remove potentially contaminated clothing.
Contaminated work clothing should not be allowed out of the workplace. Wash
contaminated clothing before reusing. Ensure that eyewash stations and safety
showers are close to the workstation location.
Eye/face protection : Safety eyewear complying with an approved standard should be used when a risk
assessment indicates this is necessary to avoid exposure to liquid splashes, mists,
gases or dusts. If contact is possible, the following protection should be worn,
unless the assessment indicates a higher degree of protection: safety glasses with
side-shields.
Skin protection
Hand protection : Chemical-resistant, impervious gloves complying with an approved standard should
be worn at all times when handling chemical products if a risk assessment indicates
this is necessary. Considering the parameters specified by the glove manufacturer,
check during use that the gloves are still retaining their protective properties. It
should be noted that the time to breakthrough for any glove material may be
different for different glove manufacturers. In the case of mixtures, consisting of
several substances, the protection time of the gloves cannot be accurately
estimated.
Body protection : Personal protective equipment for the body should be selected based on the task
being performed and the risks involved and should be approved by a specialist
before handling this product.
Other skin protection : Appropriate footwear and any additional skin protection measures should be
selected based on the task being performed and the risks involved and should be
approved by a specialist before handling this product.
M348 Buffer Pack
SECTION 8: Exposure controls/personal protection

Respiratory protection : Use a properly fitted, air-purifying or air-fed respirator complying with an approved
standard if a risk assessment indicates this is necessary. Respirator selection must
be based on known or anticipated exposure levels, the hazards of the product and
the safe working limits of the selected respirator.
Environmental exposure : Emissions from ventilation or work process equipment should be checked to ensure
controls they comply with the requirements of environmental protection legislation. In some
cases, fume scrubbers, filters or engineering modifications to the process
equipment will be necessary to reduce emissions to acceptable levels.
SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
Appearance
Physical state : M348 7.382 Calibration Standard Liquid.
M348 6.838 Slope Standard Liquid.
Colour : M348 7.382 Calibration Standard Blue.
M348 6.838 Slope Standard Blue.
Odour : M348 7.382 Calibration Standard Odourless.
M348 6.838 Slope Standard Odourless.
pH : M348 7.382 Calibration Standard 7.38
Melting point/freezing point : M348 7.382 Calibration Standard Not available.
M348 6.838 Slope Standard Not available.
Initial boiling point and boiling : M348 7.382 Calibration Standard Not available.
range M348 6.838 Slope Standard Not available.
Flash point : M348 7.382 Calibration Standard Not available.
Evaporation rate : M348 7.382 Calibration Standard Not available.
Flammability (solid, gas) : M348 7.382 Calibration Standard Not available.
Burning time : M348 7.382 Calibration Standard Not applicable.
Burning rate : M348 7.382 Calibration Standard Not applicable.
Upper/lower flammability or : M348 7.382 Calibration Standard Not available.
explosive limits M348 6.838 Slope Standard Not available.
Vapour pressure : M348 7.382 Calibration Standard Not available.
Solubility in water : M348 7.382 Calibration Standard Not available.
Partition coefficient: n-octanol/ : M348 7.382 Calibration Standard Not available.
water M348 6.838 Slope Standard Not available.
Auto-ignition temperature : M348 7.382 Calibration Standard Not available.
Decomposition temperature : M348 7.382 Calibration Standard Not available.
Viscosity : M348 7.382 Calibration Standard Not available.
Explosive properties : M348 7.382 Calibration Standard Not available.
Oxidising properties : M348 7.382 Calibration Standard Not available.
M348 Buffer Pack
SECTION 9: Physical and chemical properties

9.2 Other information
SADT : Not available.
Aerosol product
Type of aerosol : Not applicable.
Heat of combustion : Not available.
Ignition distance : Not applicable.
Enclosed space ignition - : Not applicable.
Time equivalent
Enclosed space ignition - : Not applicable.
Deflagration density
Flame height : Not applicable.
Flame duration : Not applicable.
SECTION 10: Stability and reactivity

10.1 Reactivity : M348 7.382 Calibration Standard No specific test data related to reactivity
available for this product or its
ingredients.
M348 6.838 Slope Standard No specific test data related to reactivity
available for this product or its
ingredients.
10.2 Chemical stability : M348 7.382 Calibration Standard The product is stable.
M348 6.838 Slope Standard The product is stable.
10.3 Possibility of : M348 7.382 Calibration Standard Under normal conditions of storage and
hazardous reactions use, hazardous reactions will not occur.
M348 6.838 Slope Standard Under normal conditions of storage and
use, hazardous reactions will not occur.
10.4 Conditions to avoid : M348 7.382 Calibration Standard No specific data.

10.5 Incompatible materials : M348 7.382 Calibration Standard No specific data.

10.6 Hazardous : M348 7.382 Calibration Standard Under normal conditions of storage and
decomposition products use, hazardous decomposition products
should not be produced.
M348 6.838 Slope Standard Under normal conditions of storage and
use, hazardous decomposition products
should not be produced.
SECTION 11: Toxicological information

11.1 Information on toxicological effects
Acute toxicity
M348 Buffer Pack

Product/ingredient name Result Species Dose Exposure
M348 6.838 Slope
Standard
reaction mass of: LD50 Oral Rat 53 mg/kg -
[EC no. 247-500-7] and
2-methyl-2H-
isothiazol-3-one [EC no.
220-239-6] (3:1)
Conclusion/Summary : M348 7.382 Calibration Standard Not available.

Acute toxicity estimates
Not available.
Irritation/Corrosion
Product/ingredient name Result Species Score Exposure Observation
reaction mass of: Skin - Severe irritant Human - 0.01 Percent -
[EC no. 247-500-7] and
2-methyl-2H-
isothiazol-3-one [EC no.
220-239-6] (3:1)
Conclusion/Summary
Skin : M348 7.382 Calibration Standard Not available.
Eyes : M348 7.382 Calibration Standard Not available.
Respiratory : M348 7.382 Calibration Standard Not available.
Sensitisation
Conclusion/Summary
Skin : M348 7.382 Calibration Standard Not available.
Respiratory : M348 7.382 Calibration Standard Not available.
Mutagenicity
Carcinogenicity
Reproductive toxicity
Teratogenicity
Specific target organ toxicity (single exposure)
M348 Buffer Pack

Product/ingredient name Category Route of Target organs
exposure
4-morpholinopropanesulphonic acid Category 3 Not applicable. Respiratory tract
irritation

4-morpholinopropanesulphonic acid Category 3 Not applicable. Respiratory tract
irritation
Specific target organ toxicity (repeated exposure)
Not available.
Aspiration hazard
Not available.
Information on the likely : Not available.

routes of exposure
Potential acute health effects
Eye contact : M348 7.382 Calibration Standard No known significant effects or critical
hazards.
hazards.
Inhalation : M348 7.382 Calibration Standard Exposure to decomposition products
exposure.
M348 6.838 Slope Standard Exposure to decomposition products
exposure.
Skin contact : M348 7.382 Calibration Standard No known significant effects or critical
hazards.
M348 6.838 Slope Standard May cause an allergic skin reaction.
Ingestion : M348 7.382 Calibration Standard No known significant effects or critical
hazards.
hazards.
Symptoms related to the physical, chemical and toxicological characteristics

Eye contact : M348 7.382 Calibration Standard No specific data.
Inhalation : M348 7.382 Calibration Standard No specific data.
Skin contact : M348 7.382 Calibration Standard No specific data.
M348 6.838 Slope Standard Adverse symptoms may include the
following:
irritation
redness
Ingestion : M348 7.382 Calibration Standard No specific data.
Delayed and immediate effects and also chronic effects from short and long term exposure
Short term exposure
M348 Buffer Pack

Potential immediate : M348 7.382 Calibration Standard Not available.
effects M348 6.838 Slope Standard Not available.
Potential delayed effects : M348 7.382 Calibration Standard Not available.
Long term exposure
Potential immediate : M348 7.382 Calibration Standard Not available.
effects M348 6.838 Slope Standard Not available.
Potential delayed effects : M348 7.382 Calibration Standard Not available.
Potential chronic health effects
Not available.

General : M348 7.382 Calibration Standard No known significant effects or critical
hazards.
M348 6.838 Slope Standard Once sensitized, a severe allergic
reaction may occur when subsequently
exposed to very low levels.
Carcinogenicity : M348 7.382 Calibration Standard No known significant effects or critical
hazards.
hazards.
Mutagenicity : M348 7.382 Calibration Standard No known significant effects or critical
hazards.
hazards.
Teratogenicity : M348 7.382 Calibration Standard No known significant effects or critical
hazards.
hazards.
Developmental effects : M348 7.382 Calibration Standard No known significant effects or critical
hazards.
hazards.
Fertility effects : M348 7.382 Calibration Standard No known significant effects or critical
hazards.
hazards.
Interactive effects :
Other information : Not available.
SECTION 12: Ecological information

12.1 Toxicity
12.2 Persistence and degradability

12.3 Bioaccumulative potential

Not available.
M348 Buffer Pack
SECTION 12: Ecological information
12.4 Mobility in soil

Soil/water partition : M348 7.382 Calibration Standard Not available.
coefficient (KOC) M348 6.838 Slope Standard Not available.
Mobility : M348 7.382 Calibration Standard Not available.
12.5 Results of PBT and vPvB assessment

PBT : M348 7.382 Calibration Standard Not applicable.
vPvB : M348 7.382 Calibration Standard Not applicable.
12.6 Other adverse effects : M348 7.382 Calibration Standard No known significant effects or critical
hazards.
hazards.
SECTION 13: Disposal considerations

The information in this section contains generic advice and guidance. The list of Identified Uses in Section 1 should be
consulted for any available use-specific information provided in the Exposure Scenario(s).
13.1 Waste treatment methods
Product
Methods of disposal : The generation of waste should be avoided or minimised wherever possible.
Disposal of this product, solutions and any by-products should at all times comply
with the requirements of environmental protection and waste disposal legislation
and any regional local authority requirements. Dispose of surplus and non-
recyclable products via a licensed waste disposal contractor. Waste should not be
disposed of untreated to the sewer unless fully compliant with the requirements of
all authorities with jurisdiction.
Hazardous waste : M348 7.382 Calibration Standard Within the present knowledge of the
supplier, this product is not regarded as
hazardous waste, as defined by EU
Directive 91/689/EEC.
M348 6.838 Slope Standard The classification of the product may
meet the criteria for a hazardous waste.
Not available.
Packaging
Methods of disposal : The generation of waste should be avoided or minimised wherever possible. Waste
packaging should be recycled. Incineration or landfill should only be considered
when recycling is not feasible.
Special precautions : This material and its container must be disposed of in a safe way. Care should be
taken when handling emptied containers that have not been cleaned or rinsed out.
Empty containers or liners may retain some product residues. Avoid dispersal of
spilt material and runoff and contact with soil, waterways, drains and sewers.
SECTION 14: Transport information

ADR/RID
14.1 UN number M348 7.382 Calibration Standard Not regulated.
M348 6.838 Slope Standard Not regulated.
14.2 UN proper M348 7.382 Calibration Standard -
shipping name M348 6.838 Slope Standard -
M348 Buffer Pack

14.3 Transport M348 7.382 Calibration Standard -
hazard class(es) M348 6.838 Slope Standard -
14.4 Packing M348 7.382 Calibration Standard -

group M348 6.838 Slope Standard -
14.5 M348 7.382 Calibration Standard No.
Environmental M348 6.838 Slope Standard No.
hazards
Additional M348 7.382 Calibration Standard -
information M348 6.838 Slope Standard -
ADN

hazards
IMDG

hazards
IATA
M348 Buffer Pack


hazards
14.6 Special precautions for : M348 7.382 Calibration Standard Transport within user’s premises:
user always transport in closed containers
that are upright and secure. Ensure that
persons transporting the product know
what to do in the event of an accident or
spillage.
M348 6.838 Slope Standard Transport within user’s premises:
always transport in closed containers
that are upright and secure. Ensure that
persons transporting the product know
what to do in the event of an accident or
spillage.
14.7 Transport in bulk : Not available.

according to Annex II of
MARPOL 73/78 and the IBC
Code
SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
EU Regulation (EC) No. 1907/2006 (REACH)
Annex XIV - List of substances subject to authorisation
Annex XIV
None of the components are listed.
Substances of very high concern
None of the components are listed.
Annex XVII - Restrictions : M348 7.382 Calibration Standard Not applicable.
on the manufacture, M348 6.838 Slope Standard Not applicable.
placing on the market
and use of certain
dangerous substances,
mixtures and articles
Other EU regulations
Europe inventory : Not determined.
Seveso II Directive
M348 7.382 Calibration Standard This product is controlled under the Seveso II Directive.
M348 6.838 Slope Standard This product is controlled under the Seveso II Directive.
M348 Buffer Pack
SECTION 15: Regulatory information

Named substances
Name
formaldehyde Concentration >= 90%

formaldehyde Concentration >= 90%
International regulations
Chemical Weapons : M348 7.382 Calibration Standard Not listed
Convention List Schedule I M348 6.838 Slope Standard Not listed
Chemicals
Convention List Schedule II M348 6.838 Slope Standard Not listed
Chemicals
Convention List Schedule III M348 6.838 Slope Standard Not listed
Chemicals
15.2 Chemical Safety : This product contains substances for which Chemical Safety Assessments are still
Assessment required.
SECTION 16: Other information
Abbreviations and acronyms : ATE = Acute Toxicity Estimate

CLP = Classification, Labelling and Packaging Regulation [Regulation (EC) No.
1272/2008]
DMEL = Derived Minimal Effect Level
DNEL = Derived No Effect Level
EUH statement = CLP-specific Hazard statement
PBT = Persistent, Bioaccumulative and Toxic
PNEC = Predicted No Effect Concentration
RRN = REACH Registration Number
vPvB = Very Persistent and Very Bioaccumulative
Skin Sens. 1, H317 Calculation method
Full text of abbreviated H : M348 7.382
statements Calibration Standard
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
M348 6.838 Slope

Standard
H301 Toxic if swallowed.
H311 Toxic in contact with skin.
H314 Causes severe skin burns and eye damage.
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H319 Causes serious eye irritation.
H331 Toxic if inhaled.
H335 May cause respiratory irritation.
H400 Very toxic to aquatic life.
H410 Very toxic to aquatic life with long lasting effects.
M348 Buffer Pack
SECTION 16: Other information

Full text of classifications : M348 7.382 Calibration
[CLP/GHS] Standard
Eye Irrit. 2, H319 SERIOUS EYE DAMAGE/ EYE IRRITATION - Category 2
Skin Irrit. 2, H315 SKIN CORROSION/IRRITATION - Category 2
STOT SE 3, H335 SPECIFIC TARGET ORGAN TOXICITY (SINGLE
EXPOSURE) [Respiratory tract irritation] - Category 3
M348 6.838 Slope

Standard
Acute Tox. 3, H301 ACUTE TOXICITY: ORAL - Category 3
Acute Tox. 3, H311 ACUTE TOXICITY: SKIN - Category 3
Acute Tox. 3, H331 ACUTE TOXICITY: INHALATION - Category 3
Aquatic Acute 1, H400 ACUTE AQUATIC HAZARD - Category 1
Aquatic Chronic 1, H410 LONG-TERM AQUATIC HAZARD - Category 1
Eye Irrit. 2, H319 SERIOUS EYE DAMAGE/ EYE IRRITATION - Category 2
Skin Corr. 1B, H314 SKIN CORROSION/IRRITATION - Category 1B
Skin Irrit. 2, H315 SKIN CORROSION/IRRITATION - Category 2
Skin Sens. 1, H317 SKIN SENSITIZATION - Category 1
STOT SE 3, H335 SPECIFIC TARGET ORGAN TOXICITY (SINGLE
EXPOSURE) [Respiratory tract irritation] - Category 3
Full text of abbreviated R : R23/24/25- Toxic by inhalation, in contact with skin and if swallowed.
phrases R34- Causes burns.
R43- May cause sensitisation by skin contact.
R50/53- Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
Full text of classifications : T - Toxic
[DSD/DPD] C - Corrosive
N - Dangerous for the environment
Date of printing : 1/15/2016.
Date of issue/ Date of : 1/15/2016.
revision
Date of previous issue : 5/5/2015.
Version : 1.02
Notice to reader
To the best of our knowledge, the information contained herein is accurate. However, neither the above-named
supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the
information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present
unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot
guarantee that these are the only hazards that exist.

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Conforms to Regulation (EC) No. 1907/2006 (REACH), Annex II, as amended by Regulation (EU) No.

SAFETY DATA SHEET

SECTION 1: Identification of the substance/mixture and of the company/

1.3 Company/undertaking identification

Manufactured/supplied : Siemens Healthcare Diagnostics Limited

Phone: +44 (0) 1276 696000

1.4 Emergency telephone : Poison Control:

CHEMTREC: 0870-8200418 (UK only)

SECTION 1: Identification of the substance/mixture and of the company/

SECTION 2: Hazards identification

2.2 Label elements

Signal word : M348 7.382 Calibration Standard No signal word.

SECTION 2: Hazards identification

2.3 Other hazards

Other hazards which do : M348 7.382 Calibration Standard None known.

SECTION 3: Composition/information on ingredients

SECTION 3: Composition/information on ingredients

M348 6.838 Slope

SECTION 4: First aid measures

SECTION 4: First aid measures

SECTION 4: First aid measures

SECTION 4: First aid measures

SECTION 5: Firefighting measures

5.2 Special hazards arising from the substance or mixture

5.3 Advice for firefighters

SECTION 6: Accidental release measures

6.3 Methods and materials for containment and cleaning up

SECTION 6: Accidental release measures

6.4 Reference to other : See Section 1 for emergency contact information.

SECTION 7: Handling and storage

7.2 Conditions for safe storage, including any incompatibilities

M348 6.838 Slope Standard

7.3 Specific end use(s)

SECTION 8: Exposure controls/personal protection

8.2 Exposure controls

SECTION 8: Exposure controls/personal protection

SECTION 9: Physical and chemical properties

SECTION 9: Physical and chemical properties

SECTION 10: Stability and reactivity

10.4 Conditions to avoid : M348 7.382 Calibration Standard No specific data.

10.5 Incompatible materials : M348 7.382 Calibration Standard No specific data.

SECTION 11: Toxicological information

SECTION 11: Toxicological information

Conclusion/Summary : M348 7.382 Calibration Standard Not available.

SECTION 11: Toxicological information

M348 6.838 Slope Standard

Information on the likely : Not available.

Symptoms related to the physical, chemical and toxicological characteristics

SECTION 11: Toxicological information

Conclusion/Summary : M348 7.382 Calibration Standard Not available.

Other information : Not available.

SECTION 12: Ecological information

12.2 Persistence and degradability

12.3 Bioaccumulative potential

SECTION 12: Ecological information

12.4 Mobility in soil

12.5 Results of PBT and vPvB assessment

SECTION 13: Disposal considerations

SECTION 14: Transport information