BUN
BUN
BUN
2. Hazards identification
Physical state : Liquid.
OSHA/HCS status : This material is considered hazardous by the OSHA Hazard Communication Standard
(29 CFR 1910.1200).
Emergency overview : WARNING!
CAUSES EYE AND SKIN IRRITATION. CONTAINS MATERIAL THAT MAY CAUSE
TARGET ORGAN DAMAGE, BASED ON ANIMAL DATA.
Irritating to eyes and skin. Avoid breathing vapor or mist. Avoid contact with eyes, skin
and clothing. Contains material that may cause target organ damage, based on animal
data. Wash thoroughly after handling.
Not available.
Potential acute health effects
Inhalation : No known significant effects or critical hazards.
Ingestion : No known significant effects or critical hazards.
Skin : Irritating to skin.
Eyes : Irritating to eyes.
Potential chronic health effects
Chronic effects : Contains material that may cause target organ damage, based on animal data.
Carcinogenicity : No known significant effects or critical hazards.
Mutagenicity : No known significant effects or critical hazards.
Teratogenicity : No known significant effects or critical hazards.
Developmental effects : No known significant effects or critical hazards.
Fertility effects : No known significant effects or critical hazards.
Target organs : Contains material which causes damage to the following organs: blood, kidneys, upper
respiratory tract, skin, eye, lens or cornea.
Over-exposure signs/symptoms
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2. Hazards identification
Inhalation : No specific data.
Ingestion : No specific data.
Skin : Adverse symptoms may include the following:
irritation
redness
Eyes : Adverse symptoms may include the following:
pain or irritation
watering
redness
See toxicological information (section 11)
3. Composition/information on ingredients
United States
Name CAS number %
glycerin 56-81-5 30
mannitol, d- 69-65-8 20
poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy- 25322-68-3 5
Canada
Name CAS number %
glycerin 56-81-5 30
There are no additional ingredients present which, within the current knowledge of the supplier and in the
concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in
this section.
5. Fire-fighting measures
Flammability of the product : In a fire or if heated, a pressure increase will occur and the container may burst.
Extinguishing media
In case of fire, use water spray (fog), foam or dry chemical.
Not suitable : None known.
Special exposure hazards : Promptly isolate the scene by removing all persons from the vicinity of the incident if
there is a fire. No action shall be taken involving any personal risk or without suitable
training.
Hazardous combustion : Decomposition products may include the following materials:
products carbon dioxide
carbon monoxide
Special protective : Fire-fighters should wear appropriate protective equipment and self-contained breathing
equipment for fire-fighters apparatus (SCBA) with a full face-piece operated in positive pressure mode.
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11 . Toxicological information
United States
Acute toxicity
Product/ingredient name Result Species Dose Exposure
glycerol LD50 Rat 4420 mg/kg -
Intraperitoneal
LD50 Intravenous Rat 5566 mg/kg -
LD50 Oral Rat 12600 mg/kg -
LD50 Rat 100 mg/kg -
Subcutaneous
LDLo Rat 10 mL/kg -
Intramuscular
LDLo Rat 10 mg/kg -
Intramuscular
TDLo Rat 8 mL/kg -
Intramuscular
TDLo Rat 4 mL/kg -
Intramuscular
TDLo Rat >5000 mg/kg -
Intramuscular
TDLo Rat 4000 mg/kg -
Intramuscular
Chronic toxicity
Not available.
Carcinogenicity
Not available.
Mutagenicity
Not available.
Teratogenicity
Not available.
Reproductive toxicity
Not available.
Canada
Acute toxicity
Product/ingredient name Result Species Dose Exposure
glycerol LD50 Rat 4420 mg/kg -
Intraperitoneal
LD50 Intravenous Rat 5566 mg/kg -
LD50 Oral Rat 12600 mg/kg -
LD50 Rat 100 mg/kg -
Subcutaneous
LDLo Rat 10 mL/kg -
Intramuscular
LDLo Rat 10 mg/kg -
Intramuscular
TDLo Rat 8 mL/kg -
Intramuscular
TDLo Rat 4 mL/kg -
Intramuscular
TDLo Rat >5000 mg/kg -
Intramuscular
TDLo Rat 4000 mg/kg -
Intramuscular
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11 . Toxicological information
Chronic toxicity
Not available.
Carcinogenicity
Not available.
Mutagenicity
Not available.
Teratogenicity
Not available.
Reproductive toxicity
Not available.
12 . Ecological information
Environmental effects : No known significant effects or critical hazards.
United States
Aquatic ecotoxicity
Product/ingredient name Test Result Species Exposure
glycerol - Acute LC50 54 to Fish - Rainbow 96 hours
57 ml/L Fresh trout,donaldson
water trout -
Oncorhynchus
mykiss - 0.9 g
Polyethylene glycol 135 - Acute LC50 Fish - Rainbow 96 hours
>20000000 ug/L trout,donaldson
Fresh water trout -
Oncorhynchus
mykiss - 25 to 50
g
- Acute LC50 Fish - Atlantic 96 hours
>1000000 ug/L salmon - Salmo
Fresh water salar - Parr - 8.2
to 11.7 cm - 5.1
to 14.1 g
Biodegradability
Not available.
Canada
Aquatic ecotoxicity
Product/ingredient name Test Result Species Exposure
glycerol - Acute LC50 54 to Fish - Rainbow 96 hours
57 ml/L Fresh trout,donaldson
water trout -
Oncorhynchus
mykiss - 0.9 g
Polyethylene glycol 135 - Acute LC50 Fish - Rainbow 96 hours
>20000000 ug/L trout,donaldson
Fresh water trout -
Oncorhynchus
mykiss - 25 to 50
g
- Acute LC50 Fish - Atlantic 96 hours
>1000000 ug/L salmon - Salmo
Fresh water salar - Parr - 8.2
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12 . Ecological information
to 11.7 cm - 5.1
to 14.1 g
Biodegradability
Not available.
13 . Disposal considerations
Waste disposal : The generation of waste should be avoided or minimized wherever possible. Empty
containers or liners may retain some product residues. This material and its container
must be disposed of in a safe way. Dispose of surplus and non-recyclable products via
a licensed waste disposal contractor. Disposal of this product, solutions and any by-
products should at all times comply with the requirements of environmental protection
and waste disposal legislation and any regional local authority requirements. Avoid
dispersal of spilled material and runoff and contact with soil, waterways, drains and
sewers.
Not available.
Disposal should be in accordance with applicable regional, national and local laws and regulations.
Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
for additional handling information and protection of employees.
14 . Transport information
International transport regulations
DOT Classification
UN number Not regulated.
Proper shipping -
name
Classes -
PG* -
Label
Additional - No additional remark.
information
TDG Classification
UN number Not regulated.
Proper shipping -
name
Classes -
PG* -
Label
Additional -
information
Mexico
Classification
UN number Not regulated.
Proper shipping -
name
Classes -
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14 . Transport information
PG* -
Label
Additional -
information
IMDG Class
UN number Not regulated.
Proper shipping -
name
Classes -
PG* -
Label
Additional -
information
IATA-DGR Class
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15 . Regulatory information
United States
HCS Classification : Irritating material
Target organ effects
U.S. Federal regulations : TSCA 8(b) inventory: mannitol, d-; .Water; glycerin
SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: glycerol
SARA 311/312 MSDS distribution - chemical inventory - hazard identification:
glycerol: Immediate (acute) health hazard, Delayed (chronic) health hazard
Clean Water Act (CWA) 307: No products were found.
Clean Water Act (CWA) 311 No products were found.
Clean Air Act (CAA) 112 accidental release prevention: No products were found.
Clean Air Act (CAA) 112 regulated flammable substances: No products were found.
Clean Air Act (CAA) 112 regulated toxic substances: No products were found.
State regulations : Rhode Island Hazardous Substances: glycerin
Pennsylvania RTK Hazardous Substances: glycerin: (generic environmental hazard)
Minnesota: poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-; glycerin
Massachusetts Substances: glycerin
United States inventory : All components are listed or exempted.
(TSCA 8b)
Use only for medical diagnostic (R&D) purposes
Canada
WHMIS (Canada) : Not a WHMIS controlled material.
Canadian lists : CEPA DSL: mannitol, d-; Water; glycerin
16 . Other information
EU regulations
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16 . Other information
To the best of our knowledge, the information contained herein is accurate. However, neither the above-named
supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the
information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present
unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot
guarantee that these are the only hazards that exist.
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