SALT Room STA-Reference-and-Resources-Guide-022819-RED

Dry Salt Therapy
(Halotherapy)
Reference & Resource Guide
Clinical Studies and Medical Research
DISCLAIMER: While there are many clinical and scientific studies conducted on dry salt therapy (halotherapy) throughout the world, the FDA has not
evaluated the statements made throughout this document. Dry salt therapy is not intended to diagnose, treat, cure or prevent any disease.
Copyright © 2019 Salt Therapy Association All rights reserved. Reproduction of this content without the express written consent of Salt Therapy Association is
prohibited.
Table of Contents Page
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The Evolution of Halotherapy (Dry Salt Therapy) 5
The Halogenerator 6
Halotherapy in the United States 6
How Dry Salt Therapy Works (The 3 Fundamentals of Dry Salt Therapy) 7
Dry Salt Therapy and the Skin 7
Who Benefits from Dry Salt Therapy 8
How Dry Salt Therapy is Offered 9
Length of Session 9
Side Effects/Contraindications 10
Salt Concerns 10
Salt Type and Quality 10
Treatment Sessions 11
Dry Salt Therapy Treatment Protocols 11
Clinical Research and Medical Evidence 12
Salt Therapy Association  www.SaltTherapyAssociation.org  844-STA-INFO

Clinical Studies: Click on the page name to go there directly

Pulmonary and Sleep Disorders. 13
Halotherapy in Patients with Cystic Fibrosis: A Pilot Study. 14-16

Halotherapy of Respiratory Diseases. 17-26
Halotherapy in Controlled Salt Chamber Microclimate for Recovering Medicine. 27-35
Halotherapy History and Experience of Clinical Application. 36-42
Prospects of Halotherapy in Sanatorium and Spa Dermatology and Cosmetology. 43-44
Halotherapy for Treatment of Respiratory Diseases. 45-56
Effect of Dry Sodium Chloride Aerosol on the Respiratory Tract of Tobacco Smokers 57-60
The scientific validation and outlook for the practical use of halo-aerosol therapy.
Halotherapy for treatment of respiratory diseases. 61
The use of halotherapy for the health improvement in children at institutions of

general education. 62
The use of halotherapy for the rehabilitation of patients with acute

63
bronchitis and a protracted and recurrent course.
SALT-ED (salt therapy education) What All Types of Spas, Wellness Facilities, and
Salt Therapy Providers Need to Know about Misconceptions Regarding Himalayan 64-69
Salt.
Halotherapy in the combined treatment of chronic bronchitis patients. 70
The use of an artificial microclimate chamber in the treatment of

71
patients with chronic obstructive lung diseases.
Effectiveness of halotherapy of chronic bronchitis patients. 72
Effects of halotherapy on free radical oxidation in patients with chronic bronchitis. 73

Efficacy of therapeutic use of ultrasound and sinusoidal modulated currents
combed with halotherapy in patient with occupational toxic-dust bronchitis. 74
Salt caves as simulation of natural environment and significance of halotherapy. 75

Halotherapy as asthma treatment in children: A randomized, controlled,
76
prospective pilot study.

Clinical Studies: Click on the page name to go there directly

Halotherapy in the combined treatment of chronic bronchitis patients. 77
The role of non-medicamental technologies in the rehabilitation of the children

presenting with acute rhinosinusitis. 78
Theoretical basis and clinical benefits of dry salt inhalation therapy. 79
Bronchial hyperreactivity to the inhalation of hypo- and hyperosmolar aerosols

and its correction by halotherapy. 80
The Effect of Salt Chamber Treatment on Bronchial Hyperresponsiveness in

Asthmatics. 81-86
Salt Halo Therapy and Saline Inhalation Administered to Patients

87-91
with Chronic Obstructive Pulmonary Disease: A Pilot Study.
Impact assessment of saline aerosols on exercise capacity of athletes. 92-96
Surveys on therapeutic effects of "halotherapy chamber with artificial

salt-mine environment" on patients with certain chronic allergenic respiratory 97-101
pathologies and infectious-inflammatory pathologies.
SALTMED: The Therapy with Sodium Chloride Dry Aerosols. 102-105
A Review of Halotherapy for Chronic Obstructive Pulmonary Disease. 106-113
Double-Blind Placebo-Controlled Randomized Clinical Trial on Efficacy of

Aerosal® in the Treatment of Sub-Obstrucive Adenotonsillar Hypertrophy and 114-120
Related Diseases.
Halotherapy and Buteyko Breathing Technique - a possible successful

combination in relieving respiratory symptoms. 121-122
Halotherapy - An Alternative Method for the Treatment of Respiratory

Diseases. 123-127
Halotherapy - Benefits and Risks 128-132

Dry Sodium Chloride Against Acute Respiratory Infections 133-138

The Evolution of Halotherapy (Dry Salt Therapy)

Modern dry salt therapy (halotherapy) can date its origins to the salt mines in Europe and
Russia, where it was called speleotherapy, a respiratory therapy which involves the
breathing of salt-infused air in a micro-climate of a salt mine. It was first officially
recognized as a therapy in 1843 by Polish physician Dr. Feliks Boczkowski, who noticed
that the salt mine workers rarely suffered from respiratory issues.
Miners, who chiseled, ground, and hammered the salt, produced micro-sized particles that
were dispersed into the air and inhaled. Additionally, there were ideal conditions below
the Earth’s surface where air pressure and circulation, and humidity and temperature
affected the quality of the environment. The air lacks airborne pollutants such as pollen
and radon. In this environment, miners were receiving many natural health benefits by
breathing in the salt particles.
Impressed with the positive health benefits he witnessed in the salt mines, Dr. Boczkowski
founded and opened the first health resort facility at the Wieliczka Salt Mine in Poland.
Throughout Eastern Europe, others started using hollowed-out areas of salt mines, which
were referred to as "caves", as underground health resorts and sanatoriums.
People would often spend days in the salt mines since speleotherapy was providing a
significant positive impact on their health and wellbeing. Realizing that most people didn’t
have the time to spend in a salt mine or "cave", nor the financial resources to travel there,
the Russians started to investigate developing the technology of how to recreate the
microclimate of these micro-sized particles for inhalation.
In 1976, Russian doctors and scientists created the first halogenerator, which replicated
the conditions of salt mines, and halotherapy, the above-ground alternative for
speleotherapy, was born.

The Halogenerator
A halogenerator is a machine that intakes air and is comprised of a salt feeder, and a
grinder or blade cutting mechanism that transforms pure grade sodium chloride into
precise micro-sized salt particles and disperses the dry salt aerosol via a fan through an
opening into a salt therapy room.
The depth of penetration into the airways is largely determined by particle size. In order
to guarantee that the inhaled salt reaches not only the main respiratory tract and the
bronchi but also the bronchiole and alveoli, the particle size should be between 0.1 and
5 microns, with 80% or greater smaller than 2 microns.
In Europe, halogenerator technology has evolved to the point that some medical device
companies are now manufacturing halogenerators, which are being used by medical
facilities and hospitals throughout Europe. When you can control the particle size and
the concentration of how much salt is being inhaled; that’s where the efficacy comes
from this modality. Clinical studies have been done with halogenerators that have
consistent particles sizes where concentration levels can be controlled, and dosing and
protocols can be established.
Halotherapy in the United States

In the United States, dry salt therapy (halotherapy) started approximately 10 years ago
with about a dozen facilities, and over the years, growing not as a trend but as an
industry, over 1,000 salt therapy facilities are now expected by 2020. The restraints of
the United States healthcare system, which includes FDA approval, pharmaceutical and
insurance companies, medical lobbyists, and other restrictions are the only deterrents
affecting its progress.
More clinical studies need to be performed and validated in the United States in order
to be more widely accepted by the medical community, but there is proven success,
effectiveness, and results in using dry salt therapy as a complementary and alternative
treatment in conjunction with respiratory issues, skin conditions, and overall general
wellness.

How Dry Salt Therapy Works

The 3 Fundamentals of Dry Salt Therapy
There has been lots of science about hypertonic saline solutions in terms of nebulizer
treatments, wet salt therapy solutions and saline, so utilizing salt and saline in medical
environments is not something that is foreign. This is a dry salt application designed through
a delivery mechanism of inhalation, and due to the particle size, it’s able to penetrate the
epidermis at the surface level.
Super Absorbent - Dry salt acts like a sponge attracting foreign substances along its path
through the respiratory tract. The dry salt can be imagined behaving like a toothbrush that
cleans the respiratory system removing the build-up of foreign elements that cause various
respiratory ailments and conditions. Dry salt aerosol is also very hygroscopic. As quickly as it
can, it attracts as much moisture as possible. When salt particles are inhaled and deposited
on the mucus on the bronchial tree, the mucus is liquefied, which facilitates its easy
expectoration. Sputum is loosened and can then be removed by coughing. The obvious
advantage of this is that any blocking of the airways caused by the mucus is removed.
Dry salt aerosol also works as a mucokinetic agent and can increase the effectiveness of a
cough, either by increasing expiratory cough airflow or by unsticking highly adhesive
secretions from the airway walls. Salt stimulates the bronchial self-cleaning mechanism and
can, therefore, act as an expectorant. This slight stimulation removes the mucus faster.
Anti-Inflammatory - Inhaled dry salt particles may help to reduce inflammation in the entire
respiratory tract and widen the airway passages. Clinical studies have found that the
inhalation of dry salt aerosol results in decreased colonization of pathogenic bacteria flora. A
clean respiratory system naturally results in higher oxygen intake, increased energy, and an
improved immune system.
Anti-Bacterial - The dry salt particles act as an anti-bacterial agent, dissolving bacteria and
pollutants lodged in the respiratory tract. These are then either coughed up or naturally
expelled by the body.
Dry Salt Therapy and the Skin

The micro-particles of salt also have a beneficial influence to the integument system
(skin protective layer) and hairs providing healing and cosmetic effects. This increases
activity of skin cell ion channels and activates electrophysiological activity that determines
the skin’s protective properties. The dry salt impacts the skin microcirculation and assists
cellular membrane activity used in dermatology and cosmetology and enhances their
effectiveness.
Who Benefits from Dry Salt Therapy?

Halotherapy benefits adults and children alike, as well as athletes and animals. It is
natural and safe and there are no known side effects. Many people who undergo
halotherapy as a complementary treatment on a regular basis may find relief from a
variety of respiratory conditions such as:
• Allergies • Pneumonia
• Asthma • Rhinitis
• Bronchitis • Sinus Infections
• Bronchial Infections • Sinusitis
• Cold and Flu • Smoker’s Cough
• COPD • Snoring & Sleep Apnea
• Cystic Fibrosis • Stress & Fatigue
• Emphysema • Wheezing
Dry salt therapy is also extremely beneficial to your skin in treating:
• Acne • Dermatitis • Swelling & Inflammation

• Eczema • Rosacea • Dry & Flaky Skin
• Psoriasis • Itching • Rashes
• Skin Aging
In addition, dry salt therapy has been shown to reduce:
• Anxiety
• Fatigue
• Stress
The best thing about dry salt therapy, however, is that despite the fact that it can be
used to help treat the respiratory issues and skin conditions listed above, it can be used
by anyone to enhance their overall respiratory hygiene and combat the poor quality of
today's indoor and outdoor air.

How Dry Salt Therapy is Being Offered

Typically, salt therapy is offered via salt therapy rooms in public environments such as
standalone salt therapy facilities, day spas, fitness clubs, med spas and wellness centers,
doctor offices, private country clubs, and destination resorts.
These rooms are specifically designed to control the proper salt concentration and air
ventilation inside a room for people to be able to sit back, relax, breathe, and inhale in
the micro-sized salt particles.
Salt therapy rooms are sometimes referred to as "salt caves" when such things as
Himalayan salt are added to the floor, walls, and ceiling in an effort to make them look
like the original salt caves and mines in Europe. This Himalayan salt, however, is just
decor, and provides no therapeutic value.
Oftentimes, salt therapy is being offered along with yoga, massage, reiki, acupuncture,
sound therapy, and meditation. Children's play rooms are beginning to incorporate salt
therapy, and businesses are starting to hold company meetings in salt rooms.
Length of Session
The amount of salt aerosol inhalation is dependent on two factors:
1. The concentration of salt in the air

2. The length of salt aerosol inhalation
The duration of a salt therapy session is based on the size and cubic volume of air space
in the environment and can be anywhere from 45 minutes in a salt therapy room down
to 10 minutes in smaller, portable salt therapy units. Skin that is exposed will absorb
the micro-sized salt particles that are not inhaled.

Side Effects/Contraindications
There have been a number of clinical studies and research on halotherapy, and, to date,
there are no known contraindications otherwise than what has been recommended based
on the properties of sodium chloride, as well as in health code situations in public
environments, people with any type of:
• Active tuberculosis
• Contagious conditions
• Late stage lung cancer
• Acute issues & fever
• Open wounds & sores
• Cardiac insufficiency
We understand more studies are needed to understand if there are any further
contraindications, but we can confidently say that thousands of individuals have
experienced salt therapy throughout the decades, and none have suggested the
contraindications were present. We also encourage individuals to consult their local
physician before beginning any regiment of dry salt therapy.
Salt Concerns
Some people are concerned about the intake of salt because of issues relating to diet, high
blood pressure, and hypertension. This type of salt intake is connected to the digestive
tract. Dry salt therapy is different as it is associated with the respiratory system. When
inhaled, the amount of micro salt particles entering your respiratory system is extremely
low, so it doesn’t present any risk to your health. It kills bacteria, reduces inflammation, and
expands airways.
There have been no reports stating that inhaling the amount of salt being utilized in a salt
therapy session can provide any type of disruption or elevation of high blood pressure or
hypertension.
Salt Type and Quality

Halotherapy requires the highest-quality salt available, which means that the cleanest salt
available should be used. All the clinical studies and research for halotherapy involve only
using 99.99% pure grade sodium chloride. This salt comes from the earth and seas but goes
through a process eliminating and removing all debris and contaminants. It is not processed
with any additives or caking agents such as table salt.
Treatment Sessions
Based on an individual's condition and symptoms, this can vary, since like many wellness
and health regimens, individuals respond differently. Many individuals will notice a positive
effect in just in one session, however, a series of sessions is recommended for optimal
results.
Some people go two to three times a week for a three to four-week ritual during allergy and
cold seasons, some people go twice a week for six to eight weeks for more chronic
conditions. Those who go for general wellness, stress relief, and relaxation simply go as
often as they like.
For best results, a series of treatments is recommended. The Salt Therapy Association
additionally recommends using dry salt therapy as a continuous preventive measure to
strengthen the immune system against colds, cough, allergies, and sinusitis. There are some
people who have salt therapy in their homes and do a daily ritual. You cannot overdose
from salt therapy.
*Dry Salt Therapy Treatment Protocols

Although the FDA has yet to establish official protocols for dry salt therapy in the United
States, some European countries have incorporated the following duration of treatment:
*SOURCE:
• Asthma (mild): 12-14 days
• Asthma (severe): 18-21 days MINISTRY OF PUBLIC HEALTH OF THE RUSSIAN FEDERATION, Halotherapy Application
• Acute bronchitis: 12-14 days in Treatment and Rehabilitation of Respiratory Diseases, Methodical Recommendation
No. 95/111, Moscow 1995
• Recurrent bronchitis: 12-14 days
• Chronic simple bronchitis: 18-21 days Methodical recommendation was discussed and approved by the Scientific Board of
the Institute of Pulmonology of the Russian Federation.
• Chronic obstructive bronchitis: 18-21 days
• Pneumonia after acute stage: 12-14 days Clinical-Research Respiratory Center, St. Petersburg – Doctors A.V. Chervinskaya, S.I.
Konovalov, O.V. Strashnova, N.G. Samsonova
• Cystic fibrosis: 20-25 days
• Chronic sinusitis: 14-18 days Institute of Pulmonology of the Russian Federation, Moscow – Doctors A.G. Chchalin,
I.D. Apulcina, I.E. Furman, A.A. Bondarenko, M.V. Samsonova
• Acute sinusitis: 3-5 days
• Hay fever: 12-14 days Pavlov National Medical University, St. Petersburg – Doctors M.S. Pluzhnikov, A.N.
Aleksandrov, I.M. Raznatovskiy, N.N. Tretyakova, K.N. Monachov
• Smokers: 12-14 days
PLEASE NOTE:
For best results, during a course of therapy, chronic sufferers should try to complete sessions as consecutively as possible - daily
is best, but at least 3 times a week are usually needed for challenging cases.
Back-to-back sessions - two in a row - can be greatly beneficial for sinus and skin conditions, though are not always
recommended for chronic lung conditions.
Salt Therapy Association www.SaltTherapyAssociation.org 844-STA-INFO

Clinical Research and Medical Evidence

Salt has been used for its healing and therapeutic qualities for thousands of years from a
variety of geographic regions and cultures. In modern times, dry salt therapy, also called
Halotherapy, has been observed and researched with recorded studies that go as far back
as the early 1800’s from physicians and scientists throughout Europe and the Far East. In
the past few decades, more recent and current clinical studies have been published
showing the efficacy of dry salt therapy and its application to various conditions.
Most of the current research and clinical studies are based in the countries where dry salt
therapy has been a health and wellness modality for the past few decades such as Russia,
Hungary, Poland, Finland, Israel, Italy and other geographic locations. These studies have
been conducted by licensed medical professionals, clinical researchers, and have been
published in various medical journals and publications such as the US National Library of
Medicine and the National Institutes of Health.
Some of the current research and published articles focus on how dry salt therapy impacts
bronchitis, chronic obstructive lung diseases (COPD), asthmatics, dermatology, and other
conditions.
The Salt Therapy Association is also leading the way with supporting additional medical
and clinical studies here in the United States and abroad to further the research,
development and efficacy of dry salt therapy/halotherapy.
The following are some of the published abstracts and clinical and medical studies
conducted with dry salt therapy, halotherapy, dry salt aerosol, etc.
Dr. Alina Chervinskaya, one of the founding directors of the STA, conducted many of the
studies you are about to read. Dr. Daniel T. Layish, who is also a founding director of the
STA, was not only involved with an initial study but he also wrote an article, and has
participated in other activities supporting salt therapy.

Achkar et al. Int J Respir Pulm Med 2015, 2:1
International Journal of ISSN: 2378-3516
Respiratory and Pulmonary Medicine

Research Article : Open Access
Halotherapy in Patients with Cystic Fibrosis: A Pilot Study

Morhaf Al Achkar1*, David E. Geller2, Amanshe Perera Slaney3 and Daniel T Layish3,4
1
Indiana University School of Medicine, Indianapolis, USA
2
Florida State University College of Medicine, Orlando, FL, USA
3
Central Florida Pulmonary Group, USA
4
University of Central Florida College of Medicine, Orlando, FL, USA
*Corresponding author: Morhaf Al Achkar, Indiana University School of Medicine, Indianapolis, IN 46205, USA,
E-mail: [email protected]
airways [3]. In clinical trials hypertonic saline inhalation improved

Abstract
pulmonary function [2,4], and respiratory symptoms, reduced
Objectives: Cystic fibrosis (CF) is a complex genetic disorder pulmonary exacerbations [4,5] and reduced absenteeism from school
involving the lower and upper respiratory tract. The purpose of this or work [5]. Halotherarpy (HT; “halos” means salt in Greek) aims to
study is to evaluate the effect of Halotherapy on sinusitis symptoms, deliver salt particles into the upper and lower airways, and appears to
dyspnea, pulmonary function tests, and quality of life in CF patients.
be a promising alternative method.
Study design: This was a pilot open-label before-and-after-study.
For centuries, especially in Eastern Europe, people have visited
Settings: The study was performed at the Salt Room® Orlando. natural salt caves for the healing properties of the air. Halotherapy
Participants were from a single CF care center, and were enrolled (HT) simulates conditions in a natural salt cave by dispersing salt
in the study between January and June, 2012. particles in a controlled air medium. While similar in principles
Subjects and methods: Patients with clinically stable CF were to hypertonic saline, HT differs in that it delivers dry aerosol
included in the study. Participants received 9 sessions of HT, 45 microparticles (1-5μm) of salt rather than a wet solution [6]. Typically,
minutes each, completed over a 3-week period. Study endpoints a person visits a facility that provides HT services for a period of
include: FEV1 and FVC, Borg dyspnea index test, Cystic Fibrosis 30-60 minutes, where they read or perform relaxing activities while
Questionnaire-Revised (CFQ-R), and the Sino-Nasal Outcome
undergoing halotherapy. Breathing through the nose and mouth
Test (SNOT-20).
allows treatment effect to target the upper and lower airways.
Results: Twelve patients completed the study protocol. FEV1 and
FVC did not change significantly (p= 0.49 and 0.87, respectively). While considered spa treatment, Halotherapy’s effectiveness was
SNOT-20 score improved by 0.62 points (95% CI -1.03 to -0.2, P = evaluated in multiple clinical trials. HT was studied in 139 patients with
0.007). There was a trend for improvement in Borg Dyspnea index; respiratory diseases, among whom 5 had CF. Improvements in flow-
the mean score decreased by 0.79 (95% CI -1.64 to 0.05, P=0.065). volume loop parameters and decreased bronchial resistance measured
There was significant improvement in the physical domain, the by plethysmography were reported after 10-20 sessions. The CF
health perception domain, and the digestive domain.
patients were reported to have similar response with the treatment [7].
Conclusion: HT is associated with improvement in symptoms Another recent study showed an increase in lung function and sputum
of sinus disease in CF, and should be explored as an adjunct production in 6 CF subjects after only 5 halotherapy sessions [7].
treatment for CF patients.
As a pilot work to assess feasibility, evaluate effectiveness, and
gather clinical data to better estimate sample size for an experimental
Introduction study, we used a pre- and post- test study design to assess the effect of
Cystic fibrosis (CF) is a complex genetic disorder characterized by HT on the pulmonary and sinus symptoms, dyspnea, and quality of
dehydration of the respiratory epithelial surface resulting in impaired life in CF patients.
mucociliary clearance [1,2]. Thick, sticky secretions obstruct the lower
Methods
airways and sinuses, providing an environment for chronic infection.
A significant proportion of CF patients experience experience sinus This open-label study was performed at the Salt Room Orlando,
symptoms and almost all have radiographic findings of chronic which provided the facilities for HT. Patients from a single CF care
sinusitis. Increasing the volume of airway surface liquid improves center (Central Florida Pulmonary Group, Orlando, FL, USA) were
mucus clearance in patients with CF [2,3]. Inhaled hypertonic saline enrolled in the study between January and June of 2012. Study
is one method used in patients older than 6 years to rehydrate the endpoints were measured twice: before the first and after the last HT
Citation: Achkar MA, Geller DE, Slanely AP, Layish DT (2015) Halotherapy in Patients
with Cystic Fibrosis: A Pilot Study. Int J Respir Pulm Med 2:009
ClinMed Received: November 28, 2014: Accepted: December 30, 2014: Published: January
04, 2015
International Library Copyright: © 2015 Achkar MA. This is an open-access article distributed under the terms of
the Creative Commons Attribution License, which permits unrestricted use, distribution, and
reproduction in any medium, provided the original author and source are credited.
Table 1: Baseline Characteristics of the 12 Patients
3
Age 35.11
2.5
Female 8 (66.7%)
2
FEV1 (L)(% predicted) 1.841.7 +/- 0.75 (56.17)
FVC (L) 2.8183 +/- 0.98 1.5
FEV1/FVC 65.3% +/-12.73% 1

SNOT 20 1.48 +/-0.65
0.5
Borg Dyspnea Score 2.17 +/- 1.09
0
CFQ-R
Before After
The physical domain 57.6+/-23.0
The Vitality Domain 56.9 +/- 15.8 Figure 1: Individual patient SNOT 20 scores before and after HT
The Emotion Domain 83.3 +/- 14.6

The eating domain 96.3 +/- 9.9
4.5
The treatment burden 55.5 +/- 20.6
4
Health perception 63.9 +/- 12.6
3.5
The Social Domain 65.7 +/- 12.3
3
Body Image 84.2 +/-23.4
2.5
Role Domain 85.4 +/- 13.4
2
Weight domain 66.7 +/- 37.6
1.5
Respiratory domain 54.6 +/- 18.9
1
The digest domain 81.5 +/- 13.8
0.5
All values except gender are stated +/- SD 0
Before After
Table 2: Effect of Halotherapy on Lung Function, SNOT, and Borg Score
Figure 2: Individual patient Borg scores before and after HT
FEV1 -0.0192 (95% CI -0.0781 to 0.0398, P=0.49)
FVC -0.010(95% CI -0.1202 to 0.1402, P=0.87).
Table 3: Effect of Halotherapy on CFQ-R**
SNOT 20 -0.62(95% CI -1.03 to -0.2, P=0.007)*.
Borg Score -0.79(95% CI -1.64 to 0.05, P=0.065). Physical domain 8.33 (95% CI 4.09 to 12.57, P = 0.001)*
Vitality Domain 6.25 (95% CI -2.97 to 15.47, P = 0.16)
Emotion Domain 3.95 (95% CI -1.98 to 9.90, P = 0.176
session. The ethics committee at Quorum Review Board approved the
Eating domain 0 (correlation and t test can’t be computed since values
study. Each participant provided written informed consent or assent. were unchanged)
The trial was designed and executed by the academic investigators. Treatment Burden 1.85 (95% CI -9.72 to 13.42, P = 0.73)
The Salt Room Orlando provided the HT sessions and information Health perception 10.18 (95% CI 3.19 to 17.15, P = 0.008)*
on participants attendance but otherwise did not participate in the Social Domain 5.092 (95% CI 1.95 to 12.14, P = 0.14)
design and conduct of the study, in the analysis and interpretation of Body Image -4.62 (95% CI -11.03 to 1.77, P = 0.14)
the data, or in the writing or review of the manuscript. Role Domain 0.00 (95% CI -6.81 to 6.81, P = 1.0)
The inclusions criteria were the following: History of CF and the Weight domain 5.55 (95% CI -10.54 to 21.65, P = 0.46)
following, age 15 years and older, clinically stable on their medical Respiratory domain 9.25 (95% CI -2.94 to 21.46, P = 0.124)
regimen for at least a month prior to enrollment, forced vital capacity Digestive domain 10.18 (95% CI 4.39 to 15.97, P = 0.002)*
(FVC)>40% of predicted value, forced expiratory volume in one * Statistically significant difference
second (FEV1) between 30% and 85% of predicted value, and a score
** For each domain in the CFQ-R a higher score indicated improvement.
of 10 or above on the rhinologic domain of the Sino-Nasal-Outcome Highest possible =100.
Test-20 (SNOT 20), which is a validated patient-outcome reported
measure with four sub-domain: psychological function, rhinological
symptoms, sleep function, and ear and/or facial symptoms [8]. Physical*
100
Participants who had received antibiotics or corticosteroids for the Digest* Vitality
80
treatment of a pulmonary exacerbation within 30 days, had taken
60
hypertonic saline within two weeks, or had used HT previously were Respiratory Emotion
40
all excluded from the study. Patients were screened for eligibility in the
clinic, prior to enrollment. Eligible participants, based on the available 20
Before
Weight Eating
clinical information, returned for a baseline visit within one week of 0
After
screening. At the baseline visit patients provided written consent,
had a medical history and physical exam, performed spirometry, Role Treatment Burden
and answered questionnaires, including the Borg dyspnea index test,
Cystic Fibrosis Questionnaire-Revised (CFQ-R), and the Sino-Nasal Body Image Health Perceptions*
Outcome Test (SNOT-20). Social
Results Figure 3: CFQR domains
The score on the CFQ-R domains ranges from 0, the worst score (poor
Between January and June of 2012, twelve participants completed health), to 100, the best score (good health). Asterisks indicate P<0.05 for the
the study protocol, including all 9 sessions of HT. Two additional comparison between before- and after- treatment.
patients met the inclusion criteria but they developed respiratory
exacerbations before starting the treatment and were excluded
SNOT-20 Table 2 score (Figure 1) improved by 0.62 points (95% CI
from the analysis. Every participant completed medical history and
-1.03 to -0.2, P=0.007). There was a trend for improvement in Borg
physical exam, spirometry test, and sets of questionnaires (Borg,
Dyspnea index (Figure 2); the mean score decreased by 0.79 (95%
CFQ-R, SNOT-20). During the course of the study the participants
CI -1.64 to 0.05, P=0.065). Among the CFQ-R Table 3 domains
continued on their standard regimen of treatment for CF.
there was significant improvement in the physical domain, the
The baseline characteristics of the participants are shown in Table health perception domain, and the digestive domain. The respiratory
1. The average duration of follow up was 3 weeks. FEV1 and FVC domain improved by an average of 9.25 points, and while this is well
did not change significantly (p value of 0.49 and 0.87, respectively). above the recognized clinically important difference of 4 points, the
Achkar et al. Int J Respir Pulm Med 2015, 2:1 ISSN: 2378-3516 • 31
change did not reach significance (p=0.124). All the other domains In conclusion, this exploratory study has demonstrated that
showed no significant change (Figure 3). There were no reports of HT may have some benefit in CF patients with symptomatic sinus
chest tightness or wheezing as a direct result of the HT. disease. Longer studies, using particularly a randomized controlled
study design, are necessary to better evaluate the effects of HT on
Discussion other outcomes and on patients with asymptomatic sinus disease.
This pilot study of HT is the first to include assessment of Acknowledgment
pulmonary function, dyspnea scores, sinus symptoms, and quality
We thank the Salt Room® Orlando for the treatment sessions. We also thank
of life exclusively in patients with CF. Hypertonic saline has long the Central Florida Pulmonary Group for performing the pulmonary function tests.
been used successfully in CF, and HT is thought to work similarly in
The authors thank Global Clinical Research Management for their assistance
clearing the thick mucus secretions. A potential advantage of HT is with data organization.
the osmotic effects of salt particles both in the nose and sinuses as well
as the lower airways. Hypertonic saline inhalation functions mainly Conflict of interest
in the lower airways, and may also be used via lavage or nebulization Daniel Layish MD sits on the Board of Directors of the Salt Therapy
to the sinuses, but this is a separate procedure. Hypertonic saline Association and serves as Medical Advisor for the Salt Room® Orlando. Dr.
can provoke bronchospasm in susceptible individuals; none of the Geller is currently employed by AbbVie, Inc in North Chicago, IL.
participants in our study reported such symptoms.
The symptomatic improvement in the sinus symptoms may relate References
to the ability of the salt particles from HT to reach a target in the 1. Flume PA, Robinson KA, O’Sullivan BP, Finder JD, Vender RL, et al. (2009)
sinuses and stimulate mucus clearance. In this study, we enrolled Cystic fibrosis pulmonary guidelines: airway clearance therapies. Respir Care
only participants with significant baseline sinus symptoms (score >10 54: 522-537.
on the SNOT-20 rhinosinusitis domain). HT may not have similar 2. Donaldson SH, Bennett WD, Zeman KL, Knowles MR, Tarran R, et al. (2006)
effects on patients with absent or minimal sinus symptoms. Mucus clearance and lung function in cystic fibrosis with hypertonic saline. N
Engl J Med 354: 241-250.
The improvement in some of the CFQ-R domains must be
3. Ong T, Ramsey BW (2013) Modifying disease in cystic fibrosis: current and
interpreted with caution as the study population was relatively small. future therapies on the horizon. CurrOpinPulm Med 19: 645-651.
The improvement in physical activity score may infer improved
4. Elkins MR, Robinson M, Rose BR, Harbour C, Moriarty CP, et al. (2006) A
exercise capacity, which helps preserve pulmonary function [10]. controlled trial of long-term inhaled hypertonic saline in patients with cystic
The improvement was also significant in the health perception and fibrosis. N Engl J Med 354: 229-240.
digestive domains. One could speculate that the digestive domain 5. Elkins MR, Robinson M, Rose BR, Harbour C, Moriarty CP, et al. (2006) A
may be influenced by better sinus function by improving olfactory controlled trial of long-term inhaled hypertonic saline in patients with cystic
sensation, and therefore appetite. fibrosis. N Engl J Med 354: 229-240.
Our study had some limitations. Since this was an open-label 6. Chervinskaya AV, Zilber NA (1995) Halotherapy for treatment of respiratory
diseases. J Aerosol Med 8: 221-232.
study, we could not evaluate whether the improvement in the
reported symptoms were due to subjective effects or objective 7. Graepler-Mainka U (2011) Dry powder inhalation with NaCl for increasing
secretolysis in cystic fibrosis patients-a pilot study. Preneted at the European
physical benefits. While there were clear trends toward improvement Cystic Fibrosis Conference, Hamburg, Germany.
in dyspnea perception, our pilot study was not powered enough to
8. Pynnonen MA, Kim HM, Terrell JE (2009) Validation of the Sino-Nasal
detect the change. The improvement in sinus symptoms was based on
Outcome Test 20 (SNOT-20) domains in nonsurgical patients. Am J Rhinol
patient report, but was not validated by objective measures like sinus Allergy 23: 40-45.
imaging. While the study was too short to evaluate outcomes like
9. Chaaban MR, Kejner A, Rowe SM, Woodworth BA (2013) Cystic fibrosis
reduction in antibiotics or surgery, our initial findings suggest that a chronic rhinosinusitis: a comprehensive review. Am J Rhinol Allergy 27: 387-
more detailed and longer-term study may be worthwhile to evaluate 395.
those important outcomes. Longer-term studies are also necessary 10. Hulzebos E, Dadema T, Takken T (2013) Measurement of physical activity
to evaluate the effect of HT on pulmonary exacerbations and lung in patients with cystic fibrosis: a systematic review. Expert Rev Respir Med
function. Examining the quantity or rheologic characteristics of 7: 647-653.
sputum might also be considered in further studies, as well as the
effects of HT on bacterial colonization.
Achkar et al. Int J Respir Pulm Med 2015, 2:1 ISSN: 2378-3516 • Page 3 of 3 •

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BIOKLlMATOLOGIA
Halotherapy in Controlled Salt Chamber

Microclimate for Recovering Medicine
Prof. dr med. ALlNA CHERVINSKAYA *
Clinical Research Respiratory Center of Central Clinical Hospital 122 of Federal
Medical and Biological Agency, St. Petersburg
Summary
The review presents the method of halo therapy which models the microclimate
parameters of salt speleoclinics. It gives historical data on the method develop-
ment, principles and advantages of halo therapy by means of controlled microc-
limate. The influence of the main curing factor - the dry fine-grained sodium
chloride aerosol, and pathophysiological basis of curing effect of the halotherapy
method are under review in the article. The article describes the method of con-
trolled halotherapy and its technology, that is the halo complex equipped with
a controlled halogenerator.
Data on clinical efficacy and the grounds for the method usage in the recovering
treatment for bronchopulmonary and otorhinolaryngologic pathologies, skin
diseases and combined cardiovascular pathology, as well as preventive measures
against respiratory diseases are cited. Efficacy of halotherapy in treatment and
recovery of children is under review. Foundations for perspective usage of halo-
therapy in all kinds of medical and recovering establishments are given.
Key words: halotherapy, speleotherapy, drug free method, salt room, salt cave,
salt chamber, halochamber, halocomplex, halogenerator, dry sodium chloride ae-
rosol, respiratory diseases.
Balneol. Pal. TOm 49 Nr 2 (108) str. 133-141
Beginnings of halotherapy to assume, that air sated with particles of salt has
a therapeutic action. In 1958 in the salt mines of
In the last decade the usage of therapeutic air with Velichka, Krakow province, the first salt medical
the modeling of natural factors has become notable resort for patients with lung diseases was founded.
among physical methods used in recovering and Today speleotherapy has become a conventional
resort medicine. effective non-drug method of treatment. In many
Speleotherapy (ST) is one of the methods which countries they created speleotheraputic clinics on
have given rise to further development of the the basis of natural caves - Austria (Salzebad-
whole trend in modern recovering medicine. ST Salzeman), Poland (Velichka), Romania (Siget), r
«<speleon»- Greek - «cave») - means usage of the Azerbaijan (Nakhichevan), Kirgistan (Chon-Tuz),
underground caves micro climate for treatment. Russia -Perm area (Berezniki), Carpatho-Ukraine
The most perspective and popular trend ofST is the
treatment in the microclimate of salt caves(as a rule
(Solotvino), Ukraine (Artemovsk, Donetsk area),
Byelorussia (Soligorsk). Speleotherapeutic clinics
t
they are former salt mines). The overwhelming mass are mainly located at a depth of 200 - 300 meters.
of all rock-salt deposit was formed in the Permian
geological epoch. Ancient underground salt deposit
Some of them (Duz-Dag, Chon-Tuz) are situated
at a height of midmontane above sea level.
1
is used for salt extraction (halite, sylvinite). The microclimate of different speleotherapeutic
In 1843 a Polish doctor F.Bochkowski was the first clinics (temperature, humidity, air composition, t
133 Balneologia
IIi!l!1ID 11 <WleClen-czerWlec
.. , . 2007
t
•r
HALOTHERAPY IN CONTROLLED SALT CHAMBER MICROCLlMATE FOR RECOVERING MEDICINE
presence of aeroions and others) has specific salt speleoclinics in ground-based premises. The
features. It is characterized by temperature and method of usage the salt caves microclimate in
pressure constancy, gas corn position of the air, low ground-based premises in mid 80s was given the
relativehumidity, increased content of negativeions, name of «halotherapy» in St. Petersburg, Russia
absence of bacterial flora and allergens, slightly «<hals»-Greek- «salt»). Later while using premises
increased content of carbonic acid. The main for treatment they started to apply other names,
component that determines special efficacy of such as «speleoclimatotherapy», «speleotherapy»
treatment especially in salt caves is the presence of and others. In the scientific publications method
the finest salt particles in the air - dry salt aerosol halotherapy (HT) is called «haloaerosol therapy»
of certain density (concentration) and particle size. as well.
The salt speleoclinics treat patients with chronic Aggregate usage of active factors of salt caves, and
lung diseases (CLD) with the medical action of namely dry sodium chloride aerosol as the main
air sated with particles of rock salt. factor, certain stable comfortable room temperature
Aerosol composition in speleoclinics depends on and optimum air moisture have recently got the
the structure of speleo forming rocks. The main definition of «speleo impact».
component of aerosol in salt caves is sodium
chloride. It is the main component of halite Technique of the method
speleoclinics (Solotvino, Velichka, Chon-Tuz
and others) and constitutes the major part (60- While modeling the salt cavemicroclimate various
80%) of aerosol in sylvinite speleoclinincs (Perm techniques have been used. Long since the first
Region). Density (concentration) of salt aerosol in attempts to create the microclimate it has been
different speleoclinics varies within 1 to 20 mg/ determined that indoors it is impossible to create
m3, (often from 2 to 5 mg/m3). The fact that the the atmosphere of fine sodium chloride aerosol
natural salt aerosol contains considerable amount with the only use of such passive methods as salt
of respirable particles (1-5fLm) which are the most coating of walls(halite or sylvinite)(23).This method
effective in respiratory tract is of high significance. turned out to be ineffective. Salt bricks which cover
Moreover, it is the salt aerosol which cleans the air the walls can be used only in decorative purposes.
of underground clinics by creating nonbacterial In the premises where along with salt blocks so
and almost sterile atmosphere. called filters -saturators, labyrinth partitions and
ventilation systems served as presumable sources
ST in the microclimate of saltmines has a nonspecific of sodium chloride aerosol, the concentration of
hyposensitizing effect, leads to reduction of aerosol particles has been insignificant or they
infectious and inflammatory process in respiratory were absent; that is the necessary concentration and
apparatus, and stimulates different units oflocal and dispersion of particles has not reproduced.
general protective mechanisms. In the process of Modern theoretical ideas and accumulated practical
treatment the organism adapts to specific properties experience on the formation means and mode
of microclimate which causes reorganization of of behavior of aerosols have revealed that for
functioning of all body systems. Research held in indoor reproduction of therapeutically significant
different speleoclinics made possible to determine parameters of aerosol (concentration, necessary
the ST prescriptions and to develop differentiated contents of respirable particles) special aerosol
complexes of its usage (1, 27, 37). equipment is needed, that is halogenerators - the
ST in salt caves has won the recognition of generators of sodium chloride aerosol. Walls with
patients and physicians as an efficient drug-free salt coating may fulfill only auxiliary functions
method. However, undoubted exclusiveness of the like mental and emotional impact on patients,
method and related to it small number of beds, some maintenance of temperature and moisture
high price of treatment and necessity to move to conditions and air purity (due to interaction
other climatic zones have naturally restricted its with sodium chloride aerosol produced by the
spreading. ST prescription is also restricted with halogenerator), contribute to noise absorbing.
contra-indications which considerably constrict Air saturation with moist aerosol as a result of
the circle of patients. saline solution dispersion by means of inhalers
Tendency to use medicinal quality of salt caves is sometimes used to create the microclimate. The
microclimate for treatment of the wider circle essence of such method is a group inhalation of
of patients has motivated for the search for ways saline solutions. Besides, because ofinstability of
of reconstruction of artificial microclimate in moist aerosol in the indoor air it is almost impossible
medical establishments. ST has underlain the to measure it. Inhalations of saline solutions are
methods which use micro climatic factors of more well-handled through nebuliser.
m!'ID
Balneologial1 ....
{WleClen-czerWlec 200 7 134
Alina Chervinskaya
Another important function of the dry sodium

~
chloride aerosol is to maintain hypobacterial
and allergen-free air. Indoors, where there is
necessary level of dry sodium chloride aerosol, no
"h3no
I
IT7l
'. __ -§-::
LI - I -1 ~_ '~,I.
air purification occurs, and during the treatment 4" -
patients run the risk ofinfectious contamination
]iJi] A
--j
:11' B
... ~C
/'1
concerned with accumulation of products from ~2 n:I=71 6:J1 '"
expired air and secretion of respiratory tract. The
problem also occurs when spraying moist sodium
chloride aerosol which does not possess bactericidal
activity.
Analysis of the impact of sodium chloride
1. Halogenerator 5. Elements of design
micro climate has revealed that for optimization 2, Sensor of salt aerosol 6. Heating appliances
of the one treatment and the whole course duration, 3. Vacuum fan 7. Amlchairs for patients
its high efficacy and safety it is necessary to measure 4. Lamps of general lighting A, B, C, D - doors
out the level of the dry sodium chloride aerosol
concentration taking into account the characteristic A- Main room (halochamber) for patients to stay
features of respiratory diseases as well as those in Band C - Auxiliary premises - Operator's room
of other pathologies. With regard to modern (A) and cloakroom (B)
requirements for representation the microclimate
of salt speleoclinics the method of controlled HT is Fig. 1. Sample plan of controlled halocomplex.
now used (12, 29). The controlled HT provides for
creation and maintenance of all the parameters of
the method, differentiated dosing and controlling treatment modes in the treatment room a sensor of
the level of sodium chloride aerosol in the process continuous control of aerosol mass concentration
of treatment. is installed. The halogenerator's microprocessor
Together with studies of the method acting the processes sensor's signals by feed back coupling and
equipment for its implementation has been developed maintains the prescribed salt aerosol parameters
and improved. The method of controlled HT is by means of automatic tuning to different space of
carried outwith the halocomplex equipment based the room. Microprocessor block can also provide
on the halogeneratorwhich creates and maintains for lightning and ventilation systems between the
the level of natural concentration and parameters treatments. In the treatment room the sensors
of sodium chloride aerosol with several modes of maintain the microclimate with the temperature
treatment by monitoring in the medical facilities of 20-24°C and humidity of 40-60%. As it was
like halochamber, haloroom, haloward. Some mentioned earlier salt coated walls are of auxiliary
institutions with the aim of attraction of clients significance.
call the facility equipped with the halocomplex Halorooms where the halogenerator is located
«salt room», «salt grotto», «salt cave» etc. Such directly in the treatment room have been used
names are often used for rooms with salt coating for HT recently. Halorooms can also function in
of walls bu t not equi pped with halogenerators. The their full value without salt coating. Such a variant
main difference is in the fact that without special which is the most cost-effective has been widely
aerosol equipment it is impossible to create natural used in pediatric practice, preschool institutions
environment of sodium chloride aerosol. and schools where playing environment and special
The halocomplex with controllable microclimate interior design are created.
consists of two equipped rooms as a rule. The main
treatment room is meant for patients sitting in Main treatment factors of
comfortable armchairs. In the adjacent room, the halotherapy in controlled
operator's room is for the staff, the operator, who microclimate
operates the halogenerator and registers patients
(fig.!). The halogenerator provides for feeding of Dry fine-grained sodium chloride aerosol of
the dry fine-grained aerosol composed of prevailing certain ranges with controllable medicinal con-
respirable particles fraction (over 80%). centrations (modes).
At present halogenerators GDA 01.17,HALOSPA- The main mass of particles in aerodispersed envi-
Ol (UAB Halomed, Lithuania) and ASA-01.3(JSC ronment (over 80%) consists of respirable fraction
Aeromed, Russia) is used to equip halocomplexes. (1-5ILm), and it is because of that the aerosol ef-
For the purpose of maintenance of prescribed fectively influence all sections of respiratory tract.
135 Balneologial
~ .. ,
kWleClen-czerwiec 2007
Due to dispersant method of dry aerosol forma- sections of respiratory tract right up to the deepest.
tion by means of heavy mechanical effect on salt Surface energy of dry salt aerosol produced in the
crystals, particles obtain high surface energy and halogenerator is higher if compared with aerosol
negativeelectric charge. Physicochemical properties produced by dispersion ofliquid. Particlesof negative
of dry aerosol determines the specific character of charged aerosol possessonemore important property,
the HT method which characteristic feature is in and namely they stimulate the work of respiratory
multi component curing effect of extremely small epithelium cilia. Studies of absorption ofliquid-
doses of the substance. The concentration of fi- droplet (moist) and dry aerosol of sodium chloride
ne-grained sodium chloride aerosol in treatment in respiratory organs ascertained that the extent of
room is from 1 to 10 mg/m3 and is maintained delay of particles with equal dispersity is higher
within certain limits (modes): the 1st mode - 1,0 in dry aerosol. Moist sodium chloride aerosol
mg/m3; 2nd mode -1,0-3,0 mg/m3; 3rd mode - 3,0- which is fed indoors by means of different types
-5,0 mg/m3; 4th mode - 7,0-10,0 mg/m3 (12). of nebulisers (jet, ultrasound etc.) is less effective as
Dosing and management of salt aerosol parame- compared with the dry one (31,38). Moreover, high
ters are necessary for efficient and safe usage of humidity indoors can cause respiratory discomfort
the method taking into account variety of no- and other side effects.
sological forms. It makes optimization of treat- . Experimental and clinical data have allowed
ment and course duration possible which becomes formulating the idea of mechanisms of HT action.
more and more topical for medical and sanitary The main acting factor is the dry fine-grained
ins ti tu ti ons. sodium chloride aerosol which:
Hypobacterial and allergen-free air. - acts as a physiological osmolar stimulus, improves
Particles of dry salt aerosol which interconnect due rheological properties of bronchial mucus and
to electrostatic interacting forces with particles of assists in ciliated epithelium function;
aerial contamination quicken their settling thus -causes fluid outflow from vessels to bronchus gap
purifying the air in the room. thus assisting in decrease of edema in bronchus
Aeroionization. At decomposition of salt particles walls and stagnation in their vessels;
as a result of heavy mechanical effect in the halo- -stimulates elimination of opportunistic microflora
generator obtain high surface energy and negative (5. neumoniae, H. influenzae and etc.);
electric charge. When aerosol particles interact - has a bacteriostatic effect;
with air molecules it causes aeroionization of air - increases the number of phagocytes of respiratory
(6-10 nK/m3). Light negative ions are accessory tract and intensify phagocytic activity (increase in
factors of therapeutic impact on the organism macrophages activity);
and purification of indoor air. -positively influences local immune and metabolic
Stability of optimal microclimatic parame- processes (increase in SIgA and lactoferrin in
ters. pharyngeal and bronchial wash-outs, normalization
Curing air has stable humidity of 40-60% and con- of serotonin secretion;decreasein initially heightened
stant temperature of20 -24°C which are the most level of catecholamines, serotonin, and histamine
favorable and comfortable for respiratory organs in bronchoalveolar lavage;
and stability of aerodispersion environment. - enhances electrophysiological cell activity of
Design of natural salt cave, aesthetic attraction. mucosa epithelium;
Have positive influence on mental and emotional - increases colonization resistance of epithelium
sphere, create comfortable conditions for carrying cells regarding to opportunistic microflora;
out treatment. - assists in restoring ofbiocenosis in respiratory
tract;
Action mechanisms - improves condition of systemic immunity.
Thus, the dry fine-grainedsodium chloride aerosolhas
According to experimental and clinical studies, mucolytic, bronchodrainage, antiinflammatory and
among salt aerosols the dry sodium chloride aerosol immune-response modulating effect on respiratory
(haloaerosol) is the most effectivefor the respiratory tract. It has airway«cleansing»(enhance host defense)
tract. Action mechanisms of dry sodium chloride effect and indirectly improves general host defense
aerosol present in underground clinics and used in (fig. 2). Haloaerosol has an antiphlogistic and
the HT method are well founded in the series of sanitating influence on airway surface liquid at its
studies (3, 7,8,17,18). Physical characteristics of affection caused by infection and inflammation as
haloaerosol are of great importance. Prevalence of well as by irritation due to pollutants. Improvement
respirable particles in its composition guarantees of drainage function and decrease in inflammation
the efficiency of action and penetration of all of respiratory tract contribute to abatement of
Balneologial1
IIi!ll'ID ....
(WleClen-czerWlec 2007 136
Alina Chervinskaya
ion
hyperreactivity and decrease
ofbronchospastic obstruction
Activation
Enhance
resistance of
Improvement
epithelium
rheological
component (9).
offunction
~~
ofciliated
of epithelial
colonization
mucus
properties
Light negative aeroions that
are present
activate
.~
u•..~
cells
in halochamber
Bacteriostatic effect
metabolism and local
defense of biological tissues,
c~
c
0Preventive
.•...
"0
~"Ou
Q..c
•...
•...
S
•...
:E
'"
'"
'"
Antiedematous
~ ~~
I ~q
0eJI
0:
Activation
effect
Enhance
~ activity
of phagocytes
Improvement
and biological
Pathogenesis
'" Treatment
-;i:l:l•...•.. S
of local immune
ofbiocenosis
defense
components
~action ~
~q
.;C~
.•...
'=
.5
stabilize processes of vegetative

regulation, have favourable
effect on cardio-vascular
system, endocrine system,
gastrointestinal tract, mucosa of
respiratory apparatus and have
adaptogenic effect on central
and peripheral stress-limiting
systems of the organism .
Staying in the halochamber
breaks the contact with
external unfavourable effects
as allergens and pollutants,
stabilizes vegetative nervous
system and has a positive
psycho- emotional effect.
Taking into consideration all
curing factors itwas ascertained
that the micro climate created
by halocomplex influences
the respiratory tract, immune
and cardio-vascular system,
cutaneous covering, vegetative Fig. 2. Action of dry fine-grained sodium chloride aerosol on respi-
nervous system and psycho- ratory tract (Chervinskaya A. v., 1998).
emotional sphere.
Description of the method contact and elimination of pollen allergens out

During HT procedure patients (asa rule 4-6persons) of respiratory tract.
sit in comfortable armchairs in the treatment Controlled HT provides for differentiated application
room (halochamber, haloroom). HT treatment of certain concentration (modes) of dry fine-grained
usually is accompanied by tranquil music and/ sodium chloride aerosol according to clinical
or psycho-suggestological programs; for children features of the disease and characteristics of the i
tales and calm musical entertainment programs are external respiration function (12, 16).
broadcasted. During the day several HT sessions
(4 -5 on average) are held. Between the sessions Areas of application
rooms have an airing for half an hour.
HT course consists of 10-20 daily treatment Possibility of choosing parameters of aerosol
sessions of 30 minutes for children and 40-60 speleoimpactwhich is brought about when using
minutes for adults. HT courses with rehabilitation controlled HT ensures the method adaptation
and preventive purposes are advisable to get 1-2 to conditions of various fields of medicine and
times a year. HT courses are expedient in work hygiene.
collectives during unfavorable weather seasons HT is described for all the most widespread
with the aim of prevention of acute respiratory respiratory diseases. As a rehabilitation method
viral infections and exacerbations of respiratory HT is prescribed to patients with acute bronchitis,
diseases. Preventive HT is also advisable for pollen prolonged pneumonia, chronic obstructive
allergy. It is appropriate to start treatment shortly pulmonary diseases (COPD), asthma of different
before or with the appearance ofits first symptoms. stagesand different clinical and pathogenetic variants
In that case HT contributes to interruption of of their course including hormone dependent
137 Balneologia
Ii!lIiD I kwiecien-czerwiec 2007
forms, bronchiectasia, cystic fibrosis. Dosing of of otolaryngology and dermatocosmetology.

treatment taking into account concentration of Dry aerosol of sodium chloride has an antiphlogistic
salt aerosol allows applying the method at heavy and antiedematous effect on nasal and pharyngeal
forms of diseases with considerable obstructive mucosa as well as that of accessory sinuses of nose
dysfunction. Controlled randomized placebo studies in chronic pharyngitis, rhinitis and sinusitis.
showed (3, 7, 9, 10,25) that method inclusion in the Immune-modeling effect of halo aerosol has been
complex of recovering treatment and rehabilitation proved in otolaringological pathologies (35). HT
of patients with chronic bronchopulmonary usage as a method of conservative treatment of
pathology (asthma, COPD) allows achieving nasal pathology allows attaining positive results in
maximum clinical effect at 82 - 96% of patients 72% - 87% of cases with the largest effectiveness in
at the most optimal doses of medicament therapy vasomotor and allergic rhinitis (4). Dry aerosol of
and contributes to raising efficiency of treatment sodium chloride has a favorable effect on mucosa
and prolongation of remission. of nose and accessory sinuses in chronic sinusitis
In pediatric practice HT is most frequently used (21). In 90% of patients with acute sinusitis 2-3
in treatment and rehabilitation of children with inhalations of aerosol of dry sodium chloride
asthma in post-attack period and in between aerosol prescribed after initial puncture have
attacks (efficiency of 75-85%). High efficacy was sanifying effect (28, 31).
achieved in treatment of children with recurrent Controlled HT is successful for treatment of
bronchitis especially in obstructive forms. Scope of skin diseases (diffusive neurodermatitis, allergic
HT therapeu tic effect allows considerably decrease dermatitis, eczema, psoriasis and others) (32, 36).
prescription of antibacterial medicine which prevents Staying in halochamber has a positive cleansing
dysbacteriosis and allergic reactions in children effect and restores biocenosis of skin covering,
(22,26,30). Preventive courses for frequently sick and improves microcirculation, all of which is
children diminish the risk of recurring diseases used in cosmetological programs (19).
and contribute to speeding up of recovery (24). Long-term usage of HT has shown the safety of
Long-term clinical application of HT method the method as for side effects on cardio-vascular
in various fields of medicine (pulmonology, system which allows using it in patients with COPD
allergology,paediatrics, otolaryngology, dermatology having associated cardio-vascular pathology, old
and others) as well as studies of its mechanisms age group included. HT usage in patients with
has brought to understanding that the method asthma and COPD with associated cardio-vascular
has pronounced recovering effect. In Russia pathology (ischemia,hypertension and discirculatory
halocomplexes are used in hundreds of health encephalopathy) at the old age allowed attaining
centers. Recently halocomplexes have been used positive clinical effect in the absence of any negative
in SPA-industry. Method usage in the recovering reactions (11, 34). Positive results of HT usage
complex in health and preventive centers in patients have been achieved in patients in postoperative
with lung diseases and with risk factors (those period after coronary artery bypass grafting (14).In
working in adverse conditions) makes possible to such patients rehabilitation complexes including
achieve respiratory sickness rate o?1,5-2 times less therapeutic physical training, thorax massage,
and prevents exacerbation of main disease (13). balneotherapy and local treatment of magnet
HT is used in a complex treatment of patients therapy, ultrasound and aeroion therapy along
with occupational lung diseases (25).Application with HT are advisable.
of HT is effective in 82% of patients with pollen Research and clinical experience of controlled
allergy (2). Preventive HT treatment for smokers microclimate application with the ability to choose
and patients with exogenous risk factors allows appropriate mode of curing concentration of
recovering of mucociliary clearance, liquidates dry sodium chloride aerosol on the whole have
first manifestations of obstruction and restores demonstrated positive effect of HT on the state of
respiratory tract defense (5, 6). With the help of cardio-vascular system. At present controlled HT is
preventive usage of 2 times weekly HT treatment included cardia-vascular pathology in the cardio-
during three months decrease in sickness rate of vascular pathology programs of rehabilitation of
acute respiratory viral infections was attained in patients with cardio-vascular pathology (20,33).
patients with chronic pulmonary diseases as well as
conditionally healthy but threatened with COPD Practical application of halotherapy
development (15).
Application of special modes of salt aerosol HT can be successfully combined with other
concentration makes it possible to use HT not physiotherapeutic and drug-freemethods. HT efficacy
only for respiratory diseases but also in the fields increases in conjunction with drainage gymnastics, ~
Balneologial
IImIlD ...
kWleClen-czerwiec 2007 138
__ Alina Chervinskaya
vacuum thorax massage and kinesiotherapy. HT Kurortol. Fizioter. Lech. Fiz. Kult., 1993.5,25-28.
usage together with aeroionotherapy, aromatherapy, (Russ). (A6.L\YJlJlaeBAA. II .L\p.: 3<p<peKTlIBHOCTb
phytotherapy, magneto therapy, laser therapy, CrreJleOTeparrlI1I y .L\eTeHc 6pOHXlIaJJbHOH aCTMOH
ultrasound, low-frequency electromagnetic field, B comlHblX rnaXTax rro .L\aHHbIMHerrOCpe.L\CTBeHHblx
and normobarometric hypoxitherapy has made II OT.L\aJleHHbIXHa6Jl.fO.L\eHIIH.
Borrp. KypopTOJlOrlIlI,
a god showing. <p1I31I0TeparrlIlIII Jleqe6. <plI3. KYJlbTYpbI, 1993, 5,
In Russian Federation HT has been officially 25-28).
authorized for medical usage by the Ministry of 2. A1exandrov A., Chervinskaya A. Application of
Public Health. At present controlled halo complexes dry sodium chloride aerosol in upper respiratory
have been installed in more than 1000 medical pathology. Annual Congress of European Respiratory
and sanitary institutions. Society (abstr.), Barcelona, 1995.- P. 392.
The analysis of HT application during the last 3. Bobrov L.L. et al.: Medicinal effects of dry sodium
7 years (2000 - 2006) has shown that the method chloride in patients with bronchial asthma Vopr.
is being used by various medical, preventive and Kurortol. Fizioter. Lech. Fiz. Kult., 1999,4,8-12 (Russ).
sanitary institutions. In the most demand HT (E06pOB JUI. II .L\p.: JIeqe6Hble 3<p<peKTbIcyxoro
is in sanatoria and health resorts (43%). During a3p030JUl XJloplI,L\aHaTpIDIy 60JlbHbIX6pOHXIIaJJbHOH
the last years the method has been introduced in aCTMoH. Borrp. KypopTOJlOrlIlI, <p1I31I0TeparrlIlI II
sanitary programs in SPAfacilities. Halocomplexes JleQe6. <P1I3KYJlbTypbI,1999,4,8-12).
(halochambers and halorooms) are widely used 4. Chervinskaya A et al.: Effect of halotherapy in
in out-patient department, physiotherapeutic, patients with bronchial asthma and allergic rhinitis.
therapeutic, pulmonological, rehabilitation and XV International Congress of allergology and clinical
ENT- department in hospitals, medical units immunology, Sweden, 1994, 175.
of industrial enterprises (34%). In out-patient 5. Chervinskaya A. V: Effect of dry sodium chloride
department and hospitals the most reasonable aerosol on the respiratory tract of tobacco smokers.
organizational form for HT application is a daily Europ. Respir. Joum., Abstracts of16th ERS Annual
clinic. Practical experience has shown that HT usage Congress, Munich, Germany, 2006, 106s-107s.
is advisable for children and adolescent practice in 6. Chervinskaya A. V: Respiratory hygiene with the
children pre-school facilities and schools (23%). dry sodium chloride aerosol. Abstract Book of 14th
Because of wide possibilities of preventive effect Annual Congress of the European Respiratory Society,
this segment continues growing. Glasgow, 2004, 2514.
7. Chervinskaya AV et al. : Impact of haloaerosol
Conclusion therapy on pulmonary host defenses. Therapeut. Arch.,
2002, 3, 48-52. (Russ). (1JepBIIHCKaJI A.B. II .L\p.:
Thus the ST method has been further developed BJlIIJIHlIe raJl0a3p030JlbHOH TeparrlIlI Ha 3aIll,lITHble
into a new medical technique - the controlled HT CBoHcTBapecIIIlpaTopHoro TpaKTa. TeparreBT. apx.,
The achievement of the method is in the principle 2002, 3, 48-52).
of controlling the parameters which ensures dosing 8. ChervinskayaA.V, KvetnayaA. S.: Therapeutical
and control of employed natural factor - dry sodium effects of the dry sodium chloride aerosol on
chloride aerosol. Scientific grounds for action physiological properties of the respiratory mucosa.1
mechanism, proven clinical efficiency verified by Pulmonology. Supplement abstract book, 3-rd Congress
research on standards of evidence-based medicine of European Region International Union against
and practical application in various fields of public Tuberculosis and Lung Diseases (IUATLD), 14-
health determine broad prospect of the method th National Congress on Lung Diseases, Moscow,
in rehabilitation, sanatoria and health resorts and 2004,322.
preventive medicine. Numerous research and wide 9. Chervinskaya A.V, Zilber N.A.: Halotherapy for
experience of practical application confirm the treatment of respiratory diseases. Journ. Aeros. Med.,
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of King a Spa in Wieliczka salt mines. Materia Medica 2000, 1, 122-124. (Russ). (CTerraHeHKo H.II. ll,n;p.:
Polona, 1986, 1/57,36-38. 3<jJ<jJeKTllBHoCTbraJIOTeparrllll rrpll XpOHllqeCKllX
28. Ostrinskaya TV: Estimation of antimicrobial activity <jJapllHrOTOH311JIJIllTaX, a,n;eHOll,n;llTax y ,n;eTell.
of nasal secretion at halotherapy in patients with KYPopTOJIOrM,<jJ1l311oTeparrM,BoccTaHOBllTeJIbHM
acute sinusitis. News of otorhinolaryngology and Me,n;llIJ;llHa XXI BeKa: MaTepllaJIbI Me)!(,n;YHap.
logopathology,2000, 1,66-67. (Russ). (OCTpllHcKa~ KOHrpecca, IIepMb, 2000, 1, 122-124).
TB.: OIJ;eHKaaHTllMllKpo6HOll aKTllBHOCTllHOCOBoro 36. Tretiakova N.N, Chervinskaya AV, Raznatovsky LM.:
ceKpeTa rrpll raJIOTeparrllll 60JIbHbIX c OCTpbIMll Experience of halo therapy application in treatment of
CllHYCllTaMll. HOBOCTll OTOpllHOJIapllHrOJIOrllll II skin diseases. Pulmonology. 5'hNational Congress on
JIororraTOJIOfllll, 2000, 1, 66-67). Respiratory diseases: Collection of abstracts ed. by AG.
29. Patent for invention: Method of treatment of respiratory Chuchalin, Moscow, 1995,614 (Russ). (TpeTb~KoBa
diseases. AChervinskaya, S. Konovalov /RF/.-f. H.H., qepBllHcKa~ AB., Pa3HaToBcKllll H.M.: OmIT
96102904/14: Application 14.02.96; Published rrpllMeHeHll~ raJIOTeparrllll ,n;JI~JIeqeHll~ KO)!(HbIX
10.10.99. Bulletin 28. (Russ). (IIareHTHa 11306pereHHe: 3a6oJIeBaHllll. IIYITbMoHoJIorM. 5-bIll HaIJ;llOHaJIbHbIll
Crroco6 JIeqeHll~ 3a6oJIeBaHllll opraHoB ,n;bIxaHll~. KOHrpecc rro 60JIe3~ opraHoB .L\bIXaHM:C6. pe3IOMe
AB.qepBHHcKM, C.H. KOHOB3JIOB 1P<1>/.-<jJ.
96102904/ rro,n;.pe,n;. ArqyqanllHa, M., 1995,614).
14:-3allB. 14.02.96; Orry6JI. 10.10.99. DIOJIJI.28). 37. Torokhtin M.D, Chonka Ia.V., Lemko 1.S.:
30. Pluiskene L., Norvaisas G. A.: Halotherapy in Speleotherapy of respiratory diseases in conditions
management of asthma and chronic obstructive of salt-mine microclimate, Uzhgorod, «Zakarpattia»,
pulmonary diseases in 'children. Allergie&Innnunologie, 1998,287 p.). (Russ). (TOPOXTllHM)l .., qOHKa 51.B.,
1995,27,7,1995,241. 20 JIeMKo H.C.: CrreJIeOTeparrM 3a6oJIeBaHllll opraHOB
31. Ponomarenko G.N., Chervinskaya AV, Konovalov ,n;bIxaHM B YCJIOB~ MllKpOKJIllMaTaCOMHbIXrnaXT,
S.l.: Inhalation therapy. St. Petersburg, SLP, 1998. Y)!(ropo,n;, «3aKaprraTT~», 1998,287 c.).
234 p. (Russ). (IIoHoMapeHKo f.H., qepBllHcKa~ 38. Zaripova T.N, SminIova LN., Antipova I.I.: Medication-
A.B., KOHOBaJIOBC.H.: HHraJI~IJ;llOHHa~ Teparrll~, free aerosol therapy in pulmonology, Tomsk, STT,
CII6., CJIII, 1998,234 c.). 196 p. (Russ). (3apllrroBa TH., CMllpHoBa H.H.,
32. Ponomareva V.N, Frolova M.M.: Efficiency of AmrrrrOBa H.H. HeMe.L\llKaMeHT03HM mp030JIbrep3ITllll
halotherapy in the complex of rehabilitation in atopic B rrYJIbMOHOJIOfllll,TOMCK,STT, 196 c.).
dermatisis in children. Modem problems and prospects
of development of regional system of complex child
aid, Collection of materials ofInternational Research Artykul nadeslano: 11. 05. 07
and Practice Conference, Arkhangelsk, 2000 (Russ). Zaakceptowano do druku: 28. 05. 07
(IIoHoMapeBa B.H., <1>pOJIOBa M.M.: 3<jJ<jJeKTllBHOCTb
••••••••••••••••••••• e ••
raJIOTeparrllll B KOMrrJIeKCe pea611JIllTaIJ;1l1l rrpll
aTOrrllqeCKOM ,n;epMaTllTe y ,n;eTell. COBpeMeHHbIe Address of author:
rrp06JIeMbI II rrepCrreKTllBbIpa3BllTM perllOH3JIbHOll
CllCTeMbIKOMrrJIeKCHOll rrOMOIu;llpe6eHKY, C60pHllK ':'Prof dr med. Alina Chervinskaya
MaTepll3JIOBMe)I()J;)'Hapo,n;Holl
HayqHo-rrpaKTWIecKoll Clinical-Research Respiratory Center,
KOH<jJepeHIJ;llll,ApxaHreJIbcK, 2000). Hospital-122, Kultury, 4
33. Rehabilitation of cardiological patients. Ed. by St. Petersburg 194291, Russia
K.VLiadov, VN.Preobrazhensky, Moscow, GEOTAR- Phone: +7 921 9346498
Media, 2005, 67-68. (Russ). (Pea611JIllTaIJ;1l~ Fax: + 7 (812) 336 9081
Kap,n;llOJIOrllqeCKllX60JIbHbIX.IIo,n;pe,n;.K.B.m,n;oBa, E-mail: [email protected]
141 Balneologia
~ I k WleClen-czerWlec
' , . '2007
1
HALOTHERAPY: HISTORY AND EXPERIENCE OF CLINICAL

APPLICATION
A.V. Chervinskaya, A.N. Alexandrov, S.I. Konovalov
Clinical and Science-Research Respiratory Center, Saint-Petersburg, Russia
This is the first article of the series concerning the role of dry sodium chloride
aerosol in managing upper and lower respiratory tract pathologies, mechanisms of its action,
clinical results, and technical approaches to aerosol delivery to patients.
Speleotherapy forms the background for the development of halotherapy.
Last years demonstrate the increase of doctors and researches who understand the
reasonability of use of therapeutic methods based on application of natural or physical factors
for stimulating mechanisms of sanogenes, and restoration of organism compensatory abilities.
Modern pharmaceuticals provide sufficiently effective and quick eradication of acute
pathology, resolution of exacerbation of chronic diseases. Frequently repeated, prolonged or,
what is worse, continuous drug therapy, however, is associated with possible development of
allergic or toxic reactions, development of antibiotic tolerant species of microorganisms, wide
spreading of dysbacterios and other side effects.
The off-stated reason inspires physicians to revise centenary experience of our
forefathers and to work out new drug free and physiotherapeutic methods of treatment.
Speleotherapy (from Greek "speleon"- cave), in particular, is used for managing respiratory
tract pathologies.
Speleotherapy is a therapeutic method based on prolonged staying under the specific
microclimate of caves, salt mines, grottoes, mines etc. Specific microclimate features depend
upon character of underground cavities. The microclimate is characterized by constant
temperature, pressure, gaseous and ion air composition, low relative humidity, increased
ionization, prevalence of negatively charged ions, presence of various salt aerosols, increased
radioactivity (in caves), the absence of bacterial flora and allergens, slightly increased
contents of carbon dioxide.
The management of respiratory tract diseases by staying in caves was scientifically
explained in the 40's of our century. German researches compiled data on positive influence
of prolonged staying of many people in the cave of Klutert that was used during the Second
World War as a bomb shelter by citizens of Ennepetal. Those time many patients with
bronchial asthma and chronic bronchitis demonstrated complete resolution of the diseases or
considerable improvement of their condition. Further, due to clinical and experimental studies
carried out by K. Spannagel, M.D., Ph.D. [38] a new scientifically explained trend —
speleoclimatotherapy — aimed at the management of respiratory tract pathologies was
developed.
At present several countries have speleotherapeutic clinics developed on the basis of
natural caves — Hungary, Slovenia, Bulgaria, Austria, Germany, Georgia.
Artificial caves are, as well, applicable for the therapy as natural ones. Among these
may be exhausted salt mines or specially cut niches in the salt stratum where such clinics are
created.
Polish doctor F. Bochkowski for the first time offered supposition that air saturated
with salt particles provides the main therapeutic influence in 1843. Salt mines of Velichka in
Krakow province was the place where he created salt spa, and where more than hundred years
ago in 1958, research and clinical resort for pulmonic patients were organized.
The examples of use of salt mines for therapeutic purposes may be found as well in
other countries - Salzebad-Salzeman in Austria, Velichka in Poland, Siget in Romania,
Nakhichevan in Azerbaijan, Chon-Tuz in Kirgizstan, Berezniki (Perm region) in Russia,
Solotvino (Zakarpatian region) and Artemovsk (Donetzk region) in Ukraine, Soligorsk in
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Folia ORL et PL.- V.3.- A1-2.- 1997.- 9. 82-88. (Chervinskaya A.V., Alexandrov A.N., Konovalov S.I. Halotherapy.
History and experience of clinical application. - Medical Journal “Folia Otorhinolaryngologiae et Pathologie Respiratoriae” –
1997-V.3.-N1-2-P.82-88. (Russ.)
2
Belorussia. All these clinics for patients with chronic non-specific lung diseases (CNLD) are
based on the therapeutic action produced by cave air saturated with particles of rock salt.
Thus, salt therapy or halotherapy (HT) (from Greek "halos"- salt) is a part of
speleotherapy.
Big experience in managing patients with various forms of CNLD proved high
efficacy of speleotherapy undertaken in the microclimate of salt cave in Solotvino. Achieved
therapeutic effect in patients with bronchial asthma (BA) of different age groups and variants
of the disease was confirmed by results of biochemical, immunologic, microbiological tests.
Speleotherapy in the microclimate of salt mines provides non-specific hyposensitizing effect,
decrease of infections and inflammatory process activity in the respiratory tract, stimulation
of various stages of local and general protective mechanisms. During the treatment organism
adapts to the specificity of microclimate, which causes the reorganization of all functional
systems of an organism [24]. Multiple science studies allow working out indications for
speleotherapy and differential complexes of its application.
Speleotherapy is widely recognized as highly effective drug-free therapy. However,
the necessity of acclimatization of a patient arriving from other climatic zones, difficulties
associated with crossing, shortage of beds in comparison with amount of persons seeking for
a help and a lot of contraindications hamper the wide distribution of this method of treatment.
The development of artificial microclimate of salt caves

The next step in the development of therapy with the help of inhalant substances
containing dry sodium chloride aerosol was the creation of ground clinics with artificial
microclimate similar to underground clinic environment. Among the first who started to work
in this direction was the Uzhgorod branch of Odessa Science Research Institute (SRI) of Spa
Therapy. In 1980 MD Torokhtin and V.V. Zheltvay reported about their invention on the
approach to managing BA in the ground clinic where inner microclimate is modeled to obtain
one similar to underground salt mine [25].
In 1982 in Perm Medical Institute there was made a climatic cell for managing
respiratory allergic diseases which environment, according to the report of inventors, modeled
the microclimate of speleoclinic [5]. In 1984 another kind of ground facility for managing
respiratory pathologies was introduced, it was called "Halocamera" [19]. The following years
were marked by appearing of comparable objects united under such names as "Halocamera",
"Climatic camera"[8, 9, 18, 20].
Generally, all these structures have common characteristics, which may be united in
accordance with their functional purposes. These are walls covered with various salt-derived
materials or made of rock-salt bricks, devices for preparation and conditioning of the air, and
machines for saturating cell air with salt aerosol. Another feature of all these structures is the
deficiency of technical means for microclimate parameter control and their maintaining at the
required levels. The study of halocameras produced by different manufactures revealed that
microclimate characteristics within these structures differed greatly from those in natural
objects. In particular, heat and humidity regime may be reproduced, however, such an
important parameter, as aerosol concentration can not be guaranteed by available control
equipment. The values of dispersion of sodium chloride particles and their quantity in the air
vary within broad limits.
Halocameras equipped with salt powder spraying devices based on the principle of
boiling layer demonstrate the following dynamic of air dispersed media during a session: the
first minutes of a session are characterized by peak-like increase (3 times an even more) of
salt aerosol concentration over the necessary level, by the 25-30th minute the concentration
reaches trace level [14]. That is why more than half of patients demonstrate worsening of
their condition as a reaction to management in these cells that in some cases necessitates
additional administrations [10]. Moreover, physical and chemical characteristics of salt
particles determine the specificity of their behavior, which differs greatly from that described
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1997-V.3.-N1-2-P.82-88. (Russ.)
3
in literature [16]. Due to the rapid coagulation and sedimentation of the particles the
qualitative composition of the dispersion changed with the following increase of geometrical
dimensions of particles and decrease of respirable fraction share in the cell atmosphere [14].
That is why it is important to refresh particles during a session.
In cells where salt aerosol source is represented by, so called, saturating filters,
labyrinth partitions [8,9], particles concentration does not increase higher than 1 mg/m3, that
subsequently requires the prolongation of a session and the whole course of treatment and
restricts the possibilities of HT.
However, the study on therapeutic action of dry sodium chloride aerosol revealed
that the achievement of therapeutic effect and avoidance of side effects and complications
from HT required strict maintaining of parameters of air dispersed media during HT (aerosol
concentration, dispersion of the particles), and may be provided only by permanent
monitoring of the parameters. Moreover, the experience of HT application demonstrated that
management of patients with respiratory tract diseases (RTD) necessitates differential
approach to the choice of therapeutic concentrations.
Taking into consideration medical demands for the method, a new generation
equipment based on principles of controlled and manageable air dispersed media has been
developed [11]. Modern halocomplex (manufactured by SC "Aeromed") comprises
halogenerator with a microprocessor control, probes for constant measuring of temperature,
relative humidity, and mass concentration of aerosol throughout a session. Halocomplex
generates and maintains concentration of highly dispersed haloaerosol at the preset necessary
level. Respirable fraction of this aerosol according to optic-based measuring exceeds 97%.
Concentration of dry sodium chloride aerosol in the therapeutic cell may vary from 0.5 to 9
mg/m3, accordingly to preset limits (regime);
I regime — 0.5 mg/m3, II regime — 1.0-3.0 mg/m3, III regime — 3.0-5.0 mg/m3, IV regime
— 7.0-9.0 mg/m3. Moreover, this equipment does not need any special preparations of salt
used for a session.
The assessment of microbial contamination in the therapeutic cell of halocomplex
demonstrated that during a session 1 m3 contained from 30 to 132 saprophytic
microorganisms (according to WHO standards on air sterility 1 m3 should contain less than
300 microbial bodies). Sanitary important microorganisms (viridans, haemolytic,
staphylococci, streptococci) are not revealed. These findings correspond to the sanitary and
hygienic parameters of underground speleotherapeutic clinic air.
Additional psychosugestive effect during HT sessions may be achieved through the
application of special audiovisual programs.
Mechanisms of halotherapy action

In contrary to speleotherapy based upon the therapeutic action produced by a
complex of natural factors, HT is a method of aerosol therapy. Therapeutic action is provided
by air dispersed media saturated with dry sodium chloride aerosol at mass concentration
varying from 5.5 to 9 mg/m3 and particle size of 1-5 mkm., these parameters were borrowed
from different speleotherapeutic clinics. Haloaerosol has a considerable level of volumetrical
negative charge of the particles (6-10 nK7m3). The air has comfortable temperature (18-24°C)
and relative humidity (40-60%).
Some studies demonstrated that sodium chloride aerosol improves rheologic
properties of bronchial contents facilitating normalizing of mucocellular clearance [33,36,40].
The presence of sodium chloride is necessary for normal functioning of bronchial ciliated
epithelium [69], whereas sodium chloride contents in bronchial secretion of patients with
chronic pulmonary pathology is decreased [30]. Sodium chloride aerosol provides bactericidal
and bacteriostatic impact on respiratory tract microflora [17,37], stimulates alveolar
macrophage reactivity, facilitating the increase of phagocytic elements and their phagocytic
activity [12], produces anti-inflammatory action [35]. Haloaerosol has a considerable level of
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1997-V.3.-N1-2-P.82-88. (Russ.)
4
volumetrical negative charge of the particles (6-10 nK7m3). High negative charge also has
therapeutic significance and improves stability of the aerosol [4, 14].
Together with biological properties of sodium chloride aerosol, its physical
characteristics are, as well, very important for the HT method. The prevalence of respirable
fraction (1-5 mkm) share in haloaerosol (97%) provides its penetration into all sections of
respiratory tract up to its deepest parts.
The basic nature of the method is application of dry sodium chloride aerosol. The
study of droplet and dry sodium chloride aerosol absorption in the respiratory tract revealed
that the highest degree of particles delay in case of equal dispersion was higher for dry
aerosol [13], therefore the application of dry highly dispersed aerosol allowed the
administration of lower doses and prevention of unfavorable side effects.
The use of dry aerosol permits to produce optimal temperature and humidity
parameters in the camera. That allows avoiding the development of respiratory tract mucus
edema and bronchial spasm, reactions common in patients when moist aerosols are used.
Additional effect produced by HT is explained by patient staying under conditions of
hypoallergenic, hypo bacterial air surrounding, noiseless, comfortable psychological
atmosphere.
Results of clinical application of controlled therapeutic microclimate of
halocamera for managing patients with bronchopulmonary and upper
respiratory tract pathologies
HT was used in practical health care since mid 80-s. In 1989 the method was
officially recognized by Ministry of Health Care of the USSR and was largely used in various
clinical establishments. The experience of HT demonstrated that the achievement of
therapeutic effect and avoidance of side effects and complications necessitates strict
maintaining of preset parameters of air dispersed media in halocamera. In 1995 based on
experience of clinical application of the controlled therapeutic microclimate — HT — new
practical recommendations which stipulates obligatory control and management of
microclimate parameters in HC in the regime of real time, and differential approach to the
selection of sodium chloride aerosol concentration [29] were adopted by Ministry of Health
Care and Medical Industry of the Russian Federation.
Evaluation of therapeutic results of more than 4000 of the patients management in
various clinical establishments according to improved method confirms its high efficacy.
Thus, doctors of practical medicine reported that positive results of this method application
were achieved in 82-97% of patients with different pathologic variants of BA, pollinosis,
chronic non-obstructive and obstructive bronchitis (CNB and COB), acute bronchitis (AB)
with recurred and persisting duration, bronchiectatic disease (BED), upper respiratory tract
pathologies, and some forms of skin diseases [2, 6, 15, 23, 26]. The carried out therapy
allowed to decrease the morbidity of these respiratory tract pathologies and associated with it
economical loss by 1.5-2 times [27].
The overwhelming majority of patients demonstrate positive dynamics of their
symptoms that proved the amelioration of respiratory passages drainage; easier expectoration
of sputum, which becomes less viscous; decrease in cough intensity; changes in lung
auscultation. These were associated with the number and severity of dyspnea attacks and
discomfort on exhalation. The application of HT facilitated the efficacy of drug therapy and
decrease of drug doses. Half of patients who were administrated inhalant corticosteroids as
anti-inflammatory management could stop this therapy. One third of patients could lessen the
dose of corticosteroids. 60% of patients who were treated with inhalant (3-agonists,
sympathomimetics managed to stop their intake or lessen daily dose [23, 31, 32, 34]. Long
term follow up revealed that 80% of patients demonstrated 3 to 12 months duration of
uneventful period with the mean value of 8.5 months.
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1997-V.3.-N1-2-P.82-88. (Russ.)
5
Functional testing of bronchopulmonary system may prove clinical efficacy of the

method. Thus, the analysis of volume-flow loops of forced exhale revealed significant
improvement of its parameters after HT course. However, there were no significant
differences in parameters of external breathing function prior and immediately after the HT
session [22]. While the further analysis of volume-flow loops demonstrated significant
increase of bronchial passability by the seventh day of treatment [32]. The comparison of
clinical and functional results suggests that HT does not provide direct impact on
bronchospastic component of obstruction, but improves bronchial passability due to the
gradual influence on its discrynic and inflammatory components [6, 7, 28].
Good results were also achieved in HT application for patients with vasomotor
rhinitis of neurovegetative and allergic forms. The improvement of nasal breathing occurred
in 98% of cases. The achieved positive result was proved by 21% mean decrease of nasal
resistance measured by body plethysmography in this group of patients. Simultaneously
patients with X-ray signs of edema in paranasal sinuses demonstrated considerable decrease
of its intensity and sometimes its complete resolution [3].
HT management of patients with chronic tonsillitis resulted in reduced subjective and
objective signs of concomitant pharyngitis, easier discharge of tonsil caseous contents and
tonsil cleaning in 50% of cases. No exacerbation of the disease was revealed during the
follow up period of 6 to 12 months. HT used as a part of rehabilitation therapy for patients
following endonasal and endolaryngeal surgery resulted in accelerated postoperative wound
healing due to the apparent anti-inflammatory influence of the aerosol. Moreover, patients
with acute and indolent sinusitis subjected to HT demonstrated complete absence of purulent
discharge in sinuses during repeated punctions, proving thus bactericidal effect of the therapy
[1, 2].
HT provides positive effect on humoral and cellular immune system in patients with
CNLD, stimulates metabolic activity of lung tissue, and causes non-specific desensitizing
effect on an organism [6, 21]. The study of HT efficacy suggests that local sanogenic and
anti-inflammatory action of dry highly dispersed sodium chloride aerosol provides indirect
positive impact on the general organism reactivity.
Thus, the experience of HT clinical application, the study of its efficacy for different
pathologies allowed optimizing the parameters of HT method, and working out the
differential approach to its administration and enlarging the indications. The study of the
specific action of the method was associated with the development and perfection of the
equipment meant for this method. Clinical backgrounds together with new technical solutions
permitted to work out new medical technology — manageable therapeutic halocamera
microclimate.
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6..., MD3&*4% 0.I. M!=D2L<+<R ?#&@!'!'&- >+24<!#+?&& D U42L'RJ +(<@+<&Q!(*&@ U#4'J&<4@ &
U#4'J&+2L'4O +(<@4O // 0 *'.: '4%R! @!3&W&'(*&! <!J'424>&& % ?#4X&2+*<&*! & 2!Q!'&& =+U42!%+'&O
4#>+'4% 3RJ+'&-. - \., 1990.- 9.17-23.
11.84'4%+24% 9.;., dDU&'(*+- ..0. T(<#4O(<%4 32- ?42DQ!'&- (DJ4>4 +]#4=42- ..(. 999M
A1630834, *2. . 61 G 13/00 // S+-%. 28.05.91, IV2. A5, 1993.
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+(?!*<R ?#4U2!@R 6S\ & +*<D+2L'R! %4?#4(R &J %<4#&Q'4O ?#4X&2+*<&*&. - 9-BU., 1992. - 9. 109-113.
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G., 1995. -_!=. 571.
14.84'4%+24% 9.;., G+O4#4%+ G.0., _D#DU+#4% 8.0., 6+((4'4%+ ;.;. 8 %4?#4(D 4 3&'+@&*!
?+#+@!<#4% +]#43&(?!#('4O (#!3R % >+24*+@!#! // 0.*'.: 64%R! @!3&W&'(*&! <!J'424>&& % ?#4X&2+*<&*!
& 2!Q!'&& =+U42!%+'&O 4#>+'4% 3RJ+'&-.- \.,1990.-9.55-58.
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2!Q!'&- % #!+U&2&<+W&& U42L'RJ ( &'X!*W&4''4-=+%&(&@4O U#4'J&+2L'4O +(<@4O & J#4'&Q!(*&@
4U(<#D*<&%'R@ U#4'J&<4@ // BD2L@4'424>&-, ?#&2., 4-RO 6+W&4'+2L'RO *4'>#!(( ?4 U42!='-@ 4#>+'4%
3RJ+'&-. - 9-BU., 1994. -_!=. 585.
16.M+O(< B. .]#4=42&. 0%!3!'&! % <!4#&V: B!#. ( +'>2. - G.: G&#, 1987. - 280 (.
17.9&@O4'*+ j.G., !#'Da!'*4 Y.b. .'<&U+*<!#&+2L'RO, ?#4<&%4%4(?+2&<!2L'RO,
&@@D'4@43D2&#DVc&O & >&?4(!'(&U&2&=&#DVc&O ]XX!*< (?!2!4<!#+?&& % (42-'RJ a+J<+J // _!=.
G!F3D'+#43'. (&@?4=. ?4 (?!2!4<!#+?&&.- 9424<%&'4 (T*#+&'+), 1993. - 9. 45.
18.92!(+#!'*4 0.b. P+24*+@!#+ // ..(. 999M A1587710 4< 03.02.89.
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20.92!(+#!'*4 0.b., P4#U!'*4 B.B. P+24*+@!#+ // ..(. 999M N 1621222 4< 10.05.88.
21.9<#+a'4%+ h.0., !#%&'(*+- ..0., 8&'>4 S.6. P+24<!#+?&- *+* @!<43 *4##!*W&& &@@D''RJ
'+#Da!'&O D U42L'RJ U#4'J&+2L'4O +(<@4O // BD2L@4'424>&-, ?#&2., 6-4O 6+W&4'+2L'RO 84'>#!(( ?4
U42!='-@ 4#>+'4% 3RJ+'&-, (U. <!=.-G., 1996. -9. 283.
22.9<#+a'4%+ h.0., !#%&'(*+- ..0., 94(4%+ \.9. ;=DQ!'&- '!*4<4#RJ @!J+'&=@4% 3!O(<%&-
>+24<!#+?&& // BD2L@4'424>&-, ?#&2., 5-O 6+W&4'+2L'RO 84'>#!(( ?4 U42!='-@ 4#>+'4% 3RJ+'&-, (U.
<!=.- G., 1995.-_!=. 607.
23._!2-<'&*4%+ P.0., !#%&'(*+- ..0. kXX!*<&%'4(<L ?#&@!'!'&- >+24<!#+?&& % ?#+*<&Q!(*4@
=3#+%44J#+'!'&& // BD2L@4'424>&-, ?#&2., 5-O 6+W&4'+2L'RO 84'>#!(( ?4 U42!='-@ 4#>+'4% 3RJ+'&-,
(U. <!=.- G., 1995.-_!=. 610.
24._4#4J<&' G.d. 9?!2!4<!#+?&- U42L'RJ U#4'J&+2L'4O +(<@4O. - 8&!%: "S34#4%'-", 1987. - 95 (.
25._4#4J<&' G.d., m!2<%+O 0.0. 9?4(4U 2!Q!'&- U#4'J&+2L'4O +(<@R // ..(. 999M A940384 4<
22.08.80.
26._#!<L-*4%+ 6.6., !#%&'(*+- ..0., M+='+<4%(*&O ;.G. h?R< ?#&@!'!'&- >+24<!#+?&& 32-
2!Q!'&- *4F'RJ =+U42!%+'&O // BD2L@4'424>&-, ?#&2., 5-O 6+W&4'+2L'RO 84'>#!(( ?4 U42!='-@ 4#>+'4%
3RJ+'&-, (U. <!=.- G., 1995.- _!=. 614.
27. !#%&'(*+- ..0., .2!*(+'3#4% ..6., _!2-<'&*4%+ P.0. B#&@!'!'&! >+24<!#+?&& %
?#4X&2+*<&*! & 2!Q!'&& =+U42!%+'&O 4#>+'4% 3RJ+'&-, (%-=+''RJ ( =+>#-='!'&!@ %4=3Da'4O (#!3R //
|6+DQ'4-?#+*<&Q!*&! +(?!*<R D?#+%2!'&- *+Q!(<%4@ %4=3DJ+ “04=3DJ-95”, (U. <!=.- 9 -BU., 1995. - 9. 188-
190.
28. !#%&'(*+- ..0., 8%!<'+- ..9., m!2!=4%+ \.;. hW!'*+ @4#X4XD'*W&4'+2L'4>4 (4(<4-'&-
(2&=&(<4O '4(4>24<*& & 4Uc!O &@@D'424>&Q!(*4O #!+*<&%'4(<& D U42L'RJ ?#& ?#&@!'!'&& >+24<!#+?&&
// BD2L@4'424>&-, ?#&2., 4 6+W&4'+2L'RO *4'>#!(( ?4 U42!='-@ 4#>+'4% 3RJ+'&-.- 9-BU., 1994. -_!=.
614.
____________________________________________________________________________________________________
© !#%&'(*+- ..0., .2!*(+'3#4% ..6., 84'4%+24% 9.;. ;(<4#&- #+=%&<&- & &<4>& ?#&@!'!'&- >+24<!#+?&& //
1997-V.3.-N1-2-P.82-88. (Russ.)
7
29. !#%&'(*+- ..0., 84'4%+24% 9.;., 9<#+a'4%+ h.0., 9<!?+'4%+ 6.P., DQ+2&' ..P., .?D2LW&'+
;.d., bD#@+' ;.Y., I4'3+#!'*4 ...., 9+@(4'4%+ G.0., B2DF'&*4% G.9., .2!*(+'3#4% ..6.,
M+='+<4%(*&O ;.G., _#!<L-*4%+ 6.6., G4'+J4% 8.6. B#&@!'!'&! @!3<!J'424>&& P_ % *4@?2!*('4@
2!Q!'&& & #!+U&2&<+W&& =+U42!%+'&O 4#>+'4% 3RJ+'&- // G!<43. #!*[email protected] G., 1995.- 18 (.
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Aerosol Medicine.- 1995.-V. 8, A 3.- P. 221-232.
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Pharmac.-1979.- A 7.- M.39-44.
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35.Khramov A.V., Vengerov B.B. Microcirculatory and anti- inflammatory effects of dry powder
sodium chloride aerosol treatment // Journal of Aerosol Medicine. - 1993.- V.6, suppl. - P. 78.
36.Pavia L., Thomson M.Z., Clarke S.W. Enhanced clearence of secretion from the human lung after
the administration of hypertonic saline aerosol // Amer. Rev. Resp. Dis.- 1978. -V.117, A2.- P.199-204.
37.Rein M.F., Mandell G.Z. Bacterial killing by bacteriostatic saline solutions: Potential for diagnostic
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38.Spannagel K.H. Die medizinische Wirkung der Kluterhole auf das Asthma bronchiale und die
chronische Bronchitis.- Lahresherft fun Karst.- U.Hohlenkunde, Munchen, 1961.- 28s.
39.Welch M.J. Electrolyte transport by airway epitelia // Phisiol. Rev.- 1987.- V.67, A4. - P.1143-
1184.
40.Wurtemberger G., Montag A.,Ruhle K.-U., Mattys H. Suinflussung der mukoziliaren und tussiven
clearence durch. Inhalation therapeutischer Salzlosungen bei Patienten mit chronischer Bronchitis // Atemwegs-
Zungenkr.- 1987.- V.13, A8. - S.397-399.
____________________________________________________________________________________________________
© !#%&'(*+- ..0., .2!*(+'3#4% ..6., 84'4%+24% 9.;. ;(<4#&- #+=%&<&- & &<4>& ?#&@!'!'&- >+24<!#+?&& //
1997-V.3.-N1-2-P.82-88. (Russ.)
PROSPECTS OF HALOTHERAPY IN SANATORIUM-AND-SPA DERMATOLOGY
AND COSMETOLOGY
Chervinskaya A. V., Doctor of Medical Science

Central Medical Unit 122 of Federal Medical and Biological Agency, Saint-Petersburg
In sanatorium-and-spa sector the drug-free methods for treatment of dermatoses and recovery of skin
integument become more and more popular. These methods are the part of the programs in rehabilitation
dermatology, cosmetology, rejuvenation, clearance and others.
Among the modern therapeutic methods based on the application of natural factors the mostly accepted is
halotherapy (HT) - method of treatment under conditions of salt mines microclimate, developed on the
basis of speleotherapy.
HT simulates the principal parameters of salt mines in room conditions. The main curative factor of
HT is associated first of all with the dry superfine sodium chloride aerosol. Unique effect on organism is
related with its' specific physical properties.
The researches have proved natural aerosol environment in rooms can be created by special medical
equipment - halogenerators. Due to the specific way of generation (by the using of disperse method), dry
sodium chloride aerosol acquires a negative charge and high surface energy. Due to its' physical
properties haloearosol provides electro-ionic effect on the walls respiratory tract and skin integument.
The particles of sodium chloride aerosol penetrate deeply into respiratory tract where they enhance
immune defense and provide bronchodrainage, bacteriostatic and anti-inflammatory effect. As a result,
recovery and clearance of respiratory tract internal environment occur. Efficiency of this method for
prevention and rehabilitation treatment of different respiratory diseases has been proved thus far.
Possibility of choosing aerosol effect level in a controlled halocomplex has ensured application of this
method in various branches of rehabilitation medicine and adjustment of treatment for particular patient.
This method is widely used in rehabilitation and recovery pulmonology, otorhinolaryngology,
allergology and pediatrics. At present time the using of halogenerator and monitoring devices
enables the application of special dermatocosmetological modes of dry sodium chloride aerosol
concentrations.
Sodium chloride particles have a beneficial influence not only on respiratory system, but integumentary
system and hairs as well, providing healing and cosmetic effect. Depositing on open skin areas,
haloearosol increases activity of skin cell ion channels and activates electrophysiological activity that
determines skin protective properties. Research of skin microbiocenosis showed normalization of
superficial autoflora composition after administering HT. Also bacteriostatic, antiedematous and anti-
inflammatory effect of dry superfine sodium chloride aerosol was confirmed.
Salt aerosol microcrystals effect results in Ph normalization and induction of reparative- regenerative
processes in derma, increases skin turgor, stimulates growth and improves hears health. Dry salt aerosol
takes beneficial effect on skin microcirculation. Increasing of permeability and electrophysiological
activity of the cellular membrane dry salt aerosol helps in penetration of various remedies, used in
dermatology and cosmetology and potentate their effectiveness.
Multipurpose physiological effect of dry sodium chloride aerosol ensures perspective application
ofHT for various skin problems.
By the end of HT course the positive dynamics has been observed in 65-75% patients with atopic
dermatitis. It resulted in decreasing of itching, solution or reduction of lichenification, drying of small
fissures, scratches, reducing of sympathicotonia symptoms. Positive effect is more apparent in patients
with exudative form of the disease within the remitting phase of acute inflammatory exudative events.
Good and sufficiently immediate effect can be achieved in patients with secondary streptoderma
implications. Soon after 2-3 procedures elements of skin eruption were disappearing and by the end of
the course almost complete solution of streptoderma
;;!lJepeUHCKaJl A.B. B03Mo:JICHocmu zallomepanuu e caHamopHo-KypopmHou ()epMamOJlOZuu U KOCMemOJlOZuu//

KypopmHble ee()oMocmu. - 2006. - M.3 (36) - C.74-75. (ChervinskayaA. v:
Prospects of halotherapy in sanatorium-and-spa dermatology and cosmetology. -
Resort bulletin.- 2006. - N. 3 (36). - P. 74- 75. (Rus.)
2
implications has been noted. In patients with pyoderma there was observed improvement, expressed in of
exanthema elements solution between the 2 and 3 procedures. Positive effect of HT was observed in
patients with psoriasis (resulted in infiltration reduction, and central resolutiondf plates).
Considerable anti edematous and anti-inflammatory effect of dry sodium chloride aerosol is used in post
surgical rehabilitation. which is especially important for aesthetic surgery. Improvement of local
microcirculation, edema reduction and clearance under the influence of haloaerosol may be efficiently
applied in curative cellulite programs. During the dissociation, sodium chloride microcrystals within skin
area increase passive transport, which exponentiates application of various curative and cosmetological
agents. This effect is perspective to combine HT with local use of creams, ointments and etc.
Respiratory and intergumentary systems are physiologically closely interrelated. Combination of
pulmonary and cutaneous pathology (e.g. bronchial asthma and neurodermatitis) is very common. By its
treating effect on respiratory tract sodium chloride aerosol provides concurrent detoxification and
lymphodrainage influence and as a result the general health improves (including sensitization reduction).
These effects contribute to skin clearance, recovery of protective properties, improvement of skin tone
and turgor. (This phenomenon can be strictly shown in women who have given up smoking).
There is no doubt that that in order to gain a permanent positive effect when treating cutaneous pathology
it is necessary to restore systemic biological protection. In this meaning HT is proved to be the method,
which along with the local effect ensures systematic immunobiological action as well. As a result of HT
application the positive shifts in systemic humoral and cell- mediated immunity with the background of
decreasing of inflammatory process activity and antigens elimination are observed. Positive dynamics of
parameters featuring imbalance in lipid peroxidation - antioxidants (LPO-AD) system is extremely
important as it comes as an evidence of the systemic antioxidant effect of HT. Systemic
immunobiological effect of HT is also highly significant for its application in cosmetological and
rejuvenating programs.
Psycho-emotional factor in ethology and pathogenesis of cutaneous pathology is very important as well.
During the staying in halochamber any contact with external disturbances (allergic agents, pollutants,
noise and others) is cut off and gives positive psycho-emotional and antidepressant effect. Light negative
air ions inside of chamber stabilize the vegetative regulation processes; beneficially influence on
cardiovascular and endocrine systems and gastrointestinal tract.
Common indications for HT application in skin and cosmetologic programs:
- atopic dermatitis, diffuse and exudative form in maintenance phase;
- recurrent urticaria;
- psoriasis in maintenance phase;
- eczema;
- sebaceous hypersecretion (seborrhea adiposa);
- pyodermatites;
- pinta and onychomycosis;
- thermal cutaneous lesions;
- postoperative states (aesthetic surgery);
- comedogenous disease (acne); - cellulite;
- fading skin; - trichopathy.
Efficient application of the controlled halotherapy combined with the comfort and positive impression of
procedures specifies its perspective in sanatorium-resort and spa industry.
KOCMemOJlOcuu//KypopmllbleeeiJoMocmu. -2006. -M.3 (36) -C.74-75. (ChervinskayaA.JI: Prospects of

halotherapy in sanatorium-and-spa dermatology and cosmetology. -
Resortbulletin.-2006. -N.3(36). -Po 74-75. (Rus.)
JOURNAL OF AEROSOL MEDICINE
Volwne 8, Nwnber 3, 1995
Mary Ann Liebert, Inc~
Halotherapy for Treatment

of Respiratory Diseases
ALINA V. CHERVINSKAYAI,2 and NORA A. ZILBER2
1Saint-Petersburg Pavlov National Medical University, Russia

2Joint-Stock Company Aeromed, ·Saint-Petersburg, Russia
ABSTRACT
This work elucidates the questions upon the development of a new drug-free method of
a respiratory diseases treatment. Halotherapy (HT) - is mode of treatment in a controlled air
medium which simulates a natural salt cave microclimate. The main curative factor is d~
sodium chloride aerosol with particles of 2 to 5 mkm in size. Particles density (0.5-9 mg/m )
varies with the type of the disease. Other factors are comfortable temperature- humidity
regime, the hypobacterial and allergen- free air environment saturated with aeroions.
The effect of HT was evaluated in 124 patients (pts) with various types of respiratory
diseases. The control group of 15 pts received placebo. HT course consisted of 10-20 daily
I
procedures of hour. HT resulted in improvements of clinical state in the most of patients.
The positive dynamics of flow-volume loop parameters and decrease of bronchial resistance
measured by bodyplethysmography were observed. The changes in control group parameters
after HT were not statistically significant. The specificity of this method is the low
concentration and gradual administration of dry sodium chloride aerosol. Data on healing
mechanisms of a specific airdispersive environment of sodium chloride while treatment the
respiratory diseases are discussed.
INTRODUCTION
The considerable increase of allergic diseases and reactions and of other serious
complications due to drug therapy explains the interest of clinicians to the development of
drug-free methods of treatment. Halotherapy ( "halos" in Greek means a salt) is one of such
methods. Halotherapy (HT) is mode of treatment in a controlled air medium which simulates
a natural salt cave microclimate.
Treatment in natural salt cave (speleotherapy) has been known since long. The efficacy
of speleotherapy is associated with unique cave microc1imate. The natural dry sodium
chloride aerosol is the major curative factor of the cave microc1imate. It is formed by the
convective diffusion from salt walls. Other factors such as comfortable temperature and
humidity regime, the hypobacterial and allergen-free air environment saturated with aeroions
enhance the therapeutic effect.
A suggestion that it is the air saturated with saline dust that causes the main curative effect
in the speleotherapy of patients with respiratory diseases was first formulated by a
Key words: halotherapy, speleotherapy, dry sodium chloride aerosol, respiratory diseases.
221
Polish physician F.Bochkowsky in 1843. Salt mines are known to be used for therapeutic
purposes in other countries as well such as Austria (Solzbad-Salzeman), Rumania (Sieged),
Poland (Wieliczka), Azerbaijan (Nakhichevan), Kirgizia (Chon-Tous), Russia (Berezniki,
Perm region), the Ukraine (Solotvino, Carpathians); Artiomovsk, Donietsk region).
Speleotherapy has been recognized as highly effective drug-free treatment method.
Great experience in the treatment of patients with various forms of chronic nonspecific
pulmonary diseases has proved speleotherapy to be very effective under the conditions of the
salt mine microclimate of Solotvino. The therapeutic effect has been proved by the data of
biochemical, immunological, and microbiological research (Simyonka, 1989, Slivko, 1980,
Yefimova et aI, 1990, Zadorozhnaya et aI, 1986 ). It is assumed that during treatment, the
organism adapts to specific features of the microclimate and alters all its functional systems.
However adaptation of patients who came from different climate areas, trave.l and
transport problems, limited number of beds keep back its wide spreading. So HT has been
worked out.
DESCRIPTION OF HALOTHERAPY
HT is performed in a special room with salt coated walls - Halochamber. Dry sodium
chloride aerosol (DSCA) containing the dominating amount of 2 to 5 mkm particles (Table
I) is produced by special nebulizer.
TABLE 1
Fractions of dry sodium chloride aerosol fractions in halochamber ( according to data of

optical devices).
Size of particles, mkm 0.003

61.8±3.3
2.8
35.4±Fractions,
±0.4
2.1 %
>
5 -Ilala
2-5 -2
TABLE 2
Composition criteria requirements for salt to be used in halotherapy.
Water
Chemical composition
Moisture
pH ofNaCI
Chemical
Fe203,
Na2S04 of more6.5
insoluble
salt 0.25
in composition
not rock-salt,
solution
%than
%-0.50
0.01
0.45
0.50 8.0
97.70
0.10
1.20
(mass)
(mass)
of
han
222
The constant level of desirable aerosol mass concentration in the range of 0.5-9 mg/m3
is maintained automatically. Composition of the salt used for HT is shown in Table 2 (The
Russian State Standard is 13830-84). The temperature of 18-22oC and 45-55% humidity of
the medium are maintained by air conditioning system and heating devices. The HT process
and microclimate parameters are controlled with computer.
The treatment in Halochamber is conducted daily, the duration of the procedure is 1.0
hour, and that of the course - 12-25 days. The duration of each course and parameters of
aerosol medium depend on nosology, clinical features, phase of the disease, etc. and are
prescribed by the physician (Table 3). The duration of the course and the DSCA
concentration may be changed during the period of treatment in accordance with the
requirement of the changing state of the patient.
The patients breathed quietly while reclining in a special chairs. Therapy is
accompanied by musical psychosuggestive program and demonstration of slides. HT is
carried out either alone or in association with base medication and other methods of
treatment.
TABLE 3
Concentrations of dry sodium chloride aerosol and duration of halotherapy.
Disorders
0.5>
<- -21
1FEVl
7-9
(mg/m3) 18
221
60112
ConcentrationHT 21
-- -25
25
14
8(days)
21 0.5 - 1
duration
Specificity Allergic < 60 3-5
MATERIAL AND METHODS
HT was administrated in a group of 124 patients (54 males and 70 females) aged from
16 to 62 years (mean age 34.3 + 2.5 years) with various types of chronic nonspecific
pulmonary diseases (Table 4). In all of the patients (pts) , the disease was in the stage of a
prolonged exacerbation. Before treatment 95% of pts of the main group had cough, half them
(47% had severe attacks of coughing with scanty viscous sputum. Most of pts (81 %) suffered
from attacks asthma so that one third of them used combined medication to control it.
Auscultation revealed harsh and weakened breathing, and dry rales in 58% of patients.
60% of pts received a base therapy (beta-agonists, theophyllines, chromoglycate natrii,
corticosteroids, etc.), the effect of which was insufficient and did not allow to achieve a
complete remission. The pts had not taken any antibacterial medicine.
The control group was presented by 15 pts (7 females and 8 males) aged from 18 to 56
years (mean age 38.4+ 1.5 years). Placebo course consisted only of 10 procedures of musical
psycho suggestive program with slides demonstration in an ordinary room.
The pts condition was assessed by daily medical supervision, with functional and
laboratory tests made before and after HT, as well as every 7th day during treatment. A series
of examinations in the control group consisted of tests similar to those for the main group of
pts.
223
TABLE 4
Studied patients.
Disease 21
12124
32
34
14 26
87
56
Number of patients
structive
nobstructive
vere
ld
hiectasis
ic
derate
bronchitis:
fibrosis
Bronchial asthma:
Standard method of flow-volume loop was registered by "Pneumoscreen"

("Jager" ,Germany).The following parameters were assessed: vital capacity (VC), forced VC
(FVC), forced expiratory volume in the 1st sec (FEV I)' peak expiratory flow (PEF), forced
expiratory flow at 50% FVC (FEF 50)' The character and the extent of bronchial patency
impairment were estimated according to predicted values and limits of norm and its deviation
(Klement et ai, 1986). Dynamics of the indices was assessed from differences in their absolute
meaning before and after therapy and was expressed in % of the initial value. Individual
assessment of the results was achieved by comparing changes in the parameters and their
variability. Inhalation bronchospasmolytic test with 0.4 mg of Berotec was carried out in 56
patients before and after therapy (Melnikowa & Zilber, 1990). When the test was positive
obstruction was considered to be reversible Le., bronchospastic component was significant in
the genesis of obstruction. Airway resistance (Raw) and intrathoracic gas volume (ITGV)
were measured by "Bodyscreen" ("Jager" , Germany). Total lung capacity (TLC), residual
volume (RV) and their ratio (RV/TLC) were calculated on the base of spirography and
bodyplethysmography data. Raw analysis was carried out in absolute values, whereas other
parameters were given in Predicted values ( Kristufec et ai, 1979). Diffusion capacity of the
lungs by steady state method (DLss) was measured by "Transferscreen" in absolute values
and as % of predicted values (Pivotean & Dechour, 1968).
Standard methods of variation statistics were used for group analysis of the material, t-
Students test being used for significant differences in independent and correlated samples.
RESULTS
Clinical studies
After 3-5 sessions of HT 70-80% of pts (according to nosology) presented some

improvements: expectoration of good amount of sputum- it being less tenacious and easier to
discharge, better auscultatory pattern of the lungs, less frequent occurrence of cough attacks
or respiratory discomfort. Some pts with severe and moderate bronchial asthma (BA) (35
patients - 27% of the total number) experienced difficulty in brining up phlegm and
worsening of cough during 3-4 days after 3-4 sessions. These manifestation seem to be due to
temporal bad bronchial drainage resulting from hypersecretion of mucus and discharge of old
clots of secretion from bronchi of smaller diameter. Expiratory dyspnea appeared or became
more pronounced in 18 patients (15% of cases) at different periods of HT. Those were mainly
224
the patients with exercise-induced asthma and aspirin-induced asthma. None of the pts
complained of bad condition during HT procedures.
By the end of the course of HT all pts felt better: they slept well, had no fatigue and
weakness, and their nervous system stabilized. Clinical symptoms analysis demonstrated that
the number of asthma attacks and respiratory discomfort cases decreased significantly as
compared to the initial ones (81% and 52%, respectively, p<O.OO1). The number of asthma
attacks controlled by combined medication also decreased (32% and 2%, respectively,
p<O.OOI).
The cases with cough occurred more rarely (95% and 70%, respectively, p<O.OOI), cough
became easier and more productive, the amount of sputum reduced, it became mucousal. The
number of patients with signs of vasomotor rhinitis decreased (61% and 24%, respectively,
p<O.OOl).
Corticosteroids were discontinued in 50% (11 pts) of pts with corticosteroid therapy (22
pts). Those were the cases when inhaled corticosteroids were prescribed as antiinflammatory
agents. In 7 pts it was possible to reduce the dose. 41 pts (60% of pts who inhaled beta-
agonists) were able to discontinue beta-agonists or reduce the their dose. Reduction (or
cancellation) in bronchodilator and inhaled corticosteroid consumption was an indicator of
clinical benefit.
The clinical state of 85% pts with mild \lnd moderate BA, 75%-with severe BA, 98%-
with chronic bronchitis, bronchiectasis and cystic fibrosis improved after HT. The pts were
examined 6 and 12 months after the first HT course. No aggravation of the disease were seen
from the 3d to the 12th month. The average duration of remission was 7.6 - 0.9 m. Most of
the pts (60%) used no medication and sought no medical advice.
Lung function studies
Before HT bronchial obstruction was found in 83 pts (67% of all cases), 1/3 of them (25
pts) had marked impairment. By the end of the therapy bronchial obstruction was found in
50% of the pts but the number of cases with marked impairment were diminished (16 pts)
(Fig. 1).
Direct effect of a HT procedure on bronchial patency was studied in 12 pts. The
difference between the average flow-volume loop parameters in the group after 1 procedure
was insignificant (p>0.05) when compared to the initial values.
Idividual analysis showed that 5 pts had a significant increase of the parameters, a
decrease was seen in 4 pts and in 3 cases there were no changes. On the basis of these data it is
impossible to estimate the real action of DSC A on bronchial patency.
The patients showed significant increase of FVC, FEVl, PEF, FEF50 by the 7th day; of
FVC and FEF 50 by the 14th day and of FVC, VC and PEF by the end of HT (Table 5).
There was no difference in the extent of the parameter changes after the 7th day and by the
end of the treatment.
I
.<,~~X{~
MEF50(% Pr.)
I_ <22 I
-
• <51
I
-- . • <31
- 0>62
Before HT After HT
FIGURE 1. Bronchial obstruction before and after halotherapy (number of patients - 124)
225
TABLES
Change of flow-volume loop parameters at various terms of halotherapy (Mean±SE)
3722±1.3
End14 124
98 Treatment
3232±1.3
2±2.0
±of
± 0.9*
2.9*
1.3*
1.2*
days
± 1.0*
1.9
course 4732o±±0.9
1.6 liS
0.9*
1.4*
I.S*
1.2*
7 days
* significant (p < O.OS,here and further) changes vs initial values (paired t-test)
Findings of bodyplethysmography and diffusion capacity of the lungs are given in

Table 6. After the HT there was a significant decrease in Raw and RV/TLC, other parameters
changes were insignificant.
To know whether the initial extent of obstruction had any effect on the dynamics of
bronchial patency during HT all pts were divided into four groups according to the extent of
obstruction (Table 7). Group I included patients with normal indices of forced expiration
(FEFSO >62%Pr.); group II - with mild impairment of bronchial patency (FEFSO <SI%Pr.);
group III - with moderate (FEF SO<31%Pr.) , and group IV - with severe obstruction (FEF SO
TABLE 6
Bodyplethysmography and diffusion capacity of lung before and after halotherapy
( M ± SE), number of patients-8S.
126
79±4
0.28
9983 ±±±
139±7
133
109±3
102±3
lll±
IS6
141
0.37 ±S
after 66*
±3±4
±7
142± S before Treatment
20.02*
0.04
x in kPa/l/s
* significant differences as compared to "before"
226
TABLE 7
Dynamics of bronchial obstruction indices at the end of halotherapy as compared to initial
extent of obstruction (M ±SE).
-I25 31
-I27
5± 3I4±4.2
±4.9*oX
2.9 Groups
Parameter, 37
14±
25
14± IV
-811
22
-1±1.I7FEF50
±
IIIoIO±IA
-33±11.9*oX
-3±1.3 FEF50±±I10.2*0
± 4.9*0
±1.6
2.5*
±4.20
1.9
3.741
9.0*0
1.3
1.2
2.9
8.1*0
I << 51%
22
31%
* significant changes as compared to initial values

o significant difference from groups I and 11
x significant difference from groups Ill.
<22%Pr.). At the end of HT the indices in groups I and 11 did not differ from the initial ones.
In group III values of FEF 50 became significantly higher and in group IV all indices
significantly increased. The extent of changes of group IV indices was significantly greater
than of groups I and 11. Similar findings were obtained on the 7th and 14th day HT.
Irrespectively of the therapy duration the greatest dynamics in bronchial patency was found
in group IV (severe obstruction), not so marked one was in group III (moderate obstruction),
and no dynamics was seen in groups I and 11 (slight or no obstruction).
Relationship between the character of obstruction disorders and the changes in indices
during the course of therapy was studied. According to the findings of broncholytic tests the
pts were divided into two groups: those with reversible, and irreversible obstruction. No
significant differences in the parameter changes by the end of HT as compared to initial
parameters were found (p>0.05). Both in the presence of bronchospasm and its absence the
efficacy of HT on bronchial patency was the same.
Control group.
One-two day after beginning of therapy many placebo pts (80%) felt better and slept
normally which seemed to be associated with psychotherapeutic effects. However, no
objective improvement in their lung auscultation picture was noted. There were no significant
changes of flow-volume loop parameters as compared to initial values after the course of
placebo (VC- -3±5.0; FVC- -3±4.3; FEV 1- -3 ±3A; PEF- -6±2.6; FEF 50- -2±3.8).
At the same time, 20% of pts with prevailing allergic mechanism of the disease had
positive dynamics of function values which was probably associated with no exposure to
allergens.
DISCUSSION
The course of HT resulted in improvements of clinical state in the most pts. In the
overwhelming majority of cases, the number and intensity of asthma attack and respiratory
discomfort decreased or disappeared, which allowed, in a number of cases, to cancel or
227
reduce the dosage of beta-agonists. The most pts showed positive dynamics of symptoms
indicative of a better drain function of their airways: sputum secretion alleviates, it becomes
less viscous, coughing relieves, and the auscultative picture of the lungs alters. The difficulty
in brining up phlegm and worsening of cough during 3-4 days seemed to be due to temporal
bad bronchial drainage resulting from hypersecretion of mucus and discharge of old clots of
secretion from bronchi of smaller diameter.
The similar clinical results were obtained in other investigations. Efficacy of this
method has been noted in pts with various pathogenic variants of BA, chronic bronchitis,
acute bronchitis, bronchiectasis, upper airways diseases, etc. (Alexandrov & Chervinskaya,
1994, Chervinskaya et ai, 1993, 1994, Norvaishas et ai, 1992, Pokhaznikova et ai, 1992,
Telyatnikova et ai, 1992, Tikhomirova et ai, 1993).
In our investigation the improvement in the clinical state of pts was accompanied by
positive dynamics of the functional measurements. HT gave significant improvement in
bronchial patency which started on the 7th day and persisted to the end of the course. There
was no direct bronchospasmolytic effect. The dynamics of bronchial patency depended upon
the initial extent of obstruction: the more marked was bronchial obstruction, the better were
the results of HT. The effect depended not upon the character of obstruction (reversible or
irreversible).
Thus, clinical functional results suggest, that HT have gradual positive influence on
bronchial obstruction. With this mode of therapy which is based on cumulative action, there
should be series of procedures. It seems to be associated with improvement of mucociliary
clearance and decrease of bronchial inflammation. Conception of antiinflammatiry influence
is confirmed by the data of cytobacteriologic examinations (Chervinskaya et ai, 1994). The
evaluation of brush samples from nosopharynx mucosa in HT showed that the average
amount of neutrophils, macrophages and lymphocytes diminished. The index of epitheliocyte
infection with pneumococci and that of adhesion the average number of pneumococci per
one affected epithelicyte decreased. These indices are indicative of elimination in pathogenic
microorganisms and of decrease in inflammatory reaction of the mucosa. Other investigation
demonstrated decrease the amount of neutrophils and pathogenic microorganisms and
increase the amount of alveolar macrophages in bronchial secretion of pts with BA, chronic
obstructive bronchitis and cystic fibrosis after HT (Voronina et ai, 1994). Research testified
of positive effects of HT on the state of humoral and cellular immunity in patients with BA
(Spesivykh et ai, 1990, Torokhtin et ai, 1987); decrease of IgE level was observed
(Dityatkovskaya et ai, 1993). Certainly, the arguments of mucociliary clearance change of pts
in HT are necessary.
HT is type of aerosol therapy, taking from speleotherapy main acting factor. Curative
effect of HT is caused by aerodispersed environment saturated with dry sodium chloride
aerosol with predominance amount of particles of 2 to 5 mkm in size. Such particles can
penetrate deep into the smallest airways.
In our view, the positive effect of HT can be accounted for the following. One of the
pathogenetic mechanisms of obstructive pulmonary diseases is mucociliary clearance
impairment. Normal function of mucociliary clearance depends on the amount and
viscoelastic properties of the airway surface liquid, together with the number and function of
the cilia. Aerosol of sodium chloride initiates the fluid release into the bronchial lumen, and
influences the viscoelastic properties of the bronchial secretion by changing the conformation
of protein molecules and releasing water into the outer layers of the clots which promotes
evacuation of bronchial sputum (Clarke et ai, 1979, Pavia et al,1978, Wurtemberger et ai,
1987). In addition, sodium chloride is the main component of the airway surface liquid, the
mucus layer and the periciliary fluid, it is needed for normal functioning of bronchial ciliary
epithelium (Welch M.l., 1987). According to the evidence by certain authors, the amount of
sodium chloride in bronchial secretions in patients with chronic pulmonary pathology is
lower (Brogan et ai, 197 I). It is possible, inhalation of this chemical compound compensates
for its deficit in the lungs and improves the ciliary epithelium drainage function.
Sodium chloride aerosol causes bactericidal and bacteriostatic effects on the respiratory
airways microflora and prevents the development of inflammatory processes (Simyonka,
1989, Rein & Mandell, 1973). The intensity of this action depends on the concentration of the
aerosol that causes dehydration of microbial cells and the impairment of the albuminous
228
structure of the cells killing the microorganisms. Another mechanism is possible which causes
adhesion of small particles of salt to microbial bodies. As their mass grows, they precipitate
rapidly.
The experiments show that low doses of DSCA have a beneficial effect on phagocytic
activity of alveolar macrophages (Konovalov et ai, 1992) and hence on bronchial clearance
and elimination of foreign agents.
Thus, sodium chloride aerosol improves rheological properties of the bronchial
contents, decreases edema of bronchial mucosa and contributes to functioning of cilia
epithelium, it has an bactericidal action, enhances functioning of alveolar macrophages.
The study of halochamber aerodisperse environments allowed to establish that the
negative volumetric charge of dry aerosol particles was considerable (6-10 nK/m3)
(Konovalov et ai, 1990). Higher negative charge of particles is of therapeutic significance as
well (Afanasyev, 1990).
However, it is known, that sodium chloride aerosol is an osmolar stimulus, it can result
in the airways hyperreactivity (Schoeffel et ai, 1981). The HT specificity is the low
concentration and gradual administration of DSCA. Salt consumption during a procedure
depends upon the regimen chosen and is about 1-9 mg. In compare: sodium chloride aerosol
inhalation challenge is used for diagnosing hyperreactivity of the airways. Hypotonic (less
than 0.9%) or hypertonic (2-5%) solutions of sodium chloride are usually employed. When
I
the inhalator production is ml per minute, 20 mg of sodium chloride (measured as a dry
substance) gets into the airways during I min of the challenge test with 2% solution and the
amount reaches 50 mg in case of 5% solution. Compare: during a minute session of HT 0.05-
0.10 mg of dry sodium chloride penetrates into the patient's airways when the concentration
in the Halochamber is 5 mg/m3. Sodium chloride aerosol in low concentration does not affect
the airway mucosa thus preventing any side effects. Besides, using of dry aerosol permits to
achieve the suitable humidity of environment and to avoid the adverse reactions of airways,
associated with humidification (Linker, 1982).
In summary, theoretical prerequisites and the data of clinical functional studies
obtained allow to suggest that efficacy of HT results from the combination of the curative
properties of sodium chloride aerosol and the way of its administration. At the same time HT
mechanisms of influence are not yet studied well enough, which fact requires continuation of
research.
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H3MeHeHI1eKJIeTOQHbIX rrOKa3aTeJIeHI1MMYHI1TeTa y 60JIbHbIX 6pOHXI1aJIbHOHaCTMoH
rro,n:BJII1~Hl1eM JIeQeHI1~B KaMepax I1CKyccTBeHHoroMI1KpOKJII1MaTa. B KH. HMMYHOJlOZU51
U aJlJlepZllfl, 6bW. 21. Kl1eB, c.5-7).
VORONINA L.M., CHERNIAEV A.L., SAMSONOV A M.V., DOUBINSKA Y A A.V.
(1994). Cytobacteriologic estimation of bronchial secretion in halotherapy. In The 4th
National Congress on Respiratory Diseases. Moscow, abstr. 166. (Russ). (BOPOHI1HA
JI.M., llEPH5IEB A.JI., CAMCOHOBA M.B., )];YEHHCKAJI A.B. (1994).
U:I1TOJIOrI1QeCKa~11 l.\I1T06aKTepI10CKOrrI1QeCKa~ xapaKTepl1CTI1Ka 6POHXI1aJIbHbIX
CMbIBOBrrpl1 CrreJIeOTeparrl1l1.B KH. 4 HalfUOHaJlbHblU KOHzpecc no 60Jle3HJlM opzaH06
oblXaHUJl. MocKBa, pe3. 166).
231
WELCH M.I. (1987). Electrolyte transport by airway epithelia. Physiol.Rev.
67 (4), 1143-1184.
WURTEMBERGER G., MONTAG A., RUHLE K.-H., MATTHYS H. (1987).
Beeinflussung der mukoziIiaren und tussiven Clearence durch Inhalation
therapeutischer Salzlosungen bei Patienten mit chronischer Bronchitis. Atemwegs-
Zungenkr. I3 (8), 397-399.
YEFIMOVA L.K., ZHENEVATYUK L.P., DVORTSINA L.Y., SIMULlK V.D., BILAK
V.M. (1990). Speleotherapy effects on the immunologic reactivity in children with
bronchopulmonary diseases. In Current methods of immunology in bronchopulmonary
pathology. Lenin~rad, p. 86-91.(Russ). (E<1>HMOBA JI.K., )l{EHEBATIOK JI.lI.,
,n:BOPI(HHA JI.H., CHMYJIHK B.,n:., EHJIAK B.M. (1990). BmulHHe CrreJIeOTeparrHH
Ha HMMYHOJIOrH'lecKYlOpe3HcTeHTHocTb .Il:eTeH, 60JIbHbIX 6pOHXOJIerO'lHbIMH
3a6oJIeBaHH51MH.B KH. C06peMeHHble MemoObl UM)WYHOJi02uunpu 6pOHXOJle20'tHoil
namOJl02uu. JIeHHHrpa.Il:,c.86-9 I).
ZADOROZHNAYA T.A., KIREY E.Y., KOPINETS LL (1986). Hormonal interactions in
bronchial asthma and the effect of speleotherapy. In Physiotherapy and health resort
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KOlIHHEI( H.H. (l986)~ rOpMOHaJIbHbleB3aHMO.Il:eHCTBH51 rrpH 6pOHXHaJIbHOHaCTMe
H BJIH51HHe Ha HHXCrreJIeOTeparrHH.KypopmOJl02Ufl U rjJU3uomepanUfl, 6bln.19.KHeB, c.43-
46).
Article received on June 21, 1993

in fmal form Apri124, 1995
Reviewed by:
Malcolm King, PhD
Juraj Ferin, MD, PhD
Williarn D. Bennett, PhD
Address reprint requests to:

Alina V. Chervinskaya, MD, PhD
JSCAeromed
15, Novolitovskaya
194100 St. Petersburg, RUSSIA
Fax: (7-812) 245-2697
232
E F F E C T O F D R Y SO D I U M C H L O R I D E A E R OSO L O N T H E R ESPI R A T O R Y T R A C T
O F T O B A C C O SM O K E RS
A lina V . C hervinskaya, St.Petersburg, Russia
B R I E F SU M M A R Y
To estimate the changes in the airway of tobacco smokers after inhalations of dry sodium chloride aerosol
the group included 47 males was examined. They were employees of an instrument manufacturing plant
of St. Petersburg. Men aged from 35 to 60, who have been smoking about 15-20 cigarettes a day not less
than 15 years, having no chronic pulmonary diseases and are not exposed to occupational hazards were
eligible for participation in the study. Test group (TG) (24 males) were given 20 procedures (10 min
daily) of inhalations of dry sodium chloride aerosol, and placebo group (PG) was included 23 males.
88% of smokers of TG by the end of inhalation course reported easier and/or decreased cough, changes in
the character of sputum, which became lighter and clearer. Improvement in the character of sputum was
noted only 22% volunteers of PG (p<0,001).
Cytobacteriologic study of brush bioptates taken from pharyngeal mucosa was determined that the
infection index (II - % of epitheliocytes with adhered cells of S. pneumoniae) and adhesion index (AI -
the mean number of microbial cells per one epitheliocyte) decreased significantly in the TG (p<0,01). The
amount of SIgA in epithelial cells of the oropharyngeal mucosa (estimated by indirect method of
fluorescent antibodies) increased significantly in the TG (p<0,05). There were no significant changes at
these indexes in the PG.
Conclusion. DSCA relieves the main clinical signs (character of cough and sputum), improves local
defense mechanisms and strengthens resistance of mucous membranes of tobacco smokers owing to
decreased colonization activity of pathogenic microorganisms and increased SIgA.
IN TRO DUC TI O N
It is generally accepted that persons (prs) with exogenous risk factors of COPD (tobacco smokers, prs are
exposed to industrial pollutants) are required sanitation of respiratory tract to prevent development of
lung diseases.
Considerable efforts have been directed at examining the action of dry sodium chloride aerosol (DSCA)
on respiratory tract of the patients with COPD, asthma and the persons with risk factors of COPD. DSCA
is characterized with physical properties, differing from those of the saline aerosols. DSCA demonstrated
anti-inflammatory activity in the respiratory tract, mucoregulating action. It enhances drainage of the
bronchi, activates alveolar macrophages, and improves biocenosis and local humoral immunity.
A I M O F R ESE A R C H
The aim was to study influence of DSCA on the respiratory tract of tobacco smokers.
ST U D Y D ESI G N A N D PR O C E D U R ES
47 male were examined. They were selected after medical and lung function examination. They had the
productive cough associated with smoking. Chronic respiratory pathologies had been diagnosed in none
of them. The groups did not differ significantly by sex, age, smoking duration and intensity (table 1).
TG were given 20 procedures (10 min daily) using inhaler Haloneb (fig.1), producing DSCA with
particles size of 1- (total dose is approximately 5 mg per procedure). PG
received inhalation with plain air using inhaler Haloneb, specially designed for the study. It was a single
blind study with placebo.
Cytobacteriologic study of brush bioptates taken from pharyngeal mucosa was carried out before and
_____________________________________________________________________________
Chervinskaya A.V. Effect of dry sodium chloride aerosol on the respiratory tract of tobacco smokers.
Eur Respir J 2006; 28: Suppl. 50, 16th ERS Annual Congress, Munich, Germany.- 106s-107s.
after procedures in the both groups. Brush bioptates were obtained from the anterio-medial tonsillar
surface, using an endoscope brush fixed on a holder. The degree of the adhesiveness of the strain by
microorganisms was estimated by the adhesion index (AI). The AI was found as the mean number of
microbial cells per one epitheliocyte; 50 epithelial cells participating in the adhesion process of epithelial
cells were counted. The colonizational activity was estimated by the infection index (II), i.e. the
percentage of epitheliocytes with adhered cells of pneumococcus per 50 counted cells.
T able 1 C haracteristics of the T est (T G) and Placebo (P G) groups
Parameter, M TG PG Significant
difference
Number of the persons 24 23
p>0.05
Age, years
(37-60) (35-60)
Smoking time, years p>0.05
(14-42) (15-42)
Smoking intensity (packs/years) p>0.05
The amount of SIgA in epithelial cells of the oropharyngeal micosa was estimated by indirect
method of fluorescent antibodies (RIF).
R ESU L TS
88% of smokers of TG by the end of inhalation course reported easier and/or decreased cough, changes in
the character of sputum, which became lighter and clearer. Improvement in the character of sputum was
noted only 22% volunteers of PG (p<0,001).
The character of sputum changed gradually in TG smokers during the course of DSCA inhalations. By the
5th procedure, the number of pts expectorating yellow sputum decreased, and by the 10th - there was
decrease in the number of persons expectorating gray sputum (p<0.05). By the end of the course DSCA
procedures expectorating of gray or yellow sputum was only in separate cases. The number of pts who
stopped producing sputum increased significantly, while sputum turned light in the rest (p<0.01) (fig.2).
There were no specific changes in the character of sputum in CG.
_____________________________________________________________________________
Fig. 2. Changes in the character of sputum during the course
of the dry sodium chloride (DSCA) inhalations (n-24)
100% 4
13 17 4
21
17 4
80% 4
Percentage3of3the3persons
25 54
60% yellow
54 with3grains
45
gray
40%
clear
41
none
20% 38
25 25
8
0%
1 5 10 20
DSCA%inhalation%procedure%number
Cytobacteriologic study showed that the II and AI of epithelial cells for etiologically important
microorganism decreased significantly in TG who were given DSCA (fig. 3). The II and
AI also decreased significantly as regards another opportunistic microflora (H. influenzae, S. aureus etc.).
These finding suggest decreases colonization activity of opportunistic microflora of the mucus. At the
same time, the normal microflora (IA norm.) (Neisseriae spp., S. viridans, S. salivarius etc.) increased
significantly, which indicates intensified natural colonization of the mucosa. This combination of the
processes suggests increased resistance of the mucosa under influence of DSCA in TG. There were no
significant changes in the character of sputum in CG (table 2).
Table 2.
Colonization activity of microflora of brush- samples from pharynx
of the T est (T G) and Placebo (P G) groups of smokers
before and after inhalations of dry sodium chloride aerosol (DSC A)
TG PG
Index Units of
Before DSCA After DSCA Before DSCA After DSCA
(M SD) measure
II (S. % 28.1 24,9 7.8 9,7*** 18.4 22,6 11.8 16,8
pneumoniae)
II (H. - 20.8 31,9 2.4 5,6** 6.9 14,9 5.2 10,5
influenzae, S.
aureus etc.)
IA (S. Number of 45.4 33,0 13.9 16,3*** 25.4 22,9
the microbes
17.6 18,0
pneumoniae) cells
IA (H. - 21.6 25,0 4.2 9,3** 9.8 19,5 7.8 17,6

influenzae, S.
aureus etc.)
IA norm. - 6.9 7,9 23.0 17,8*** 7.5 14,5 9.8 15,2
_____________________________________________________________________________
*Note: significant (p < 0.05) changes vs. initial values; ** significant (p < 0.01), *** p<0.001
changes vs. initial values
The amount of SIgA increased significantly in the TG (before - - 2,1
There were no significant changes at these indexes in the PG (before - -
p>0,05).
C O N C L USI O N
Dry sodium chloride aerosol inhalations produce positive effect on the airways of tobacco smokers
(versus placebo). DSCA relieves the main clinical signs of tobacco smokers (character of cough and
sputum), improves local defense mechanisms and strengthens resistance of mucous membranes of
tobacco smokers owing to decreased colonization activity of pathogenic microorganisms and increased
SIgA.
R E F E R E N C ES
1. Chervinskaya A. V. Respiratory hygiene with the dry sodium chloride aerosol. 14th Annual Congress
of the European Respiratory Society, Glasgow, September 2004: Abstract Book. 2004; Ref. 2514.
2. Chervinskaya A. V., Kvetnaya A. S. Therapeutical effects of the dry sodium chloride aerosol on
physiological properties of the respiratory mucosa. Pulmonology. Supplement abstract book: 3-rd
Congress of European Region International Union against Tuberculosis and Lung Diseases (IUATLD).
Russia respiratory Society 14-th National Congress on Lung Diseases. Moscow, 2004; Res. 322.
3. Chervinskaya A.V., Kvetnaya A.S., Cherniaev A.L. et al. Effect of halotherapy on resistance
parameters of the respiratory tract. Ter. Arkh. 2002; N.3., P. 48-52. (Russ.)
4. Chervinskaya A.V., Zilber N.A. Halotherapy for treatment of respiratory diseases. Journal of Aerosol
Medicine. 1995; V. 8, N. 3., P. 221-232.
_____________________________________________________________________________
Reference and Resource Guide
Vopr Kurortol Fizioter Lech Fiz Kult. 2000 Jan-Feb;(1):21-4.

The scientific validation and outlook for the practical use of halo-aerosol
therapy.
Chervinskaia AV.
Abstract
The paper describes a new medical technique--halo-aerosol therapy, the main acting factor
of which is dry highly dispersed aerosol of sodium chloride in natural concentration. Halo-
aerosol therapy represents a new trend in aerosol medicine. It includes two methods:
halotherapy and halo-inhalation. Biophysical and pathophysiological foundations of the new
method, how it can be realized are outlined. Clinical reasons are provided for application of
halo-aerosol therapy for prevention, treatment and rehabilitation of patients with
respiratory diseases. Characteristics and differences of the two halo-aerosol therapy
variants are analyzed.
PMID: 11094875
[PubMed - indexed for MEDLINE]
For more information, click here: http://www.ncbi.nlm.nih.gov/pubmed/11094875

Vopr Kurortol Fizioter Lech Fiz Kult. 2012 Mar-Apr;(2):31-5.

The use of halotherapy for the health improvement in children at institutions
of general education.
Khan MA, Chervinskaia AV, Mikitchenko NA.
Abstract
The objective of the present study was to estimate the influence of halotherapy performed
in a specialized salt room on the health status of the children frequently ill with acute
respiratory diseases. The application of halotherapy was shown to produce well-apparent
anti-inflammatory, draining, and sanogenic effects. Observations during 1, 3, 5, and 12-
month follow-up periods confirmed the persistence of prophylactic and therapeutic effects
of salt therapy. The results of the study were used to develop differential schemes of
halotherapy taking into consideration the initial conditions of the children.
PMID: 22908472


The use of halotherapy for the rehabilitation of patients with acute bronchitis
and a protracted and recurrent course.
Borisenko LV, Chervinskaia AV, Stepanova NG, Luk'ian VS, Goncharova VA, Pokhodzeĭ IV, Krivitskaia VZ, Vishniakova LA,
Pokhaznikova MA, Faustova ME, et al.
Abstract
Halotherapy was used for rehabilitation in 25 patients with acute bronchitis of long-
standing and recurrent types. The main therapeutic action was ensured by aero dispersed
medium
saturated with dry highly dispersed sodium chloride aerosol, the required mass
concentration being maintained in the range of 1 to 5 mg/m3. Therapy efficacy was
controlled through assessment of clinical, functional, immunological and microbiological
findings. Metabolic activity values were taken into consideration as well. Positive dynamics
of the function indices in the clinical picture resulted from elimination of pathogenic agents,
control of slowly running inflammatory lesions and stimulation of some immune system
factors. Favourable changes in metabolic activity were present: normalization of serotonin
excretion, marked decrease of unbalance in lipid peroxidation-antioxidant system.
PMID: 7785211

What All Type of Spas, Wellness Facilities, and Salt Therapy Providers Need to
Know About Misconceptions Regarding Himalayan Salt
The Scientific Research

The Salt Therapy Association was formed to provide Education, Research, and Innovation for the salt
therapy/halotherapy industry and, as such, we are providing continuing information that is relevant
and important for our Facility Members and for those in the industry. We have started a new
educational series entitled "SALT-Ed” (salt therapy education) that we will be disseminated through
white papers, documents, videos, and webinars.
This first SALT-Ed paper is a reference to the research about Himalayan salt and the ‘myth
information’ regarding health and wellness benefits from claims such as emanating negative ions,
purifying the air, and providing any respiratory relief, made about heating (or not heating) Himalayan
salt in general, which applies to salt lamps, walls, saunas, spa equipment, and décor.
Not only is there no evidence that heated Himalayan salt produces its advertised health benefits, the
notion that it could emit ions in sufficient quantities to have any impact on the surrounding
environment or aid in the treatment of respiratory conditions runs against established science and
basic chemistry.
Salt Lamps Can’t Get Hot Enough to Emit Negative Ions
Science Journalist Signe Dean:
“The usual narrative about these lamps seems to be that heating up a chunk of salt releases ions.
However, that simply isn’t possible. To break apart the ionic bond between the two chemicals
comprising salt, you’d need a far greater energy input than a tiny light bulb can provide. Besides, if that
did happen, the salt would emit chlorine gas, and you’d definitely notice that.”1
John Malin, retired chemist formerly with the American Chemical Society
“Unless Himalayan sea salt contains high concentrations of other trace minerals compared with
ordinary table salt, the predominant ions that could form from a salt lamp are sodium and chloride
ions. But salt is really stable, so you heat it up a little bit and nothing really happens."2
Salt Therapy Association • www.SaltTherapyAssociation.org • 844-STA-INFO

Jack Beauchamp, Professor of Chemistry at the California Institute of Technology:
“We have a lot of experience with observing ions. What we did with the lamp, since it’s supposed to
make negative ions, was to place it adjacent to the inlet and, just by itself, we observed no ions at all.
We turned it on and looked for negative ions. We looked for positive ions. We waited for the lamp to
heat up. The bulb inside eventually does heat the rock salt, but we didn’t see anything.
I can’t think of any physical process that would result in the formation of ions from heating rock salt,
with and without the presence of water vapor in any amount. Rock salt has a face-centered cubic
structure which would not be expected to give rise to electric fields that would generate ions around
individual crystals.”3
Dr. May Nyman, Ph.D., of the American Chemical Society and Professor of Chemistry at Oregon
State:
“The only way to get those ions or salts into the atmosphere is using very high energy radiation like
using something like x-ray and focused x-rays and we don’t have them in our house or do we want it.
The same x-ray you want to examine a broken bone or radiate a tumor. That is the kind of energy it
would take to get those salts into the air. We do not want to be exposed to these amounts of x-ray
without those amounts of health benefits. And those types of radiation do not exist in our house.”4
Dr. John Newsam, Ph.D., of the American Chemical Society and CEO of Tioga Research in San
Diego, California:
“That is not happening in a Himalayan salt lamp where you have a flame, incandescent bulb or led bulb.
You are not heating up the salt high enough to liberate any of the ions from it. The strength of
[sic] between positive and negative ions of salt is very strong and therefore, they want to stay together
– they don’t want to scoot off into the atmosphere. A block of salt is not going to liberate any sodium or
chloride ions.”5
Columbia University Medical Center:
“It would take a Himalayan salt lamp a hundred years to even come close to what an ion machine could
generate in an hour.”6

Salt Lamps Aren’t Capable of Producing Enough Negative Ions to Affect the Surrounding
Environment
Negative Ions Information Center:
“Having personally tested a popular brand of rock salt crystal lamp in our lab, we can attest that it was
all but worthless as a generator of high-density negative ions.
After measuring the negative ion output level from the salt lamp, we took our sensitive negative ion
detector outdoors and measured a far higher level of naturally occurring negative ions than the salt
lamp emitted.
If the salt lamp’s negative ion output would have been any lower, we could not have measured it. The
salt lamp put out such a small level of negative ions that just taking a reading depleted the few
negative ions that it did put out, and then the ion detector stopped indicating. We then had to remove
the ion detector from near the salt lamp for a few minutes before we could again measure negative
ions near the lamp. We couldn’t tell the exact level of ions.”7
A Breath of Reason website:
“It is possible to separate sodium from chloride with high amounts of energy, but we’re talking much
more than what is put out from a mere 15-watt lamp. But let’s just say that somehow this glowing
chunk of halite on your nightstand actually does release negative ions to combat the pollutants in the
air. What would happen is your salt lamp would basically slowly shrink down to nothing but a pile of
pure sodium (not good), and at the same time be emitting chlorine gas (really not good). And then
there’s the logical paradox that if these negative ions are floating away, leaving the positively charges
ions in the lamp, the strong attraction between positive and negative would pull these negative ions
right back onto the lamp, negating entirely the purpose of your salt lamp.
[I]f the negative ions did bind to dust particles and allergens, and other pollutants that could trigger
asthma symptoms, there’s no chance of them being heavy enough to weigh the dust down, trap it
against a grounded surface, and make it easy to just wipe away. In a brilliant post on the effectiveness
of salt lamps, author D.B. Thomas asserts the weight of the chlorine molecule to be very small.
“Chlorine has a relative atomic mass of 35.5. Basically, a ‘mole’ of chlorine atoms 6.022 x 10^23
atoms)[sic] would weigh 35.5 grams. Let’s break that down to numbers that most people can really
understand. 35.5g/6.022x10^23 = 5.887x10^-23 grams. Or, 0.00000000000000000000005887
grams.” As if that would be enough to bring down a comparatively enormous dust particle.”8

Salt Lamps Do Not Neutralize Electromagnetic Radiation
Wavelength and frequency determine another important characteristic of electromagnetic fields.

Electromagnetic waves are carried by particles called quanta. Quanta of higher frequency (short
wavelength) waves carry more energy than lower frequency (longer wavelength) fields. Some
electromagnetic waves carry so much energy per quantum that they have the ability to break bonds
between molecules. In the electromagnetic spectrum, gamma rays given off by radioactive materials,
cosmic rays and X-rays carry this property and are called ‘ionizing radiation’. Fields whose quanta are
insufficient to break molecular bonds are called ‘non-ionizing radiation’. Man-made sources of
electromagnetic fields that form a major part of industrialized life – electricity, microwaves, and
radiofrequency fields - are found at the relatively long wavelength and low frequency end of the
electromagnetic spectrum and their quanta are unable to break chemical bonds.”9
Salt Lamps Do Not Benefit Respiratory Health
“Despite numerous experimental and analytical differences across studies, the literature does not
clearly support a beneficial role in exposure to negative air ions and respiratory function or asthmatic
symptom alleviation. Further, collectively, the human experimental studies do not indicate a
significant detrimental effect of exposure to positive air ions on respiratory measures. Exposure to
negative or positive air ions does not appear to play an appreciable role in respiratory function.”10
Heated Salt Lamps Do Not Trap Positive Ions and Release Negative Ions Cleaning and Deodorizing
the Ambient Through Hygroscopy
“Some small amount of water vapor in the air might adhere to the salt’s surface, and some of the water
vapor might dissociate salt into sodium and chloride ions. But as soon as the water vaper dried, the
two ion types would immediately recombine to form salt, so that process is unlikely to produce
negative ions either…
As for the idea that water vapor in the room attracts pollutants, then sticks to the surface of the lamp,
that, too, makes little sense, he said. Some pollutants in the air might, by chance, stick to water vapor
on the surface of the lukewarm piece of rock salt, but there’s no evidence that the meager heat
produced by a light bulb could produce significant amounts of pollutant filtering…
In terms of mass removal of pollutants from the air, I just don’t think it can happen, Malin said.
Instead, a chunk of charcoal with a fan blowing over it would likely have much better filtering
properties…”11

Summation
The research has been conducted and the Salt Therapy Association agrees with the science. The
reports that Himalayan salt has magical properties, how it provides wellness, and can aid in the
treatment of respiratory issues is a myth. Himalayan salt is for décor. The truth is that wellness and
respiratory health comes from halotherapy, where pure grade sodium chloride is crushed, ground, and
dispersed by a halogenerator.
While there is some evidence that large amounts of a natural compound concentration in an enclosed
space (such as quartz, amethyst, jade or Himalayan salt) can alter the vibrational frequency of the
physical environment, since all elements resonate at different frequencies, and, thus, alter the feeling
in the room, Himalayan salt décor can create a nice, ambient environment to sit and relax.
There is some scientific evidence about chromotherapy, also known as color therapy, where the warm
orange and pink hues of the lighted Himalayan salt bricks or panels create a soothing environment to
aid emotional and mental health. The placebo effect is also strong, and Himalayan salt is also very
popular as an ingredient in food and skin products.

Citations
1 http://nevertoocurious.com/2015/06/11/salt-lamps-are-pseudoscience/
2 John Malin, retired chemist formerly with the American Chemical Society
2 https://www.snopes.com/salt-lamps-cure-everything/
3 http://www.krem.com/news/salt-lamps-dont-actually-make-you-healthy-but-they-do-look-
nice/501577955
4 http://www.krem.com/news/salt-lamps-dont-actually-make-you-healthy-but-they-do-look-
nice/501577955
6 Columbia University Medical Center
7 http://www.negativeionsinformation.org/saltcrystallamps.html
8 https://abreatheofreason.com/2014/06/18/salt-lamps
9 http://www.who.int/peh-emf/about/WhatisEMF/en/
10Dominik D. Alexander, William H. Bailey, Vanessa Perez, Meghan E. Mitchell, and Steave Su, Air
ions and respiratory function outcomes: a comprehensive review, J Negat Results Biomed. 2013; 12:14
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848581/)
11 John Malin, retired chemist with the American Chemical Society
http://www.livescience.com/59328-himalayan-salt-lamp-faq.html
Copyright © 2019 Salt Therapy Association All rights reserved. Reproduction of this content without the express written consent of Salt Therapy
Association is prohibited.

Voen Med Zh. 1999 Jun;320(6):34-7, 96.

Halotherapy in the combined treatment of chronic bronchitis patients.
Maev EZ, Vinogradov NV.
Abstract
Halotherapy proved to be a highly effective method in a complex sanatorium treatment of
patients with chronic bronchitis. Its use promotes more rapid liquidation of clinical
manifestations of disease, improves indices of vent function of lungs, especially those values
that characterize bronchial conduction (volume of forced exhalations per second, index
Tiffno), increases tolerance to physical load, normalizes indices of reduced immunity and
leads to increasing the effectiveness of patient treatment in sanatorium.
PMID: 10439712
[PubMed - indexed for MEDLINE}

Vopr Kurortol Fizioter Lech Fiz Kult. 1997 Jul-Aug;(4):19-21.

The use of an artificial microclimate chamber in the treatment of patients with
chronic obstructive lung diseases.
Chernenkov RA, Chernenkova EA, Zhukov GV.
Abstract
Halotherapy was used for sanatorium rehabilitation in 29 patients with chronic obstructive
pulmonary diseases (chronic bronchitis and asthma). Significant positive effects of this
method resulted in the improvement of the flow-volume parameters curve of lung function
and in hypotensive effects on blood pressure. Halotherapy is recommended for use in
patients suffering from chronic obstructive pulmonary diseases with hypertension or
coronary heart disease.
PMID: 9424823

Vopr Kurortol Fizioter Lech Fiz Kult. 2000 Nov-Dec;(6):21-4.

Effectiveness of halotherapy of chronic bronchitis patients.
Abdrakhmanova LM, Farkhutdinov UR, Farkhutdinov RR.
Abstract
The chemoluminescence test in 49 patients with lingering inflammatory chronic bronchitis
has revealed inhibition of generation of active oxygen forms in the whole blood,
intensification of lipid peroxidation in the serum, depression of local immunity.
Administration of halotherapy to the above patients results in correction of disturbances of
free-radical oxidation, improves local immunity and clinical course of the disease.
PMID: 11197648

Klin Med (Mosk). 2000;78(12):37-40.

Effects of halotherapy on free radical oxidation in patients with chronic
bronchitis.
Farkhutdinov UR, Abdrakhmanova LM, Farkhutdinov RR.
Abstract
Registration of luminol-dependent chemoluminescence of blood cells and iron-induced
chemoluminescence of the serum was used to study generation of active oxygen forms and
lipid peroxidation in patients with chronic bronchitis (CB). 49 patients with lingering CB
showed inhibition of blood cell function and enhancement of lipid peroxidation. The
addition of halotherapy to combined treatment of these patients promoted correction of
the disorders and improvement of CB course.
PMID: 11210350


Efficacy of therapeutic use of ultrasound and sinusoidal modulated currents
combed with halotherapy in patient with occupational toxic-dust bronchitis.
Roslaia NA, Likhacheva EI, Shchekoldin PI.
Abstract
Immunological and cardiorespiratory characteristics were studied in 88 alloy industry
workers with occupational toxic-dust bronchitis who received the following therapy:
sinusoidal modulated currents (SMC), ultrasound (US) on the chest, halotherapy (HT) (52
patients, group 1); SMC + HT (10 patients, group 2); US + HT (15 patients, group 3); HT (11
patients, group 4). The patients did also therapeutic exercise and were massaged (chest). It
was found that device physiotherapy (SMC, US) in combination with HT raise the treatment
efficacy to 86.5%. This combined treatment is recommended both for treatment and
prevention of obstructive syndrome in toxic-dust bronchitis.
PMID: 11530404

Ann Agric Environ Med. 2014;21(1):124-7.

Salt caves as simulation of natural environment and significance of
halotherapy.
Zajac J1, Bojar I2, Helbin J1, Kolarzyk E1, Owoc A3.
Abstract
INTRODUCTION:
Human activity usually leads to a deterioration in air quality; therefore, searching for places
that simulate an environment without pollution is important. Artificial salt caves play crucial
role, as a kind of therapy, known as halotherapy, based on treatment in a controlled air
medium that simulates a natural salt cave microclimate.
OBJECTIVE:
Evaluation of awareness about the existence of salt caves, basic knowledge about the
purpose for their presence among people who bought salt caves sessions and checking
their subjective estimation of salt caves influence on their well-being.
MATERIAL & METHODS:
303 inhabitants (18-51-years-old) of 3 randomly chosen cities of southern Poland were
surveyed using a validated author's questionnaire. Both genders were represented in
comparable numbers.
RESULTS:
It was observed that knowledge about the existence of salt-caves is common - 94% of
respondents. 96 persons bought at least 3 salt caves sessions. The majority of women did
this for therapeutic reasons (57%), and men for both therapeutic and relaxation reasons
(both 39%). Both among women and men, the dysfunctions intended to be cured by
sessions included problems with throat, larynx or sinus. Depression as a reason for buying
sessions was mentioned only by women. In general, those who attended felt better after
sessions in salt caves.
CONCLUSION:
Besides the health benefits, people do not have free time for rest and activities in clean air;
moreover, stress is inseparable from everyday life, and for that reasons salt caves become
places that help to support a proper lifestyle.
PMID: 24738510

Halotherapy as asthma treatment in children: A randomized, controlled,

prospective pilot study.
Bar-Yoseph R, et al. Pediatr Pulmonol. 2016.
Abstract
BACKGROUND AND OBJECTIVES:
Asthma is a chronic inflammatory disorder requiring intermittent or continuous anti-
inflammatory therapy. Patients often turn to alternative treatments as complements or
replacements to conventional treatments. We aimed to evaluate the effect of salt room
chambers (halotherapy) on bronchial hyper-responsiveness (BHR), fractional exhaled nitric
oxide (FeNO), and quality of life in children with asthma.
PATIENTS AND METHODS:
Children aged 5-13 years with a clinical diagnosis of mild asthma not receiving anti-
inflammatory therapy. Patients were randomized in this double-blind, controlled study to
salt room with halogenerator (treatment group), or without halogenerator (control group).
We evaluated the effect of salt room therapy on BHR, FeNO, spirometry, and pediatric
asthma quality of life questionnaire (PAQLQ). The treatment period lasted 7 weeks, 14
sessions.
RESULTS:
Twenty-nine patients were randomized to the salt room with halogenerator (treatment
group), and 26 patients to the salt room without salt halogenerator (control group). A
statistically significant improvement in BHR was demonstrated in the treatment group,
which remained unchanged in the control group. There was no improvement in spirometry
or FeNO levels following treatment. The treatment group showed a statistical
improvement in most parameters of quality of life questionnaires.
CONCLUSIONS:
Our pilot study suggests that salt room with halogenerator, may have some beneficial
effects in mild asthmatic children. Randomized and larger controlled trials with long-term
follow-up are necessary.
Pediatr Pulmonol. 2016; 9999:XX-XX. © 2016 Wiley Periodicals, Inc.
© 2016 Wiley Periodicals, Inc.
For more information, click here: https://www.ncbi.nlm.nih.gov/pubmed/27723955

Voen Med Zh. 1999 Jun;320(6):34-7, 96.

Halotherapy in the combined treatment of chronic bronchitis patients.
Maev EZ, Vinogradov NV.
Abstract
Halotherapy proved to be a highly effective method in a complex sanatorium treatment of
patients with chronic bronchitis. Its use promotes more rapid liquidation of clinical
manifestations of disease, improves indices of vent function of lungs, especially those values
that characterize bronchial conduction (volume of forced exhalations per second, index
Tiffno), increases tolerance to physical load, normalizes indices of reduced immunity and
leads to increasing the effectiveness of patient treatment in sanatorium.

The role of non-medicamental technologies in the rehabilitation of the

children presenting with acute rhinosinusitis.
Khan MA 1 , Khoruzhenko OV 2 , Vakhova EL 1 , Lyan NA 1 , Radetskaya LI 1
Abstract
Despite the recent achievements in diagnostics and pharmacotherapy of acute
rhinosinusitis in the children, the problem of management of this pathology, thus far
remains a serious challenge for practical medicine. The objective of the present study was
to develop a scientifically sound rationale for the application of halotherapy (HT) and
magnetic therapy (MT) or their combination for the treatment of acute rhinosinusitis in
the children. The clinical observations and special investigations were carried out in the
comparative aspect and encompassed 120 children at the age varying from 5 to 15 years
suffering from acute rhinosinusitis. The therapeutic effectiveness of the rehabilitative
treatment was evaluated based on the results of the endoscopic study of the nasal cavity,
analysis of the X-ray images of paranasal sinuses, rhinomanometry, investigations into the
ciliary activity, and assessment of the mucosal immunity. The results of the present study
gave evidence of the feasibility of incorporating HT and MT in the combined treatment of
the children presenting with acute rhinosinusitis. The integrated use of the two methods
proved to have the advantage over the separate application of either of them. The specific
effects of HT and MT on the clinical course of acute sinusitis and the functional state of
intranasal mucosa are described. The optimal methods of the treatment are proposed.
For more information, click here: http://europepmc.org/abstract/MED/26595967

Orv Hetil. 2015 Oct 11;156(41):1643-52. doi: 10.1556/650.2015.30267.

Theoretical basis and clinical benefits of dry salt inhalation therapy.
Endre L1.
Abstract
Dry salt inhalation (halotherapy) reproduces the microclimate of salt caves, with beneficial
effect on health. Sodium chloride crystals are disrupted into very small particles (with a
diameter less than 3 µm), and this powder is artificially exhaled into the air of a
comfortable room (its temperature is between 20-22 °C, and the relative humidity is low).
The end-concentration of the salt in the air of the room will be between 10-30 mg/m(3).
The sick (or healthy) persons spend 30-60 minutes in this room, usually 10-20 times. Due to
the greater osmotic pressure the inhaled salt diminishes the oedema of the bronchial
mucosa, decreases its inflammation, dissolves the mucus, and makes expectoration easier
and faster (expectoration of air pollution and allergens will be faster, too). It inhibits the
growth of bacteria and, in some case, kills them. Phagocyte activity is also increased. It has
beneficial effect on the well-being of the patients, and a relaxation effect on the central
nervous system. It can prevent, or at least decrease the frequency of the respiratory tract
inflammations. It produces better lung function parameters, diminishes bronchial
hyperreactivity, which is the sign of decreasing inflammation. Its beneficial effect is true not
only in inflammation of the lower respiratory tract, but also in acute or chronic upper
airways inflammations. According to the international literature it has beneficial effect for
some chronic dermatological disease, too, such as psoriasis, pyoderma and atopic
dermatitis. This treatment (called as Indisó) is available under medical control in Hungary,
too.

Ter Arkh. 1996;68(8):24-8.

Bronchial hyperreactivity to the inhalation of hypo- and hyperosmolar aerosols
and its correction by halotherapy.
Gorbenko PP, Adamova IV, Sinitsyna TM.
Abstract
18 bronchial asthma (BA) patients (12 with mild and 6 with moderate disease) were
examined before and after halotherapy (HT) for airways reactivity using provocative tests
with ultrasonic inhalations of purified water (UIPW) and hypertonic salt solution (HSS).
Bronchial hyperreactivity (BHR) to UIPW and HSS before treatment occurred in 13 and 11
patients (72 and 69%, respectively). HT reduced BHR in 2/3 and 1/2 of the patients,
respectively. In the rest patients BHR was unchanged or increased, being so to UIPW only in
patients with atopic asthma in attenuating exacerbation. Clinical efficacy of HT and initial
BHR to UIPW correlated (r = 0.56; p < 0.05). No correlation was found between HT efficacy
and initial BHR to HSS.

Allergy 2006: 61: 605–610 Copyright Blackwell Munksgaard 2006
ALLERGY
DOI: 10.1111/j.1398-9995.2006.01073.x
Original article
The effect of salt chamber treatment on bronchial

hyperresponsiveness in asthmatics
Background: Randomized controlled trials are needed to evaluate the effects of J. Hedman1, T. Hugg2, J. Sandell2,
complementary treatments in asthma. This study assessed the effect of salt T. Haahtela3
chamber treatment as an add-on therapy to low to moderate inhaled steroid 1
Department of Pulmonary Diseases, South Karelia
therapy in asthma patients with bronchial hyperresponsiveness (BHR). Central Hospital, Lappeenranta, Finland; 2South
Methods: After a 2-week baseline period, 32 asthma patients who exhibited BHR Karelia Allergy and Environment Institute, Joutseno,
in the histamine inhalation challenge were randomized: 17 to 2-week active Finland; 3Department of Allergy, Helsinki University
Central Hospital, Helsinki, Finland
treatment, during which salt was fed to the room by a salt generator, and 15 to
placebo. The salt chamber treatment lasted 40 min and was administered five
times a week.
Results: Median provocative dose causing a decrease of 15% in Fev1
(PD15FEV4) increased significantly in the active group (P ¼ 0.047) but not in the
placebo group. The difference in changes between the active and placebo groups
was significant (P ¼ 0.02). Nine patients (56%) in the active group and two
Key words: asthma; bronchial hyperresponsiveness;
patients (17%) in the placebo group exhibited at least one doubling dose de- complementary treatments; salt chamber;
crease in BHR (P ¼ 0.040). Six patients (38%) in the active group and none in speleotherapy.
the placebo group became non-hyperresponsive (P ¼ 0.017). Neither the peak
expiratory flow (PEF) values measured just before and after the treatment, nor Dr J. Hedman
FEV1 values measured before the histamine challenges, changed. The reduction Department of Pulmonary Diseases
in BHR was not caused by changes in the baseline lung function. South Karelia Central Hospital
Valto Kkelnkatu 1
Conclusions: Salt chamber treatment reduced bronchial hyperresponsiveness as 53130 Lappeenranta
an add-on therapy in asthmatics with a low to moderate dose of inhaled steroids. Finland
The possibility that salt chamber treatment could serve as a complementary
therapy to conventional medication cannot be excluded. Accepted for publication 13 January 2006
Complementary and alternative medicine is widely used and radiation. Different combinations of temperature,
in the treatment of asthma. However, data on the efficacy relative humidity, pressure, radiation and aerosols are
of these treatments are usually lacking. Randomized also vital elements.
controlled trials are needed for exploring their possible The effects of salt mine treatment on health in the
effects (1, 2). They can also lead to undertreatment, and it village of Solotvino, in the Carpathian Mountains have
is important to verify if they have any value in the been investigated by Russian scientists. Natural dry
treatment of asthma. sodium chloride dust which formed as a result of
Bronchial hyperresponsiveness (BHR) gives valuable convection diffusion from salty walls was proposed to
information on the patient’s symptoms and airway be the main microclimatic treatment factor. A Ôhalo-
inflammation (3). It has been used to assess the effect of chamberÕ was constructed to simulate the microclimate of
some complementary treatments; e.g. Sahaga yoga has salt mines (6).
been shown to be beneficial (4) but short-term acupunc- The Cochrane Database of Systematic Reviews evalu-
ture therapy not so (5). ated the efficacy of speleotherapy in the treatment of
Subterranean environment therapy is called speleother- asthma (7). It included controlled clinical trials that
apy. Halotherapy is a form of speleotherapy, which compared the clinical effects of speleotherapy with either
makes use of the microclimatic conditions in a salt cave. another type of intervention or no intervention at all.
Natural karst caves have been used for treating asthmatic Three trials on a total of 124 asthmatic children met the
patients in Germany, Switzerland, Hungary, Bulgaria, the inclusion criteria, but only one trial had reasonable
former Yugoslavia and the former Soviet Union. The methodological quality (8). In the study by Novotny et al.
main therapeutic factors of speleotherapy in caves and (8), slight improvement of the lung function was observed
mines are thought to be air quality, underground climate at the end of the 3-week treatment period in the
605
Hedman et al.
speleotherapy group compared with the control group. In Table 1. Baseline characteristics of the study subjects
two other trials, it has been reported that speleotherapy
Active Placebo
had a beneficial short-term effect on lung function as well. (n ¼ 17) (n ¼ 15)
It was not possible to assess any other outcome. The
conclusion was that the available evidence is insufficient Age, years 53.2 (12.2) 52.1 (14.9)
to show speleotherapeutic interventions as an effective Female, n 15 14
Atopy, n* 10 9
treatment measure for chronic asthma. Randomized Duration of asthma treatment, years 8.8 (5.9) 9.6 (7.2)
controlled trials with long-term follow up are necessary Inhaled steroid dose, mg 0.894 (0.506) 0.733 (0.232)
(7). Long-acting beta-2 agonist 9 6
We assessed the effect of the salt chamber treatment as FEV1, l 2.61 (0.77) 2.54 (0.48)
an add-on therapy in patients with persistent asthma who FEV1, % predictedà 89.5 (17.1) 91.9 (8.5)
exhibited BHR in the histamine challenge in spite of a low FVC, l 3.25 (0.97) 3.21 (0.54)
FVC, % predictedà 90.4 (15.2) 95.6 (7.1)
to moderate inhaled steroid dose.
Morning PEF, l/min 441 (78.2) 438 (68.7)
Evening PEF, l/min 455 (94.1) 448 (63.6)
PD15FEV1, mg 0.488 (0.407) 0.588 (0.407)
Short acting bronchodilator use, n/2 weeks 2.8 (2.8) 1.4 (2.2)
Material and methods
Nocturnal awakenings, n/2 weeks 2.9 (5.4) 0.4 (0.8)
Patients Symptom score, 2 weeks 3.8 (5.2) 3.6 (5.0)
We selected adult patients who remained hyperresponsive in the Data are presented as group mean (SD) values and patient numbers.
histamine inhalation challenge in spite of regular treatment with *Allergic rhinitis or atopic eczema reported by the subject.
inhaled steroids. Female and male asthmatics aged ‡18 years were Expressed as bechlometasone equivalent dose (1.0 mg budesonide or 0.5 mg
eligible for inclusion if: (1) they used inhaled glucocorticosteroids at fluticasone equivalent to 1.0 mg bechlomethasone).
a constant daily dose of ‡200 lg for ‡30 days before entry; and (2) àViljanen et al. (9).
they were histamine challenge-positive (PD15FEV1 £ 1.6 mg). Be-
fore the histamine challenge, they had to have a baseline forced patients in the active group and six patients in the placebo group
expiratory volume in 1 s (FEV1) of ‡70% predicted. used long-acting beta-2 agonists but none of the subjects used am-
Exclusion criteria included respiratory infection or worsening of inophylline or leucotriene receptor antagonists. There were no sig-
asthma within 30 days before entry into the study, current smoking nificant differences between the groups.
or a history of smoking ‡10 pack-years, other respiratory disease, The study was conducted in accordance with the guidelines of the
or severe dysfunction in other organs. Pregnant and lactating wo- Declaration of Helsinki. The Ethics Committee of South Karelia
men, as well as women of childbearing potential unable to use Central Hospital approved the study protocol and all patients gave
acceptable contraceptives were excluded. their written consent prior to the commencement of the study.
Subjects were recruited through a local newspaper advertizement
(231 responses). After a telephonic interview with a research nurse
and doctor, 153 patients were excluded (124 because of inclusion or Study design
exclusion criteria, while 29 subjects cancelled their participation
A parallel-group, double-blind, randomized placebo-controlled trial
before the histamine challenge). Seventy-eight asthmatics under-
was conducted. After a 2-week baseline period, patients were
went a histamine inhalation challenge test for evaluatation of
randomized to either a 2-week active salt chamber treatment or the
airway responsiveness (Fig. 1). Forty-six of the patients were chal-
placebo. The randomization of patients was carried out in groups of
lenge-negative and were hence excluded. Thirty-two patients (41%)
four and the treatment was blinded to the patients, study nurse and
were challenge-positive and were randomized in the study – 17 to
investigator. Patients underwent 40 min of treatment every day, five
the active salt chamber treatment and 15 to the placebo treatment.
times a week, in the salt chamber of Lappeenranta Spa.
Baseline characteristics of study subjects are given in Table 1. Nine
Patients continued their original asthma medication throughout
the study and the salt chamber treatment acted as an add-on ther-
apy. If there was a need for increasing the steroid dose because of
Assessed for eligibility
histamine challenge (n = 78) the worsening of the asthma, the patient was excluded from the
study.
Excluded = BHR negative
(n = 46)
Conditions
Randomized = BHR positive
(n = 32) The salt chamber was 12.5 m2 in area with a volume of 27.5 m3. The
roof, walls and partly also the floor were covered with 20–50-mm-
Allocated to active salt room treatment Allocated to placebo treatment (n = 15) thick coating of salt (rock salt, NaCl 98.5%). Both the active and
(n = 17) Completed treatment (n = 13)
Completed treatment (n = 16) Did not complete treatment (n = 2, the placebo treatments were administered in the same salt chamber.
Did not complete treatment (n = 1, common cold) During the active treatment, 3 g of salt was fed into the salt gen-
common cold)
erator (Polar and Iris salt generator; Polar Health Oy, Nummela,
Finland; IndiumTop LLC, Tallinn, Estonia) at intervals of 4 min,
Lost to follow up (n = 3) Completed (n = 13) Completed (n = 9) Lost to follow up (n = 4)
2 common cold 3 common cold first being pulverized and then being blown into the chamber
1 worsening of asthma 1 worsening of asthma through the feed channel. Indoor dust emission, determined by
isokinetic samples according to standard EN 13284-1 in the front of
Figure 1. Flow of subjects through study. the feed channel, ranged from 1.6 to 3.3 mg/s (three measurements).
606
Effect of salt chamber treatment in asthma
Table 2. Salt concentrations (mg/m3) in the salt chamber (Spira Elektro 2; Respiratory Care Center, Hämeenlinna, Finland).
The non-cumulative doses of histamine were 0.025, 0.1, 0.4 and
Measurements Feeding Blasting volume of Concentration 1.6 mg, administered within 0.4 s following the tidal inspiration of
mean speed of salt the salt generator (mean range) 100 ml of air. FEV1, measured with flow/volume spirometry
(Medikro, Kuopio, Finland), was used to determine the response.
1 3 g/3 min 1/1 14.7
The PD15FEV1 was calculated from logarithmically transformed
2 3 g/4 min 1/2 7.1 (5.9–8.4)
histamine doses using linear interpolation.
3 3 g/4 min 3/4 7.6 (6.7–8.1)
Peak expiratory flow (PEF) measurements, use of a rescue
4 3 g/4 min 1/4 7.4 (7.3–7.5)
bronchodilator (puffs per 24 h) and asthma symptoms (wheezing,
dyspnoea), were recorded each morning and evening by the pa-
tients on diary cards during the study. The number of nocturnal
During the placebo treatment, salt was not fed into the salt gener- awakenings were also recorded. Wheezing and dyspnoea were
ator. The generator was, however, running and patients could hear each graded on a scale of 0–3 (0 ¼ none; 1 ¼ mild; 2 ¼ moder-
its sound. ate; 3 ¼ severe). Total asthma symptom score (on a scale of 0–6)
The air blast volume of the salt generator and the feeding speed of was the sum of wheezing and dyspnoea scores. Baseline diary
the salt affected the salt concentration (Table 2). A feeding rate of data for 2 weeks were collected before randomization. The PEF
3 g every 4 min and a blasting volume of one-fourth of the salt was measured using a mini-Wright peak flow meter (Clement
generator resulted in conditions similar to those reported and used Clark, Harlow, UK), and the highest of three values was recor-
in treatment units of eastern and central parts of Europe (8). ded. The PEF was also measured just before and after salt
The treatments were administered, on average, at a temperature chamber treatment.
of 23.0C (range 18.0–27.3C, n ¼ 304) and at 41% relative
humidity (range 25–51%, n ¼ 304). Indoor air temperature (U-type
thermistor probe; Grant Instruments Ltd, Shepreth, UK) and rel- Statistical analyses
ative humidity values (Vaisala HMP 35 AG, Vaisala Oyj, Finland)
were recorded with a datalogger (Squirrell 1000 series; Grant Non-parametric statistics were mainly used. A comparison of the
Instruments Ltd). active and placebo groups was made using either the Mann–Whit-
During the active treatment, the mean salt concentrations of the ney U-test or the Fischer’s exact test, as appropriate. The Wilcoxon
indoor air of the salt chamber fluctuated from 7.1 to 7.6 mg/m3 signed-rank test was used to analyse the effect of treatments in the
(range 0–31.5 mg/m3; n ¼ 7). During the placebo treatment, the two groups. A per-protocol analysis (excluding all participants who
mean salt concentration was 0.3 mg/m3 (n ¼ 3). Salt concentrations failed to complete the protocol) was also carried out using paired
were restored to zero level (0–1 mg/m3, n ¼ 7) during the 20 min of (within-treatment effect) and unpaired (between-treatment effect)
enhanced ventilation after each treatment period. t-tests. If a patient was a non-responder (PD15FEV1 >1.6 mg) in
Stationary inhalable dust samples were collected with IOM (SKC the 2-week or in the 2-month histamine challenge, an arbitrary
Inc., Eighty Four, PA, USA) samplers. The sampling head is de- PD15FEV1 value of 3.2 mg was used. A P-value of <0.05 was
signed to meet the ACGIH and EN 481 criteria for inhalable dust at considered statistically significant. All tests were performed using
a sampling flow rate of 2.0 l/min. Time-dependent variation of dust GBSTAT software Version 6.5 (Dynamic Microsystems, Silver
concentrations was measured with a Respicon TM-SE (Helmut Spring, MD, USA).
Hund GmbH, Wetzlar, Germany). The sampler is designed to meet
the ACGIH and EN 481 criteria for size-selective sampling of
occupational dusts. Particle size distribution was determined by a
six-stage cascade impactor. The cut-off points were 10, 5, 2.5, 1.3, Results
0.65 and 0.3 lm at a sampling rate of 20 l/min. Salt dust concen-
tration, time-dependent variation of salt dust concentration and Sixteen asthmatics in the active group and 13 in the
particle size distribution were measured 1 m above the ground be- placebo group completed the 2-week salt chamber treat-
tween the seats. While the measurements were being taken, one to ment. One patient in the active group and two in the
four persons stayed in the chamber, simulating the treatment pro- placebo group failed to complete the treatment (all
tocol. A particle size <5 lm (aerodynamic diameter) constituted because of respiratory infections).
35–45% of the total particle mass, and a particle size <20 lm
correspondingly 88–97% (n ¼ 4). Depending on the measurement
time, the median of the particle size distribution ranged from 6 to Bronchial hyperresponsiveness
8 lm (n ¼ 4). According to the measurements, both the salt dust
concentration and particle size distribution were evenly distributed After the 2-week treatment, the median PD15FEV1 value
inside the chamber. Measurement of the conditions was carried out increased significantly in the active group but decreased in
by the Lappeenranta Regional Institute of Occupational Health. the placebo group compared with the baseline. In the
active group, median (range) the PD15FEV1 value before
Outcome measurements and after treatment was 0.460 mg (0.020–1.57) and
0.595 mg (0.022 to >1.6) (P ¼ 0.047); and in the placebo
The main outcome parameter was BHR. Patients underwent a group 0.720 mg (0.016–1.42) and 0.630 mg (0.085–1.25)
histamine inhalation challenge three times: at the baseline, at the (P > 0.05). The difference between the changes occurring
end of the 2-week treatment, and 2 months after the treatment. The during the treatment with the salt chamber and the
study was conducted outside the pollen season.
The histamine challenge method has been described in detail
placebo was significant (P ¼ 0.02) (Table 3).
elsewhere (10). In short, an automatic inhalation-synchronized The BHR decreased by at least one doubling dose in
dosimetric jet nebulizer with the known lung deposition of the nine patients (56%) in the active group and in two
aerosol was used to administer histamine and to control breathing patients (17%) in the placebo group (Fischer’s exact,
607
Hedman et al.
Table 3. Per-protocol analysis of changes in spirometric indices, PEF values, bronchodilator use, nocturnal awakenings and symptom scores over 2 weeks active and placebo
salt chamber treatment
Active (n ¼ 16) Placebo (n ¼ 13) Active vs placebo difference
FEV1, l 0.04 ()0.18 to 0.10) 0.01 ()0.08 to 0.06) 0.03 ()0.12 to 0.18)
FVC, l )0.04 ()0.07 to 0.15) )0.04 ()0.05 to 0.13) 0.001 ()0.13 to 0.13)
Morning PEF, l/min 7.0 ()0.09 to 14.1) 4.4 ()6.0 to 14.7) 2.7 ()9.3 to 14.7)
Evening PEF, l/min 9.3 (2.7 to 15.8)** 4.0 ()5.4 to 13.4) 5.5 ()5.6 to 16.4)
Treatment PEF, l/min 0.8 ()2.5 to 4.1) 4.0 ()0.8 to 8.8) )3.1 ()8.6 to 2.4)
Short-acting bronchodilator use, n/2 weeks 1.5 ()0.2 to 3.2) 1.1 ()0.2 to 2.3) 0.4 ()1.6 to 2.4)
Nocturnal awakenings, n/2 weeks 2.2 (0.4 to 4.0)* 0.2 ()0.2 to 0.7) 2.0 (0.1 to 3.8)
Symptom score, 2 weeks 1.7 ()1.6 to 4.9) 2.5 ()0.8 to 5.9) )0.9 ()5.3 to 3.6)
*P < 0.05, **P < 0.01 (within-group difference from baseline).
P ¼ 0.040). Six patients (38%) in the active group and

Other outcome measures
none in the placebo group became non-responsive to
histamine (Fischer’s exact, P ¼ 0.017). The changes in Changes in spirometric indices, PEF values, bronchodi-
the individual BHR in the active and placebo groups are lator use, nocturnal awakenings and symptom scores over
given in Fig. 2. 2 weeks of active and placebo salt chamber treatment are
A follow-up histamine challenge was performed given in Table 3. No significant changes in between-
2 months after the salt chamber treatment. There were group analysis were observed. Statistical significant dif-
three dropouts in the active group (two due to common ferences in evening PEF values (P ¼ 0.0085) and in
cold and one to worsening of asthma) and four nocturnal awakenings (P ¼ 0.020) were detected in with-
dropouts in the placebo group (three due to common in-group analysis of active group.
cold and one to worsening of asthma). In the active
group, the median (range) PD15FEV1 value was
0.580 mg (0.067 to >1.6) and in the placebo group
Discussion
0.620 mg (0.110 to >1.6). There were no more signi-
ficant changes compared with the baseline in the This study is the first controlled trial investigating the
within-group or in the between-group analyses. Four effect of salt chamber treatment on BHR. A 2-week salt
of 13 patients in the active group and one of nine chamber treatment reduced BHR as an add-on therapy
patients in the placebo group were non-responsive to on a low to moderate dose of inhaled steroids.
histamine (PD15FEV1 >1.6 mg) (P > 0.05). The number of patients was small, which increases the
risk of error due to chance, and hence our results should
be taken as preliminary only. BHR did not differ
10 000 statistically between active and placebo groups in the
P = 0.02 baseline. There is, however, a more reactive group in the
active treatment group and therefore any change could
tend to favour the active group. Being in a trial
1000
environment may also have helped compliance and this
Histamine PD15FEV1
would have again favoured the active treatment group.

The 2-week baseline period may have been the factor
100 leading to an apparent improvement, too. The duration
of the effects on BHR and asthma control cannot be
reliably estimated as the sample size became too small
during the 2-month follow-up. As respiratory viral
10
infections may increase BHR (11), these patients were
excluded from the follow-up.
The mechanisms of the effect of salt chamber treatment
1 are unclear and can only be speculated. BHR is a
Baseline Treatment Baseline Treatment
surrogate marker of bronchial inflammation. Sont et al.
Active Placebo
have stressed the value of a methacholine challenge in
Figure 2. Changes in airway responsiveness to histamine in the guiding treatment; reducing BHR leads to better control
active and placebo salt chamber treatment groups. PD15FEV1 of asthma (12). Airway responsiveness to direct broncho-
(lg histamine) at baseline and after the 2-week treatment. An constrictor stimulus as histamine or methacholine is,
arbitrary value of 3200 lg was used in subjects who were chal- however, only loosely related to inflammation (13, 14).
lenge-negative. Thick lines represent median values. Further studies are needed to assess the effect of salt
608
Effect of salt chamber treatment in asthma
chamber treatment on more direct inflammatory param- treatment was observed. It is, however, possible that
eters (e.g. exhaled NO or inflammatory markers in increasing salt concentrations eventually cause broncho-
induced sputum). constriction in sensitive individuals. Salt inhalation may
Airway calibre depends on the balance between the have a U-shaped effect, small and moderate doses being
force generated by airway smooth muscle (ASM) and a beneficial but higher doses causing adverse effects.
number of opposing factors, mainly autonomic nervous It is possible that the symptomatic relief the patients
mechanisms tending to limit ASM tone and mechanical reported from salt chamber treatment is associated with
forces opposing ASM shortening (15). Salt chamber the reduction in BHR. All patients used inhaled steroids
treatment did not cause any bronchodilation. Neither the but still showed a reduction in BHR to an extent which is
PEF values measured just before and after the treatment, not easy to attain by any drug treatment. The idea that
nor the FEV1 values measured before the histamine salt chamber treatment could serve as a complementary
challenges changed. Therefore, the reduction in BHR was therapy to conventional medication cannot be ruled out.
not caused by changes in baseline lung function as could No side-effects were observed.
have been one possible explanation (16, 17). Salt chamber treatment is, however, neither simple nor
Bronchial hyperresponsiveness can be reduced by cost-free. The conditions in the individual salt chambers
directly affecting airway smooth muscle contractility should be measured and standardized as we did in our
(18). Some cytokines may act directly or indirectly on study. The possible dose–response effect of salt concen-
ASM cells and alter myocyte function by modulating trations should be studied in further trials. The optimum
contractile agonist-induced calcium signalling in human duration or regularity of treatments needed are not
ASM cells (18). There is also a strong positive correlation known. In practice, the length of individual salt treat-
between bronchial reactivity and the level of intracellular ments vary widely from 20 min to hours and last five to
magnesium: magnesium intervenes in the calcium trans- 25 sessions. The length and regime of our study mirrors
port mechanism and intracellular phosphorylation reac- the common practice in Estonia and in the salt chamber
tions (19). Whether these mechanisms are involved in the of Lappeenranta Spa. Health economic aspects should be
salt chamber treatment is unknown. evaluated. There might be benefits linked to the better
Inhalation of hypertonic saline can cause bronchocon- control of asthma and reduced use of asthma medication.
striction (20). Dry powder sodium chloride has even been Expenses linked to the salt chamber treatment, as well as
used to assess BHR in asthmatics (21). As the resting travel costs to the treatment centres, should be evaluated.
ventilation is 6–10 l/min, the NaCl dose inhaled by the In future studies, the cost benefit should be compared
patients during a 40-min treatment period was about 18– with other treatment modalities, including the improve-
30 mg. This is less than the provocative dose of NaCl ment of existing drug treatment.
causing the FEV1 to fall 20% from the baseline in an
inhalation challenge test using dry NaCl (mean 103 mg)
in the study by Andersson et al. (22). It is also far less
Acknowledgments
than the daily sodium intake of female (2.36 g) and male
(3.15 g) asthmatics in the study by Sausenthaler et al. The authors would like to thank K. Mynttinen and J. Paananen for
(22). In that study, the sodium intake did not alter BHR assistance and S. Rautio for the measurement of conditions. The
assessed as PD20 to methacholine but might have study was supported by research grants from Finland’s Slot
Machine Association and The Social Insurance Institution of
increased mild BHR assessed as PD10 (22). In our study,
Finland.
no bronchoconstriction because of the salt chamber
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Krieken JHJM, Vandenbroucke JP, 1997;2:97–105. Linseisen J, Heinrich J. Sodium intake
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610
iative Care
aII
P
&
Journal of
Me
dicine
ISSN: 2165-7386
Journal of Palliative Care & Medicine Weinreich et al., J Palliat Care Med 2014, 4:4
DOI: 10.4172/2165-7386.1000185
Research Article Open Access
Salt Halo Therapy and Saline Inhalation Administered to Patients with Chronic
Obstructive Pulmonary Disease: A Pilot Study
Ulla Møller Weinreich1,2*, Tove Nilsson3, Lone Mylund1, Helle Thaarup Christiansen4 and Birgitte Schantz Laursen5
1Department of Pulmonary Diseases, Aalborg University Hospital, Denmark
2The Clinical Institute, Aalborg University Hospital, Denmark
3Department of Clinical Epidemiology, Aarhus University, Denmark
4Department of Respiratory Diseases, Sygehus Vendsyssel Frederikshavn, Denmark
5The Clinical Nursing Research Unit, Aalborg University Hospital, Denmark
*Corresponding author: Ulla Møller Weinreich, Department of Pulmonary Diseases, Mølle Parkvej 4, 9000 Aalborg, Denmark, Tel: 459764735; E-mail:
[email protected]
Received date: Jun 01, 2014, Accepted date: Aug 27, 2014, Published date: Sep 6, 2014
Copyright: © 2014 Weinreich UM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Introduction: Chronic Obstructive Pulmonary Disease (COPD) is characterised by progressive airflow limitation
associated dyspnea and impaired quality of life. Halo therapy has been suggested to relieve respiratory discomfort in
patients with COPD.
Aim: The aim of this study was to study the effect of halo therapy and isotonic saline inhalation, compared to
controls, in COPD patients.
Material and methods: In this pilot cohort study 67 patients with COPD, GOLD stage 3 and 4, were included.
Patients were assigned to 3 different groups; group 1 receiving 20 sessions of 45 minutes halo therapy with dry
aerosols of salt, less than 5 µm over 5 weeks; group 2 inhaling 5 ml isotonic Saline over 5 minutes, 5 weeks, 3 times
per day and group 3 as controls. Spirometry, 6 minute walking test, dyspnea-score (MRC) and Quality-of-life
(SGRQ) score was investigated at inclusion and at termination of the study.
Results: Group 1 improved walking distance 75 meters (p<0.01), SGRQ -6.66 points (p<0.05) and FEV1 0.4
liters (2%), (p>0.05), during the treatment period. Group 2 improved FEV1 0.7 litres (3%) (p<0.05) and walking
distance 90 metres (p<0.01). There was a drop out of 28% (7/25) in this group due to discomfort. Group 3 reduced
MRC 1 point (p<0.05) and FEV1 0.6 litres (2%) (p = 0.051) during the observation period.
Conclusion: Both Halo therapy and saline inhalation improved walking distance and FEV1 in patients. SGRQ
improved in patients treated with halo therapy. Halo therapy appeared to be better tolerated than saline therapy.
Keywords: Chronic obstructive pulmonary disease; Halo therapy; the microclimate within the caves are stable air temperature and
Saline inhalation; Quality of life; FEV1; MRC; 6 Minute walking test; humidity, the presence of fine aerosol elements (sodium, potassium,
Dyspnea magnesium and calcium), and lack of airborne pollutants and pollens.
This may be modeled above ground, in a so-called halo chamber. Halo
Introduction therapy, inhalation of micronized salt in the controlled conditions of a
halo chamber, has become increasingly popular in the general
Chronic obstructive pulmonary disease (COPD) has during the last community worldwide. Although the claimed effects of halo therapy
centuries emerged to be the most important respiratory disease are plenty, i.e. bactericidal effect, improvement of immunity,
globally [1], with an estimated 210 million people suffering from improved rheological properties of secretion [9] only a single study has
COPD worldwide. It is characterised by progressive airflow limitation, looked at immunological changes during halo therapy and suggested
often associated with dyspnea, reduced walking distance and hence changes in T-lymphocyte activity [10]. However, halo therapy has
impaired self-evaluated quality of life [1]. Treatment, in terms of been shown to relieve symptoms in smokers [11] and in patients with
smoking cessation [2], rehabilitation [3] and inhaled drug therapies [4] respiratory symptoms in general [12-14]. It has been argued that
relieve symptoms, However dyspnoea remains a major complaint in halotheraphy is beneficial in treatment of COPD patients [15], but, as
COPD [5] and has, as well as impaired walking distance, a major concluded in a recent review, further research is needed on the effect
impact on patients’ perception of quality of life [6,7]. Therefore relief and impact on the quality of life of halo therapy in COPD [16].
of symptoms and research in this field is of great importance.
Halo therapy chambers are not easily accessible; in Denmark the
In Central and Eastern Europe, natural salt caves have been used for only established chamber is situated on the remote island called
centuries to relieve chest conditions [8]. The unique characteristics of Laesoe.
J Palliat Care Med Volume 4 • Issue 4 • 1000185

ISSN:2165-7386 JPCM, an open access journal
Citation: Weinreich UM, Nilsson T, Mylund L, Christiansen HT, Laursen BS (2014) Salt Halo Therapy and Saline Inhalation Administered to
Patients with Chronic Obstructive Pulmonary Disease: A Pilot Study. J Palliat Care Med 4: 185. doi:10.4172/2165-7386.1000185
Page 2 of 5
Saline inhalation has previously been described to have possible Treatment

effect on mucus clearance in COPD patients [17]. Still, this method
may not be well tolerated as reported in a previous study; 1/3 of the During the study period patients were treated as follows:
study population had minor adverse events after inhalation due to Group 1: Seventeen patients received 20 sessions of 45 minutes halo
discomfort [18]. therapy with medical salt (Sanal®, Azco Nobel Salt, Mariager,
Thus, we hypothesized that, in patients with COPD, halo therapy Denmark), composed of 92% Natriumcloride, 3% Calciumsulfate, 2%
may relieve symptoms and improve quality of life. The same relief may Magnesiumsulfate and Magnesiumcloride and 0,3% Potassiumcloride,
be achieved by saline inhalation. Hence the specific aims of this pilot over a 5 week period. The inhalation took place in a salt chamber with
study were to investigate the possible effect of halo therapy and saline regulated micro-climate; temperature 25° Celcius, humidity<40%, and
inhalation on lung function, in terms of spirometry, dyspnea, a salt generator (Micronizer SaltPro 3®, Microsalt Medical Schwäbisch
evaluated by the MRC score; ability, evaluated by 6 minute walking Hall, Germany) distributing dry aerosols of salt, size less than 5 µm, to
test and quality of life, measured by Saint George Respiratory an even concentration of 10 mg/m3 throughout the chamber. Patients
Questionnaire (SGRQ). were resting during the sessions.
Group 2: Twenty-five patients received inhalations of 5 ml isotonic
Material and Methods Saline, 5 minutes, 3 times per day evenly distributed over the day, in 5
weeks. The inhalations took place in the patients’ home on a nebulizer,
This Pilot cohort study was conducted in the Northern Region of using a face mask. Patients were instructed to rest during the sessions.
Jutland in Denmark from September till November 2011.
Group 3: Twenty-five control patients. These patients had all
Study population recently completed a rehabilitation programme. No further actions
were taken on this group.
Patients were recruited by public announcement in writing, from an
The study was approved by the Local Ethical Committee
out patients' clinic, a rehabilitation centre and at the island of Laesoe,
(N-20110012) and data were registered and kept according to the
(1860 inhabitants), situated 29 kilometres of the coast of Jutland,
legislation of the Danish Data Protection Agency. Patients were
where the only halo therapy chamber in Denmark was located.
informed according to the Helsinki declaration.
Patients with COPD GOLD stage 3 according to the 2007 GOLD
guidelines (FEV1 30-50%) and 4 (FEV1<30%) were included [1]. Only
patients treated according to GOLD guidelines recommended at the Statistical analysis
time of inclusion participated in the study [19]. Patients were in stable Demographic data are described in means and ranges. A paired t-
state i.e. none of the study participants had exacerbations of COPD or test was applied to test differences in means on gender, age, BMI,
major changes in medication treating co morbidities, such as diabetes, smoking status and exacerbations. Furthermore subgroup analyses of
cardiac disease and mental disorders within three months of study responders versus non-responders of the SGRQ were performed in the
start. Patients were not allowed to use other types of halo therapy and three groups, applying a paired t-test. Possible differences in means on
were asked not to change smoking habits during the study period. gender, age, smoking status and exacerbations as well as walking
Patients with end stage malignant diseases were excluded. distance, lung function and MRC at the end of the study were
No more than one hour’s transportation time to treatment was investigated.
accepted. As such patients were referred to three groups; patients from
Laesoe received halotheraphy (group 1), patients in contact with the Results
outpatient clinic received saline inhalation (group 2). A third group of
patients, all in contact with a rehabilitation centre were included to Of those included in group 1 all 17 completed the study. Of the 25
elucidate possible changes in a population of COPD patients treated patients included in group 2 18 patients completed the study. Drop
after general recommendations over the same time period (group 3). outs were due to exacerbation (2) and side effects in terms of severe
Eighty-five patients were tried for inclusion by primary interview. Of dyspnea in relation to inhalations (5). Of the 25 patients included in
those 67 met the inclusion criteria; 17 were included in group 1, and group 3, 24 patients completed the study.
25 in each of groups 2 and 3. Baseline characteristics of the study groups are demonstrated in
A maximum of 3 days before study start an interview was Table 1. The table shows that the majority of the study population
performed and demographic data; age, sex, smoking status, BMI, were female although there was no statistical difference in gender
number of exacerbations one year prior to inclusion, were recorded. A within the groups (p=0.07); the three groups were comparable in age
spirometry was performed (EasyOne Spirometer®, Medizintechnik (67-71 years old) and BMI (27-28). Group 2 had more, but not
AG , Zürich, Switzerland), MRC-score was recorded [20], a 6-minute statistically significant more exacerbations (1.36) than groups 1(0.76)
walking test was performed [21,22], and quality of life was evaluated and 3(0.96) (p=0.08). There were significantly more current smokers
by the Saint George Respiratory Questionnaire (SGRQ) [23]. A similar in group 1 (10/17) than in 2 (6/25) (p=0.04) and 3(2/25) (p=0.002).
examination was performed a maximum of 3 days after the end of the There was no significant difference in the number of smokers in group
study; patients were handed out the SGRQ on the day of the final 2 and 3 (p=0.08).
examination and asked to return it by mail.
During the study period the number of exacerbations was recorded.

Page 3 of 5
Gender Age Body Mass Index current/prior smokers Exacerbations
N (male/female) Mean (range) Mean(range) Mean(range)
Group 1
17 7/10 70 (49-88) 28 (20-38) 10/7 0,76 (0-3)
(halo therapy)
Group 2
18 7/11 70 (52-84) 28 (20-35) 4/14 1,39 (0-5)
(saline inhalation)
Group 3
24 14/10 67 (58-80) 27 (23-40) 2/23 0,96 (0-3)
(control)
Table 1: Demographic data: Age, Body Mass index and Exacerbations. There was no significant difference between the groups
Table 2 shows data on FEV1, FEV1%, MRC-score and 6-minute 3(51%), (p<0.05). Group 2 also had significantly lower MRC score (4)
walking test in the groups at the time of inclusion and at the end of the at the time of inclusion than groups 1(3) and 3(3) (p<0.05). Group 1
study period. Only data from participants who completed both and 2 had a significantly shorter walking distance (336 and 301 metres
examinations are presented in the table. Group 2 had significantly respectively) in the 6 minute walking test than group 3 (458 metres)
lower FEV1% (31%) at the time of inclusion than groups 1(49%) and (p<0.01).
At inclusion End of study
N Mean (range) N Mean (range)
Group 1 FEV1 (liter) 17 1.28 (0.48-2.29) 17 1.32 (0.54-2.55)

(Halo therapy)
FEV1% 17 49 (27-78) 17 51 (21-86)
MRC 17 3 (2-4) 17 3 (2-4)*
6 minute walking test (meters)** 14 329 (167-526) 14 367 (198-543)**
Group 2 FEV1 (liter)* 18 0.84 (0.61-1.51) 18 0.91 (0.62-1.90)*

(Saline inhalations)
FEV1%* 18 31 (21-53)* 18 34 (23-54)*
MRC 20 4 (2-4) 20 3 (2-4)
6 minute walking test (meters)** 17 341 (142-513) 17 374 (180-528)**
Group 3 FEV1 (liter) 24 1.42 (0.7-2.2) 24 1.36 (0.7-2.3)

(Controls)
FEV1% 24 54 (26-77) 24 52 (29-82)
MRC 24 3 (1-4) 24 3 (2-4)*
6 minute walking test (meters) 24 457 (286-602) 24 454 (260-614)
Table 2: Comparison of FEV1, MRC, 6-minutes walking test and SGRQ within the groups 1 (halo therapy), 2 (saline inhalations) and 3 (controls)
and number of patients performing the tests. Only patients with complete dataset are reported in this table. *=p<0.05 (paired t-test). **=p<0.01
(paired t-test).
At the end of the study patients in group 1 had improved 6 minutes At the end of the study period group 3 had a significant decrease in
walking test with 75 metres(p<0.01). There was a statistically the MRC-score of 1 point (p<0.05). The decrease was due to 3
insignificant increase in FEV1% of 2% (0.04 litres) – however, sample participants, of which two had had major exacerbations during the
size calculations showed that, given a normal distribution, a 2% inter-observational period.
change in FEV1% would have been significant in a study population of
Table 3 shows the results of the SGRQ at inclusion and study end.
65.
Sixty-five % (11/17) of patients in group 1; 50% (9/18) of patients in
At the end of the study, patients in group 2 had a statistically group 2 and 58% (14/24) of patients in group 3 completed the SGRQ
significantly improved FEV1% with 3% (0.07 litres) (p<0.05) and 6 questionnaire both at study start and study end. Group 1 improved
minute walking test with 90 metres (p<0.01). Demographic data of the significantly with -6.66 points (p=0.03) and group 2 and 3 showed no
7 patients dropping out of group 2 were equally distributed compared improvement in SGRQ. Within the individual groups there were no
to the 18 patients in group 2 that completed the study period. statistical difference in age (p=0.8), gender (0.70.8), 6 minute

Page 4 of 5
walking test (0.30.7), MRC-score (0.40.7), FEV1%, study is the first to investigate the effect of halo therapy in COPD
(0.20.6), smoking status (p= 0.6) and number of exacerbations patients and to evaluate the influence on patient evaluated parameters.
(0.40.7) between responders and non-responders to the SGRQ.
A statistically significant improvement in FEV1 was found after 5
N SGRQ at inclusion N SGRQ at end of study weeks of isotonic saline treatment. However, a clinically significant
difference in FEV1, which is considered to be 100 mili Liters (mL) [28]
Group 1 * 14 50,67 14 44,01 was not seen, as FEV1 improved by 70 mL. Hypertonic saline
inhalation has previously been studied in patients with chronic
Group 2 10 52,04 12 51,65
bronchitis by the group of Clarke and Pavia who showed improved
Group 3 19 39,98 17 41,65 mucociliary clearance, yet no improvement in FEV1 was found [17].
The inconsistency of the findings may be explained by the duration of
Table 3: Number of patients completing (N) the SGRQ and the results treatment; in the studies of Clarke and Pavia patients were only treated
of the questionaire at inclusion and end of study in groups 1 (halo for 3 days. As such the optimal duration of treatment still needs to be
therapy), 2 (saline inhalations) and 3 (controls). *p=0.03 ( paired t- established, both in saline- and halo therapy.
test). A decline in MRC score was seen in group 3. As these patients had
completed rehabilitation just prior to inclusion one could expect a
Discussion decrease in physical abilities; however previously this has not been
proved this to be statistically significant till after 12 months [29]. As
This study indicates that salt inhalation, whether administered as stated previously patients with declining parameters had had
saline therapy or halo therapy, has a beneficial effect on FEV1% and 6 exacerbations, which may explain the finding.
minute walking test in COPD patients. Furthermore it indicates that
quality of life, measured by SGRQ, may improve in patients receiving This pilot study has several limitations. As the location of the salt
halo therapy. chamber was very isolated geographically patients were stratified to
group 1 when living in an acceptable distance from the salt chamber.
All patients receiving halo therapy completed the study despite that This was chosen to enable the study population to complete the study
fact that they had to go to the salt chamber 4 times a week, 45 minutes despite physical impairment. This disposition may of course have
per session, in 5 weeks. No patients experienced side effects which biased the results. Although all patients met the inclusion criteria they
indicate that the treatment is safe and well tolerated. In contrast, a turned out to differ in certain parameters which resulted in skewed
large drop out occurred in the saline group despite the fact that data on FEV1% and MRC. This calls for caution in interpretation of
treatment was fast and easy accessible as it was carried out in the the data, even though patients were evaluated within the groups,
patients’ homes. The drop out was mainly due to side effects. A before and after intervention, which validates the inter-group results.
possible explanation could be that the patients in the saline group had
more severe COPD judged by FEV1% and MRC score; however, there Patients were asked to forward the SGRQ per mail correspondence;
was no difference in these characteristics in those completing the a number of study participants did not complete the questionnaire.
treatment and those who dropped out. This is a weakness of the study design and calls for caution in the
interpretation of data.
It is interesting to notice that even though patients in group 1 had
better lung function than those in group 2, the walking distance of This study has not evaluated long term effects of the therapies; a
patients in group 2 was better than those in group 1 at all times. Also follow up of the patients could have been wished for.
patients in group 1 had better lung function than group 3 at the end of All in all larger randomised studies in this field are needed; not only
the study period, still the walking distance of patients in group 3 was to establish the effect but also to seek the optimal inhalation
better compared to group 1. It has previously been shown that FEV1 concentration, duration of treatment and investigation of possible long
and walking distance does not decline at the same rate [24]. However, term effect of treatment.
the interesting figure in this context must be the intra-group variation
over time; inter-group differences have not been considered.
Conclusion
As such both patients in groups 1 and 2 improved walking distance
significantly. Not only was this statistically significant, but also The results of this study indicate that both saline and salt halo
clinically significant according the Wise et al; the minimal clinical therapy has a positive effect on walking distance. An improvement in
important improvement is considered to be 54-80 meters dependent FEV1% is registered in both groups although only statistically
on initial distance [25]. significant in saline inhalation. Patients receiving halo therapy had
significant improvement of SGRQ. Halo therapy appears to be better
The existing literature on halo therapy is sparse. Chervinskaya et al. tolerated than saline inhalation. However, further randomised studies
has investigated a group of patients with various respiratory diseases are needed in this area.
and found a 3% improvement in lung function, judged by FEV1 [12].
Hedman et al. has investigated the effect of halo therapy on FEV1 in
Acknowledgement
asthma patients and found no improvement in FEV1 during treatment
[26,27]. However, none of these studies are directly comparable to this Thanks to the Opel family foundation for financial support.
study as none of the studies have investigated verified COPD patients
only; neither was the duration of the study period nor the References
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Available online at www.sciencedirect.com
Procedia - Social and Behavioral Sciences 46 (2012) 4141 – 4145
WCES 2012
Impact assessment of saline aerosols on exercise capacity of

athletes
a a
S *, S , Sandu Ion c
a
Gh. Asachi Tehnical University of Iassy, Romania
b
Al. I. Cuza University of Iassy, Romania
cb
Al. I. Cuza University of Iassy, Romania
Abstract
The treatment in natural salt mines (speleotherapy) was known since a very long time ago; the miners and other persons involved
in these activities might have known about the great effects of the microclimate within salt mines upon human health, long before
they were described in a book published by a Polish doctor in 1843. The effectiveness of speleotherapy is associated with the
unique cave microclimate; the sodium chloride aerosols represent the main curative factor. The saline aerosols are formed off the
salt walls by convective diffusion.[1] Halotherapy is the natural therapy method which boroughs the main curative factor for
speleotherapy, meaning the saline aerosol particles dispersed in the salt mine microclimate.[2]The salt room microclimate should
have a constant humidity (a relative air humidity of 40-60%) and a temperature of 18-
favourable conditions for patients and they are a stable environment for aerosols.[3-4] The precinct should also ensure a stable
environment, bacteria- and allergen-free; studies have shown that the microbial contamination during a halotherapy session is of
130-200 saprophyte microorganisms to 1m3 of air (the WHO standards regarding air 3
air). Thus, a 10-20 minutes break after each session is necessary to purify the air within the chamber.[1]
© 2012 Published by Elsevier Ltd. Selection and/or peer review under responsibility of Prof. Dr. Hüseyin Uzunboylu
Open access under CC BY-NC-ND license.
Keywords: saline aerosols, halotherapy, athletes, performances;
1. Introduction
1.1.The Benefices of Halotherapy

As concerns the breathing system of the person in the precinct of the salt room, there is a permanent high
concentration of dry saline aerosols. This concentration is considered therapeutic if it exceeds 1mg/m 3. By inhaling
present at adults
and especially children which trigger and maintain many respiratory conditions (in most cases with relapses,
becoming chronic) and gradually lead to a decrease in the body immunity. Salt is bactericide by nature, not allowing
the microbial cultures to develop, behaving like a disinfectant in most cases. Through the deposition or absorption of
salt ions, both for the superior and the inferior airways, mostly in case of small aerosols, conjugated with the
hygroscopic property, an effect of dilution of impurity or foreign matter depositions takes place (including
microorganisms). These microorganisms lead to breathing disorders or dysfunctions, starting from simple
hoarseness, and up to bronchitis and asthma. [1,6-8]
* Stirbu Catalina. Tel.: +40 722 565 969

E-mail address: [email protected]
1877-0428 © 2012 Published by Elsevier Ltd. Selection and/or peer review under responsibility of Prof. Dr. Hüseyin Uzunboylu
Open access under CC BY-NC-ND license. doi:10.1016/j.sbspro.2012.06.214
4142 Stirbu C_t_lina et al. / Procedia - Social and Behavioral Sciences 46 (2012) 4141 – 4145
The observations over time regarding the persons with breathing disorders showed that the respiratory tract
mucus thickens when losing humidity and salt; the body cannot compensate the lack of necessary fluid and salt
(especially Na+ ions). [8]
Through its electro-chemical properties, salt, and mostly saline ions, once deposed on the respiratory tract,
not only eliminate bacteria and microorganisms, but also determine the emollition, liquefaction and fluidization of
the mucus off the airways, thus extracting the foreign matters among the cilia within the micro-cavities of the
respiratory tract, determining the progressive and long-term relief of breathing, the natural and easy expectoration,
the elimination of allergen or bacterial matters through the reflex phenomena of coughing, nose secretions,
[4-7]
1.2. Main Objective

The study concerns the adapting leve
saline underground factors, insufficiently valorised, or not properly used in sports, and elaborating effective
halotherapy technologies
1.3. Hypothesis
We will try to extend the research referring to the effect of exposing athletes to saline aerosols, of adapting
the cardiovascular system to effort and of improving the sports performances, as well as to the influence of
halotherapy upon certain indices of the breathing system. Concretely, our hypothesis is that saline aerosols are
es.
Material and Methods

The study was carried on with a sample of 12 middle-distance runners, aged between 14 and 16. The
assessment of their cardiovascular and respiratory functions will take place at the Laboratory of functional
explorations, testing t
Within the research we will be monitoring the following factors:
Respiratory indices: vital capacity (VC), maximum expiratory volume per second (MEVS), maximum
ventilation (V max), peak expiratory flow (PEF);[5]
cardiovascular indices: Blood pressure at rest (BP), heart rate at rest (HR);[4]
cardiovascular indices during effort: the Martinet test (lab test) allows the momentary evaluationand the
evolution in time regarding the functional capacity of the cardiovascular system, being a useful means,
often used in carrying on sports training [6-7]. The test proposed by Martinet assesses the cardiovascular
response tolow-intensity, standard, non-specific, cabinet, short-term effort.
The investigations concerning the respiratory and cardiovascular system took place after 21 days of salt
therapy. The halotherapy was carried on in an air-proof chamber, providing a precinct with saline aerosols through
domestic SALINE ae
forcing the air to pass through the NaCl recrystallized granules, leading to alterations in the air composition and
quality due to salt nanodispersion, as air ions with negative charge. The chamber was clean, well ventilated, with
comfortable temperature and humidity.[2]
There was a daily exposition after practices, as recovery period after the training effort. There was a
gradual exposition to the saline aerosols 20 minutes the first day, 25 minutes the second day, up to 60 minutes a
day. The last four days the exposition was reduced by 5 minutes, thus avoiding the sudden interruption of the
treatment. During the halotherapy session the subjects breathed normally, being relaxed, and the post-effort recovery
had a total of 21 sessions per participant.
3. Results and Discussion

Respiratory parameters
Stirbu Catalina. Tel.: +40 722 565 969
Stirbu C_t_lina et al. / Procedia - Social and Behavioral Sciences 46 (2012) 4141 – 4145 4143
Table 2. Proportion of subjects with alterations of respiratory parameters
Initial test Final test

Increase Decrease Increase Decrease
Respiratory parameters c.a. % c.a. % c.a. % c.a. %
VC (litres) 6 50 6 50 11 91 1 9
MEVS (l/s) 9 75 3 25 12 100
V max. (l/min) 9 75 3 25 12 100
PEF (l/s) 8 67 4 33 11 87.5 1 9
Before halotherapy, half of the subjects had higher values of vital capacity, compared to the normal one,
and the other half lower values. After halotherapy the percentage of those with higher vital capacity increased
(Table 2).
The same positive aspect applies to MEVS and V max.: after the treatment all the subjects presented
increased values.
Of all the subjects, only one had a decrease in the VC and PEF after the treatment (possibly caused by a
momentary indisposition).
Analysing the average values of the four breathing volumes, registered before and after the treatment, we
see they increased after the halotherapy session attended by the subjects.
Table 3. Average values of respiratory indices
Initial test Final test P

Respiratory indicators Subjects m m
VC (litres) 12 481.1 102.09 542.7 99.9 0,1494

MEVS (1/s) 12 425.3 68.4 484.8 74.4 0,0530
PEF (1/s) 12 8.1 1.25 10.3 1.20 0,0002
Vmax (1/min.) 12 1276.1 205.3 1454.6 223.3 0,0002
All subjects had higher values of the four respiratory volumes after halotherapy, with significant
differences four three of them (Table 3). For the VC, with no significant differences, we should mention as
favourable aspect the increase tendency.
Respiratory index
The respiratory index is calculated with the following formula:
R = VC (cm) / G (kg) x 1/10
It is very useful to calculate the R, because we can easily orient towards the functional lung potential of the
subject, thus being a compulsory functional parameter when determining the general biologic potential. In our case,
the subjects sc
stress the fact that, after the halotherapy treatment, there was an increase in the percentage of subjects who scored
over 8 the maximum score (Table 4).
Table 4.
1 Stirbu Catalina. Tel.: +40 722 565 969

4144 Stirbu C_t_lina et al. / Procedia - Social and Behavioral Sciences 46 (2012) 4141 – 4145
Initial test Final test

Score c.a. % c.a. %
Low (0-4)
Average (4-5)
Good (5-6)
Very good (6-8) 8 67 3 25
Excellent (over 8) 4 33 9 75
Total 12 100 12 100
Cardiovascular indices
Table 5. Assessment of the cardiovascular system initial and final test
Heart rate at rest Systolic BP at rest Diastolic BP at rest

Initial test 71.30 118 67.9
Final test 69.12 116.5 66.6
Reference values 60-90 b/min 100-140 mmHg 60-90 mmHg
The assessment of the cardiovascular system at rest is very important during the medical examination
because we can detect problems that would become acute during sports effort. We followed the heart rate at rest,
which was within the normal rates approved by WHO. The rest bradycardia was registered at athletes with increased
sports value, the average value, towards the inferior limit of heart rate, being the expression of the bio-positive
adaptation to effort, which means an economical work of the heart at rest. Bradycardia in case of athletes is
secondary to the increase in the systolic volume, allowing a constant, basic heart debit.[8]
WHO admits the following values of blood pressure at rest: BP max. 100-140 mmHg; BP min. 60-90
mmHg; differential BP 40-50 mmHg. and average BP of 90-100 mmHg., for both athletes and non-athletes . Blood
pressure at rest, in case of human subjects within our research, registered values within the range approved by
WHO.
Cardiovascular indices during effort
Table 6. The Martinet test initial and final test average values of heart rate
Clinostatism Orthostatism Effort Post effort Post effort Post effort Dorgo index
1 min 3 min 5 min
Initial test 64.7 73.4 107.3 89.6 64.6 64.6 -1.66
Final test 60.3 70.5 103.8 84.71 60.3 60.3 -3.43
Reference values 60-90 b/min + 10-12 b/min B

(-5-0)
The initial Martinet test indicated normal values of heart rate at rest, between 60 and 90 beats/minute.
There were values of 60- 80 beats/minute in clinostatim, and in orthostatism the average values of heart rate
indicated an increase by 10-12 beats/minute.[5-9]
The values of post-effort heart rate registered a 40-50%, increase, without exceeding 120 beats/minute. The
HR values came back to normal three minutes post-effort in case of all the athletes, which shows a good functional
state.
The Dorgo index of recovery was calculated at the end of the test, using the average HR values. The index
had values between -2.05 and -0.01, with a -1.66 average; the GOOD qualifier [4-6].
The final Martinet test showed an improvement of heart rate at rest by 5-10 beats/minute, with values
between 60 and 75 beats/minute. The average values of post-effort heart rate have also improved 98-108
beats/minute, without exceeding 120 beats/minute.
The Dorgo index of recovery, calculated for average HR vales during the intermediary tests, was also
positively altered, with values between -3.95 and 1.46, with GOOD qualifier.
The cardiovascular regulation tests are indicators of body adaptation to effort, and only indirectly of the
effort capacity, allowing to assess the effectiveness of training methods used for a certain amount of time [6]. The
Stirbu Catalina. Tel.: +40 722 565 969

Stirbu C_t_lina et al. / Procedia - Social and Behavioral Sciences 46 (2012) 4141 – 4145 4145
quality of cardiovascular regulation is the better, the lower the heart rate and blood pressure values on the same
effort scale, the sooner values at rest come back to normal, and if the Dorgo values are negative [7].
4. Conclusions
After the halotherapy treatment, there was an increase in the respiratory volumes (VC, MEVS, V
max., PEF) for all subjects investigated. There was also an increase in the percentage of subjects
As concerns the breathing system, there was an improvement in the breathing mechanics, as well as an
increase in the oxygen saturation of arterial blood and in the resistance to apnea and hypoxia.
Due to the recovery, which took place in mediums with saline aerosols, the breathing was more effective,
both regarding he gaseous exchanges, and using tissue-level oxygen.
The assessment of standard cardiovascular system during effort, the Martinet test, indicated better values
during the final tests, and the cardiovascular assessment tests are indicators of body adaptation to effort and
only indirectly of the effort capacity, allowing to assess the effectiveness of training methods used for a
certain amount of time.
We have also noticed a decrease in the heart rate and breathing rate during the training session effort,
sm.
References
1. Apostol, I. (1998). .
2. Bompa, T.O., (2001). periodizarea, Ex. .
3. Bota, C., (2002). Fiziologie gener .
4. Dragnea, A., (1996). Antrenamentul Sportiv, Editura Sport- .
5. (1994). .
6. Dragan, I., (2002). .
7. (1997). .
8. Enache, L., (2001). . Analele
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9. Georgescu, M., (1989). Caracteristici medico-
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10. Jaba, E., (2002). Statistica, Editur .
11. Sandu, I., Stirbu, C., Chirazi, M., Stirbu, C., Sandu, A.V., (2009a) Artificial Halochamber for Multiple Users, Romanian Patent
Application A200900899/11.05.2009.
1 Stirbu Catalina. Tel.: +40 722 565 969

Journal of Medicine and Life Volume 7, Special Issue 2, 2014
Surveys on therapeutic effects of “halotherapy chamber with artificial salt-

mine environment” on patients with certain chronic allergenic respiratory
pathologies and infectious-inflammatory pathologies
Lazarescu H, Simionca I, Hoteteu M, Munteanu A, Rizea I, Iliuta A, Dumitrascu D, Dumitrescu E
National Institute of Rehabilitation, Physical Medicine and Balneoclimatology, Bucharest, Romania
Correspondence to: Horia Lăzărescu, MD

National Institute of Rehabilitation, Physical Medicine and Balneoclimatology,
2 Sfântul Dumitru Street, Bucharest
Phone/ Fax: 0213155050, E-mail: [email protected]
Abstract
Halotherapy (HT), derived from speleotherapy in salt mines, is also a drug-free therapeutic method. HT effects vary depending on
the therapeutic method and the structure of halotherapy environment.
The purpose of this article is to show the HT effects of “halotherapy chamber with artificial salt-mine environment” of the National
Institute of Rehabilitation, Physical Medicine and Balneoclimatology (INRMFB), on patients with bronchial asthma and other chronic,
infectious-inflammatory and allergic respiratory diseases, describing the clinical effects on certain nonspecific resistance factors, on
markers of inflammatory processes and on certain immunological changes.
Patients were clinically assessed, with the application of hematologic investigations, analysis of nonspecific resistance to infection
and of inflammatory process markers, immunologic assessments, analysis of sodium and potassium concentrations, of
mineralocorticoid function and other biochemical tests.
For the experimental HT therapy performed in the “halotherapy chamber with artificial salt-mine environment” of INRMFB, 15
patients suffering from bronchial asthma, allergic rhinitis, chronic bronchitis, chronic obstructive bronchopneumopathy were selected,
based on specific medical indications and contraindications and applying ethical principles, as well as 4 patients with similar
pathologies for the control group, who underwent in-home drug treatment.
After the specific halotherapy treatment on patients with bronchial asthma, chronic bronchitis and chronic obstructive
bronchopneumopathy, which also showed other chronic, infectious-inflammatory and allergic respiratory pathologies, triggering of
anti-inflammatory (and also anti allergic) mechanisms and healing effects on inflammatory process were noted. Data acquired also
proved the halo therapeutic effect causing the reduction of sensitiveness of body in patients with bronchial asthma.
Keywords: Halotherapy, bronchial asthma, inflammatory process, therapeutic effects
Abbreviations: HT=Halotherapy, INRMFB=National Institute of Rehabilitation, Physical Medicine and Balneoclimatology
Introduction
Halotherapy, derived from speleotherapy in salt mines, is also a drug-free therapeutic method, applied especially
on patients with bronchial asthma and chronic bronchitis. Following the “survey for the innovative use of potentially
therapeutic salt-mine environment factors, in health and balneoclimateric tourism; modeling solutions”, the conceptual
model was elaborated, subsequently converted into an experimental functional model entitled “halotherapy chamber with
artificial salt-mine environment”, destined for surface halotherapy and built within the National Institute of Rehabilitation,
Physical Medicine and Balneoclimatology.
This model was followed by surveys in the underground salt-mine environment, destined to assess the presence
and quality of factors with speleotherapeutic / halotherapeutic potential, medical-biological multi-discipline surveys,
including organismic and cellular-level analysis, before and after the experimental halotherapy treatment, on lab animals
– Wistar rats with pathology experimentally induced by sensitization with ovalbumin.
Based on the experimental results acquired [1,2], the “Inception medical indications for the selection of patients
with certain chronic respiratory pathologies for experimental halotherapy treatment” were elaborated.
Notably, in the infectious–inflammatory or allergic process, various systems and mechanisms of the body and
organismic or cellular components were involved.
The phagocytosis process is one of the promptest defensive mechanisms against infection. The phagocytic cells
are generated from precursor cells of bone marrow and they divide into macrophagous and microphagous cells. In
blood, macrophagous cells are represented by monocytes, and microphagous cells – by polymorphonuclear neutrophils
(PMN), which account for app. 60% of leukocytes and which are also the most significant phagocytic cells [4].
Materials and methods

The selection of patients intended for the application of experimental HT treatment in the “halotherapy chamber
with artificial salt-mine environment” of INRMFB was made based on medical indications and contraindications obtained,
including:
83
I. Indications
1. Patient age: 7-60 years old; infants under 10 years must be accompanied by parents.
2. Gender: female or male.
3. Non-allergic / intrinsic / non-atopic asthma, allergic / extrinsic / atopic asthma, asthmatic bronchitis:
(1) With negative allergological tests or atopic skin tests (for non-allergic / intrinsic / non-atopic asthma) or
positive tests (allergic / extrinsic / atopic asthma);
(2) eosinophils (Eo) – high or normal count in blood and ⁄ or in expectorated sputum;
(3) relatively non-severe clinical evolution;
(4) asymptomatic period with or without bronchial obstruction, without asthmatic seizures;
(5) symptomatic period with proven bronchial obstruction, without asthmatic seizures or severe asthmatic
conditions;
4. intermittent bronchial asthma, without medication or with symptomatic medication (patient’s medication):
(1) with no asthmatic seizures or severe asthmatic conditions;
(2) with no negative evolution (frequent seizures or severe asthmatic conditions) caused by physical stress
(Exercise-Induced Asthma);
(3) with no negative evolution (frequent seizures or severe asthmatic conditions) caused by humidity, changes
in air temperature, gases of other microclimatic parameters (Airways Asthma);
(4) with or without non-allergic rhinitis;
(5) with or without nasal polyposis;
(6) with or without sensitiveness to aspirin or other drugs;
5. chronic bronchitis, asymptomatic or symptomatic period without a negative evolution, without medication or with
symptomatic medication (patient’s medication);
6. chronic obstructive bronchopneumopathy (BPOC), asymptomatic or symptomatic period without a negative
evolution (no aggravation / acute exacerbation, no wheezing respiration, persistent cough with the production of
sputum and shortness of breath), without medication or with symptomatic medication (patient’s medication);
7. allergic and chronic, infectious-inflammatory rhinitis and sinusitis, intermittent or slightly persistent,
asymptomatic or symptomatic period without a negative evolution, without medication or with symptomatic
medication (patient’s medication);
II. Contraindications:
1. Complications of asthmatic seizures (status asthmaticus, atelectasis - relatively frequent, mediastinal and
subcutaneous emphysema, cor pulmonale, pneumothorax, respiratory acidosis).
2. Severe persistent form of bronchial asthma, with no drug control.
3. Asthma with continuous dyspnea and severe asthmatic conditions with violent, subintrant seizures, with a
duration of 12-48 hours, treatment-resistant, no cough and expectoration, with: polypnea, asphyxia, cyanosis,
vascular collapse, drowsiness.
4. Bronchial asthma with negative evolution (frequent seizures or severe asthmatic conditions) caused by physical
stress (Exercise-Induced Asthma).
5. Bronchial asthma negative evolution (frequent seizures or severe asthmatic conditions) caused by humidity,
changes in air temperature, gases of other microclimatic parameters (Airways Asthma).
6. Severe medication-related complications (severe bronchospasm, asphyxia, severe allergic reaction,
anaphylactic reaction and swelling Kwinke, anaphylactic shock, status asthmaticus).
7. Acute bronchitis.
8. Heart failure II – III.
9. Tuberculosis.
10. Sub-compensated and decompensated cardiopathies.
11. Cardiosclerosis.
12. Hypertonia II-III.
13. Acute renal diseases, lithiasis, enuresis.
14. Acute hyperacid gastritis.
15. Hepatitis or acute cholecystitis.
16. Diabetes, severe form.
17. Colagenosis, acute rheumatic diseases.
18. Cerebral trauma, neuroinfections, cerebral dysfunctions / central or peripheral neurologic diseases, epilepsy.
19. Otitis, acute internal ear diseases.
20. Claustrophobia, depressions, neurosis.
21. Emphysema and BPOC complications (acute respiratory failure with acute infections, chronic cor pulmonale /
right side ventricular hypertrophy due to pulmonary hypertension, pneumothorax).
84
22. Post-surgery period up to 2 months.

23. General contraindications for referral to balneary treatment and physiotherapy.
Fig. 1 Halotherapy chamber with artificial salt-mine environment” of INRMFB, Bucharest, 11A, Ion Mihalache Blvd.
When patients for the experimental HT treatment were selected, 18 patients were investigated (16 adults and 2
infants with ages between 6–13 years) with bronchial asthma and chronic bronchitis, chronic obstructive
bronchopneumopathy, of whom 14 had bronchial asthma with therapeutic control and partial control (atopic - 2, mixed-
12; moderate - 2), also suffering from other pathologies like allergic rhinitis (including moderate persistence),
rhinosinusitis, respiratory virosis, viral post-pneumonia condition, chronic gastritis, duodenal ulcer, ischemic coronary
disease, light mitral failure, atopic dermatitis, chronic bronchitis, hypertensive cardiomyopathy, HTAE 1-2 degree, lumbar
discopathy, cervical spondylosis, osteoporosis, hypothyreosis, hemorrhoid disease, dyslipidemia, obesity III degree,
urinary infection; 4 patients with chronic bronchitis or chronic obstructive bronchopneumopathy (II and III) with acute
exacerbation of GOLD (1 case), showing arrhythmia, tachycardia, dyslipidemia.
Subsequently, all the patients underwent medical-biological investigations.
After medical and medical-biological investigations, 15 patients (suffering from bronchial asthma, but also from
allergic rhinitis, chronic bronchitis, chronic obstructive bronchopneumopathy) were chosen for the experimental
halotherapy (HT) treatment in the “halotherapy chamber with artificial salt-mine environment” of INRMFB (Fig. 1).
A control group was also investigated, which included 4 patients with bronchial asthma, chronic bronchitis, chronic
obstructive bronchopneumopathy, which was subject to in-home drug therapy, with no speleotherapy in salt mines or
halotherapy [3].
Results
Thus, during the first 3-7 days of HT procedure, occurrence and onset of irritative cough was noticed in 7 patients
(5 patients with bronchial asthma, 1 – with chronic bronchitis and 1 – with chronic obstructive bronchopneumopathy) out
of the 15 patients from the group subjected to HT treatment. The clinical adaptation of patients to the underground
environment condition was found after 5–10 days of HT procedures, depending on the pathology and clinical progress of
illness. After 10 days of HT procedures, a scarceness of cases and significant reduction in severity – until full regress –
of irritative dry cough was seen in investigated patients, and after 12–15 of specific HT treatment – absence of dry cough
and wheezing, and also for 2/3 of investigated patients (suffering from bronchial asthma, chronic bronchitis, chronic
obstructive bronchopneumopathy) – rare cases of cough with viscous expectoration (1–3 expectorations in the last HT
treatment procedures), and also cough with liquid expectoration and increase of expectorated sputum volume was
noticed (in 3 patients with bronchial asthma and 1 patient with obstructive bronchopneumopathy).
During the treatment period, no severe asthmatic conditions or additional infections occurred. ¼ of the
investigated patients were characterized after 15 days of HT procedures, or 5–10 days after the HT treatment was
ceased, or after gradually reducing the dose of specific medications (antihistaminic, bronchiolitis drugs, corticosteroids
inhalers) to 20-30%.
The patient with bronchial asthma and duodenal ulcer ceased the halotherapeutic treatment during the 3rd HT
procedure, upon recommendation of the INRMFB physician, due to duodenal pains, and another patient with chronic
bronchitis – during the 7th HT procedure, due to digestive issues occurred at home before the HT procedure, and
resumed treatment after three days. The halotherapeutic treatment was also interrupted in one patient with bronchial
asthma, during the 10th HT procedure, on the family doctor’s recommendation, due to acute exacerbation of cervical
spondylosis pains.
85
The data gathered proved the need for additional specific surveys on patients with chronic infectious-inflammatory
and allergic respiratory diseases accompanied by other pathologies.
The average blood count of phagocytes – neutrophils PMN in patients with bronchial asthma and other respiratory
allergies, as well as in patients with chronic bronchitis or chronic obstructive bronchopneumopathy was found to be lower
compared to the lower limit of “normal (“reference”) values”, cases with lower test values being noted in 9 of 13 patients
with bronchial asthma and other allergies (namely, for app. 2/3 of the respective patients group, P<0,05) and in patients
with infectious-inflammatory bronchopulmonary diseases (chronic bronchitis, chronic obstructive bronchopneumopathy).
The relative count of formasan-positive PMN neutrophil cells (in nitroblue tetrazolium test) was found to be high in blood
for most investigated patients (12/13 – cases of bronchial asthma and other allergies P<0,01) and for patients with
chronic bronchitis or chronic obstructive bronchopneumopathy. Thus, most of the investigated patients showed a deficit
in the phagocytosis activity prior to the halotherapeutic treatment and also a decrease in the oxidative metabolism of
phagocytes – granulocytes PMN in blood being noted.
Bronchial asthma Average

STDEV
Chronic bronchitis Average
STDEV
Control Group Average
Phagocytes PMN., % pre HT Phagocytes PMN., % after HT NBT in PMN neutrophils, % pre HT NBT in PMN neutrophils, % after HT
Fig. 2 The results of the phagocytosis process for neutrophils PMN (in blood) in patients with bronchial asthma and other chronic
infectious-inflammatory or allergic respiratory pathologies prior and after the experimental halotherapy treatment in “halotherapy
chamber with artificial salt-mine environment” (11A Ion Mihalache Blvd., INRMFB) and in control group patients
Based on data acquired after the experimental halotherapy (HT) treatment, the triggering of non-specific
resistance parameters of the body was noted (phagocytosis of neutrophils PMN, intra-cellular redox of neutrophils in
NBT test) in patients (including infants) subjected to specific halotherapy treatment, compared to “normal values” and to
values found in control patients, respectively with chronic respiratory pathology and drug treatment (P>0,05<0,1 and
P>0,1).
The results obtained showed the positive effect of experimental halotherapeutic treatment related to the
stimulation of phagocytosis process and the increase in non-specific anti-infection resistance of the body, a fact noted
based on the ascendant trend of phagocytes PMN in blood and the activation of oxygen-dependent bactericide action of
granulocytes PMN (nitroblue-tetrazolium test) in patients with bronchial asthma and allergic rhinitis and in those with
chronic bronchitis, chronic obstructive bronchopneumopathy (P>0,1). Still, the fact that the low number of patients with
chronic bronchitis and chronic obstructive bronchopneumopathy did not allow the mentioning of significant positive
changes should be mentioned, and, therefore, in this case, the extension of the respective surveys is needed.
Conclusions
The assessment of results achieved in the investigated patients with bronchial asthma, chronic bronchitis and
chronic obstructive bronchopneumopathy, after a specific halotherapy treatment, indicates the triggering of an anti-
inflammatory (including anti-allergic mechanisms) mechanism and a decreasing trend of the inflammatory process.
Data acquired indicate a decrease in the body’s sensitiveness and in infectious-inflammatory process in patients
with bronchial asthma after HT treatment, and it also proves the need to extend the period or to repeat the
halotherapeutic treatment.
86
References
1. Gorbenko PP, Adamova IV, Sinitsyna TM. Bronchial hyperreactivity to the inhalation of hypo- and hyperosmolar aerosols and its correction
by halotherapy. Ter Arkh. 1996; 68(8):24-8.
2. Chervinskaya A. II: Halotherapy of respiratory diseases. Physiotherapy, balneology and rehabilitation. 2003; 6:8-15.
3. Simionca I, Hoteteu M, Lazarescu H, Grudnicki N, Stoian G, Enache L, Munteanu C, Mera O, Calin MR. Haloterapia – descendenta a
speleoterapiei in minele saline; realitati si perspective de haloterapie stiintifica in Romania. 2012; 73: 56-57.
4. Olinescu A, Dolganiuc A. Imunologie Clinica. Viata Medicala Romaneasca. 2001, 276.
87
Therapeutics, Pharmacology and Clinical Toxicology
Vol XIV, Number 3, September 2010 ORIGINAL PAPERS
Pages 201-204
© Copyright reserved 2010
SALTMED - THE THERAPY WITH

SODIUM CHLORIDE DRY AEROSOLS
B. Opriţa, C. Pandrea, B. Dinu, B. Aignătoaie
Dep. UPU (Emergency Ward) – SMURD, Bucharest Emergency Hospital
Abstract.To assess the effects of halotherapy, we conducted a retrospective study on patients with obstruc-
tive bronchial disorders (asthma and chronic obstructive pulmonary disease), treated in the UPU-SMURD
department of the Bucharest Emergency Hospital. The respiratory frequency, the ventricular aspect and
the oxygen saturation were measured in all patients (initially and every 20 minutes, for an hour), as well
as the blood gases (initially and after an hour). Saline inhalation determines a quicker improvement of
parameters defining the respiratory failure in the worsening of obstructive pulmonary diseases.
Keywords: obstructive bronchial disorders, SaltMed, halotherapy
Introduction microparticles and through which the air was

inhaled, while exhalation was nasal.
Background In Romania, the company TehnoBionic con-
H alotherapy (gr. halos = salt) uses aerosol ceived a filter cartridge with saline microparticles
microparticles of salt (sodium chloride) that are nebulized by force under pressure of air
to treat respiratory diseases. It appeared as an or dehumidified oxygen, being connected to a face
alternative to speleotherapy (gr. speleos = cave), oxygen mask [3].
a therapeutic method used in Eastern Europe in Principle of the method
salinas from the beginning of 19th century [1]. The micronized sodium chloride (1-5 µm) is
In the 80’s in the Soviet Union “halochambers” easily breathed in the upper and lower respiratory
are conceived and used, which render the salina mi- tract. At this level, it dissolves in the sol phase of the
croclimates. The method is subsequently extended mucus layer that covers the respiratory epithelium.
in Europe and North America to treat especially Here, through local osmotic effect, the water in the
asthma [2]. interstitial tissue is attracted to the respiratory tract
The specialists focused then on the creation of lumen. The inflammatory edema thus decreases and
“portable” devices that can be used in ambulances, the mucus quantity increases [4].
in hospitals as well as at home. In Hungary a “ce- The mucus becomes more fluid and is easily
ramic pipe” was conceived that contained saline mobilized to the cilia of respiratory epithelial cells,
to be eliminated at pharynx level and then expec-
torated through coughing.
Through this easy mechanism the sodium chlo-
Bogdan Oprita ride (NaCl) has a beneficial effect at respiratory
Emergency Hospital tract level, improving a number of symptoms that
8 Calea Floreasca Str., Bucharest, Romania appear in the acute disorders of the respiratory
XIV, Vol.14, Number 3/2010 201
SaltMed Therapy
tract [5,6,7]. oxygen and 204 of them were additionally treated

Thus, the nebulization of saline microparticles with saline inhalations.
in the respiratory tract is a therapeutic method to The respiratory frequency, the ventricular as-
be used in respiratory disorders such as: asthma, pect and the oxygen saturation were measured
chronic obstructive pulmonary disease, pneumonia in all patients (initially and every 20 minutes, for
etc. an hour), as well as the blood gases (initially and
It seems that the method acts in pulmonary after an hour).
infectious disorders by decreasing the microbe For statistic purposes, the Mann-Whitney U
contamination of upper respiratory tract (especially test was used in the univariate analysis (the vari-
with staphylococci) in children with respiratory able distribution was not normal) for parameter
allergy. The capacity to kill bacteria could be ex- comparison between the SaltMed group and the
plained through the complex immunomodulatory standard therapy group, as well as for the assess-
effects that the procedure determines: it increases ment of differences between the average improve-
the number and activation of T lymphocytes, it ment of PaO2 and PaCO2 during the first hour,
normalizes the number of B lymphocytes, it in- between the group treated with SaltMed and the
creases the level of IgA [3]. untreated group. In order to evaluate the differ-
Though there are studies regarding the effects of ences between the two groups as far as the other
halotherapy in other pulmonary pathologies as well: repeatedly measured parameters are concerned
cystic fibrosis, acute respiratory distress syndrome, (respiratory frequency and SaO2, measured 4 times
acute pulmonary injury etc., the effect is not fully each, every 20 minutes), the General Linear Model
demonstrated, though it seems to be favorable [4,8]. for repeated measures was used, in which the initial
To assess the effects of halotherapy, we conduct- PaO2, age and sex were introduced as covariable.
ed a retrospective study on patients with obstructive The statistic analysis was conducted with SPSS 16.0
bronchial disorders (asthma and chronic obstructive for Windows, SPSS Inc.
pulmonary disease), treated in the UPU-SMURD
department of the Bucharest Emergency Hospital. Results
Material and methods Out of 393 patients, 204 received standard

treatment and SaltMed treatment, while 189 only
We conducted a retrospective group study received standard treatment. The basal character-
on 393 patients who came to the UPU-SMURD istics of the two groups are presented in table I.
department of the Floreasca Emergency Hospital, This table shows that the patients in the group
Bucharest, or who were transported by cars be- treated with SaltMed were in general in a more
longing to SMURD Bucharest due to worsening serious condition as they were older and the CO2
of asthma or of chronic obstructive pulmonary partial pressure was higher, while the oxygen satu-
disease. All patients received standard treatment ration and partial pressure were lower.
with inhalatory betamimetics, corticotherapy and Despite this situation, at the end of the first hour
SaltMed treatment Standard treatment

Characteristic P
(n=204) (n=189)
Age* 64 (35. 88) 59 (3. 88) 0.001
Males ** 115 (61%) 131 (64%) 0.532
Basal respiratory frequency * 23 (18. 37) 23 (18. 36) 0.764
Basal SaO2 * 90 (78. 97) 94 (75. 99) <0.001
Basal PaO2 * 61.5 (47. 96) 80 (42. 97) <0.001
Basal PaCO2 * 58 (35. 80) 44 (35. 95) <0.001
Table I. Basal characteristics of the two groups of patients

* Average (min, max) (distribution was not normal); data were compared based on Mann-Whitney U test
**Number (percentage); data were compared based on X2 test
202 Therapeutics, Pharmacology and Clinical Toxicology

B. Opriţa et al
of therapy all parameters were significantly better Moreover, the SaO2 and the respiratory fre-
in the SaltMed group (table II). quency were significantly improved in the SaltMed
SaltMed treatment Standard treatment

Parameter P
(n=204) (n=189)
Respiratory frequency * 17 (15. 32) 19 (16. 32) 0.764
Basal SaO2 * 98 (82. 100) 97 (83. 99) <0.001
Basal PaO2 * 92 (56. 98) 85 (54. 97) <0.001
Basal PaCO2 * 38 (32. 77) 41 (34. 99) <0.001
Table II. Respiratory parameters of the two groups of patients after the first 60 minutes of treatment
* Average (min, max) (distribution was not normal); data were compared based on Mann-Whitney U test
The PaO2 improvement was significantly better group as compared to the witness group after
in the SaltMed group as compared to the group adjustment for age and initial PaO2, which were
without SaltMed (p<0.001, fig. 1); the same was valid significantly different between groups (in favor of
with respect to PaCO2 decrease (p<0.001, fig. 2). the witness group) (p<0.01, fig. 4).
Figure 1. Improvement of PaO2 in the two groups of pa-

tients (SaltMed group and witness group)
Figure 3. SaltMed effect on respiratory frequency, gross (a)

and adjusted for initial PaO2 and age (b)
Figure 2. Improvement of PaCO2 in the two groups of
patients (SaltMed group and witness group)
XIV, Vol.14, Number 3/2010 203

SaltMed Therapy
the patient.
The fast improvement of the respiratory failure
in the emergency room makes it possible for the
patient to be quickly hospitalized in a unit where
no intensive care measures are needed, avoiding
thus the agglomeration or even the blocking of the
emergency room.
One of the study limits is that it is only an ob-
servational study and the results can be affected by
systematic selection errors. Based on data analysis,
it seems that SaltMed treatment was applied espe-
cially to patients in a more serious condition (table
I) and in this case the treatment results are more
spectacular. It is necessary to conduct a randomized
clinical trial that confirms these results as other
confusion factors may be involved, which were not
recognized or measured in this study.
Another limit is that patients were only moni-
tored during the first hour since the SMURD team
was requested or since they came to the emergency
room, so we do not know if the good results in
the first hour were maintained over the following
hours or if the results extended to the necessity of
hospitalization, hospitalization duration, life quality,
necessity of intubation or even mortality, for which
further studies are requested.
References
Figure 4. SaltMed effect on oxygen saturation, gross (a) and
adjusted for initial PaO2 and age (b) 1. Halotherapy – Adjuvant therapy in the treatment of respi-
ratory disorders; www.scientiapress.com. 31.03.2009.
2. Chervinskaya Alina, Zilber Nora. Halotherapy for
Discussions treatment of respiratory diseases. Journal of aerosol medicine,
Volume 8, Number 3, 1995. Mary Ann Licbert, Inc.
This study proves that halotherapy added to the 3. Tudorache V, Mihăicuţă S, Potre Rodica, Kigyosi
initial treatment of patients with chronic obstruc- Anca. Aeroionizarea forţată a aerului din încăpere ca şi
tive pulmonary disease and asthma with acute terapie adjuvantă în terapia astmului şi bronşitei cronice.
respiratory failure leads to significant improvement www.SaltMed.blogspot.com. 03.04.2009.
during the first hour of all clinical and paraclinical 4. Wark PAB, McDonald V, Jones AP. Nebulised hyper-
tonic saline for cystic fibrosis. Cochrane Review.
parameters: respiratory frequency, O2 saturation
5. Anderson S, Spring J, Moore B and colab. The effect of
and partial pressure of blood gases. inhaling a dry powder of sodium chloride on the airways of
No orotracheal intubation was necessary in the asthmatic subjects. Eur. Respir. J. 1997 Nov; 10(11): 2465-73.
group that benefited from halotherapy in order to 6. Laube B, Swift D, Wagner H Jr and colab. The effect
facilitate mechanical ventilation during the first hour of bronchial obstruction on central airway deposition of a
of therapeutic assistance, so it can be an option saline aerosol in patients with asthma. Am. Rev. Respir. Dis.
1986 May, 133 (5): 740-3.
in the non-invasive management of such patients. 7. Phipps P, Gonda I, Anderson S and colab. Regional de-
Though it was not quantified, it needs to be position of saline aerosols of different tonicities in normal and
stated that patients that benefited from halotherapy asthmatic subjects, Eur. Respir. J. 1994, Aug.; 7(8): 1474-82.
with SaltMed tolerated very well the administration 8. Elkins M, Robinson M, Rose Barbara, Harbour C,
of saline microparticles and presented no emetic Moriarty C, Marks G et al. A Controlled Trial of Long-Term
Inhaled Hypertonic Saline in Patients with Cystic Fibrosis.
side effects, as it usually happens when humid nebu- The new England journal of medicine. January 19, 2006 vol.
lization is used, where the use of bronchodilating 354, no. 3, pag.229-240.
and/or mucolytic substances has a strong emetic 9. Longenecker C. Respiratory Acidosis. In: High-Yeld
effect, which makes the action hard to tolerate by Acid-Base.1998, Lippincott Williams & Wilkins, pag.56-60.
204 Therapeutics, Pharmacology and Clinical Toxicology

International Journal of COPD Dovepress
open access to scientific and medical research
Open Access Full Text Article Review
A review of halotherapy for chronic obstructive

pulmonary disease
This article was published in the following Dove Press journal:

International Journal of COPD
21 February 2014
Number of times this article has been viewed
Rachael Rashleigh 1 Background: Chronic obstructive pulmonary disease (COPD) is a chronic, progressive disease
Sheree MS Smith 1,2 and is treated with inhaled medication to optimize the patient’s lung health through decreasing
Nicola J Roberts 3 their symptoms, especially breathlessness. Halotherapy is the inhalation of micronized dry salt
within a chamber that mimics a salt cave environment. Recent media reports suggest that this
1
Family and Community Health
University Research Group, School therapy may help with the symptoms of COPD.
of Nursing and Midwifery, University Objective: To critically evaluate and summarize the evidence for the use of halotherapy as a
of Western Sydney, Campbelltown
treatment for COPD.
Campus, Sydney, NSW, Australia;
2
Centre for Pharmacology Design: A review using systematic approach and narrative synthesis.
and Therapeutics, Division of Data sources: Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, MEDLINE,
Experimental Medicine, Imperial
College, South Kensington, London, EMBASE, CINAHL, and Google Scholar were searched. Two reviewers independently reviewed
United Kingdom; 3Institute of Applied abstracts and selected eligible studies based on predetermined selection criteria.
Health Research, School of Health Results: Of the 151 articles retrieved from databases and relevant reference lists, only one ran-
and Life Sciences, Glasgow Caledonian
University, Glasgow, Scotland domized controlled trial met the inclusion criteria. A meta-analysis was unable to be conducted
due to the limited number of published studies. Inclusion criteria were subsequently expanded
to allow three case-control studies to be included, ensuring that a narrative synthesis could be
completed. From the pooled data of the four studies, there were 1,041 participants (661 in the
intervention group and 380 in the control group). The assessment of methodological quality
raised issues associated with randomization and patient selection. Three themes were identified
from the narrative synthesis: respiratory function, quality of life, and medication use.
Conclusion: Themes generated from the narrative synthesis data reflect outcome measures
regularly used for interventional research associated with COPD. From this review, recommenda-
tions for inclusion of halotherapy as a therapy for COPD cannot be made at this point and there
is a need for high quality studies to determine the effectiveness of this therapy.
Keywords: salt therapy, speleotherapy, lung disease, aerosol, chronic disease, salt cave
Introduction
Chronic obstructive pulmonary disease (COPD) is a chronic, progressive disease with
symptoms of dyspnea, increased respiration rate, sputum production, and a reduced
exercise intolerance.1 In 2008, the World Health Organization estimated that COPD
was the tenth most prevalent cause for moderate to severe disability,2 and was the
Correspondence: Rachael Rashleigh
Family and Community Health fourth leading cause of death, worldwide.3 With this significant burden, the impact
University Research Group, School of this disease on individuals, families’ quality of life, and the associated health care
of Nursing and Midwifery, University
of Western Sydney, Locked Bag 1797,
expense, COPD is recognized as an international health priority.1,3,4
Penrith, NSW 2751, Australia COPD is managed with inhaled medication with the view to optimize the patient’s
Tel +61 2 4620 3532
Fax +61 2 4620 3199
pulmonary function and reduce symptoms. Pulmonary rehabilitation is recommended
Email [email protected] for those patients with Medical Research Council dyspnea score of 3 or more1 as
submit your manuscript | www.dovepress.com International Journal of COPD 2014:9 239–246 239
Dovepress © 2014 Rashleigh et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0)
http://dx.doi.org/10.2147/COPD.S57511
License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further
permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on
how to request permission may be found at: http://www.dovepress.com/permissions.php
Rashleigh et al Dovepress
there is substantial evidence of its benefit to these patients.5,6 commercial halotherapy treatment centers in Australia, the
However, other therapies such as speleotherapy and halo United States of America, Europe, and Canada that are aimed
therapy are being recommended in the wider community7 at treating respiratory and other medical conditions.
and are often described as well-researched treatments for Halotherapy has received prominent television media
people with COPD.8 In Eastern Europe, natural salt caves coverage in Australia from Channel 9’s A Current Affair8,14,15
have been used to help relieve symptoms of chest conditions.9 and Channel 7’s Today Tonight7,16 and abroad from Cable
This therapy is known as speleotherapy, where a natural salt Network News’ Vital Signs,17 as well as from other television
cave climate is used as a therapy for ill health.10 The unique program providers such as the British Broadcasting Corpora-
characteristics of the microclimate within the caves are stable tion18 and the National Broadcasting Corporation.19 National
air temperature, moderate to high humidity, the presence and international media current affair and news reports14–16,19
of fine aerosol elements (sodium, potassium, magnesium suggest that halotherapy may help with a variety of respira-
and calcium), as well as a lack of airborne pollutants and tory illnesses including relieving the symptoms of COPD. The
pollens.11 Halotherapy builds on this premise and is used as assertion behind these reports is that inhaled dry salt therapy
an above-ground alternative for speleotherapy.12 Halotherapy may assist people with COPD by increasing the liquefaction
is a treatment consisting of inhalation of small salt particles of airway secretions, which, in turn, enhances the expectora-
in a controlled environment of a halochamber.11,12 This room tion of airway mucous secretions. With the increase in the
is designed to replicate the natural microclimate of a salt commercial availability of halotherapy as an alternative
cave. Halotherapy treatment has been associated with relief complementary treatment, it is timely to undertake a review
of respiratory conditions such as asthma, cystic fibrosis, and of this therapy for COPD to appraise the evidence for the
COPD, as well as relieving integumentary conditions such as complementary therapy. An extensive search of a number of
eczema and dermatitis.9,11 A recent study of bronchiectasis databases did not identify any published systematic reviews
patients found halotherapy to be of little benefit.13 Despite that assessed halotherapy as an intervention for people
these findings, there appears to be an increasing number of with COPD. Therefore, this review sought to investigate
Table 1 Summary of included review articles

Article Aim Sample Method
Nurov (2010)24 To assess the One hundred twenty-four participants randomized into Randomized control trial.
immunological features two groups. Treatment group 103 participants (60 male, Immunological studies at time
of COPD patients after 43 female) and control group 25 participants (14 male, one (before treatment), at
speleotherapy 11 female). time two (after treatment),
and time three (6 months after
treatment).
Chervinskaya and To assess the effect of Treatment group – 124 participants, 54 males, Prospective case-control study.
Ziber (1995)11 halotherapy on various 70 females, mean age 34.3±2.5 years. Control group – Lung function studies before and
types of respiratory 15 participants not described. after trial.
diseases
Oprita et al To assess the effects of Two hundred four participants (61% males, mean age Retrospective case-control
(2010)23 halotherapy on patients 64 years) received standard treatment and SALTMED study. Respiratory characteristics
with asthma and chronic treatment. One hundred eighty-nine received only reported before treatment and
obstructive pulmonary standard treatment (64% males, mean age 59 years). 1 hour after treatment.
disease
Horvath (1986)10 To examine whether One hundred fifty-one participants – (89 males, Retrospective case-control
a stay in a cave 62 females, mean age 46 years, 101 participants with study. Clinical state reported
microclimate could chronic bronchitis, 50 with bronchial asthma) treatment as improved, unchanged, or
further improve with climatotherapy. Two hundred thirty participants – deteriorated. Medication request
respiratory symptoms of (137 males, 93 females, mean age 49 years, dosage changes before and after
patients with COPD or 141 participants had chronic bronchitis, 89 had 3 weeks of treatment. Mean FEV1
bronchial asthma bronchial asthma) treatment was CRR consisting of before and after treatment.
speleotherapy in combination with rest, breathing
exercises and relaxation training.
Abbreviations: COPD, chronic obstructive pulmonary disease; CRR, complex respiratory rehabilitation; FEV1, forced expiratory volume in 1 second; FVC, forced vital
capacity; PaCO2, partial pressure of carbon dioxide in arterial blood; PaO2, partial pressure of oxygen in arterial blood; PEF, peak expiratory flow; SALTMED, saline inhalation;
SaO2, oxygen saturation.
240 submit your manuscript | www.dovepress.com International Journal of COPD 2014:9

Dovepress
Dovepress Halotherapy for chronic obstructive pulmonary disease
h alotherapy as a therapeutic intervention for people with reviewers (RR and SMSS) (Table 1). A third reviewer (NJR)
COPD to determine the effectiveness of this therapy. was the arbiter should any disagreement regarding the inclu-
sion of articles occur.
Methods
Search strategy and selection criteria Quality assessment
A search of electronic databases was conducted from January The methodological quality of the selected articles was
2013 to February 2013. The electronic databases searched assessed by two reviewers (RR and SMSS) using the Scottish
were the Cochrane Central Register of Controlled Trials Intercollegiate Guidelines Network (SIGN) methodology
(CENTRAL), PubMed, MEDLINE, EMBASE, CINAHL, quality checklists for controlled trials and case-control
and Google Scholar. The literature review search strategy studies (Table 2).20 These checklists were used to assess
(Supplementary material) used a combination of MeSH terms issues pertinent to well-conducted randomized controlled
found in the title and/or abstract for halotherapy and chronic trials and case-control studies. The risk of bias was assessed
obstructive pulmonary disease and the following search using the Cochrane classification with four criteria: sequence
terms were used: COPD; chronic bronchitis; emphysema; generation; allocation concealment; blinding; and incomplete
halotherapy; halochamber; speleotherapy; spelaeotherapy; outcome measurement.21 Any disagreements regarding risk of
cave; salt mine; potash mine; vital air room; climate chamber; bias were resolved through discussions between the reviewers
saltpipe; and sopipa. Reference lists in retrieved papers were and the arbiter (RR, SMSS, NJR).
hand-searched for other possible studies. All prospective
randomized controlled trials were included where trials Data abstraction
compared halotherapy or speleotherapy with a control group. The search revealed 151 published abstracts after excluding
Abstract and full text articles that were not in English were the duplicates. The abstracts were screened using the selec-
excluded. After abstracts were retrieved, two reviewers tion criteria and 150 articles were excluded. The flow diagram
applied the inclusion and exclusion criteria. Full text articles of the selection process is illustrated in Figure 1. Only one
were subsequently obtained and reviewed by two independent randomized study met the inclusion criteria; therefore, it
NHMRC level Major findings Strengths and limitations

of evidence
II Increase in concentration subpopulations in all studied One treatment facility. Moderate sample size. Randomization
lymphocytes, normalization and correlation of unblinded. Unequal chance of allocation. Recruitment
subpopulations of CD4+ and CD8+ lymphocytes, and increase strategy not identified. Nil ethical considerations. Patients’
in neutrophil phagocytosis activity. Overall immune status clinical status not reported.
improvement in 97.8% of treatment group and 67.5% of
control group.
III-2 After treatment – decreased bronchial obstruction, One treatment facility. Moderate sample size. Recruitment
decreased medication use, and increase in FVC, FEV1, PEF. strategy not identified. Many respiratory diseases grouped
Participants slept better, decreased fatigue. Cough became together. Nil ethical considerations reported. Control group
less frequent, easier, and more productive. not adequately described before or after treatment.
III-2 Respiratory rate, SaO2, PaO2, and PaCO2 were all significantly One treatment facility. Large sample size. Only short term
improved in the group receiving the standard treatment in results, no longer term follow up. Asthma and COPD
combination with the SALTMED treatment as compared results reported together.
to the group receiving only the standard treatment.
III-2 Clinical state improved in group receiving CRR compared One treatment facility. Large sample size. Asthma and
to 72.8% receiving climatotherapy. For patients receiving COPD results reported together. Initial clinical state of
CRR, FEV1 improved from 1,468±631 mL to 1,676±706 mL group receiving CRR was more severe than group receiving
compared to the patients receiving climatotherapy FEV1 climatotherapy.
who improved from 1,638±613 mL to 1,666±684 mL.
International Journal of COPD 2014:9 submit your manuscript | www.dovepress.com

241
Dovepress
was not possible to undertake the meta-analysis. The inclu- to 98% in the treatment group (n=204) as compared to
sion criteria were expanded and a further three case-control the control group (n=189) improving from 94% to 97%.
trials were included. A number of commentary papers Similarly, the improvement in partial pressure of oxygen in
were excluded. The two reviewers (RR and SMSS) were arterial blood for the treatment group was from 61.5 mmHg
in agreement for the studies to be included and the arbiter to 92 mmHg compared to 80 mmHg to 85 mmHg for the
(NJR) was not required to resolve any conflicting opinion. On control group. The partial pressure of carbon dioxide in
completion of the methodological quality assessment, each arterial blood considerably decreased in the treatment group
manuscript was summarized and, due to the heterogeneity from 58 mmHg to 38 mmHg and in the control group from
of reported outcomes, a thematic analysis was conducted. 44 mmHg to 41 mmHg.
Thematic analysis is a process that seeks to describe the data Horvath10 documented an improved respiratory func-
in rich detail in order to identify, analyze, and report patterns tion by measuring the FEV1 before and after treatment. The
known as themes from within the data.22 The combined data mean FEV1 for the treatment group (n=230) improved from
of the four studies were analyzed thematically. 1.47±0.631 L to 1.68±0.71 L after patients were enrolled
in a complex respiratory rehabilitation that included spe-
Findings leotherapy for a specific time period. The control group
Thematic analysis (n=151), who received climatotherapy, had an improvement
Summary data including characteristics of the study regard- from 1.64±0.61 L to 1.67±0.68 L. Nurov’s24 study reported
ing the four studies are summarized in Table 1. The three improved immune function after speleotherapy but did not
themes identified from the data were respiratory function, report specifically on lung function of COPD patients. Nurov
quality of life, and medication use. concluded that patients with COPD receiving speleotherapy
improved their immunological status and, as a consequence,
Respiratory function reduced the inflammatory process particularly during
All of the case-control studies (n=3) reported improved respi- exacerbations.
ratory function to varying degrees and detailed improvements
in many lung function tests including forced vital capacity, Quality of life
forced expiratory volume in 1 second (FEV1), oxygen satura- Horvath10 and Chervinskaya and Ziber11 reported speleother-
tion, partial pressure of oxygen in arterial blood, and partial apy and halotherapy (respectively) as improving the quality
pressure of carbon dioxide in arterial blood. Although the of life for patients suffering from COPD. Horvath reported
lung function tests utilized by the researchers are a reliable that 90.4% of patients receiving the speleotherapy improved
method to assess respiratory function, each study reported their clinical state in comparison to 72.8% of patients in the
using different tests which made any comparison of the control group. The participants’ clinical state was scored each
results difficult. day by the participant and physician jointly on the basis of
Oprita et al23 report that, after 60 minutes of treatment, symptoms and complaints. The authors suggested that the
there was an improvement in oxygen saturation from 90% improved clinical state for COPD patients improves their life
Table 2 Methodological assessment of included articles

Q1 Q2 Q3 Q4 Q5 Q6
Randomized Aims Randomization Concealment Double blinding Similar TG and CG Treatment is the only
controlled trial difference between
TG and CG
Nurov (2010)24   Unable to report   
Case-control Aims Comparable Consistent Percentage of cases Comparison of cases Clearly defined cases
studies populations exclusion criteria and controls and controls
Chervinskaya and  Unable to Unable to report Unable to report  
Ziber (1995)11 report
Oprita et al    Unable to report  
(2010)23
Horvath (1986)10   Unable to report Unable to report  
Note: Overall acceptability is indicated by (-) unacceptable, (+) acceptable, and (++) excellent.
Abbreviations: Q, question number; CG, control group; TG, treatment group.

Dovepress
quality by decreasing exacerbations, reducing hospitalization, Specifically, in Nurov’s study, the method of randomization
improving physical tolerance, and reducing fatigue. Nurov24 appeared unclear and there was a lack of detail regarding
reported that positive shifts in immunological status resulted demographic and disease related information including
in improved clinical symptoms, but elaboration or description medications being used by participants.
of clinical symptoms were not provided. Other concerns related to the studies included in
this review pertain to the lack of detail in regard to the
Medication use participants’ primary medical condition of either asthma
The use of medication was an outcome measured in two halo- or COPD and discrimination in the results between these
therapy studies. Chervinskaya and Ziber11 and Horvath10 indi- two medical conditions. Medication information including
cated that patients were able to decrease their medications. type and dosage was also lacking in all studies. There were
Chervinskaya and Ziber reported that up to 50% of patients significant differences at baseline between treatment and
in their study were able to discontinue their inhaled cortico control arms in the study by Oprita et al23 and the treatment
steroids therapy and nearly a third of participants continued group appeared to have more severe COPD. In Horvath’s5
their inhaled steroid therapy at reduced dosages. In Horvath’s study, the patients in the treatment group had a significantly
study, medication use was recorded as a bi-level outcome with lower FEV1 prior to the intervention than the control group.
the first outcome being reduction or omission and the second Whilst the Oprita study appears to be a well-constructed
outcome being an unchanged dosage. However, with 95% of retrospective case-control study with positive results for the
participants having either reduced or omitted medication, the use of sodium chloride dry aerosols, as the investigators only
type of medication or dosage is not detailed. assessed patients 1 hour after treatment, longer term conclu-
sions such as quality of life would be difficult to assess.
Discussion In light of the lack of scientific evidence for the use of
From this review of literature, it has become apparent that halotherapy in COPD, future studies need to be designed to
there have been very few rigorous studies published on this provide the best available evidence and randomized con-
topic and, hence, this reduces the potential for evidence to trolled trials need to be considered. This approach would
support this therapy. It should be noted that only one random- address the methodological concerns identified through this
ized trial was found after an extensive search of the literature. review such as participant selection bias, blinding of partici-
As a result, the inclusion criteria for this review were widened pants to the intervention, and the concealment of allocation
to include relevant case-control studies that met all other to intervention or control group.
inclusion criteria. The randomized trial by Nurov24 studied
the immunological features of patients with COPD before Study limitations
and after speleotherapy, demonstrating increased levels of The limitations associated with this review were restricted
lymphocytes and increased neutrophil phagocytosis activity. by the availability of published research associated with
When assessing the methodological quality of studies halotherapy as a therapeutic intervention for COPD.
included in this review, a number of concerns were identified. The studies included in this review were found to have a
Q7 Q8 Q9 Q10 Q11
Outcome measured Drop out Intention to treat Results comparable – Overall acceptability
in standard, valid, percentage analysis for all sites (++, +, -)
reliable way
 Not reported  N/A +
Clearly defined Concealment Outcome measured in Address possibility of Confidence intervals Overall acceptability
controls standard, valid, reliable way confounding factors provided (++, +, -)
 Unable to report    –
 Retrospective    ++
case-control study
 Retrospective    +
case-control study

243
Dovepress
234 records 8 additional

identified through records identified
database through other
searching sources
151 records after

duplicates were removed
151 abstracts screened 131 records excluded
20 full text articles 19 records excluded

retrieved with reasons
Reviewed inclusion/exclusion
1 RCT on halotherapy and
criteria changed to include
COPD
case-control studies
3 case-control studies
relevant to halotherapy and
COPD
4 studies to be included in
a narrative synthesis
Figure 1 Flow chart of systematic search.

Abbreviations: COPD, chronic obstructive pulmonary disease; RCT, randomized controlled trial.
number of methodological concerns and limited reporting undertaken to fully examine the effects of this therapy and its
of baseline data. All studies in this review lacked detail on impact on the quality of life of people with COPD.
ethical considerations such as ethical approval, processes
for informed patient consent, and funding disclosure. The Disclosure
outcome measurements using lung function tests varied The authors report no conflicts of interest in this work.
between studies and, as such, a comparison of their results
was not possible. References
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Conclusion 2010. Available from: http://guidance.nice.org.uk/CG101. Accessed
January 14, 2014.
For halotherapy to be considered as an evidence based therapy 2. World Health Organization. The Global Burden of Disease 2004 Update.
for people with COPD, there needs to be high quality research 2008. Accessed January 10, 2014.

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245
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Supplementary material h alochamber* or spelaeo* or speleo* or cave* or salin*

Search strategy or “salt min*” or “potash min*” or subterraneotherap* or
A systematic search of the bibliographic databases was “vital air room” or “climat* chamber” or karst* or SaltPipe
conducted using the following search terms: COPD or or Sopipa.
“Chronic bronchitis” or Emphysema and Halotherapy* or
International Journal of COPD Dovepress

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International Journal of Pediatric Otorhinolaryngology 77 (2013) 1818–1824
Contents lists available at ScienceDirect
International Journal of Pediatric Otorhinolaryngology

journal homepage: www.elsevier.com/locate/ijporl
Double-blind placebo-controlled randomized clinical trial on the

efficacy of Aerosal1 in the treatment of sub-obstructive adenotonsillar
hypertrophy and related diseases §§
Matteo Gelardi a,*, Lucia Iannuzzi a, Antonio Greco Miani b, Simone Cazzaniga c,
Luigi Naldi c,d, Concetta De Luca a, Nicola Quaranta a
a
Section of Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari, Italy
b
Paediatrics ASL BA, Bari, Italy
c
Centro Studi GISED, Fondazione per la Ricerca Ospedale Maggiore, Bergamo, Italy
d
Unità di Dermatologia, Ospedali Riuniti di Bergamo, Bergamo, Italy
A R T I C L E I N F O A B S T R A C T
Article history: Background: Adenotonsillar hypertrophy (ATH) is a frequent cause of upper airways obstructive
Received 30 November 2012 syndromes associated to middle ear and paranasal sinuses disorders, swallowing and voice disorders,
Received in revised form 7 August 2013 sleep quality disorders, and occasionally facial dysmorphisms. ATH treatment is essentially based on a
Accepted 9 August 2013
number of medical–surgical aids including nasal irrigation with topical antibiotics and corticosteroids
Available online 22 August 2013
and/or treatment with systemic corticosteroids, immunoregulators, thermal treatments, adenotonsil-
lectomy, etc.
Keywords:
Objectives: The aim of the present study is to assess the efficacy of Aerosal1 halotherapy in the treatment
Adenotonsillar hyperthrophy
Otitis media
of sub-obstructive adenotonsillar disease and correlated conditions compared to placebo treatment.
Sleep disorders Methods: A total of 45 patients with sub-obstructive adenotonsillar hypertrophy were randomized to
Nasal cytology receive either Aerosal1 halotherapy or placebo for 10 treatment sessions. The main outcome was a
Halotherapy reduction greater than or equal to 25% from the baseline of the degree of adenoid and/or tonsillar
Aerosal hypertrophy.
Results: In the intention-to-treat analysis, a reduction of the degree of adenoid and/or tonsillar
hypertrophy 25% from baseline after 10 therapy sessions was found in 44.4% of the patients in the
halotherapy arm and in 22.2% of the patients in the placebo arm (P = 0.204). Among the secondary
outcomes, the reduction of hearing loss after 10 treatment sessions in the halotherapy arm was higher
than the placebo arm (P = 0.018) as well as the time-dependent analysis showed significantly improved
peak pressure in the Aerosal1 group (P = 0.038). No side effects were reported during the trial. In
addition, the therapy was well accepted by the young patients who considered it as a time for play rather
than a therapy.
Conclusions: Aerosal1 halotherapy can be considered a viable adjunct, albeit not a replacement, to
conventional medical treatment of sub-obstructive adenotonsillar syndrome and related conditions.
Further research is however needed to improve ATH treatment.
ß 2013 The Authors. Published by Elsevier Ireland Ltd. Open access under CC BY-NC-SA license.
1. Introduction
Symptomatic adenotonsillar hyperthrophy (ATH) is a frequent

cause of obstructive syndromes ascribable to mechanic obstruction
in the oropharynx and resulting upper aerodigestive tract encum-
brance [1]. The syndrome, which usually affects children aged 3–10
§§
Trial registration number: NCT01574885 (ClinicalTrials.gov Identifier). years, is characterized by middle ear, nasal passages, paranasal sinus
* Corresponding author at: Otolaryngology, University of Bari, Piazza G. Cesare n8 symptoms, voice and swallowing disorders, poor sleep quality, and
11, 70124 Bari, Italy. Tel.: +39 0805023966; fax: +39 0805593315. occasionally facial dysmorphisms and dental malocclusion [2–7].
E-mail addresses: [email protected] (M. Gelardi), [email protected] ATH has a typical onset after the third year of life with
(L. Iannuzzi), [email protected] (A. Greco Miani),
symptoms progressively worsening with a peak age incidence
[email protected] (S. Cazzaniga), [email protected] (L. Naldi),
[email protected] (C. De Luca). between 4 and 8 years [8].
0165-5876 ß 2013 The Authors. Published by Elsevier Ireland Ltd. Open access under CC BY-NC-SA license.
http://dx.doi.org/10.1016/j.ijporl.2013.08.013
M. Gelardi et al. / International Journal of Pediatric Otorhinolaryngology 77 (2013) 1818–1824 1819
The management of this condition has changed dramatically

over the last few years thanks to technological advances in
diagnostic criteria specificity that once used to rely almost
exclusively on rather empirical and vague clinical parameters
[9,10]. As a result, it has been possible to define a more accurate
nosologic picture of ATH which has allowed for a more targeted
therapeutic strategy essentially based on the use of several
therapeutic aids (topical antibiotics and corticosteroids to clear
nasal passages and/or systemic corticosteroids, etc.) [11–19]. In
this connection, in the past few years several investigators have
studied the beneficial effects of salt (halotherapy from the Greek
word for salt, halos) on a number of respiratory system conditions
(rhinosinusitis, allergic rhinitis, otitis, bronchitis, and asthma) [20–
23] as well as on some dermatological pathologies (atopic
dermatitis and psoriasis) [24–26]. Halotherapy is based on a
non pharmacological approach as it relies on the release of
micronized medical sodium chloride into an indoor climate- Fig. 1. ‘‘Salt Clinic’’. 3D design: reception/welcome area (a); waiting room with
children’s recreation area (b); ‘‘Aerosal1’’ halotherapy room (c). ENT Care Unit (d).
controlled environment. The release is meant to recreate the
Cabinet containing the Dry Salt Aerosol Generator – University General Hospital –
conditions occurring in nature in salt mines and caves. Occasion- Bari (Italy).
ally a small amount of micronized iodine is added to mimic the
experience of being on a real naturally occurring seashore. Salt
therapy has been practised in old salt mines of Central and Eastern 2.2.2. Dry salt aerosol generator
Europe for centuries where it is still common being considered a The dry salt aerosol generator is encased in a cabinet placed
full-fledged medical treatment. outside of, albeit contiguous to, the salt room (Fig. 1d). A standard
The aim of the present study was to assess the efficacy of amount of NaCl (salt sachet) is fed into the dry salt aerosol
Aerosal1 in the treatment of sub-obstructive adenotonsillar generator to be blown into the salt room in the form of aerosol
hypertrophy and correlated disease versus placebo treatment. through a PVC (polyvinyl chloride) connector. The size of NaCl,
micronized particles ranges from 0.23 to 20 mm (data collected by
2. Materials and methods portable laser aerosol spectrometer Model 1.109 with GRIMM1
technology). Particle density ranges from 20 to 35 mg/m3 and is
2.1. Patients kept constant over time thanks to an electronic system.
Patients were recruited from the Department of Otolaryngology 2.2.3. Salt sachet: salt features
(ENT) of Bari University General Hospital after approval had been The salt sachet contains 30 g of NaCl, 20 g of micronized RG
obtained by the institutional ethics committee. Inclusion criteria (Reagent Grade) salt (according to Ph Eur Current Edition), and 10 g
were as follows: age range: 4–12 years; genders: both; pathology: of non micronized ESCO iodized feed salt to prevent aggregation
sub-obstructive adenoid hypertrophy lasting from at least six and keep an appropriate level of iodine exposure.
months and associated with sleep-disordered breathing (respira-
tory pauses or sleep apnea) and/or recurrent serous otitis media; 2.3. Clinical and instrumental evaluation
suspension for over 3 months from the start of the study of any
immunosuppressive treatments (cyclosporin and systemic ster- After collection of medical history, all the patients underwent
oids). Exclusion criteria: patients with acute bronchopulmonary clinical and instrumental exams as follows: ENT visit with
disease, tuberculosis, severe hypertension, hyperthyroidism, inspection of the oropharyngeal tract and tonsillar hypertrophy
cancer (chemotherapy), intoxication, heart failure, bronchial staging (08–48) [27], flexible fiberscope nasal endoscopy (ENT 2000
asthma or iodine allergy. Patients were still allowed to use topical
therapy with nasal washings and topical steroids.
2.2. Technical specifications of salt room ‘‘Aerosal1’’
2.2.1. Salt room

Both walls and ceiling of the multilayer sea wood salt room
(2.30 mt. 2.90 mt. 2.20 mt.) are completely covered with ESCO
(European Salt Company) type certified-origin iodized rock salt.
The floor, which is also made of multilayer sea wood, is covered
with about 500 kg of RESIMAX type certified-origin rock salt
(Figs. 1 and 2).
The room environment is not contaminated with pathogenic
microorganisms (as certified by SAS 901 measurements). Patients
can settle into comfortable chairs inside the room where the dry
salt aerosol is blown through a PVC pipe (described below). A
centrifugal extractor fan (air flow rate 90 m3/h), placed on the side
opposite to the PVC pipe ensures a number of complete changes of
air in full compliance with requirements in terms of CO2 ppm
values, i.e. <750 ppm. Also temperature and humidity are kept at Fig. 2. ‘‘Aerosal’’1 Haloterapy Salt Room where children are always highly
constant values ranging between 20 8C and 24 8C and 44% and 60%, compliant as they consider treatment sessions as opportunities for play and
respectively (TESTO 435-41 Digital Multimeter measurements). recreation. ENT Care Unit–University General Hospital – Bari (Italy).
1820 M. Gelardi et al. / International Journal of Pediatric Otorhinolaryngology 77 (2013) 1818–1824
flexible Ø 3.4 mm fibroscope – Vision Sciences1, USA) to assess the (adjusted index, 1 h–1), reduction of sleep time percentage with
degree of adenoidal hypertrophy [10]. Pure tone audiometry was SpO2 levels <95%; any reductions of the main inflammatory
performed in a sound-proofed cabin using pure tones (250 ms immune cells (neutrophils, eosinophils, and mast cells) as assessed
duration, 25 ms rise/fall time, 50% duty cycle) at octave frequencies by nasal cytology. The number of side effects reported either
from 125 Hz to 8000 Hz with a maximum intensity of 120 dB SPL during treatment period or after the end of treatment, if suspected
with an Amplaid 309 clinical audiometer (Amplaid, Milan, Italy). to be related with this latter, was also included in secondary
Tympanometric measurements were performed using a 220 Hz outcome measures.
probe tone with an Amplaid 770 clinical tympanometer (Amplaid,
Milan, Italy). Air conduction pure tone average was obtained by the 2.6. Statistical analysis
mean of thresholds at 0.5, 1, 2 and 4 kHz. Tympanograms were
classified according to Jerger in types A, B and C [28]. Nasal Data were presented as medians with ranges and/or inter-
cytology was performed by anterior rhinoscopy, using a nasal quartile ranges (IQRs), or numbers with percentages. Baseline
speculum and good lighting. Scrapings of the nasal mucosa were variables and changes in outcomes were compared between
collected from the middle portion of the inferior turbinate, using a groups by using the Mann–Whitney U test for continuous data and
Rhino-Probe1 [29]. Samples were placed on a glass slide, fixed by Fisher’s exact test for categorical ones. Overall time-dependent
air drying and then stained with the May-Grunwald Giemsa (MGG) variations in primary and secondary outcomes were evaluated by
method (Carlo Erba1, Milan, Italy) [30]. Cell counts, bacterial and Friedman’s test for repeated measures with Page’s test for trend in
fungal analysis were carried out by a semi-quantitative grading, as time variations. An intention-to-treat approach was adopted in
proposed by Meltzer and Jalowayski [31]. The semiquantitative primary analyses. This approach considered patients withdrawn
evaluation of the biofilms [32] was performed by counting the prematurely from the study as treatment failures in the two study
number of infectious spots (ISs) in 50 microscopic fields, always at arms. Intention-to-treat analysis was then complemented by per-
a 1000 magnification (oil immersion). Sleep evaluation was protocol analyses which considered only those patients who had
carried out overnight by means of wrist-worn pulse oximeters completed the study period. In the study design phase it had been
Wrist 0x2TM Model 3150. The parameters studied were: basal calculated that a total of 64 patients would be needed for the study
SpO2%; event data index (adjusted index, 1 h–1) and time (%) with to have a 40% success rate in terms of primary outcome in the
SpO2 value below 95%. It was decided to use pulse oximetry [33] halotherapy group as against 10% in the placebo group (a = 0.05,
instead of ‘‘gold standard’’ polysomnography [34] to study b = 0.20). Statistical analysis was carried out by using MATLAB
patients’ sleep patterns as the former makes overnight studies software (MathWorks, Natick, MA, USA). Two-sided P-values
easier for patients at home (the protocol envisaged three such <0.05 were considered to indicate statistical significance in all
studies in three months, two of them with only a 15-day interval). tests.
In addition, important guidelines [35,36] do indicate pulse
oximetry as a method with a high positive predictive value of 3. Results
OSASs (97%) [37].
Between February 2012 and March 2012, 49 patients were
2.4. Study design screened, 45 of whom (24 boys and 21 girls, average age 6 years)
underwent randomization. The reason for exclusion was age
After having given their written informed consent all the outside the study inclusion criteria age range (n = 4). Recruitment
eligible patients were randomized on a 3:2 basis to receive either halted prematurely due to technical and legal issues related to the
Aerosal1 or placebo. Central stratified blocked randomization certification of the device. The baseline characteristics of
using telephone was adopted with patients, investigators and randomized patients in the two arms of the study are given in
outcomes assessor being all blinded to randomization rules. Table 1. One patient, randomized to the placebo group, withdrew
Aerosal1 treatment consisted of 10 daily sessions (5 sessions for after the first week of treatment for an episode of acute tonsillitis
week) of micronized iodized salt (sodium chloride) – with the requiring antibiotic treatment, and one patient, randomized to the
addition of iodine – inhalation in a chamber reproducing the Aerosal1 arm, withdrew during the follow-up period for exacer-
microclimate of a natural salt cave. Each daily session lasted bation of upper airways symptoms. Both arms were matched in
30 min. Treatment with placebo comparator was performed in the baseline characteristics (data not shown).
same way as halotherapy but with no salt release in the room. All
patients underwent a complete clinical evaluation at baseline, at 3.1. Effectiveness
the end of therapy period (10 sessions) and 3 months after the end
of treatment (follow-up). Fig. 3 shows the distribution of variations of measurements
from baseline in both arms after 10 treatment sessions in terms of
2.5. Outcome measures (i) reduction of the degree of adenoid and/or tonsillar hypertrophy;
(ii) reduction of hearing loss and (iii) tympanometry improvement.
The primary outcome measure, evaluated both after 10 sessions All outcome measures and their departure from baseline at the end
of therapy and at the 3-month follow-up, was an adenoid and/or of treatment sessions and at the 3-month follow up are reported in
tonsillar hypertrophy reduction 25% from baseline as assessed by Table 2. Assuming intention-to-treat analysis as a reference, a
the physician on a standardized four-point rating scale. Secondary reduction of the degree of adenoid and/or tonsillar hypertrophy
outcome measures included instrumental assessments: any 25% from baseline after 10 therapy sessions was found in 44.4% of
reductions in terms of adenoid and/or tonsillar hypertrophy the patients in the halotherapy arm and in 22.2% of the patients in
degree; any reductions of hearing loss 10 dB of the 4-frequency the placebo arm (P = 0.204). These results increased to 59.3% and
(0.5, 1, 2 and 4 kHz) pure tone average, as well as any other 38.9%, respectively at the 3-month follow up (P = 0.231). Other
significant gain; any improvements in of tympanometric values, substantial changes in adenoid or tonsillar hypertrophy were not
i.e. transition from type B curve to type C/A curve or from type C found to have a statistical significance at any other point in time.
curve to type A curve for both sides; any change in tympanogram Among secondary outcomes hearing loss reduction was found
peak pressure (daPa); any changes in pulse-oximetric values to be significant (P = 0.018) after 10 treatment sessions in the
(increase in SpO2% mean levels, reduction of the event data index halotherapy arm compared to the placebo arm, even though the
Table 1
Baseline characteristics of randomized patients.
Aerosal (N = 27) Placebo (N = 18)
N (%) Median (IQR) Range N (%) Median (IQR) Range
Gender (male/female) 14 (51.9) 10 (55.6)

Age 6 (4) 4–12 4.5 (2) 4–10
Weight (kg) 25 (13.5) 15–56 20 (5.5) 14–41
Height (cm) 120 (24.2) 97–160 110 (10) 95–131
BMI (kg/m2) 17.4 (2.3) 14.3–25.5 16.9 (3.5) 11.6–23.9
ATH age at onset (years) 3 (2.5) 0–7 2 (1) 1–6
ATH duration (years) 3 (5.2) 1–9 2 (1) 1–5
ATH familiarity 13 (48.2) 6 (33.3)
Previous topical treatments 19 (70.4) 13 (72.2)
Previous systemic treatments 21 (77.8) 10 (55.6)
Previous ENT pathologies 22 (81.5) 14 (77.8)
Current topical treatments 5 (18.5) 4 (22.2)
Adenoid hypertrophy degree 3 (0) 3–4 3 (0) 2–4
Tonsillar hypertrophy degree 3 (0.8) 1–4 3 (1) 1–4
Nasal cytology
Neutrophils (any) 17 (63.0) 11 (61.1)
Eosinophils (any) 9 (33.3) 2 (11.1)
Mast cells (any) 3 (11.1) 1 (5.6)
Audiometry (dB)a 17.5 (19.4) 10–40 15 (25) 10–45
Tympanometry (right)
Type A curve 10 (37.0) 4 (22.2)
Type B curve 12 (44.4) 7 (38.9)
Type C curve 5 (18.5) 7 (38.9)
Tympanometry (left)
Type A curve 6 (22.2) 5 (27.8)
Type B curve 18 (66.7) 8 (44.4)
Type C curve 3 (11.1) 5 (27.8)
Tympanometric peak, right (daPa) 168 (126) 0–302 214 (123.8) 0–296
Tympanometric peak, left (daPa) 223.5 (124) 0–304 240 (133.5) 28–300
Pulse-oximetry indexes
Mean SpO2% levels 96 (1.6) 91.4–97.6 96.1 (2.2) 89.3–97.5
Apnea events (1 h–1) 1.2 (4.1) 0–24.5 1 (1.4) 0–9
Sleep time % with SpO2 <95% 11.4 (25.7) 0.1–95.9 8.5 (41.5) 0–87.6
ATH, adenotonsillar hypertrophy; ENT, otolaryngology; IQR, interquartile range; range = Min Max. There were no significant differences in baseline characteristics between
the two arms of the study.
a
Average audiometry (left/right) evaluated at the frequencies of the tone range (0.5, 1, 2, 4 kHz).
difference between the two arms was not statistically significant at (P = 0.010) in the treatment arm, while no significant trend was
follow up (P = 0.107). The overall time-dependent analysis of observed in the placebo arm (P = 0.165).
variations showed a significant difference between the two arms The analysis of the tympanograms showed that after 10
for hearing loss reduction with a significant decreasing trend treatments tympanogram type improved in 29.6% of the patients
in the Aerosal1 arm compared to 5.6% of patients in the placebo
arm (P = 0.064). No difference was however observed between the
two arms at the 3-month follow up. Also in this case the time-
dependent analysis showed significantly improved tympanogram
in the Aerosal1 group compared to the placebo group on both sides
(P = 0.002). A significant trend was observed for both sides in the
treatment arm (P = 0.005 for the right side and P < 0.001 for the left
side), while in the placebo arm a significant improvement was
observed only on the left side (P = 0.015). The analysis of the peak
compliance showed that even if at T1 and T2 there were no
significant differences between the two groups in terms of peak
changes, the time-dependent analysis showed significantly
improved peak pressure in the Aerosal1 group compared to the
placebo group on both sides (P = 0.038).
The other secondary outcomes did not exhibit major differences
between the two arms.
In more detail, as far as nasal cytology is concerned, 37.0% of
patients in the Aerosal1 arm and 22.2% of patients in the placebo
group exhibited a reduction I50% of the principal inflammatory
immune cells after 10 treatment sessions (P = 0.343). These
proportions were found to be 37.0% and 33.3%, respectively at
follow up evaluation (P = 1).
Fig. 3. Distribution of study arms after 10 treatment sessions from baseline Regarding pulse oximetry values, baseline SpO2 did not show
according to reduction of adenoid and/or tonsillar hypertrophy degree, hearing loss any statistically significant variation after 10 sessions (P = 0.880),
reduction and tympanometry improvement. as was the case for the other two parameters under study, i.e.
Table 2
Intention-to-treat analysis of primary and secondary outcomes at T1 (10 sessions of therapy) and T2 (3 months from the end of treatment) compared to baseline.
Aerosal (N = 27) Placebo (N = 18) P-valuea
N (%) Median (IQR) N (%) Median (IQR)
T1
Reduction of adenoid hypertrophy degree (%) 0 (25) 0 (0) 0.734
Reduction 25% 8 (29.6) 3 (16.7) 0.482
Reduction of tonsillar hypertrophy degree (%) 0 (31.2) 0 (0) 0.197
Reduction 25% 9 (33.3) 3 (16.7) 0.308
Reduction of adenoid and/or tonsillar
hypertrophy degree 25% 12 (44.4) 4 (22.2) 0.204
Hearing loss reductionb (dB) 5 (13.8) 0 (10) 0.018
Reduction 10 dB 10 (37.0) 2 (11.1) 0.086
Tympanometry improvementc 8 (29.6) 1 (5.6) 0.064
Tympanometric peak pressure change (daPa) 21.5 (79.5) 1 (74) 0.141
Nasal cytology reductiond 50% 10 (37.0) 4 (22.2) 0.343
Increase of mean SpO2% levels 0.1 (1.9) 0.1 (2.8) 0.880
Reduction of apnea events (1 h–1) 0.5 (4.9) 0 (1.4) 0.372
Reduction of sleep time % with SpO2 <95% 3.6 (14.6) 2.5 (57.4) 0.424
T2
Reduction of adenoid hypertrophy degree (%) 0 (18.8) 0 (25) 0.967
Reduction 25% 7 (25.9) 6 (33.3) 0.739
Reduction of tonsillar hypertrophy degree (%) 0 (31.2) 0 (0) 0.070
Reduction 25% 11 (40.7) 3 (16.7) 0.111
Reduction of adenoid and/or tonsillar hypertrophy degree 25% 16 (59.3) 7 (38.9) 0.231
Hearing loss reductionb (dB) 2.5 (14.4) 0 (10) 0.107
Reduction 10 dB 10 (37.0) 4 (22.2) 0.343
Tympanometry improvementc 9 (33.3) 3 (16.7) 0.308
Tympanometric peak pressure change (daPa) 60.5 (104.4) 44 (78.5) 0.509
Nasal cytology reductiond 50% 10 (37.0) 6 (33.3) 1
Increase of mean SpO2% levels 0.2 (2.2) 0.2 (2) 0.772
Reduction of apnea events (1 h–1) 0.2 (2.8) 0.9 (2.1) 0.102
Reduction of sleep time % with SpO2 <95% 0.4 (28.5) 0.3 (22.2) 0.917
IQR, interquartile range.

a
Mann–Whitney U-test for continuous variables, Fisher’s exact test for categorical variables.
b
Reduction of average audiometry (left/right) evaluated at the frequencies of the tone range (0.5, 1, 2, 4 kHz).
c
Improvement was defined as defined as the passage from type B curve to type C/A curve or from type C curve to type A curve for both ears sides.
d
Any reduction of principal inflammatory immune cells (neutrophils, eosinophils, and mast cells).
reduction of the event data index (P = 0.372), and reduction of different ailments by assimilating dust-like salt particles goes back
sleep time with SpO2 <95% (P = 0.424). Pulse oximetry values to ancient times. These caves used for therapeutic purposes are still
remained mostly unchanged at follow up. in use in many Central and Eastern European countries including
The results of the per-protocol analysis did confirm the main Austria (Solzbad-Salzetnan), Romania (Sieged), Poland (Wieliczka,
findings and were generally overlapping intention-to-treat out- one of the UNESCO World Heritage Sites), Azerbaijan (Nakhiche-
comes (data not shown). van), Kirgizia (Chon-Tous), Russia (Berezniki-Pern), and Ukraine
(Solotvino-Carpathians e Artiomovsk-Donietsk).
4. Discussion The possibility of recreating the microclimate (Table 3) of these
caves in a room has given a new impulse to studies and research
The growing prevalence of conditions (both allergic and efforts on the potential therapeutic effects of this treatment.
infectious) affecting the upper airways has stimulated a whole As far as the present study is concerned, the first finding has
series of studies on topical treatments in a view to reducing the been the absence of adverse effects. None of the children enrolled
side effects of systemic treatments and improving clinical response in the study exhibited episodes of respiratory distress (dyspnea,
in terms of improvement of nasal symptoms [38–40]. bronchial hyperactivity, asthma), skin itch or eyes disorders, both
The latest guidelines issued by EPOS 2012 [41] on obstructive during treatment and in the hours immediately after treatment. In
and infectious nasal sinus disease include among therapeutic aids addition, a high compliance to treatment has been observed as
(antibiotics, topical steroids, and topical decongestants) also nasal children did not consider their HT sessions as a therapy, but rather
saline irrigation, thus emphasizing the crucial role of this as a time for play or recreation as they spent their 30-min sessions
treatment in reducing nasal congestion and mucopurulent playing, watching TV (cartoons, wildlife shows, etc.) (Fig. 2). Only
discharge by a washing process that restores mucociliary clearance two children withdrew from the study; one of them (in the placebo
and prevents both locoregional (otitis, rhinosinusitis) and distant arm) withdrew during the first week of halotherapy for an episode
inflammation (rhinobronchial syndrome, bronchitis, pneumonia,
asthma, etc.) [42–44].
In addition, in the last few years some literature studies [20–26]
Table 3
have reported a new therapeutic-preventive role for sodium Salt room microclimate features.
chloride in what has come to be called ‘‘halotherapy’’ and in the
Size of iodized NaCl particles released 0.23–20 mm
applications of this latter in the different branches of medicine, in Particles density 35–50 mg/m3
particular respiratory and dermatological disease. As a matter of Air exchange 90 m3/h
fact, for hundreds of years salt has been recognized as an agent to CO2 ppm <750
Temperature 20–24 8C
treat respiratory and skin conditions. The history of using salt caves
Humidity 44–60%
for healing (speleotherapy from Greek speleos = cave and therapy)
of acute tonsillitis with high fever, the other dropped out in the 5. Conclusions
follow-up period for increased adenotonsillar hypertrophy associ-
ated with sleep respiratory disorders with an indication for Haloterapy accounts for a relatively new, completely natural
adenotonsillectomy. Being specific to the natural course of the therapeutic remedy which does not call for any pharmacological
conditions in question, these episodes have not been considered as administration and is based on the healing capacities of natural salt
adverse events connected to the halotherapeutic treatment. micronized and released into an indoor environment by means of
However the most interesting aspects emerging from the specific techniques. Halotherapy administered by Aerosal1 system
present study have been those related to the assessment of the real has been shown to have a statistically significant effect on OME.
impact of halotherapy on both the lymphatic component Aerosal1 halotherapy has also been found to be partially effective
(adenotonsillar component) and co-morbidities, namely ear in reducing adenotonsillar hypertrophy. The beneficial effects of
conditions and sleep disorders. Actually, the numerous studies the treatment in question have been shown for some ‘‘time-
conducted so far on halotherapy have mainly been focused on dependent’’ parameters, therefore additional studies should be
lower airways conditions (cystc fibrosis, bronchitis, and asthma conducted in a view to defining treatment modalities likely to
[21–23]). result in a better clinical response. New double-blind, placebo-
Our study has highlighted a 25% reduction of the adenoton- controlled, randomized clinical studies should also be performed
sillar tissue in 44.4% of the patients treated versus 22.2% of the on more complex conditions including asthma, cystic fibrosis,
placebo controls. In our view, far from being statistically significant chronic pulmonary disease and dermatological conditions.
(P = 0.204), this finding has a clinical value that deserves further In addition to being a safe treatment, the Aerosal1 Haloterapy
study. This pattern has also been confirmed by the pulse-oximetric system has been well accepted and tolerated by our young patients
data that, far from being statistically significant, have shown a who experienced their halotherapeutic sessions as a time for play
decreased event data index (adjusted index) as well as a reduction and recreation and not as a real medical treatment. Therefore
of the sleep time percentage with SpO2 <95%. Based on our results Aerosal1 Haloterapy might constitute a valuable adjunct (and not
it is possible to calculate that approximately 140 patients (70 in a replacement) to current orthodox medical treatment of
each arm) would be needed to show a significant reduction of the adenotonsillar disease and correlated conditions.
adenotonsillar tissue as expressed in the primary outcome. It is
therefore unlikely that the loss of power due to the reduced Funding
number of patients enrolled in the study (45) compared to the
planned number (64) had a significant impact on our findings. The This study has been funded by a TECNOSUN srl scholarship.
reduction of some clinical and endoscopic parameters also in the
control group should however be justified by the fact that the very
Conflict of interest
young patients actually spent their time in a ‘‘salted’’ environment
where their same manipulation of salt released microparticles of
None declared.
sodium chloride available for inhalation.
Among secondary end-points, end-of-treatment improvement
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IF : 4.547 | IC Value 80.26 Volume : 3 | Issue
VOLUME-6, : 11 | November
ISSUE-5, MAY-20172014 • ISSN
• ISSN NoNo 2277- 8160
2277 - 8179
Original Research Paper Medicine

Halotherapy and Buteyko Breathing Technique – a possible
successful combination in relieving respiratory symptoms
Radu CRIȘAN- Clinic Of Pulmonary Diseases Iași, University of Medicine and Pharmacy”Grigore T.
DABIJA Popa” Iași
Clinic Of Pulmonary Diseases Iași, University of Medicine and Pharmacy”Grigore T.
Traian MIHĂESCU Popa” Iași
ABSTRACT Speleotherapy and halotherapy are relatively old therapeutic methods sometimes recommended for chronic
obstructive disorders. As part of reahabilitation programs, the need to introduce a natural approach on patient
already receiving classical therapy seems to improve their clinical status as well as their quality of life. Buteyko breathing technique has
known bene ts in pulmonary rehabilitation and it is used to improve respiration and control chronic respiratory symptoms as part of
respiratory exercising. In this short study we assessed the improvement of the control pause – a parameter used in Buteyko breathing
exercising on patients receiving halotherapy for a day. The results showed a small improvement in their control pause, meaning that
halotherapy, combined with Buteyko breathing technique may be a solution to enhance the respiratory status of chronic respiratory
patients.
KEYWORDS : halotherapy, Buteyko, control pause, chronic respiratory patients.
Introduction production and the disposal of CO2. Thus, he states that breathing
Halotherapy is a well-known natural therapy using NaCl aerosols for more results in insufficient elimination of CO2 and therefore
the relief of respiratory symptoms. Although the method has been disruption of metabolism.
known for centuries, the actual scienti cally proof of the NaCl
aerosols has been rst documented by Felicz Bockowski in 19th Materials and Methods
century by observing the health of miners working in the salt mines The known mechanism of halotherapy are: boosting local immunity
(1). in the respiratory system (by phagosomal acidi cation),
bacteriostatic effect of the Chloride ion, increased mucociliary
NaCl aerosols resulted from natural sources are poly-dispersed clearance (by osmotic mechanisms and thinning of the secretions),
systems with special nano-structural properties that have a anti-in ammatory effect and local hypo-sensitization.
different distribution and concentration within the environment -
resulting a different environmental activity depending on The lm of mucus is constantly renewed due to the kinetics of ciliary
temperature, humidity and probably the most important factor – epithelium - performing cilia movement of "sweeping" with a
the source (2). Many authors have theories about the efficiency of frequency of 10-20 times / second by moving to the throat mucus
NaCl sources on respiratory symptoms relief, some claiming that layer at a rate of about 1cm / minute. This mucus containing
natural saline environments – such as salt caves and natural formed particulate matter captured (which can be bacterial inclusions) is
halo-chambers are more efficient, others considering that a subsequently removed by coughing or swallowed. This mechanism
controlled saline environment – such as aerosoling devices are more is added nasal turbulence due to its efficiency particle diameter no
efficient. Considering the difficulty of conducting a clinical study in a larger than 5 microns can penetrate the lungs (3).
natural halo-chamber and multiple biases that can occur, it is
pertinent to affirm that the conclusions of the scienti c data
In the light of this theory, the Buteyko technique uses a new
collected from studies, conducted with arti cial saline sources,
parameter – named„the control pause” – a method of measuring the
provide enough evidence that a controlled NaCl aerosols emitting
rough tolerance of CO2. The control pause basically means the
device is at least as efficient as any natural halo-chamber, and also
amount of seconds that a subject can hold his breath after a full
safer and more accessible.
expiration, Buteyko linking this capability proportional to the CO2
metabolism and respiratory disorders by stating that a lower control
All areas are kept moist by airway mucus production - produced by
mucous cells in the airway epithelial layer and submucosal glands in pause is associated to a lower control of the respiratory disorder (5).
partially. This secretion (3) captures and encompasses particles in
the air we breathe, preventing reaching and deposited in the Considering these two alternative medicine methods used in
airways and alveoli. relieving respiratory symptoms, we proposed a trial in order to
determine if using halotherapy for 20 minutes a day modi es the
Buteyko technique is known to be responsible for reducing by 90% control pause of clinical healthy subjects, thus raising the
the use of rescue medication in asthma and up to 30% of probability of improving the Co2 metabolism.
background medication (4). Dr. Buteyko brought together as
"diseases of civilization" diseases such as: allergies, asthma, COPD, We selected 33 subjects, 22 males (all smokers) and 11 female (non
brosis (asbestoses, silicosis, anthracnose, etc). smokers), about the same age, and we assessed the initial control
pauses before halotherapy (Table 1).
The common cause of these diseases is, after Dr. K. Buteyko, alveolar
hyperventilation or breath deeply unjusti ed. In the 80s, he For these subjects we assessed the peripheral oxygen saturation
proposed to study a simple, respiratory dimming or "normalization" (SaO2) and calculated a mean for each gender group (M – male
respiratory rate as physical exercise in patients with pulmonary group, F – female group), the mean cardiac frequency (bpm – beats
pathology. per minute) and mean control pauses.
Based on the theory that there is a certain tolerability of CO2 After using a clinical tested Dry Salt Inhaler for 20 minutes (nasal
produced as a resultant oh human body metabolism he de nes breathing through the inhaler), we assessed the control pauses of
normal respiration as a balanced equilibrium between the the subjects again.
GJRA - GLOBAL JOURNAL FOR RESEARCH ANALYSIS X 673

Volume : 3 | Issue
VOLUME-6, : 11 | November
ISSUE-5, MAY-2017 2014 • ISSN
• ISSN No 2277
No 2277 - 8179
- 8160 IF : 4.547 | IC Value 80.26
Gende Mean Smoki Initial Initial After HT After The technique uses the principle that hyperventilation and
r Age ng Pulsoxymetry Contr Pulsoxymetry HT subsequent or coexisting hyperin ation during an asthma attack is
status ol Contr an endless feedback loop that eventually leads to increased CO2
Pause ol metabolism disturbance.
Mean Mean Mean Mean Mean Pause
SaO2 Car- Values SaO2 Car- In 2006, Russian Breathing Center stated that the procedure is the
diac diac most effective non-pharmacological management of asthma and
Freqv Freqv respiratory pathology generally practiced so pulmonologists,
ency ency pediatricians and free – professionals. It consists of a series of
M 35 yes 97% 92 22,82" 97% 89 27,55" lectures and exercises that revolutionizes the concept of
F 32 no 97% 72 28,44" 99% 71 32,53" "Respiratory Physical Education”
Table 1. The data collected from the subjects before and after using References:
halotherapy (HT). SaO2 – peripheral saturation in oxygen measured 1. Crisan, Radu and Mihaescu, Traian. The effects of using Dry-Salt-Inhaler on Patients
with Asthma and COPD. Iasi : Scienti c Report - Doctorship PhD Thesis - Iasi University
by pulsoximetry. of Medicine and Pharmacy, 2010.
2. Sandu, I., et al. Research on naci saline aerosols. II. New arti cial halochamber
Results characteristics. 8, Iasi : "Gheorghe Asachi" Technical University of lasi, Romania,
August 2010, Environmental Engineering and Management Journal, Vol. 9, pp. 1105-
The results centralized in Table 1 showed a signi cant improvement 1113.
of the control pauses of all three subjects but the most important 3. CRIȘAN, R. and MIHĂESCU, Traian. Haloterapia - o abordare naturală a patologiei
aspect, it seems that the smokers had a better control pause after pulmonare. Iasi : Technopress, 2014. CNCSIS code 89. ISBN 978-606-687-123-5.
4. Bowler, Simon D., Green, Amanda and Mitchel, Charles. Buteyko breathing
using halotherapy than the non-smoker. techniques in asthma: a blinded randomised controlled trial. 1998, Medical Journal of
Australia, Vol. 169, pp. 575-578.
The average improvement of the control pause was by 20% - 4,73 5. Novozhilov, Andrey. Buteyko Control Pause (CP). The Breathing Man. [Online]
december 2, 2009. [Cited: june 15, 2015.]
seconds in the male group showing signi cant improvements of the https://thebreathingman.wordpress.com/article/buteyko-control-pause-cp-
smokers, comparable with the non-smoker – female group 4,09 202i29i90v7sn-16/.
seconds – 14%. 6. Chervinskaya, AV and Zilber, NA.Halotherapy for treatment of respiratory diseases. 3,
Saint-Petersburg : J Aerosol Med., 1995, Vol. 8, pp. 221-32.
7. Wikipedia. Buteyko Method. Wikipedia, the free encyclopedia. [Online] April 25,
We observed also a decrease in mean cardiac frequency – male 2015. [Cited: June 15, 2015.] https://en.wikipedia.org/wiki/Buteyko_method.
group scored a mean CF of 89 bpm and female group had a mean CF 8. Crisan, R. and Mihaescu, T. Utilizarea Haloterapiei la Pacientii cu Patologie Obstructiva
Pulmonara - Teza de Doctorat. Iasi : Universitatea de Medicina si Farmacie „Grigore T.
of 71 bpm. Popa” Iași, 2011.
Conclusions
Although the tests were ran on a very small group, the results are
promising and open the way to a more complex and extended
clinical trial to be conducted on healthy subjects as well as on
patients with obstructive respiratory disorders.
Halotherapy seems to improve the control pauses of healthy

subjects after a 20 minutes cure, accented in smokers, but
implications on CO2 metabolism and further long-term bene ts on
respiratory function needs a more extensive clinical study with the
assessments of CO2 arterial levels in dynamics.
Discussions:
In a 1993 publication, Dityatkovskaya et al., Cited in the publication
"Respiratory Diseases for Halotherapy" (6), researchers observed a
signi cant decrease in IgE effect and improved humoral and
immune status of patients bronchial cells with asthma who were
doing and meetings halotherapy inside mines. Notable observation
is the same researchers con rmed an increase in mucociliary
clearance and an increase ciliary movements in the same patients.
Another important aspect of halotherapy is the ability to reduce the

chance of respiratory infections by default bactericidal effect of Cl-
ion and by activating phagocytosis. This is an important bene t for
patients with COPD exacerbations infectious as life threatening
danger. As more and more studies are trying to elucidate and
demonstrate the exact action mechanism of saline aerosols on the
human respiratory system, the halotherapy gets the attention of
more and more doctors and patients (3).
Another important technique used in relieving respiratory

symptoms is the method attributed to the Ukrainian researcher and
doctor Konstantin Buteyko. The Buteyko method or Buteyko
Breathing Technique is a form of physical therapy, rst formulated in
1950 by dr. Buteyko, that proposes the use of breathing exercises as
a complementary treatment for asthma symptoms as well as other
conditions (7). Although downgraded from evidence A to evidence
B in GINA 2015, the asthma management guide still lists the
breathing exercises as important tools of helping the patients
achieve normal functioning.
674 X GJRA - GLOBAL JOURNAL FOR RESEARCH ANALYSIS

Сърце-бял дроб, 21, 2015, 1-2, 31-35 Heart-Lung (Varna), 21, 2015, 1-2, 31-35
Медицински университет - Варна Medical University of Varna
ХАЛОТЕРАПИЯТА – АЛТЕРНАТИВА HALOTHERAPY – AN ALTERNATIVE

ЗА ПАЦИЕНТИТЕ С БЕЛОДРОБНИ METHOD FOR THE TREATMENT
ЗАБОЛЯВАНИЯ OF RESPIRATORY DISEASES
Евгения Владева Evgeniya Vladeva

Катедра по физиотерапия, рехабилитация, Department of Physiotherapy, Rehabilitation,
морелечение и професионални заболявания, Thalassotherapy and Occupational Diseases,
Факултет по Обществено здравеопазване, Faculty of Public Health,
МУ-Варна Medical University of Varna
РЕЗЮМЕ ABSTRACT
Халотерапията е алтернативен метод за лечение на Halotherapy is an alternative method of treating respiratory
множество респираторни заболявания. През послед- diseases. This kind of treatment has become more and more
ните десетилетия се радва на доверието на все повече popular in last decades. Sodium chloride has a proven an-
хора в целия свят. Натриевият хлорид има доказано tibacterial, antimycotic and anti-inflammatory effect and is
антибактериално, антимикотично и противовъз- of great importance for the normal function of the bronchial
палително действие и е абсолютно необходим за нор- ciliated epithelium. This article reveals the benefits of salt in
малното функциониране на бронхиалния ресничест regard to the respiratory system, indications and contrain-
епител. Статията разкрива благоприятните ефекти на dications for this kind of treatment and the possibilities for
солта върху дихателната система, показанията и про- combining it with some other physical therapy methods.
тивопоказанията за провеждане на това лечение, както
и възможностите за комбиниране с други средства на Keywords: halotherapy, respiratory diseases, salt inhala-
физикалната терапия. tions
Ключови думи: халотерапия, белодробни заболявания,

инхалации с натриев хлорид
Salt has been used for millennia in different parts of
Солта е използвана заради оздравителните си ка- the world by different cultures because of its health
чества и терапевтичните си ефекти от хилядолетия benefits and therapeutic effect. Nowadays, the use
в различни географски региони и различни култу- of salt, known as halotherapy, has been the subject
ри. В наши дни употребата на солта, известна като of numerous scientific studies conducted by scien-
халотерапия е проучвана в множество научни tists from Europe and the Far East, encompassing the
изследвания, обхващащи периода от 1800 година period from 1800 up to present times. Many studies
до наши дни, от учени в цяла Европа и Далечния have been published in the last few decades. They pre-
Изток. През последните десетилетия са публику- sent the efficiency of halotherapy and its application
вани множество проучвания, които доказват ефек- in various diseases. Salt as a means of treatment was
тивността на халотерапията и приложението ѝ first described in 1843 by the Polish therapist Feliks
при различни заболявания. Солта като средство за Boczkowski. He noticed that people working in the
лечение е документирана за първи път през 1843 salt mines in Poland enjoyed excellent health despite
година, от полския терапевт Феликс Бочковски. the harsh working conditions and the lack of sufficient
Той забелязал, че хората, работещи в солните food. In addition to this, they almost never suffered
мини в Полша, се радват на отлично здраве, въ- from colds or any respiratory diseases, which were
преки тежките условия на работа и недоимъчното frequently observed among the rest of the population.
хранене. Освен това, те почти никога не страдали This prompted the physician to conduct research by
от простуда и всякакви белодробни заболявания, which he established that all this was due to the satu-
които били често срещани при останалото населе- rated with salt air that the miners breathed daily. Thus,
ние. Това накарало лекаря да направи проучвания, salt mines in Poland and Eastern Europe gradually be-
при които се установява, че това се дължи на на- came popular sanatoriums, attracting visitors from all
ситения със сол въздух, който миньорите вдишват over the world.
ежедневно. Така постепенно солните мини в Пол- In the last decades halotherapy has gained the trust of
ша и Източна Европа стават популярни санатори- more and more people around the world and has been
уми, привличайки посетители от целия свят. spreading quickly to Western Europe, Canada, Israel,
31
Evgeniya Vladeva
През последните десетилетия халотерапията се North America, and many other countries.
радва на доверието на все повече хора в целия The efficiency of salt therapy is mainly due to two rea-
свят и се разпространява бързо в Западна Европа, sons:
Канада, Израел, Северна Америка и много други • salt has an antibacterial, antimycotic and anti-
страни. inflammatory effect (it has been established that
Ефективността на лечението със сол се дължи the environment in salt rooms is three times more
главно на две причини: sterile than the cleanest operating room);
• солта има антибактериално, антимикотич- • salt has a natural ability to emit negative ions,
но и противовъзпалително действие (уста- neutralizing a positive charge.
новено е, че средата в солните стаи е 3 пъти It has been proven that this is a highly effective way of
по-стерилна дори и от най-чистата хирургиче- positively influencing numerous respiratory diseases
ска зала). with a prompt resolution of symptoms, improvement
• солта има естествената способност да излъч- of pulmonary ventilation and tolerance of physical
ва отрицателни йони, с което се неутрализира strain, and an increase in the immunity and protective
положителният заряд. capacity of the organism (6).
Доказано е, че това е един високо ефективен метод The main therapeutic factor is sodium chloride with
за благоприятно повлияване на редица белодроб- an aerosol particle size of 2 to 5 millimicrons. A study
ни заболявания с бързо обратно развитие на сим- by Chervinskaya, including 124 patients with differ-
птоматиката, подобряване на белодробната вен- ent pulmonary diseases, showed a considerable im-
тилация и толеранса при физическо натоварване, provement of the clinical status of the majority of the
като също се повишават имунитета и защитните participants after a one-hour stay in a salt room daily,
сили на организма (6). for a period of 15-20 days (3). Similar results were ob-
Основен лечебен фактор е натриевият хлорид с served in another study based on a chemiluminescent
размер 2 до 5 милимикрона на частиците в аеро- test in 49 patients with chronic obstructive bronchitis.
зола. Проучване на Червинская, включващо 124 Halotherapy led to positive changes in the oxidation
пациента с различни белодробни заболявания, of free radicals and improved local immunity and the
показва значително подобрение в клиничния ста- clinical presentation of the disease (2,4).
тус при по-голямата част от тях след пребиваване Immunological and cardiorespiratory indicators were
в солна стая за един час в продължение на 15 – studied in 88 metallurgists diagnosed with toxic dust
20 дни (3). Подобни резултати представя и друго bronchitis. The conducted therapy consisted of sinu-
проучване, базирано на хемолуминисцентен тест, soidal modulated current and ultrasound in the inter-
при 49 пациента с хроничен обструктивен брон- costal region, and respiratory exercises combined with
хит. Халотерапията води до позитивни промени в massage and halotherapy.
оксидацията на свободните радикали, подобрява The patients were divided into three groups:
локалния имунитет и клиничната картина на забо- 1. halotherapy and ultrasound treatment;
ляването (2,4). 2. halotherapy and sinusoidal modulated current
Имунологични и кардиореспираторни показатели treatment, and
са изследвани при 88 металурзи с доказан токси- 3. halotherapy alone.
чен прахов бронхит. Проведена е терапия с със The study proves that combining halotherapy with
синусоидално модулирани токове и ултразвук the use of physiotherapy equipment increases the ef-
в междуребрената зона, дихателни упражнения, ficiency of salt therapy by 86.5%. The combination
комбинирани с масаж и халотерапия. of electric current procedures and halotherapy can be
Пациентите са разделени в три групи: used both for treatment and prevention of obstructive
1. лечение с халотерапия и ултразвук syndrome in toxic dust bronchitis (7).
2. лечение с халотерапия и синусоидално Sodium chloride is vital for the normal functioning of
модулирани токове the bronchial ciliated epithelium. The observed effects
3. само халотерапия. of the aerosol therapy are as follows: a relief in expec-
Проучването доказва, че комбинирането на ха- toration, decrease in sputum viscosity, cough improve-
лотерапия с методи на апаратната физиотерапия ment, and positive changes in the auscultatory find-
повишава ефекта от солната терапия с 86.5%. А ings. In addition, sodium chloride has a bactericidal
комбинацията от електропроцедури и халотера- and bacteriostatic effect on the respiratory microflora.
пия може да се използва, както за лечение, така The cytobacteriological examination of bronchial and
и за профилактика на обструктивния синдром при nasopharyngeal secretions from patients with asthma,
32
Halotherapy – An Alternative Method for the Treatment of Respiratory Diseases
токсичния прахов бронхит (7). chronic obstructive pulmonary disease (COPD), and
Натриевият хлорид е абсолютно необходим за cystic fibrosis shows that halotherapy leads to a de-
нормалното функциониране на бронхиалния рес- crease of neutrophils and pathogenic microorganisms,
ничест епител. В резултат на аерозолотерапията по and increases the alveolar macrophages. Halotherapy
време на процедурите се установява облекчение has mucolytic, antibacterial, anti-inflammatory, im-
на експекторацията, намаляване на вискозитета munomodulating and hyposensitive effect (3).
на храчките, облекчение на кашлицата и положи- Halotherapy can successfully be combined with other
телни промени в аускуталтаторната картина. Ос- physical therapy methods. Its efficiency is increased
вен това натриевият хлорид осигурява бактерици- when accompanied by postural drainage, vacuum
ден и бактериостатичен ефект върху дихателната massage on the projection of the lung apices, respira-
микрофлора. Цитобактериологично изследване на tory gymnastics, as well as laser therapy, ultrasound
бронхиални и назофарингеални секрети на паци- or a magnet, applied in the pulmonary area. The syn-
енти с астма, хронична обструктивна белодробна ergic action of halotherapy and physiotherapy is a step
болест (ХОББ) и муковисцидоза доказва, че хало- towards the holistic approach in the treatment of vari-
терапията води до намаляване на неутрофилните ous respiratory and cardiovascular diseases.
клетки и патогенните микроорганизми и увелича- The treatment is conducted in special salt rooms,
ва алвеоларните макрофаги. Халотерапията има equipped with a halogenerator, which disperses the
муколитично, антибактериално, противовъзпали- salt in the room. The halotherapy rooms have air with
телно, имуномодулиращо и хипосенсибилизира- low humidity and a temperature in the comfort zone –
що действие (3). 22-24°. When conducting the procedure, the patients
Халотерапията може успешно да се комбинира с are left in the salt room or cave for 45 minutes and
други методи на физикалната терапия. Ефектив- breathe the saturated with salt air, which is transported
ността ѝ се увеличава при комбинирането с по- to the smallest of the bronchi as well as to the sinuses
стурален дренаж, вакуумен масаж в проекцията and the nasal cavity. The low humidity in the room is
на белодробните върхове, дихателна гимнасти- of vital importance.
ка, както и лазертерапия, ултразвук или магнит, The number of sessions depends on the patient’s
приложени в белодробната област. Синергичното condition and the nature of the disease. For chronic
действие на халотерапията и физиотерапията са respiratory diseases, such as asthma, bronchitis, sinus-
крачка към холистичния подход в лечението на itis, and allergy, it is highly recommended to conduct
редица заболявания на дихателната и сърдечно- at least 12 to 20 sessions, 45 minutes each and for the
съдовата система. shortest period of time possible. The more frequently
Лечението се провежда в специални солни стаи, conducted they are, i. e. the shorter the time between
оборудвани с халогенератор, който диспергира two procedures, the faster the results are observed and
солта в помещението. Помещенията за халотера- the longer-lasting they are. It is recommended to con-
пия са с ниска влажност на въздуха и температура duct halotherapy 3 times per year in order to maintain
в зоната на комфорта – 22-24°. При провеждането and stabilize the positive results.
на самата процедура пациентите се настаняват в Halotherapy is indicated in most respiratory diseas-
солната стая или пещера и в продължение на 45 es, including:
минути и дишат наситения със сол въздух, който • respiratory tract infections;
се транспортира до най-малките бронхи, както и в • asthma;
синусите и носната кухина. От особена важност е • allergic and chronic bronchitis;
ниската влажност в помещението. • frequent colds;
Броят на сесиите зависи от състоянието на паци- • pharyngitis;
ента и естеството на неговото заболяване. За хро- • sinusitis;
нични дихателни заболявания, като астма, брон- • rhinitis;
хит, синузит, алергии е силно препоръчително да • tonsillitis;
се извършат поне 12 до 20 сесии, по 45 минути • pneumonia, after an acute stage;
всяка и то в колкото е възможно най-кратък пери- • chronic obstructive pulmonary disease (COPD).
од от време. Колкото по-често се провеждат, т.е. The main contraindications include hyperthyroid-
колкото по-малко е отстоянието между две про- ism, active tuberculosis, high-grade hypertension, car-
цедури, толкова по-бързо настъпват резултатите и diovascular and respiratory failure, acute-stage blood
толкова по-трайни са те. Препоръчително е хало- disorders, and malignant diseases. Caution should be
терапията да се повтаря до 3 пъти годишно, за да exercised when prescribing this therapy to patients
33
Evgeniya Vladeva
се поддържа и затвърди положителния резултат. with claustrophobia.

Халотерапията е показана при повечето заболява- During the treatment itself, certain side effects might
ния на дихателната система, включително: be observed, such as increased coughing and more
• инфекции на дихателните пътища; abundant secretion, which is actually considered
• астма; a positive effect because it leads to respiratory tract
• алергичен и хроничен бронхит; clearing and it is a signal for a change and adaptation
• чести настинки; of the organism to the specific irritant.
• фарингит; Skin irritations are rare side effects and are normally
• възпаления на синусите; resolved by the third or fifth session. Conjunctivitis as
• ринит; result of irritation of the mucoid membrane is rarely
• тонзилит; observed. It is not a reason to interrupt the sessions. In
• пневмония след остър стадий; such cases, it is recommended to keep the eyes closed
• ХОББ. when spending time in the salt room (1).
Основните противопоказания включват хи-
перфункция на щитовидната жлеза, активна ту- CONCLUSION
беркулоза, високостепенна хипертония, сърдеч- Halotherapy is an alternative treatment method in nu-
но-съдова и белодробна недостатъчност, кръвни merous respiratory diseases. It has insignificant side
заболявания в остър стадий, злокачествени забо- effects. It is conducted in a pleasant and cosy envi-
лявания. На пациенти с клаустрофобия е желател- ronment, which has a beneficial effect on the psycho-
но терапията да се изписва предпазливо. emotional state of the patients. The positive results
По време на самото лечение могат да се наблю- from the therapy last for more than a year. The possi-
дават странични ефекти като засилена кашлица bility to combine it with other physical therapy meth-
и усилено отделяне на секрети, което по-скоро се ods, as well as with pharmacological therapy, makes
смята за положителен ефект, тъй като осигурява it a treatment of choice in mild and moderate forms
прочистване на дихателните пътища и сигнал за of bronchial asthma, chronic obstructive bronchitis,
пренагласа и реакция на адаптация на организма post-pneumonia states and various other respiratory
към съответния дразнител. diseases.
Редки странични ефекти са са кожните раздразне-
ния, които нормално отзвучават след 3-ия до 5-ия
сеанс, Появата конюнктивит в резултат на раздра- Address for correspondence:
за на мукоидната мембрана на окото е рядък стра- Evgeniya Vladeva, MD
ничен ефект. Той не е причина за прекъсване на St. Marina University Hospital
сесиите. Препоръчва се в тези случаи престоят в 1 Hr. Smirnenski Blvd
phone.: 052 / 302-851 (ext. 378, 381)
солната стая да е със затворени очи (1).
e-mail: [email protected]
ЗАКЛЮЧЕНИЕ
REFERENCES
Халотерапията е алтернативен метод за лечение
1. A.V.Chervinskaya, S. (1999). HALOAEROSOL
на множество респираторни заболявания. Мето-
THERAPY IN THE REHABILITATION OF
дът е с незначителни странични ефекти. Провежда ASTHMA PATIENTS. Annual meeting, “Interast-
се в приятна и уютна обстановка, което въздейства ma”, Palanga, Lithuania, May 28-30.
благоприятно върху психоемоционалното състоя-
2. Abdrakhmanova LM, F. U. (2000). Effectiveness of
ние на пациентите. Положителния ефект от лече- halotherapy of chronic bronchitis patients. Vopr Ku-
нието се задържа повече от година. Възможността rortol Fizioter Lech Fiz Kult., (6):21-4.
да се комбинира с други средства на физикална- 3. Chervinskaya AV, Z. N. (1995). Halotherapy for
та терапия, както и с медикаментозно лечение, го treatment of respiratory diseases. J Aerosol Med,
прави добър метод на избор при леките и средно 8(3):221-32.
тежки форми на бронхиална астма, хроничен об- 4. Farkhutdinov UR, A. L. (2000). Effects of halother-
структивен бронхит, състояния след пневмония и apy on free radical oxidation in patients with chronic
редица други белодробни заболявания. bronchitis. Klin Med (Mosk). , 78(12):37-40.
5. https://www.salttherapyassociation.org/research-
education/. (n.d.).
6. Maev EZ., V. N. (1999). Halotherapy in the com-
34
Halotherapy – An Alternative Method for the Treatment of Respiratory Diseases
Адрес за кореспонденция: bined treatment of chronic bronchitis patients. Woen

д-р Евгения Петрова Владева, Med Zhurnal, 320(6):34-7, 96.
Катедра по морелечение, физиотерапия, рехабилитация и
7. Roslaia NA, L. E. (2001). Efficacy of therapeutic
професионални заболявания,
МУ„Проф. д-р Параскев Стоянов” Варна use of ultrasound and sinusoidal modulated currents
МБАЛ „Св. Марина” combed with halotherapy in patient with occupa-
бул. Хр. Смирненски 1 tional toxic-dust bronchitis. Vopr Kurortol Fizioter
тел.: 052 / 302-851 (вътр. 378, 381) Lech Fiz Kult., 1):26-7.
eл. адрес: [email protected]
35
REVIEWS
HALOTHERAPY – BENEFITS AND RISKS

Evgeniya Vladeva, Liliya Panajotova
Department оf Physiotherapy, Rehabilitation, Thalassotherapy аnd Occupational

Diseases, Faculty оf Public Health, Medical University оf Varna
ABSTRACT
Salt has been used for millennia in different parts of the world by different cultures because of its health
benefits and therapeutic effect. Halotherapy is a dry salt therapy that is provided in environments, with spe-
cial equipment called a halogenerator. In the last decades halotherapy has gained the trust of more and more
people around the world and has been spreading quickly in many countries. The positive results from the
therapy last for more than a year. The possibility to combine it with other physical therapy methods, as well
as with pharmacological therapy, makes halotherapy a treatment of choice in mild and moderate forms of
bronchial asthma, chronic obstructive bronchitis, post-pneumonia states and various other respiratory and
skin diseases. The insignificant side effects, together with the conduction of this treatment in a cosy envi-
ronment, have a beneficial effect on the psycho-emotional state of adult patients and children.
The aim of the article is to reveal the benefits of halotherapy as an alternative method for treating pulmo-
nary and skin diseases and some other conditions. Technology and application method are mentioned as
well as main therapeutic factors, the positive effects, contraindications for its application and some side re-
actions that may occur during treatment.
Keywords: halotherapy, salt therapy, application, indications, side effects
INTRODUCTION salt mines in Poland enjoyed excellent health despite

Salt has been used for millennia in different the harsh working conditions and the lack of suffi-
parts of the world by different cultures because of its cient food. In addition to this, they almost never suf-
health benefits and therapeutic effect, but this was fered from colds or any respiratory diseases, which
initially proved in 1843 by the Polish therapist Feliks were frequently observed among the rest of the pop-
Boczkowski. He noticed that people working in the ulation. This prompted the physician to conduct re-
search by which he established that all this was due
to the saturated with salt air that the miners breathed
Address for correspondence:
daily. Thus, salt mines in Poland and Eastern Europe
Evgeniya Petrova Vladeva, MD, PhD gradually became popular sanatoriums, attracting
Department of Physiotherapy, Rehabilitation, visitors from all over the world. A new method of
Thalassotherapy and Occupational Diseases treatment was established – Halotherapy (salt ther-
St. Marina Univesity Hospital of Varna
apy). Lately, in many places, predominantly in East-
1 Hr. Smirnenski Blvd
e-mail: [email protected] ern Europe, artificial salt rooms and caves have been
established, because of uncomfortable feelings when
visiting salt mines, their difficult accessibility and
Received: May 14, 2018
Accepted: June 5, 2018
too high expenses for their visitation.
Scripta Scientifica Salutis Publicae, vol. 4, 2018, pp. 22-26

22
Medical University of Varna
In the last decades halotherapy has gained the tive and passive salt therapy, and halotherapy and
trust of more and more people around the world and salt therapy.
has been spreading quickly to Western Europe, Can- Technology of halotherapy:
ada, Israel, North America, and many other coun- At the base of this technology is the Halocom-
tries. Lots of studies that prove its effectiveness and plex. The Halocomplex consists of a chamber with a
application with different diseases are published. halogenerator, and walls and floor covered with salt.
The aim of the article is to reveal the benefits In most of the cases the walls and floors are made
of halotherapy as an alternative method for treat- of sea salt, and do not provide the real treatment.
ing pulmonary and skin diseases and some other The special salt covering on the walls and floor acts
conditions. as a buffer for air. Dry sodium chloride is produced
Halotherapy and salt therapy – what is the in this room by a special nebulizer – halogenerator,
difference? which brings a flow of clean, dry air, saturated with
Salt therapy can be dry or wet. Halotherapy is highly dispersed negatively charged particles of sodi-
a dry salt therapy that is provided in environments, um chloride into the salt room. The halogenerator is
supplied with special equipment called a halogen- supplied with microprocessor that monitors the tem-
erator. The halogenerator disperses a precise dry perature, relative humidity and mass concentration
salt aerosol into the salt chamber. According to the of aerosol in the chamber (2).
Salt Therapy Association there are two types of salt Application method:
rooms – active and passive. Active salt room is sup- When conducting the procedure, the patients
plied with a special piece of equipment known as a are left in the salt room or cave for 45 minutes and
halogenerator where pure sodium chloride is placed breathe the saturated with salt air, which is trans-
and dispersed into microsized particles into the air of ported to the smallest of the bronchi as well as to the
the salt room. This kind of salt therapy is called halo- sinuses and the nasal cavity. The halotherapy rooms
therapy. Wet salt therapy includes gargling, drink- have air with low humidity and a temperature in the
ing salt water, bathing in salt water or nasal irriga- comfort zone – 22-24°. The low humidity in the room
tions (1). is of vital importance. There are no requirements for
On the other hand in many SPAs there are special clothing or other equipment. Benefits are bet-
rooms filled with large amounts of varying types of ter if patients are bare-legged. The number of ses-
salt such as Dead Sea, Himalayan, rock salt, Mediter- sions depends on the patient’s condition and the dis-
ranean, Caribbean, etc. There is no halogenerator in ease treated. Twelve to twenty sessions for 45 min-
these chambers and they are created to look like salt utes each and for a short period of time are recom-
caves but they do not provide the same salt air parti- mended for patients with chronical pulmonary dis-
cles present in natural salt caves. They are known as eases like asthma, bronchitis, sinusitis, COPD, aller-
passive salt rooms. The temperature, humidity and gic disease (3).
airflow are controlled but the concentration of sodi- The main therapeutic factor is sodium chloride
um chloride is smaller than in dry salt rooms and the with an aerosol particle size of 2 to 5 millimicrons. A
stay in these rooms is not considered to be halother- study by Chervinskaya, including 124 patients with
apy. Passive salt rooms provide an environment suit- different pulmonary diseases, showed a considerable
able for relaxation, meditation and improve the psy- improvement of the clinical status of the majority of
cho-emotional condition of a person (1). As a result the participants after a one-hour stay in a salt room
of many scientific searches it is proven that salt ther- daily for a period of 15-20 days (4). Similar results
apy is based on the inhalation of salt particles into were observed in another study based on a chemilu-
the upper and lower parts of the respiratory system minescent test in 49 patients with chronic obstruc-
and penetration through the skin of microsized par- tive bronchitis. Halotherapy leads to positive changes
ticles. This is possible to happen only by using halo- in the oxidation of free radicals, improves local im-
generators. That clarifies the difference between ac- munity and the clinical presentation of the disease
(5,6).

Medical University of Varna 23
Halotherapy – Benefits and Risks
The mechanisms of action of halotherapy are times more sterile than the cleanest operating
manifold: room);
mucolytic 2. salt has a natural ability to emit negative ions,
antibacterial neutralizing a positive charge;
anti-inflammatory 3. salt is superabsorbent when it is dry.
immunomodulating Indications for use:
hyposensitizing. Halotherapy is indicated in most respiratory
Halotherapy is a natural and safe treatment diseases, including:
without serious side effects. This method is very ben- respiratory tract infections
eficial for the overall wellness of a person by improv- asthma (8,9)
ing function and removing toxic substances from re- allergic and chronic bronchitis
spiratory system, improving the function and ap- frequent colds
pearance of the skin, boosting the immune system pharyngitis
and reducing stress.
sinusitis
There is evidence from several scientific re-
rhinitis
searches that inhaled dry salt particles have bacteri-
tonsillitis
cidal, moistening and anti-inflammatory properties,
pneumonia, after an acute stage
which may reduce inflammation in the entire respi-
ratory tract and widen the airway passages. Salt in- cystic fibrosis.
halation leads to a quicker improvement of the pa- It has been proven that this is a highly effective
rameters of respiratory failure, which can be ob- way of positively influencing numerous respiratory
served in the worsening of obstructive pulmonary diseases with a prompt resolution of symptoms, im-
diseases (6). Dry salt particles accelerate the trans- provement of pulmonary ventilation and tolerance of
portation of mucus, the elimination of residual toxic physical strain, as well as increase in the immunity
substances and foreign allergens. The application of and protective capacity of the organism (10).
salt therapy thus results in a clean respiratory system Immunological and cardiorespiratory indica-
with higher oxygen intake, increases energy and im- tors were studied in 88 metallurgists diagnosed with
proves the immune system. a toxic dust bronchitis. The conducted therapy con-
Scientific researches have confirmed that halo- sisted of sinusoidal modulated current and ultra-
therapy has an influence over superficial and deep- sound in the intercostal region, and respiratory exer-
er skin layers providing healing and cosmetic effects. cises combined with massage and halotherapy. The
This increases activity of the skin cell ion channels, patients were divided into three groups:
activates electrophysiological activity and improves 1. halotherapy and ultrasound treatment;
skin’s protective properties. Halotherapy leads to pH 2. halotherapy and sinusoidal modulated current
normalization and stimulates reparative and regen- treatment, and
erative processes in the epidermis and derma, in- 3. halotherapy alone.
creasing skin rigidity (7). Dry salt improves skin mi- The study proves that combining halotherapy
crocirculation and cellular membrane activity, en- with the use of physiotherapy equipment increases
hances skin regeneration and elasticity, and reduces the efficiency of salt therapy by 86.5%. The combi-
wrinkles and edema. nation of electric current procedures and halother-
The positive effects of halotherapy: apy can be used both for treatment and prevention
The efficiency of salt therapy is mainly due to of obstructive syndrome in toxic dust bronchitis (11).
three reasons: Because of the influence of halotherapy over su-
1. salt has an antibacterial, antimycotic and an- perficial and deeper skin layers which increases the
ti-inflammatory effect (it has been established activity of the skin cell ion channels, activates elec-
that the environment in salt rooms is three trophysiological activity and improves skin’s protec-

24
tive properties this treatment can provide healing Skin irritations are rare side effects and are nor-
and cosmetic effects. Halotherapy leads to pH normally resolved by the third or fifth session. Conjunc-
malization. It stimulates restorative and regenera- tivitis as result of irritation of the mucoid membrane
tive processes in the epidermis and derma, resulting is rarely observed. It is not a reason to interrupt the
in an increase in skin rigidity (7). Dry salt improves sessions. In such cases, it is recommended to keep the
skin microcirculation and cellular membrane activ- eyes closed when spending time in the salt room (14).
ity, enhances skin regeneration and elasticity, and re- Contraindications include hyperthyroidism,
duces wrinkles and edema. Halotherapy can be ap- active tuberculosis, high-grade hypertension, cardio-
plied in some skin diseases (12) such as: vascular and respiratory failure, acute-stage blood
Psoriasis disorders, contagious diseases, fever, open wounds
Eczema and malignant diseases. Caution should be exer-
Dermatitis cised when prescribing this therapy to patients with
Acne claustrophobia.
Rosacea
CONCLUSION
Onychomycosis
Halotherapy is an alternative treatment method
Skin aging
in numerous respiratory and skin diseases. It has in-
Halotherapy is conducted in a pleasant and cosy significant side effects. It is conducted in a pleasant
environment, which has a beneficial effect on the and cosy environment, which has a beneficial effect
psycho-emotional state of the patients. This treat- on the psycho-emotional state of the patients. This
ment can be used with some psychosomatic condi- treatment is easily workable with children. The posi-
tions including: tive results from the therapy last for more than a year.
stress and fatigue; The possibility to combine it with other physical ther-
headache, apy methods, as well as with pharmacological thera-
and also for increasing immune reactivity. py, makes halotherapy a treatment of choice in mild
Salt therapy is recommended as an additional and moderate forms of bronchial asthma, chronic
treatment for some pediatric diseases. It is safe, non- obstructive bronchitis, post-pneumonia states and
invasive, with no side effects and potential health various other respiratory and skin diseases.
risks. Clinical researches have proven that children REFERENCES
react quicker and more intensively. There is evidence
1. https://www.salttherapyassociation.org/
about the high effectiveness of halotherapy for pro- about-salt-therapy/types-of-salt-therapy/
phylaxis in frequently ill children and the possibili-
2. Chervinskaia A. The scientific validation and out-
ty of its use for the treatment of acute respiratory dis-
look for the practical use of halo-aerosol therapy.
eases with children affected with chronic ears, nose Vopr Kurortol Fizioter Lech Fiz Kult. 2000; (1):21-4.
and throat (ENT) disorders, respiratory and skin
3. Chervinskaya AV, Zilber NA. Halotherapy for
problems (13). This treatment is easily workable with
treatment of respiratory diseases. J Aerosol Med.
children. There are special salt rooms supplied with
1995; 8(3):221-32.
toys and occupational appliances which makes chil-
4. Abdrakhmanova LM, Farkhutdinov UR, Farkhut-
dren feel calm and comfortable.
dinov RR. Effectiveness of halotherapy of chronic
Side effects: bronchitis patients. Vopr Kurortol Fizioter Lech Fiz
During the treatment itself, certain side effects Kult. 2000; (6):21-4.
might be observed, such as increased coughing and 5. Farkhutdinov UR, Abdrakhmanova LM, Farkhut-
more abundant secretion, which is actually consid- dinov RR. Effects of halotherapy on free radical ox-
ered a positive effect because it leads to respiratory idation in patients with chronic bronchitis. Klin
tract clearing and it is a signal for a change and adap- Med (Mosk). 2000; 78(12):37-40.
tation of the organism to the specific irritant. 6. Opriţa B, Pandrea C, Dinu B, Aignătoaie B. Salt-
med – the therapy with sodium chloride dry aero-

Medical University of Varna 25
Halotherapy – Benefits and Risks
sols. Therapeutics, Pharmacology and Clinical

Toxicology. 2010; 14(3): 201-4.
7. Chervinskaya AV. Prospects of Halotherapy in
Sanatorium and SPA Dermatology and Cosmetolo-
gy. Kurortnye vedomosty. 2006; 3(36):74-5.
8. Chervinskaya AV, Konovalov SL. Haloaerosol
Therapy in the Rehabilitation of Asthma Patients.
Annual meeting, “Interasthma”, Palanga, Lithua-
nia. 1999; May 28-30.
9. Hedman J, Hugg T, Sandell J, Haahtela T. The ef-
fect of salt chamber treatment on bronchial hy-
perresponsiveness in asthmatics. Allergy. 2006;
1(5):605-10.
10. Maev EZ, Vinogradov NV. Halotherapy in the
combined treatment of chronic bronchitis patients.
Woen Med Zhurnal, 1999; 320(6):34-7, 96.
11. Roslaia NA, Likhacheva EI, Shchekoldin PI. Effi-
cacy of therapeutic use of ultrasound and sinusoi-
dal modulated currents combed with halotherapy
in patient with occupational toxic-dust bronchitis.
Vopr Kurortol Fizioter Lech Fiz Kult. 2001;(1):26-7.
12. Chereshnev VA, Barannikov VG, Kirichenko LV,
Varankina SA, Khokhryakova VP, Dement’ev
SV.The new directions in the physiotherapeutic
applications of the natural potassium salts of the
Western Ural. Vopr Kurortol Fizioter Lech Fiz Kult.
2016; 93(6):21-6.
13. Khan MA, Kotenko KV, Korchazhkina NB,
Chervinskaya AV, Mikitchenko NA, Lyan NA. The
promising directions for the further development
of halotherapy in pediatric medicine. Vopr Kuror-
tol Fizioter Lech Fiz Kult. 2006; 93(6):61-6.
14. http://chervinskaya.com/halotherapy_101/clinical-
efficacy-of-halotherapy.html

26
1

Dry sodium chloride aerosol against acute respiratory infections

Alina Chervinskaya
St.Petersburg, Russian Federation

This poster was presented at the European Respiratory Society (ERS) Annual Congress on
14.09.2009 in Session 206: "Treatment modalities in chest physiotherapy".
Chairs : D. Inal Ince (Ankara, Turkey), K. Wadell (Umea, Sweden)

Brief description
In order to study the preventing efficacy of inhaled dry sodium chloride aerosol against acute
respiratory viral infection randomized placebo investigation was provided. Dry salt inhalations
ZLWK +DORQHE LQKDOHU ZHUH SURYLGHG DV D SUHYHQWLYH PHWKRG DW WKH LQGXVWULDO SODQW 7KH
working persons were undertaken by the inhalations twice a week during three month. They
had number of cases and days of acute respiratory viral infection and exacerbation of
respiratory diseases significantly less in compare with control placebo group. Morbidity with
temporary disability was decreased considerably in compare with the ones at the same period
of the previous year. Preventive action of dry salt aerosol against respiratory viral infection was
proved. Inhalations of dry sodium chloride aerosol, consisting of two weekly procedures are
effective preventing method against acute respiratory viral infections.
Finding can be in use for the medical practice application of the dry salt inhalations and the
halotherapy.

Introduction
Dry sodium chloride aerosol (DSCA) is the main acting factor of the speleotherapy (salt
cave therapy) and halotherapy (therapy in a controlled air medium which saturated with
dry salt aerosol). The researches have been directed at examining the action of dry
sodium chloride aerosol on respiratory tract of the patients with COPD, asthma and at
risk factors of COPD.
DSCA is characterized with physical properties, differing from those of the saline
aerosols. DSCA demonstrated anti-inflammatory activity in the respiratory tract,
mucoregulating action. It enhances drainage of the bronchi, activates alveolar
macrophages, improves biocenosis and local humoral immunity.

Eur Respir J 2009; 34: Suppl. 53, 401s.

2
The aim of the study

The main objective was to estimate the preventing efficacy of inhaled dry sodium
chloride aerosol (DSCA) against acute respiratory viral infection (ARVI).

Study design
Type: Randomized single-blind placebo study.
Participants: 160 persons were recruited from personnel of an industrial enterprise.
They were randomized in 2 groups - WHVWJURXS7PDOHIHPDOH\UV
DQGFRQWUROJURXS&PDOHIHPDOH\UV
The groups were comparable as regards age, sex, smoking addiction, exposure to the
adverse industrial factors (table 1) and clinical health condition (table2).

Methods:
6SHFLDOTXHVWLRQQDLUHVIRUWKHVWXG\UHFUXLWLQJ
3K\VLFLDQH[DPLQDWLRQ
6SHFLDO TXHVWLRQQDLUHV IRU UHJistration of the symptoms acute respiratory viral
infections
$QDO\VLV RI RIILFLDO VWDWLVWLFDO GDWD RI WKH WHPSRUDU\ GLVDELOLW\ SDUWLFLSDQWV GXULQJ WKH
study period from January 25 till April 25, years of 2000 and 2001.

Table 1. Exposure to industrial pollutants


3
Table 2. Clinical characteristics of the participants of the study

Intervention

T-group was undertaken with 10 min inhalations using a table-mounted Haloneb Salt
Inhaler (Aeromed Ltd., Russia) (pic. 1), producing DSCA with particles size mainly of 1-
P SLF and 0.8-1.2 mg/min density flow. Rock salt from Artyomovsk
(Ukraine) salt mine was used. The participants inhaled quietly the dry salt aerosol,
using a mouthpiece, in the sitting position.
The C-group received 10 min inhalations with plain air.
Each subject was given 2 dry salt inhalations a week during 12 weeks. A
physician regularly examined the subjects of the both groups for possible ARVI.

Haloneb Dry Salt Inhaler


4

Fractional composition of dry sodium chloride aerosol, producing by Haloneb

Outcome

For three months observation there were only 14 cases of ARVI and 104 days marked by symptoms
of ARVI in the T-group. In the C-group there were 55 cases of ARVI and 585 days of symptoms. T-
group participants were affected by ARVI four times less frequently than C-group participants, and
the number of days marked by symptoms of ARVI was 5.6 times less (pic. 3).
Analysis of incidences of ARVI showed that they occurred in 60% of participants with risk factors of
COPD in C-group subjects against only 18% of subjects with risk factors in the TG (p<0.01). On the
whole, 13 subjects (16%) developed ARVI in the T-group against 50 subjects (63%) in the CG
(p<0.001).


5
Pic.3. Influence of dry sodium chloride aerosol on the incidence of acute
respiratory viral infections during 3 months term

Respiratory morbidity with temporary disability in the T-group during 3 months in 2001
was considerably less in compare with the same period in 2000. The number of
disability cases and disability days were significantly less in the T-group in compare with
the C -group in the 2001.
The analysis of the efficiency index (ratio of the respiratory disease cases and
respiratory disease days in 2000 to those in 2001) showed that this index decreased
considerably in the T-group (6.3 and 5.7 times, respectively) compared with the C-
group (1.3 and 1.4 times, respectively) (pic. 4).


6
Pic.4. Respiratory morbidity with temporary disability (per 100 persons) in the
groups during 3 months of 2000 and 2001 year

Conclusion

Inhalations of dry sodium chloride aerosol, consisting of two weekly procedures are effective
preventing method against acute respiratory viral infections.
Finding can be in use for the medical practice application of the dry salt inhalations and the
halotherapy.
This approach may be recommended to healthy persons and patients with chronic respiratory
diseases prior to or during cold season.

Key words
Dry sodium chloride aerosol, salt inhalations, halotherapy, respiratory viral infection, prevention

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What is dry salt therapy?

What is dry salt therapy?

What conditions may benefit from dry salt therapy?

What conditions may benefit from dry salt therapy?

Dry Salt Therapy

Clinical Studies and Medical Research

The Evolution of Halotherapy (Dry Salt Therapy) 5

Halotherapy in the United States 6

Dry Salt Therapy and the Skin 7

Who Benefits from Dry Salt Therapy 8

How Dry Salt Therapy is Offered 9

Salt Type and Quality 10

Dry Salt Therapy Treatment Protocols 11

Clinical Research and Medical Evidence 12

Salt Therapy Association  www.SaltTherapyAssociation.org  844-STA-INFO

Table of Contents Page

Clinical Studies: Click on the page name to go there directly

Halotherapy in Patients with Cystic Fibrosis: A Pilot Study. 14-16

The use of halotherapy for the health improvement in children at institutions of

The use of halotherapy for the rehabilitation of patients with acute

Halotherapy in the combined treatment of chronic bronchitis patients. 70

The use of an artificial microclimate chamber in the treatment of

Effectiveness of halotherapy of chronic bronchitis patients. 72

Effects of halotherapy on free radical oxidation in patients with chronic bronchitis. 73

Salt caves as simulation of natural environment and significance of halotherapy. 75

Salt Therapy Association  www.SaltTherapyAssociation.org  844-STA-INFO

Table of Contents Page

Clinical Studies: Click on the page name to go there directly

The role of non-medicamental technologies in the rehabilitation of the children

Theoretical basis and clinical benefits of dry salt inhalation therapy. 79

Bronchial hyperreactivity to the inhalation of hypo- and hyperosmolar aerosols

The Effect of Salt Chamber Treatment on Bronchial Hyperresponsiveness in

Salt Halo Therapy and Saline Inhalation Administered to Patients

Impact assessment of saline aerosols on exercise capacity of athletes. 92-96

Surveys on therapeutic effects of "halotherapy chamber with artificial

SALTMED: The Therapy with Sodium Chloride Dry Aerosols. 102-105

A Review of Halotherapy for Chronic Obstructive Pulmonary Disease. 106-113

Double-Blind Placebo-Controlled Randomized Clinical Trial on Efficacy of

Halotherapy and Buteyko Breathing Technique - a possible successful

Halotherapy - An Alternative Method for the Treatment of Respiratory

Halotherapy - Benefits and Risks 128-132

Salt Therapy Association  www.SaltTherapyAssociation.org  844-STA-INFO

The Evolution of Halotherapy (Dry Salt Therapy)

Salt Therapy Association  www.SaltTherapyAssociation.org  844-STA-INFO

Halotherapy in the United States

Salt Therapy Association  www.SaltTherapyAssociation.org  844-STA-INFO

How Dry Salt Therapy Works

Dry Salt Therapy and the Skin

Who Benefits from Dry Salt Therapy?

Dry salt therapy is also extremely beneficial to your skin in treating:

• Acne • Dermatitis • Swelling & Inflammation

In addition, dry salt therapy has been shown to reduce:

Salt Therapy Association  www.SaltTherapyAssociation.org  844-STA-INFO

How Dry Salt Therapy is Being Offered

1. The concentration of salt in the air

Salt Therapy Association  www.SaltTherapyAssociation.org  844-STA-INFO

Salt Type and Quality

*Dry Salt Therapy Treatment Protocols

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Clinical Research and Medical Evidence

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