7 Calculation of Concentration of Solution1

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RED RIVER COLLEGE

NURSING SKILLS LABORATORY

DOSAGE CALCULATIONS:
ADDITIONAL PRACTICE QUESTIONS

CALCULATION OF CONCENTRATION OF A SOLUTION

Using “ratio and proportion” can help to simplify calculation of the concentration of a solution:

Amount of drug (e.g. mg, units) = X_


Volume of solution (mL) 1 mL

When answering the following questions, be sure to:


• round off to 2 decimal points for mL and mg (where appropriate)
• state the unit of measurement in each answer

1. The physician’s order reads:


Aminophylline 60 mg/ h IV
The drug is supplied in a syringe containing 500 mg of Aminophylline in 50 mL of
solution.

a. What is the concentration (mg/ per mL) of Aminophylline in the syringe?

b. At what rate (mL/ h) would you deliver the medication?

c. At what rate (mL/ h) would you deliver the medication if the physician’s order
was for 100 mg/ h?
2. The physician’s order reads:
Heparin at 750 units/ h IV
The drug is supplied in a syringe containing 10,000 units of Heparin in 40 mL of
solution.

a. What is the concentration (units/ per mL) of Drug in the syringe?

b. At what rate (mL/ h) would you deliver the medication?

c. At what rate (mL/ h) would you deliver the medication if the physician’s order
was for 1400 units/ h?

3. The physician’s order reads:


Regular Insulin at 2 units/ h IV
The drug is supplied in a bag containing 22 units of Regular Insulin 100 mL of solution.

a. What is the concentration (units/ per mL) of insulin in the bag?

b. At what rate (mL/ h) would you deliver the medication?

c. At what rate (mL/ h) would you deliver the medication if the physician’s order
was for 5 units/ h?

4. The physician’s order reads:


Dopamine at 75 mg/ h IV
The drug is supplied in a syringe containing 500 mg of Dopamine in 50 mL of solution.

a. What is the concentration (mg/ per mL) of Dopamine in the syringe?

b. At what rate (mL/ h) would you deliver the medication?

c. At what rate (mL/ h) would you deliver the medication if the physician’s order
was for 60 mg/ h?
5. The physician’s order reads:
Morphine at 0.3 mg/ h IV
The drug is supplied in a syringe containing 20 mg of Morphine in 50 mL of solution.

a. What is the concentration (mg/ per mL) of Morphine in the syringe?

b. At what rate (mL/ h) would you deliver the medication?

c. At what rate (mL/ h) would you deliver the medication if the physician’s order
was for 0.5 mg/ h?

6. The physician’s order reads:


Flagyl 500 mg IV over one hour
Flagyl is supplied in a bag containing 500 mg of Flagyl in 100 mL of solution.

a. What is the concentration (mg/ per mL) of Flagyl in the bag?

b. At what rate (mL/ h) would you deliver the medication?

7. The physician’s order reads:


Crystapen 750,000 units IV over 3 hours
Crystapen is supplied in a bag containing 750,000 units of Crystapen in 250 mL of
solution.

a. What is the concentration (units/ per mL) of Crystapen in the bag?

b. At what rate (mL/ h) would you deliver the medication?


CALCULATION OF CONCENTRATION OF A SOLUTION ANSWER KEY

1a. 500 mg = X__ X = 10 mg/ mL


50 mL 1 mL

1b. 60 mg X 1 mL = 6 mL/ h
10 mg

1c. 100 mg X 1 mL = 10 mL/ h


10 mg

2a. 10,000 units = X__ X = 250 units/ mL


40 mL 1 mL

2b. 750 units X 1 mL = 3 mL/ h


250 units

2c. 1400 units X 1 mL = 5.6 mL/ h


250 units

3a. 22 units = X_ X = 0.22 units/ mL


100 mL 1 mL

3b. 2 units X 1 mL = 9.09 mL/ h


0.22 units

3c. 5 units X 1 mL = 22.7 mL/ h


0.22 units

4a. 500 mg = X_ X = 10 mg/ mL


50 mL 1 mL

4b. 75 mg X 1 mL = 7.5 mL/ h


10 mg

4c. 60 mg X 1 mL = 6 mL/ h
10 mg

5a. 20 mg = X_ X = 0.4 mg/ mL


50 mL 1 mL

5b. 0.3 mg X 1 mL = 0.75 mL/ h


0.4 mg

5c. 0.5 mg X 1 mL = 1.25 mL/ h


0.4 mg
6a. 500 mg = X_ X = 5 mg/ mL
100 mL 1 mL

6b. 500 mg X 1 mL = 100 mL/ h


5 mg

7a. 750,000 units = X_ X = 3000 units/ mL


250 mL 1 mL

7b. Calculate the # of units to be


given per hour:

750,000 units = X_
3h 1h

X = 250,000 units

Then calculate the rate:

250,000 units X 1 mL =
3000 units 83.3 mL/ h

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