Rabeprazole, sold under the brand name Pariet among others, is a medication that

decreases stomach acid.[5] It is used to treat peptic ulcer disease, gastroesophageal reflux disease,
and excess stomach acid production such as in Zollinger–Ellison syndrome.[5] It may also be used in
combination with other medications to treat Helicobacter pylori.[6] Effectiveness is similar to
other proton pump inhibitors (PPIs).[7] It is taken by mouth.[5]
Common side effects include constipation, feeling weak, and throat inflammation.[5] Serious side
effects may include osteoporosis, low blood magnesium, Clostridium difficile infection,
and pneumonia.[5] Use in pregnancy and breastfeeding is of unclear safety.[8] It works by
blocking H+/K+-ATPase in the parietal cells of the stomach.[5]
Rabeprazole was patented in 1986 and approved for medical use in 1997.[9] It is available as
a generic medication.[6] A month supply in the United Kingdom costs the NHS about £1 as of
2019.[6] In the United States the wholesale cost of this amount is about 11 USD.[10] In 2016 it was the
285th most prescribed medication in the United States with more than a million prescriptions.[11]

Contents

 1Medical uses
o 1.1Available forms
o 1.2Specific populations
 2Contraindications
o 2.1Hypersensitivity
o 2.2Rilpivirine
 3Adverse effects
 4Overdose
 5Interactions
o 5.1Drug-drug interactions
o 5.2Food-drug interactions
 6Pharmacology
o 6.1Mechanism of action
o 6.2Pharmacokinetics
o 6.3Pharmacogenetics
 7Chemistry
o 7.1Synthesis
o 7.2Physiochemical properties
 8History
o 8.1Development
 9Society and culture
o 9.1Legal status
o 9.2Brand names
 10Research
 11References
 12External links

Medical uses[edit]
Brand-name rabeprazole.

Bottle of rabeprazole 20 mg tablets.

Rabeprazole, like other proton pump inhibitors such as omeprazole, is used for the purposes of
gastric acid suppression.[12] This effect is beneficial for the treatment and prevention of conditions in
which gastric acid directly worsens symptoms, such as duodenal and gastric ulcers.[12] In the setting
of gastroesophageal reflux disease (GERD), whose pathophysiology is characterized by prolonged
exposure to gastric acid in the esophagus (often due to changes in stomach and/or esophagus
anatomy, such as those induced by abdominal obesity),[13] acid suppression can provide
symptomatic relief.[12] Acid suppression is also useful when gastric production of acid is increased,
including conditions with excess gastric acid secretion (hypersecretory conditions) like Zollinger-
Ellison syndrome, multiple endocrine adenomas, and systemic mastocytosis.[12]
Rabeprazole is also useful alongside antibiotic therapy for the treatment of the
pathogen Helicobacter pylori, which otherwise thrives in acidic environments.[12] Notably, H.
pylori eradication with antibiotics and rabeprazole was also shown to prevent development of
second gastric cancer in a randomized trial in high-risk South Korean patients with early stomach
cancer treated by endoscopy.[14]
 Thus, rabeprazole is FDA approved for the treatment of symptomatic GERD in adolescents and
adults, healing duodenal ulcers in adults, eradication of Helicobacter pylori, and pathologic
hypersecretory conditions.[15]

Contents

 1Medical uses
o 1.1Available forms
o 1.2Specific populations
 2Contraindications
o 2.1Hypersensitivity
o 2.2Rilpivirine
 3Adverse effects
 4Overdose
 5Interactions
o 5.1Drug-drug interactions
o 5.2Food-drug interactions
 6Pharmacology
o 6.1Mechanism of action
o 6.2Pharmacokinetics
o 6.3Pharmacogenetics
 7Chemistry
o 7.1Synthesis
o 7.2Physiochemical properties
 8History
o 8.1Development
 9Society and culture
o 9.1Legal status
o 9.2Brand names
 10Research
 11References
 12External links

Medical uses[edit]

Brand-name rabeprazole.
Bottle of rabeprazole 20 mg tablets.

Rabeprazole, like other proton pump inhibitors such as omeprazole, is used for the purposes of
gastric acid suppression.[12] This effect is beneficial for the treatment and prevention of conditions in
which gastric acid directly worsens symptoms, such as duodenal and gastric ulcers.[12] In the setting
of gastroesophageal reflux disease (GERD), whose pathophysiology is characterized by prolonged
exposure to gastric acid in the esophagus (often due to changes in stomach and/or esophagus
anatomy, such as those induced by abdominal obesity),[13] acid suppression can provide
symptomatic relief.[12] Acid suppression is also useful when gastric production of acid is increased,
including conditions with excess gastric acid secretion (hypersecretory conditions) like Zollinger-
Ellison syndrome, multiple endocrine adenomas, and systemic mastocytosis.[12]
Rabeprazole is also useful alongside antibiotic therapy for the treatment of the
pathogen Helicobacter pylori, which otherwise thrives in acidic environments.[12] Notably, H.
pylori eradication with antibiotics and rabeprazole was also shown to prevent development of
second gastric cancer in a randomized trial in high-risk South Korean patients with early stomach
cancer treated by endoscopy.[14]
Thus, rabeprazole is FDA approved for the treatment of symptomatic GERD in adolescents and
adults, healing duodenal ulcers in adults, eradication of Helicobacter pylori, and pathologic
hypersecretory conditions.[15]