Scribd Logo
Upload

Welcome to Scribd!

  • 179 views

    Water CoA 1880510010 - HC72729851 - SU - EN PDF

    Uploaded by

    piagiopersempre
    This document describes a certified reference material for coulometric Karl Fischer titration. The material is a 1-methoxy-2-propanol solution with a certified water content value of 0.0997% ± 0.0020%. The value is directly traceable to SI units and was determined using coulometric Karl Fischer titration according to ISO standards. The reference material is intended to check the accuracy of Karl Fischer equipment and measurements.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Water CoA 1880510010 - HC72729851 - SU - EN PDF

    Uploaded by

    piagiopersempre
    179 views2 pages
    This document describes a certified reference material for coulometric Karl Fischer titration. The material is a 1-methoxy-2-propanol solution with a certified water content value of 0.0997% ± 0.0020%. The value is directly traceable to SI units and was determined using coulometric Karl Fischer titration according to ISO standards. The reference material is intended to check the accuracy of Karl Fischer equipment and measurements.

    Original Title

    Water CoA 1880510010_HC72729851_SU_EN.pdf

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    This document describes a certified reference material for coulometric Karl Fischer titration. The material is a 1-methoxy-2-propanol solution with a certified water content value of 0.0997% ± 0.0020%. The value is directly traceable to SI units and was determined using coulometric Karl Fischer titration according to ISO standards. The reference material is intended to check the accuracy of Karl Fischer equipment and measurements.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    179 views2 pages

    Water CoA 1880510010 - HC72729851 - SU - EN PDF

    Uploaded by

    piagiopersempre
    This document describes a certified reference material for coulometric Karl Fischer titration. The material is a 1-methoxy-2-propanol solution with a certified water content value of 0.0997% ± 0.0020%. The value is directly traceable to SI units and was determined using coulometric Karl Fischer titration according to ISO standards. The reference material is intended to check the accuracy of Karl Fischer equipment and measurements.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    AquastarTM Certified Reference Material

    Producer: Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.

    Accreditation: Merck KGaA, Darmstadt, Germany is accredited as calibration


    laboratory according to DIN EN ISO/IEC 17025.

    Description of CRM: Water Standard 0.1%


    certified reference material for coulometric Karl Fischer Titration

    Ord. No.: 1.88051.0010

    Lot No.: HC72729851

    Composition: 1-Methoxy-2-propanol

    Certified value and uncertainty: 0.0997 % ± 0.0020 %


    (0.997mg/g ± 0.020 mg/g)
    water content with expanded uncertainty UCRM

    Traceability: The certified value of this reference material is directly traceable to SI-
    Unit (kg) and verified by NIST SRM 2890.
    NIST: National Institute of Standards and Technology, Gaithersburg, USA.

    Method of Analysis: The water content is determined by coulometric Karl Fischer Titration
    on 10 ampoules according to ISO 760.

    Storage: +15°C to +25°C tightly closed in the original container

    Application and correct use: This certified reference material is intended for use as a standard for
    checking the accuracy of Karl Fischer equipment according to ISO
    9001 chapter 7.1.5 “Monitoring and measuring resources” of
    coulometric Karl Fischer Titrators.
    It can also be used to check measuring results according to European
    Pharmacopeia (Ph.Eur.) chapter 2.5.32 “Water Micro Determination”.

    For the daily verification we recommend to accept a deviation


    of ± 0.0030 % (± 0.030 mg/g) from the certified value.

    Date of release: 2017/04/27

    Minimum shelf life: 2022/04/30

    Dipl.-Ing. Ayfer Yildirim


    (Laboratory manager)

    Merck KGaA – Frankfurter Straße 250, 64293 Darmstadt, Germany: +49 6151 72-0
    EMD Millipore Corp. – 290 Concord Road, Billerica, MA 01821, USA: (781) 533-6000
    Expanded uncertainty UCRM: The expanded uncertainty UCRM is calculated as UCRM=k·uCRM, where
    k=2 is the coverage factor for a 95 % coverage probability and uCRM is
    the combined standard uncertainty in accordance to ISO Guide 34.

    uCRM  u 2 Characterisation  u 2 Homogeneity  u 2 Stability


    The combined standard uncertainty uCRM is obtained from the standard
    uncertainties of the characterisation, the homogeneity and the
    stability.

    uCharacterisation is the uncertainty in accordance with DIN EN ISO/IEC


    17025 which includes the contributions of the primary
    reference material and the measuring system.
    ucharacterisation in the certified value is calculated
    in accordance to EA-4/02 and GUM.
    UCharacterisation is 0.0007 % (0.007 mg/g) (calculated as
    UCharacterisation = k·uCharacterisation with k=2)

    uHomogeneity is the between-bottle variation in accordance with


    ISO Guide 34. The assessment of homogeneity is
    performed by analysis of a representative
    number of systematically chosen sample units.

    uStability is the uncertainty obtained from short-term and long-


    term stability in accordance with ISO Guide 34. The
    stability studies are the basis for the quantification of
    the minimum shelf life of this water standard for the
    unopened ampoule.

    Instructions for correct use 1. Open ampoule at the marked point of break.
    2. Rinse a plastic syringe 1-2 times with about 1 ml of standard
    solution.
    3. Draw up the entire ampoule content into the rinsed syringe.
    4. Weigh the filled syringe before injection.
    5. Inject about 1-2 ml of standard solution into the titration cell and
    start the titration.
    6. Determine the exact standard solution weight by reweighing the
    syringe after injection.
    7. Repeat the determination. The content of one ampoule is
    sufficient for 3 determinations. Open the ampoule only directly
    prior to starting of measurement. Solvent in the opened ampoule
    can absorb moisture and distort results.

    Merck KGaA – Frankfurter Straße 250, 64293 Darmstadt, Germany: +49 6151 72-0
    EMD Millipore Corp. – 290 Concord Road, Billerica, MA 01821, USA: (781) 533-6000

    You might also like