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    Ergotamine

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    Anonymous xv9UDvKL
    Ergotamine is used to treat migraines. It can be administered sublingually or via inhalation. The recommended dosage for adults is 2 mg sublingually at onset of migraine, then 2 mg every 30 minutes as needed, up to a maximum of 6 mg per 24 hours and 10 mg per week. For inhalation, the recommended dosage is one 360 mcg dose at onset and repeating every 5 minutes as needed, up to a maximum of 6 doses per 24 hours and 15 doses per week. Ergotamine has vasoconstrictor effects and acts as a partial agonist at serotonin receptors to constrict blood vessels and relieve migraines. It is contraindicated in patients with hypertension,

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    Ergotamine

    Uploaded by

    Anonymous xv9UDvKL
    108 views2 pages
    Ergotamine is used to treat migraines. It can be administered sublingually or via inhalation. The recommended dosage for adults is 2 mg sublingually at onset of migraine, then 2 mg every 30 minutes as needed, up to a maximum of 6 mg per 24 hours and 10 mg per week. For inhalation, the recommended dosage is one 360 mcg dose at onset and repeating every 5 minutes as needed, up to a maximum of 6 doses per 24 hours and 15 doses per week. Ergotamine has vasoconstrictor effects and acts as a partial agonist at serotonin receptors to constrict blood vessels and relieve migraines. It is contraindicated in patients with hypertension,

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    Ergotamine is used to treat migraines. It can be administered sublingually or via inhalation. The recommended dosage for adults is 2 mg sublingually at onset of migraine, then 2 mg every 30 minutes as needed, up to a maximum of 6 mg per 24 hours and 10 mg per week. For inhalation, the recommended dosage is one 360 mcg dose at onset and repeating every 5 minutes as needed, up to a maximum of 6 doses per 24 hours and 15 doses per week. Ergotamine has vasoconstrictor effects and acts as a partial agonist at serotonin receptors to constrict blood vessels and relieve migraines. It is contraindicated in patients with hypertension,

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    108 views2 pages

    Ergotamine

    Uploaded by

    Anonymous xv9UDvKL
    Ergotamine is used to treat migraines. It can be administered sublingually or via inhalation. The recommended dosage for adults is 2 mg sublingually at onset of migraine, then 2 mg every 30 minutes as needed, up to a maximum of 6 mg per 24 hours and 10 mg per week. For inhalation, the recommended dosage is one 360 mcg dose at onset and repeating every 5 minutes as needed, up to a maximum of 6 doses per 24 hours and 15 doses per week. Ergotamine has vasoconstrictor effects and acts as a partial agonist at serotonin receptors to constrict blood vessels and relieve migraines. It is contraindicated in patients with hypertension,

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    of 2

    MIMS

    Ergotamine
    Indications Migraine.
    Dosage Adult : Sublingual As ergotamine tartrate: 2 mg on the onset of attack, then
    2 mg every 30 min if necessary. Max: 6 mg/24 hr, 10 mg/wk. Inhalation As
    ergotamine tartrate: Inhale single dose (360 mcg) at the onset of attack and
    repeat at 5-min intervals, if necessary. Max: 6 inhalations/24 hr, 15
    inhalations/wk.
    Dosage Details Inhalation/Respiratory
    Migraine
    Adult: As ergotamine tartrate: Inhale single dose (360 mcg) at the onset of
    attack and repeat at 5-min intervals, if necessary. Max: 6 inhalations/24 hr,
    15 inhalations/wk.

    Sublingual
    Migraine
    Adult: As ergotamine tartrate: 2 mg on the onset of attack, then 2 mg every
    30 min if necessary. Max: 6 mg/24 hr, 10 mg/wk.
    Renal
    Contraindicated.
    Impairment
    Hepatic
    Contraindicated.
    Impairment
    Administration May be taken with or without food.
    Contraindications Patient w/ severe or uncontrolled HTN, severe or persistent sepsis, shock,
    peripheral vascular disease, temporal arteritis, ischaemic heart disease,
    hyperthyroidism; basilar or hemiplegic migraine. Renal or hepatic
    impairment. Pregnancy. Concomitant admin w/ potent CYP3A4 inhibitors
    (e.g. azole antifungals, protease inhibitors, macrolide antibiotics).
    Special
    Patient w/ anaemia. Lactation.
    Precautions
    Adverse Drug Nausea and vomiting, abdominal pain, tingling of fingers and toes,
    Reactions weakness, muscle pains in the extremities and numbness, localised oedema,
    itching, bradycardia, transient tachycardia.
    Pregnancy
    Category (US PO/Rectal/SL: X
    FDA)
    Patient May cause dizziness and feelings of anxiety, if affected, do not drive or
    Counselling operate machinery.
    Monitoring
    Evaluate CV status prior to initiation and periodically thereafter.
    Parameters
    Overdosage Symptoms: Numbness, vomiting, tingling, pain, cyanosis of the extremities
    associated w/ diminished or absent peripheral pulses; HTN or hypotension;
    stupor, drowsiness, convulsions, shock, coma; reversible bilateral papillitis
    w/ ring scotomata. Management: Maintain adequate pulmonary ventilation,
    correction of hypotension and control or BP and convulsions. Keep the
    extremities warm to treat peripheral vasospasm. Vasodilators may be
    beneficial.
    Drug Interactions Increased risk of peripheral vasoconstriction w/ β-blockers. Increased
    vasoconstrictor effect w/ sympathomimetics (e.g. epinephrine).
    Potentially Fatal: Increased risk of ergotism w/ potent CYP3A4 inhibitors
    (e.g. azole antifungals, protease inhibitors, macrolide antibiotics).
    Food Interaction May enhance toxicity w/ grapefruit juice.
    Mechanism of Description: Ergotamine has marked vasoconstrictor effects and partial
    Action agonistic action at serotonin (5-HT) receptors. It causes constriction of
    peripheral and cranial blood vessels and produces central vasomotor center
    depression. It also has a powerful oxytocic action on the uterus.
    Pharmacokinetics:
    Absorption: Poorly absorbed from the GI tract. Bioavailability: Approx
    ≤5%. Time to peak plasma concentration: 2 hr (oral).
    Distribution: Crosses the blood-brain barrier; enters breast milk. Volume
    of distribution: 1.85 L/kg. Plasma protein binding: Approx 93-98%.
    Metabolism: Undergoes extensive hepatic metabolism, including high
    first-pass effect.
    Excretion: Via faeces (90%, mainly as metabolites); urine (approx 4%).
    Biphasic elimination half-life: Approx 2 hr (initial phase); 21 hr (terminal
    phase).
    Storage Store between 20-25°C. Protect form heat and light.
    MIMS Class Antimigraine Preparations
    ATC N02CA02 - ergotamine ; Belongs to the class of ergot alkaloids
    Classification preparations. Used to relieve migraine.

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