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    4.5 Biopharmaceutics and Pharmacokinetics (Theory)

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    Kushani Desai
    This document outlines the theory and practical components of a course on biopharmaceutics and pharmacokinetics. The theory section covers topics like drug absorption, distribution, elimination, pharmacokinetic models, compartment models, and bioavailability. The practical section describes experiments involving dissolution characteristics, bioavailability studies, protein binding, and pharmacokinetic calculations to determine values like AUC and elimination half-life. References for further reading are also provided.

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    4.5 Biopharmaceutics and Pharmacokinetics (Theory)

    Uploaded by

    Kushani Desai
    134 views2 pages
    This document outlines the theory and practical components of a course on biopharmaceutics and pharmacokinetics. The theory section covers topics like drug absorption, distribution, elimination, pharmacokinetic models, compartment models, and bioavailability. The practical section describes experiments involving dissolution characteristics, bioavailability studies, protein binding, and pharmacokinetic calculations to determine values like AUC and elimination half-life. References for further reading are also provided.

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    This document outlines the theory and practical components of a course on biopharmaceutics and pharmacokinetics. The theory section covers topics like drug absorption, distribution, elimination, pharmacokinetic models, compartment models, and bioavailability. The practical section describes experiments involving dissolution characteristics, bioavailability studies, protein binding, and pharmacokinetic calculations to determine values like AUC and elimination half-life. References for further reading are also provided.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    134 views2 pages

    4.5 Biopharmaceutics and Pharmacokinetics (Theory)

    Uploaded by

    Kushani Desai
    This document outlines the theory and practical components of a course on biopharmaceutics and pharmacokinetics. The theory section covers topics like drug absorption, distribution, elimination, pharmacokinetic models, compartment models, and bioavailability. The practical section describes experiments involving dissolution characteristics, bioavailability studies, protein binding, and pharmacokinetic calculations to determine values like AUC and elimination half-life. References for further reading are also provided.

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    © All Rights Reserved
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    of 2

    76

    4.5 BIOPHARMACEUTICS AND PHARMACOKINETICS (THEORY)

    Theory : 3 Hrs. /Week

    1. Biopharmaceutics
    1. Introduction to Biopharmaceutics
    a. Absorption of drugs from gastrointestinal tract.
    b. Drug Distribution.
    c. Drug Elimination.
    2. Pharmacokinetics
    2. Introduction to Pharmacokinetics.
    a. Mathematical model
    b. Drug levels in blood.
    c. Pharmacokinetic model
    d. Compartment models
    e. Pharmacokinetic study.
    3. One compartment open model.
    a. Intravenous Injection (Bolus)
    b. Intravenous infusion.
    4. Multicompartment models.
    a. Two compartment open model.
    b. IV bolus, IV infusion and oral administration
    5. Multiple – Dosage Regimens.
    a. Repititive Intravenous injections – One Compartment Open Model
    b. Repititive Extravascular dosing – One Compartment Open model
    c. Multiple Dose Regimen – Two Compartment Open Model
    6. Nonlinear Pharmacokinetics.
    a. Introduction
    b. Factors causing Non-linearity.
    c. Michaelis-menton method of estimating parameters.
    7. Noncompartmental Pharmacokinetics.
    a. Statistical Moment Theory.
    b. MRT for various compartment models.
    c. Physiological Pharmacokinetic model.
    8. Bioavailability and Bioequivalence.
    a. Introduction.
    b. Bioavailability study protocol.
    c. Methods of Assessment of Bioavailability
    77

    4.5 BIOPHARMACEUTICS AND PHARMACOKINETICS (PRACTICAL)

    Practical : 3 Hrs./Week

    1. Improvement of dissolution characteristics of slightly soluble drugs by some methods.


    2. Comparison of dissolution studies of two different marketed products of same drug.
    3. Influence of polymorphism on solubility and dissolution.
    4. Protein binding studies of a highly protein bound drug and poorly protein bound drug.
    5. Extent of plasma-protein binding studies on the same drug (i.e. highly and poorly
    protein bound drug) at different concentrations in respect of constant time.
    6. Bioavailability studies of some commonly used drugs on animal/human model.
    7. Calculation of Ka, Ke, t1 /2, Cmax, AUC, AUMC, MRT etc. from blood profile data.
    8. Calculation of bioavailability from urinary excretion data for two drugs.
    9. Calculation of AUC and bioequivalence from the given data for two drugs.
    10. In vitro absorption studies.
    11. Bioequivalency studies on the different drugs marketed.(eg) Tetracycline,
    Sulphamethoxzole, Trimethoprim, Aspirin etc., on animals and human volunteers.
    12. Absorption studies in animal inverted intestine using various drugs.
    13. Effect on contact time on the plasma protein binding of drugs.
    14. Studying metabolic pathways for different drugs based on elimination kinetics data.
    15. Calculation of elimination half-life for different drugs by using urinary elimination
    data and blood level data.
    16. Determination of renal clearance.

    References:
    a. Biopharmaceutics and Clinical Pharmacokinetics by, Milo Gibaldi
    b. Remington’s Pharmaceutical Sciences, By Mack Publishing Company, Pennsylvnia.
    c. Pharmacokinetics: By Milo Glbaldi Donald, R. Mercel Dekker Inc.
    d. Hand Book of Clinical Pharmacokinetics, By Milo Gibaldi and Laurie Prescott by
    ADIS Health Science Press.
    e. Biopharmaceutics and Pharmacokinetics; By Robert F Notari
    f. Biopharmaceutics; By Swarbrick
    g. Bio pharmaceutics and Pharmacokinetics-A Treatise, By D. M. Brahmankar and Sunil
    B.Jaiswal, Vallabh Prakashan Pitampura, Delhi
    h. Cilincal Pharmacokinetics, Concepts and Applications: By Malcolm Rowland and
    Thomas, N. Tozen, Lea and Febrger, Philadelphia, 1995.
    i. Dissolution, Bioavailability and Bioequivalence, By Abdou H.M, Mack, Publishing
    Company, Pennsylvania 1989.
    j. Biopharmaceutics and Clinical Pharmacokinetics-An introduction 4th edition Revised
    and expanded by Rebort F Notari Marcel Dekker Inn, New York and Basel, 1987.
    k. Encyclopedia of Pharmaceutical Technology, Vol 13, James Swarbrick, James, C.
    Roylan, Marcel Dekker Inc, New York 1996.

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