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His To Pathology

This document summarizes the histopathological features of various diseases affecting the head and neck region in 3 sentences or less per disease: 1. Inverted papilloma shows cristae-laden senescent mitochondria and endophytic epithelial growth. 2. Rhinoscleroma displays Mikulicz's cells containing bacteria and Russell bodies in plasma cells. 3. Rhinosporidiosis has pseudoepitheliomatous hyperplasia, submucosal cysts, and fungal sporangia.

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38 views4 pages

His To Pathology

This document summarizes the histopathological features of various diseases affecting the head and neck region in 3 sentences or less per disease: 1. Inverted papilloma shows cristae-laden senescent mitochondria and endophytic epithelial growth. 2. Rhinoscleroma displays Mikulicz's cells containing bacteria and Russell bodies in plasma cells. 3. Rhinosporidiosis has pseudoepitheliomatous hyperplasia, submucosal cysts, and fungal sporangia.

Uploaded by

sayer
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Histopathology from Pasha

 Inverted papilloma`cristae-laden senescnt mitochdria, endophytic growth


of epithelium

 Rhinoscleroma Mikuicz`s cell (foamy histocytes containing the


bacteria, "moth-eaten" cytoplasm), Russell bodies (bloated plasma cells with
bifringent inclusions), pseudoepitheliomatous hyperplasia

 Rhinosporidosis pseudoepitheliomatous hyperplasia, submucosal cysts,


fungal sporangia with chitinous shells

 Aspergillosis histologyseptated 45 degree, Y-shaped (sabouraud`s ager


stain)

 Mucormycosis histologynonseptated, 90 degree broad branching hyphae

 Kuettner’s Tumor (Chronic Sclerosing Sialadenitis of the Submandibular


Gland)  chronic inflammation with destruction of acinar cells, sclerosis,
“cirrhotic” changes

 Radiation sialadeniits  interstitial fibrosis


 Benign Lymphoepithelial Cysts lymphoreticular infiltrate, clusters of
lymphoid tissue (germinal centers), acinar atrophy, ductal metaplasia
 Pleomorphic Adenoma

Cellular Components:
1. myoepithelial component: spindle shaped with hyperchromatic nuclei, may
be more than one cell layer thick
2. epithelial components: varied growth patterns (trabecular, solid, cystic,
papillary)
3. stromal components: product of myoepithelial cells: myxoid, chondroid,
fibroid, or osteoid components
o fibrous pseudocapsule (except minor glands)
o micro-pseudopod extensions

 Warthin’s Tumor

Biphasic Layers

o epithelial component: lines papillary projections; double lining of


oncocytes; inner or luminal cells, nonciliated, tall columnar nuclei at
luminal aspect; outer or basal cells are round, cuboidal with vesicular
nuclei
o lymphoid component: mature lymphocytes with germinal centers
mucous secreting cells
o Oncocytic Cell: metaplasia (cytoplasmic alteration) of myo- or
epithelial cells

1
 Mucoepidermoid Carcinoma

o Low-Grade (Well-Differentiated) more mucinous cystic elements,


aggregates of mucoid cells with strands of epithelial cells, positive
keratin staining
o High-Grade (Poorly-Differentiated) less mucinous elements, more
solid nests of cells, requires mucin staining to differentiate from
squamous cell carcinoma, positive keratin staining

 Adenoid Cystic Carcinoma (Cylindroma)

o low-grade  cribiform (nests of cells with round spaces, “Swiss


cheese” appearance) or cylindromatous (tubular pattern) pattern,
o high-grade  more solid pattern (dense cellular pattern with few
spaces)

 Acinic Cell Carcinoma  serous acinar cells or clear cytoplasm cells, several
configurations (microcystic, papillary, solid, follicular), lymphoid infiltrate

 TB Laryngitis  cellular inflammation, granuloma in subepithelium,


perichondritis

 Scleroma of the Larynx/Rhinoscleroma  pseudoepitheliomatous


hyperplasia of the larynx (similar to blastomycosis)

 Granular Cell Tumor  pseudoepitheliomatous hyperplasia near epithelial


borders (often confused with SSC), polygonal uniform cells with vesicular
nucleus, coarsely cytoplasmic eosinophilic granules, PAS and S-100 positive

 Graves’ Disease  hyperplasia, increased colloid material, papillary


projections

 Hashimoto’s Thyroiditis  fibrosis, lymphocytic infiltration

 Thyroid Papillary Carcinoma  papillary and follicular structures,


psammoma bodies (calcific), intranuclear vacuoles (“Orphan Annie” eyes),
multicentric

 Hürthle Cell Tumors  Hürthle cells (large granular eosinophilic cells,


trabecular pattern)

 Medullary Thyroid Carcinoma  small round cells, amyloid stroma, may


have calcification and fibrotic strands

 Anaplastic Carcinoma giant and spindle cells variation, undifferentiated


“bizarre cells”

2
 Actinomycosis  branching anaerobic gram negative bacteria, sulfur granules

 Pemphigus Vulgaris  intraepithelial cell splitting (suprabasilar), attached


rows of basal cells to lamina propria (row of tombstones), Tzank cells (free
squamous cells, more spherical from loss of intracellular attachment)

 Lichen Planus  vacuolar alteration of the basal cell layer resulting in


Civatte bodies (degenerative eosinophilic ovoid keratinocytes), “saw tooth”
pattern of epidermal hyperplasia, lymphocytic infiltration of lamina propria

 Primary Leukoplakia  hyperkeratosis, acanthosis, atypia

 Ameloblastoma  various histological patterns, most common is the


follicular pattern with islands of epithelium lined with columnar cells, central
mass of loosely arranged cells (stellate reticulum), collagenous stroma

 Pindborg Tumor (Calcifying Epithelial Odontogenic Tumor)  sheets or


islands of epithelial cells with eosinophilic cytoplasm, may contain amyloid
with concentric calcifications or psammoma-like bodies (Liesegang rings)

 Ameloblastic Odontoma  presence of dentin and enamel (similar to a


dental follicle), “ghost” cells

 Thyroglossal Duct Cyst  lined with respiratory and squamous epithelium

 Cat-Scratch Disease  intracellular, gram-negative bacillus, Warthin-Starry


stain

 Histocytosis X (Reticuloendotheliosis)  sheets of polygonal histiocytes,


Birbeck granules (“zipper” pattern)

 Sarcoidosis  noncaseating granulomas, accumulation of T-cells,


mononuclear phagocytes, derangement of normal tissue architecture

 Syphilis mononuclear infiltrate, obliterative arteritis, hydrops, gummas and


osteolytic lesions in optic capsule

 Blastomycosis  pseudoepitheliomatous hyperplasia, intraepithelial


microabscess, single bifringent broad based bud (“figure 8” formation)

 Wegener’s Granulomatosis necrotizing granulomas (with multinucleated


giant cells) with vasculitis of upper and lower respiratory tract

 Verrucous Carcinoma (Akerman’s Tumor)  benign-appearing


(nonmitotic, no infiltration), well-differentiated squamous epithelium with
papillary projections, extensive hyperkeratosis, basement membrane intact,
“pushing” margins

3
 Cholesteatoma  compact sac of keratinizing squamous epithelium with a
central core of keratin debris

 Glomus Tumors  nests of nonchromaffin staining cells clustered among


vascular channels lined by epithelioid cells

 Acoustic Neuroma Histologic Types


o Antoni Type A: histologically parallel nuclei, uniform spindle cells,
compact cells
o Antoni Type B: histologically less uniform, may have fatty or hyaline
degeneration, less cellular

 Otosclerosis (Otospongiosis) active lesions reveal spongy bone seen as


blue with staining (blue mantles of Manasse), hypercellularity, active
osteocytes and osteoblasts, increased resorption spaces, and increased vascular
channels; inactive lesions reveal resorption spaces filled with collagen and
osteoid, sclerotic bone, and narrowed vascular spaces

Done by

Dr.khalid Badr

‫متيناتي للجماع بتلتوفاق و السداد‬

‫ال يينسونت من دعتئكم‬

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