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    Irene Regine Dayandante
    The hexose monophosphate shunt, also known as the pentose phosphate pathway, is an alternative oxidative pathway for glucose that generates NADPH and ribose-5-phosphate. It is more active in adipose tissue than muscle and does not generate ATP. The pathway involves the conversion of glucose-6-phosphate to 6-phosphogluconolactone and 6-phosphogluconate, then to ribulose 5-phosphate. A key reaction is catalyzed by 6-phosphate dehydrogenase to produce NADPH, important for fatty acid and steroid synthesis. Ribose-5-phosphate is needed for nucleotide and nucleic acid synthesis. Deficiencies in 6-phosphate dehydrogenase can cause hemolytic an

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    Untitled Presentation

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    Irene Regine Dayandante
    16 views11 pages
    The hexose monophosphate shunt, also known as the pentose phosphate pathway, is an alternative oxidative pathway for glucose that generates NADPH and ribose-5-phosphate. It is more active in adipose tissue than muscle and does not generate ATP. The pathway involves the conversion of glucose-6-phosphate to 6-phosphogluconolactone and 6-phosphogluconate, then to ribulose 5-phosphate. A key reaction is catalyzed by 6-phosphate dehydrogenase to produce NADPH, important for fatty acid and steroid synthesis. Ribose-5-phosphate is needed for nucleotide and nucleic acid synthesis. Deficiencies in 6-phosphate dehydrogenase can cause hemolytic an

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    HMP Shunt

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    The hexose monophosphate shunt, also known as the pentose phosphate pathway, is an alternative oxidative pathway for glucose that generates NADPH and ribose-5-phosphate. It is more active in adipose tissue than muscle and does not generate ATP. The pathway involves the conversion of glucose-6-phosphate to 6-phosphogluconolactone and 6-phosphogluconate, then to ribulose 5-phosphate. A key reaction is catalyzed by 6-phosphate dehydrogenase to produce NADPH, important for fatty acid and steroid synthesis. Ribose-5-phosphate is needed for nucleotide and nucleic acid synthesis. Deficiencies in 6-phosphate dehydrogenase can cause hemolytic an

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    16 views11 pages

    Untitled Presentation

    Uploaded by

    Irene Regine Dayandante
    The hexose monophosphate shunt, also known as the pentose phosphate pathway, is an alternative oxidative pathway for glucose that generates NADPH and ribose-5-phosphate. It is more active in adipose tissue than muscle and does not generate ATP. The pathway involves the conversion of glucose-6-phosphate to 6-phosphogluconolactone and 6-phosphogluconate, then to ribulose 5-phosphate. A key reaction is catalyzed by 6-phosphate dehydrogenase to produce NADPH, important for fatty acid and steroid synthesis. Ribose-5-phosphate is needed for nucleotide and nucleic acid synthesis. Deficiencies in 6-phosphate dehydrogenase can cause hemolytic an

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    © All Rights Reserved
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    of 11

    HMP Shunt

    Hexo Monophosphate Shunt


    Hexo Monophosphate Shunt

    - Also called Pentose phosphate shunt or

    Phosphogluconate pathway

    - An alternative oxidative path for glucose


    - More active in adipose tissue than in muscle
    - ATP is not generated
    2 main purpose
    ● Formation of NADPH
    ● Production of Ribose-5-P
    NADPH
    - Reduced form of Nicotinamide Adenine Dinucleotide
    Phosphate (NADP+) - a coenzyme needed for the
    synthesis of fatty acids and steroids.
    Ribose-5-P
    - 5 carbon sugar
    - Needed for synthesis of nucleotides and nucleic acid
    Glucose-6-phosphate 6-phosphogluconolactone 6-phosphogluconate ribulose 5-phosphate
    The overall reaction for this process is:

    Glucose 6-phosphate + 2 NADP+ + H2O → ribulose 5-phosphate + 2 NADPH + 2 H+ + CO2


    6-phosphate dehydrogenase
    - is a cytosolic enzyme that catalyzes the chemical reaction

    D-glucose 6-phosphate + NADP+ ⇌ 6-phospho-D-glucono-1,5-lactone + NADPH + H+


    6-phosphate dehydrogenase deficiency
    Effects:

    - Hemolytic Anemia
    - Resistance to Malaria
    - Reduces NADPH levels in red blood cells
    THANK YOU :)
    Sources

    https://en.wikipedia.org/wiki/Pentose_phosphate_pathway

    https://www.youtube.com/watch?v=UQfAKnXdBwg&t=191s

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