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    Hepatitis B Vaccine: Dosage Forms & Strengths

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    Håíthãm Khãtïß
    The document summarizes information about the hepatitis b vaccine, including available dosage forms and strengths, dosing considerations, adverse effects, contraindications, cautions, mechanism of action, pharmacokinetics, and administration. It describes that the hepatitis b vaccine is routinely used to immunize against hepatitis b and protects against hepatitis D. It also lists groups that should receive the vaccine series, such as health care workers, individuals with certain medical conditions, international travelers, and sexually active individuals.

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    Hepatitis B Vaccine: Dosage Forms & Strengths

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    Håíthãm Khãtïß
    55 views3 pages
    The document summarizes information about the hepatitis b vaccine, including available dosage forms and strengths, dosing considerations, adverse effects, contraindications, cautions, mechanism of action, pharmacokinetics, and administration. It describes that the hepatitis b vaccine is routinely used to immunize against hepatitis b and protects against hepatitis D. It also lists groups that should receive the vaccine series, such as health care workers, individuals with certain medical conditions, international travelers, and sexually active individuals.

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    Hepatitis b Vaccine

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    The document summarizes information about the hepatitis b vaccine, including available dosage forms and strengths, dosing considerations, adverse effects, contraindications, cautions, mechanism of action, pharmacokinetics, and administration. It describes that the hepatitis b vaccine is routinely used to immunize against hepatitis b and protects against hepatitis D. It also lists groups that should receive the vaccine series, such as health care workers, individuals with certain medical conditions, international travelers, and sexually active individuals.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    55 views3 pages

    Hepatitis B Vaccine: Dosage Forms & Strengths

    Uploaded by

    Håíthãm Khãtïß
    The document summarizes information about the hepatitis b vaccine, including available dosage forms and strengths, dosing considerations, adverse effects, contraindications, cautions, mechanism of action, pharmacokinetics, and administration. It describes that the hepatitis b vaccine is routinely used to immunize against hepatitis b and protects against hepatitis D. It also lists groups that should receive the vaccine series, such as health care workers, individuals with certain medical conditions, international travelers, and sexually active individuals.

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    © All Rights Reserved
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    Download as docx, pdf, or txt
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    Hepatitis b vaccine

    Dosage Forms & Strengths

    IM suspension (adult formulation)


     10mcg/mL (Recombivax HB)
     20mcg/mL (Engerix B)
     40mcg/mL (Recombivax HB [dialysis formulation])

    IM solution
     Adult adjuvanted formulation (Heplisav-B)
     20mcg HBsAg and 3000mcg of CpG 1018 adjuvant per 0.5mL
     physician's discretion MMWR Dec 23, 2011/Vol 60(50);1709-11

    Dosing Considerations

    Routine immunization against hepatitis B; also protects against


    hepatitis D which always occurs in the presence of hepatitis B
    Targeted groups that should receive HepB vaccination series include
     Sexually active persons who are not in a long-term, mutually monogamous
    relationship persons seeking evaluation or treatment for a sexually
    transmitted disease (STD); current or recent injection-drug users; and men
    who have sex with men
     Health-care personnel and public-safety workers who are potentially
    exposed to blood or other infectious body fluids
     Persons with diabetes, HIV infection, or chronic liver disease
     Persons with end-stage renal disease, including patients receiving
    hemodialysis
     Household contacts and sex partners of hepatitis B surface antigen-positive
    persons; clients and staff members of institutions for persons with
    developmental disabilities; and international travelers to countries with high
    or intermediate prevalence of chronic HBV infection
     All adults in the following settings: STD treatment facilities; HIV testing
    and treatment facilities; facilities providing drug-abuse treatment and
    prevention services; health-care settings targeting services to injection-drug
    users or men who have sex with men; correctional facilities; end-stage renal
    disease programs and facilities for chronic hemodialysis patients; and
    institutions and nonresidential daycare facilities for persons with
    developmental disabilities
     Pregnant women who are at risk for hepatitis B virus infection during
    pregnancy (eg, >1 sex partner during the previous 6 months, been evaluated
    or treated for a sexually transmitted infection, recent or current injection
    drug use, or had an HBsAg-positive sex partner)
     International travelers to regions with high or intermediate levels of
    endemic hepatitis B virus infection should receive a HepB series

    Adverse Effects
    Suspected adverse events after administration of any vaccine may be reported to
    Vaccine Adverse Events Reporting System (VAERS)

    >10%
    Pain (10-29%)
    Pruritus (10-29%)
    Erythema (10-29%)
    Burning (10-29%)
    Nodules (10-29%)
    Fatigue (15%)
    Headache (15%)
    Fever (15%)
    Vertigo (15%)

    1-10%
    Lightheadedness
    Flushinig
    Insomnia
    Irritability
    Arthralgia
    Constipation
    Pruritus
    Lupus-like syndrome
    Lymphadenopathy
    Tachycardia
    Contraindications

    Severe allergic reaction (eg, anaphylaxis) after a previous dose of any hepatitis B
    vaccine or to any vaccine component, including yeast

    Cautions

    Allergic reactions reported; appropriate medical treatment and supervision must


    be available to manage possible anaphylactic reactions following administration

    Immunocompromised persons, including individuals receiving immunosuppressant


    therapy, may have a diminished immune response

    Hepatitis B has a long incubation period; immunization may not prevent hepatitis
    B infection in individuals who have an unrecognized hepatitis B infection at the
    time of vaccine administration

    Mechanism of Action

    Hepatitis B surface antigen (HBsAg) which stimulates active immunity

    Pharmacokinetics

    Duration: Not established


    Excretion: Not established
    These products convey active immunity via stimulation of production of
    endogenously produced antibodies
    The onset of protection from disease is relatively slow, but duration is long lasting
    (years)

    Administration
    IM Administration
    Do not give IV or intradermal
    Older children, adolescents, and adults: Administer IM in deltoid muscle
    Neonates, infants, and small children: Administer IM in anterolateral thigh

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