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Ovarian Cancer Causes, Risk Factors,

and Prevention
Risk Factors

A risk factor is anything that affects your chance of getting a disease such as cancer.
Learn more about the risk factors for ovarian cancer.

● Ovarian Cancer Risk Factors

● What Causes Ovarian Cancer?

Prevention

There is no known way to prevent most ovarian cancers. But there are things you can
do that might lower your risk. Learn more.

● Can Ovarian Cancer Be Prevented?

Ovarian Cancer Risk Factors

A risk factor is anything that changes your chance of getting a disease like cancer.
Different cancers have different risk factors. Some risk factors, like smoking, can be
changed. Others, like a person’s age or family history, can’t be changed.

But having a risk factor, or even many, does not mean that you will get the disease. And

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some people who get the disease may not have any known risk factors. Researchers
have discovered several risk factors that might increase a woman's chance of
developing epithelial ovarian cancer. These risk factors don’t apply to other less
common types of ovarian cancer like germ cell tumors and stromal tumors.

Factors that increase your risk of ovarian cancers

Getting older

The risk of developing ovarian cancer gets higher with age. Ovarian cancer is rare in
women younger than 40. Most ovarian cancers develop after menopause. Half of all
ovarian cancers are found in women 63 years of age or older.

Being overweight or obese

Obesity has been linked to a higher risk of developing many cancers. The current
information available for ovarian cancer risk and obesity is not clear. Obese women
(those with a body mass index [BMI] of at least 30) may have a higher risk of developing
ovarian cancer, but not necessarily the most aggressive types, such as high grade
serous cancers. Obesity may also affect the overall survival of a woman with ovarian
cancer.

Having children later or never having a full-term pregnancy

Women who have their first full-term pregnancy after age 35 or who never carried a
pregnancy to term have a higher risk of ovarian cancer.

Using fertility treatment

Fertility treatment with in vitro fertilization (IVF) seems to increase the risk of the type of
ovarian tumors known as "borderline" or "low malignant potential" (described in What Is
Ovarian Cancer?1). Other studies, however, have not shown an increased risk of
invasive ovarian cancer with fertility drugs. If you are taking fertility drugs, you should
discuss the potential risks with your doctor.

Taking hormone therapy after menopause

Women using estrogens after menopause have an increased risk of developing ovarian
cancer. The risk seems to be higher in women taking estrogen alone (without
progesterone) for many years (at least 5 or 10). The increased risk is less certain for

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women taking both estrogen and progesterone.

Having a family history of ovarian cancer, breast cancer, or colorectal cancer

Ovarian cancer can run in families. Yourovarian cancer risk is increased if your mother,
sister, or daughter has (or has had) ovarian cancer. The risk also gets higher the more
relatives you have with ovarian cancer. Increased risk for ovarian cancer can also come
from your father's side.

A family history of some other types of cancer such as colorectal and breast cancer is
linked to an increased risk of ovarian cancer. This is because these cancers can be
caused by an inherited mutation (change) in certain genes that cause a family cancer
syndrome that increases the risk of ovarian cancer.

Having a family cancer syndrome

About 5 to 10% of ovarian cancers are a part of family cancer syndromes2 resulting from
inherited changes (mutations)in certain genes.

Hereditary breast and ovarian cancer syndrome

This syndrome is caused by inherited mutations in the genes BRCA1 and BRCA2, as
well as possibly some other genes that have not yet been found. This syndrome is
linked to a high risk of breast cancer3 as well as ovarian, fallopian tube, and primary
peritoneal cancers. The risk of some other cancers, such as pancreatic cancer4 and
prostate cancer5, are also increased.

Mutations in BRCA1 and BRCA2 are also responsible for most inherited ovarian
cancers. Mutations in BRCA1 and BRCA2 are about 10 times more common in those
who are Ashkenazi Jewish than those in the general U.S. population.

The lifetime ovarian cancer risk for women with a BRCA1 mutation is estimated to be
between 35% and 70%. This means that if 100 women had a BRCA1 mutation,
between 35 and 70 of them would get ovarian cancer. For women with BRCA2
mutations the risk has been estimated to be between 10% and 30% by age 70. These
mutations also increase the risks for primary peritoneal carcinoma and fallopian tube
carcinoma.

In comparison, the ovarian cancer lifetime risk for the women in the general population
is less than 2%.

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PTEN tumor hamartoma syndrome

In this syndrome, also known as Cowden disease, people are primarily affected with
thyroid problems, thyroid cancer, and breast cancer. Women also have an increased
risk of endometrial and ovarian cancer. It is caused by inherited mutations in the PTEN
gene.

Hereditary nonpolyposis colon cancer

Women with this syndrome have a very high risk of colon cancer6 and also have an
increased risk of developing cancer of the uterus (endometrial cancer) and ovarian
cancer. Many different genes can cause this syndrome. They include MLH1, MLH3,
MSH2, MSH6, TGFBR2, PMS1, and PMS2. The lifetime risk of ovarian cancer in
women with hereditary nonpolyposis colon cancer (HNPCC) is about 10%. Up to 1% of
all ovarian epithelial cancers occur in women with this syndrome. Another name for
HNPCC is Lynch syndrome.

Peutz-Jeghers syndrome

People with this rare genetic syndrome develop polyps in the stomach and intestine
while they are teenagers. They also have a high risk of cancer, particularly cancers of
the digestive tract (esophagus, stomach, small intestine, colon). Women with this
syndrome have an increased risk of ovarian cancer, including both epithelial ovarian
cancer and a type of stromal tumor called sex cord tumor with annular tubules (SCTAT).
This syndrome is caused by mutations in the gene STK11.

MUTYH-associated polyposis

People with this syndrome develop polyps in the colon and small intestine and have a
high risk of colon cancer. They are also more likely to develop other cancers, including
cancers of the ovary and bladder7. This syndrome is caused by mutations in the gene
MUTYH.

Having had breast cancer

If you have had breast cancer, you might also have an increased risk of developing
ovarian cancer. There are several reasons for this. Some of the reproductive risk factors
for ovarian cancer may also affect breast cancer risk. The risk of ovarian cancer after
breast cancer is highest in those women with a family history of breast cancer. A strong
family history of breast cancer may be caused by an inherited mutation in the BRCA1 or
BRCA2 genes and hereditary breast and ovarian cancer syndrome, which is linked to

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an increased risk of ovarian cancer.

Smoking and alcohol use

Smoking doesn’t increase the risk of ovarian cancer overall, but it is linked to an
increased risk for the mucinous type.

Drinking alcohol is not linked to ovarian cancer risk.

Factors with unclear effects on ovarian cancer risk

Androgens

Androgens, such as testosterone, are male hormones. There appears to be a link

between certain androgens and specific types of ovarian cancer, but further studies of
the role of androgens in ovarian cancer are needed.

Talcum powder

It has been suggested that talcum powder might cause cancer in the ovaries if the
powder particles (applied to the genital area or on sanitary napkins, diaphragms, or
condoms) were to travel through the vagina, uterus, and fallopian tubes to the ovary.

Many studies in women have looked at the possible link between talcum powder and
cancer of the ovary. Findings have been mixed, with some studies reporting a slightly
increased risk and some reporting no increase. Many case-control studies have found a
small increase in risk. But these types of studies can be biased because they often rely
on a person’s memory of talc use many years earlier. One prospective cohort study,
which would not have the same type of potential bias, has not found an increased risk.
A second found a modest increase in risk of one type of ovarian cancer.

For any individual woman, if there is an increased risk, the overall increase is likely to
very be small. Still, talc is widely used in many products, so it is important to determine
if the increased risk is real. Research in this area continues.

Diet

Some studies have shown a reduced rate of ovarian cancer in women who ate a diet
high in vegetables or a low fat diet, but other studies disagree. The American Cancer
Society recommends eating a variety of healthful foods, with an emphasis on plant

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sources. Eat at least 2 ½ cups of fruits and vegetables every day, as well as several
servings of whole grain foods from plant sources such as breads, cereals, grain
products, rice, pasta, or beans. Limit the amount of red meat and processed meats you
eat. Even though the effect of these dietary recommendations on ovarian cancer risk
remains uncertain, following them can help prevent several other diseases, including
some other types of cancer.

Factors that can lower risk of ovarian cancer

Pregnancy and breastfeeding

Women who have been pregnant and carried it to term before age 26 have a lower risk
of ovarian cancer than women who have not. The risk goes down with each full-term
pregnancy. Breastfeeding may lower the risk even further.

Birth control

Women who have used oral contraceptives (also known as birth control pills or the pill)
have a lower risk of ovarian cancer. The risk is lower the longer the pills are used. This
lower risk continues for many years after the pill is stopped. Other forms of birth control
such as tubal ligation (having fallopian tubes tied) and short use of IUDs (intrauterine
devices) have also been associated with a lower risk of ovarian cancer.

A hysterectomy (removing the uterus without removing the ovaries) also seems to
reduce the risk of getting ovarian cancer by about one-third.

Hyperlinks

1. www.cancer.org/cancer/ovarian-cancer/about/what-is-ovarian-cancer.html
2. www.cancer.org/cancer/cancer-causes/genetics/family-cancer-syndromes.html
3. www.cancer.org/cancer/breast-cancer.html
4. www.cancer.org/cancer/pancreatic-cancer.html
5. www.cancer.org/cancer/prostate-cancer.html
6. www.cancer.org/cancer/colon-rectal-cancer.html
7. www.cancer.org/cancer/bladder-cancer.html

References

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Berge W, Mundt K, Luu H, et al. Genital use of talc and risk of ovarian cancer: a meta
analysis. Eur J Cancer Prev. 2017; Jul 07. PMID: 28079603.

Brinton LA, Trabert B, Shalev V, Lunenfeld E, Sella T, Chodick G. In Vitro Fertilization

and Risk of Breast and Gynecologic Cancers: A Retrospective Cohort Study within the
Israeli Maccabi Healthcare Services. Fertil Steril. 2013;99(5):1189-1196.
doi:10.1016/j.fertnstert.2012.12.029.

Cibula D, Zikan M, Dusek L, Majek O. Oral contraceptives and risk of ovarian and
breast cancers in BRCA mutation carriers: a meta-analysis. Expert Rev Anticancer
Ther. 2011;11(8):1197-1207.

Collaborative Group on Epidemiological Studies of Ovarian Cancer, Beral V, Gaitskell

K, Hermon C, Moser K, Reeves G, Peto R. Ovarian cancer and smoking: individual
participant meta-analysis including 28,114 women with ovarian cancer from 51
epidemiological studies. Lancet Oncol. 2012;13(9):946-956. Epub 2012 Aug 3.

Cook LS, Kamb ML, Weiss NS. Perineal powder exposure and the risk of ovarian
cancer. Am J Epidemiol.1997;145:459465.

Cottreau CM, Ness RB, Modugno F, Allen GO, Goodman MT. Endometriosis and its
treatment with danazol or lupron in relation to ovarian cancer. Clin Cancer Res.
2003;9:5142-5144.

Cramer DW, Vitonis AF, Terry KL, et al. The association between talc use and ovarian
cancer: a retrospective case control study in two US states. Epidemiology. 2016;27:334-
46

Diergaarde B, Kurta ML. Use of fertility drugs and risk of ovarian cancer. Curr Opin
Obstet Gynecol. 2014;26(3):125-129. doi:10.1097/GCO.0000000000000060.

Gertig DM, Hunter DJ, Cramer DW, et al. Prospective study of talc use and ovarian
cancer. J Natl Cancer Inst. 2000;92:249252.

Hemminki K, Zhang H, Sundquist J, Lorenzo Bermejo J. Modification of risk for

subsequent cancer after female breast cancer by a family history of breast cancer.
Breast Cancer Res Treat. 2008 ;111:165-169.

Houghton SC, Reeves KW, Hankinson SE, et al. Perineal powder use and risk of
ovarian cancer. J Natl Cancer Inst. 2014 Sep 10;106(9).

Kurta ML, Moysich KB, Weissfeld JL, et al. Use of fertility drugs and risk of ovarian

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cancer: results from a US-based case-control study. Cancer epidemiology, biomarkers

& prevention: a publication of the American Association for Cancer Research,
cosponsored by the American Society of Preventive Oncology. 2012;21(8):1282-1292.
doi:10.1158/1055-9965.EPI-12-0426.

McLaughlin JR, et al; Hereditary Ovarian Cancer Clinical Study Group. Reproductive
risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control
study. Lancet Oncol. 2007; 8:26-34.

Mills PK, Riordan DG, Cress RD, Young HA. Perineal talc exposure and epithelial
ovarian cancer risk in the Central Valley of California. Int J Cancer. 2004;112:458464.

National Comprehensive Cancer Network (NCCN)--Ovarian Cancer Including Fallopian

Tube Cancer and Primary Peritoneal Cancer. V2.2018. Accessed February 5, 2018,
from https://www.nccn.org/professionals/physician_gls/pdf/ovarian.pdf

Olsen CM, Green AC, Nagle CM, et al.; Australian Cancer Study Group (Ovarian
Cancer) and the Australian Ovarian Cancer Study Group. Epithelial ovarian cancer:
testing the 'androgens hypothesis'. Endocr Relat Cancer. 2008;15:1061-1068.

Olsen CM, Green AC, Whiteman DC, Sadeghi S, Kolahdooz F, Webb PM. Obesity and
the risk of epithelial ovarian cancer: a systematic review and meta-analysis. Eur J
Cancer. 2007;43:690-709.

Oral contraceptive use and the risk of ovarian cancer. The Centers for Disease Control
Cancer and Steroid Hormone Study. JAMA. 1983;249(12):1596-1599.

Prentice RL, Thomson CA, Caan B, et al. Low-Fat Dietary Pattern and Cancer
Incidence in the Women’s Health Initiative Dietary Modification Randomized Controlled
Trial. J Natl Cancer Inst. 2007;99(20):1534-1543. Epub 2007 Oct 9.

Rosenblatt KA, Weiss NS, Cushing-Haugen KL, Wicklund KG, Rossing MA. Genital
powder exposure and the risk of epithelial ovarian cancer. Cancer Causes Control.
2011;22:737742.

Rota M, Pasquali E, Scotti L, et al. Alcohol drinking and epithelial ovarian cancer risk. a
systematic review and meta-analysis. Gynecol Oncol. 2012;125(3):758-763. Epub 2012
Mar 23.

Stewart LM, Holman CD, Aboagye-Sarfo P, Finn JC, Preen DB, Hart R. In vitro
fertilization, endometriosis, nulliparity and ovarian cancer risk. Gynecol Oncol. 2013
Feb;128(2):260-4. doi: 10.1016/j.ygyno.2012.10.023. Epub 2012 Oct 29.

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Stewart LM, Holman CD, Finn JC, Preen DB, Hart R. In vitro fertilization is associated
with an increased risk of borderline ovarian tumours. Gynecol Oncol. 129 (2013)
372–376.

Terry KL, Karageorgi S, Shvetsov YB, et al. Genital powder use and risk of ovarian
cancer: A pooled analysis of 8,525 cases and 9,859 controls. Cancer Prev Res (Phila).
2013;6:811–821.

The reduction in risk of ovarian cancer associated with oral-contraceptive use. The
Cancer and Steroid Hormone Study of the Centers for Disease Control and the National
Institute of Child Health and Human Development. N Engl J Med. 1987;316(11):650-
655.

Vogt S, Jones N, Christian D, et al. Expanded extracolonic tumor spectrum in MUTYH-

associated polyposis. Gastroenterology. 2009 Dec;137(6):1976-1985.e1-10. Epub 2009
Sep 2.

Last Medical Review: April 11, 2018 Last Revised: April 11, 2018

What Causes Ovarian Cancer?

We don’t yet know exactly what causes most ovarian cancers. As discussed in Ovarian
Cancer Risk Factors, we do know some factors that make a woman more likely to
develop epithelial ovarian cancer. Much less is known about risk factors for germ cell
and stromal tumors of the ovaries.

The most recent and important finding about the cause of ovarian cancer is that it starts
in cells at the tail ends of the fallopian tubes and not necessarily in the ovary itself. This
new information may open more research studies looking at preventing and screening
for this type of cancer.

There are many theories about the causes of ovarian cancer. Some of them came from
looking at the things that change the risk of ovarian cancer. For example, pregnancy
and taking birth control pills both lower the risk of ovarian cancer. Since both of these
things reduce the number of times the ovary releases an egg (ovulation), some
researchers think that there may be some relationship between ovulation and the risk of
developing ovarian cancer.

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Also, we know that tubal ligation and hysterectomy lower the risk of ovarian cancer. One
theory to explain this is that some cancer-causing substances may enter the body
through the vagina and pass through the uterus and fallopian tubes to reach the
ovaries. This would explain how removing the uterus or blocking the fallopian tubes
affects ovarian cancer risk.

Another theory is that male hormones (androgens) can cause ovarian cancer.

Gene changes related to ovarian cancer

Researchers have made great progress in understanding how certain mutations

(changes) in DNA can cause normal cells to become cancerous. DNA is the chemical
that carries the instructions for nearly everything our cells do. We usually look like our
parents because they are the source of our DNA. However, DNA affects more than the
way we look. Some genes (parts of our DNA) contain instructions for controlling when
our cells grow and divide. Mutations in these genes can lead to the development of
cancer.

Inherited genetic mutations

A small portion of ovarian cancers occur in women with inherited mutations linked to an
increased risk of ovarian cancer. These include mutations in the BRCA1 and BRCA2
genes, as well as the genes related to other family cancer syndromes linked to an
increased risk of ovarian cancer, such as PTEN (PTEN tumor hamartoma syndrome),
STK11 (Peutz-Jeghers syndrome), MUTYH (MUTYH-associated polyposis, and the
many genes that can cause hereditary nonpolyposis colon cancer (MLH1, MLH3,
MSH2, MSH6, TGFBR2, PMS1, and PMS2).

Genetic tests can detect mutations associated with these inherited syndromes. If you
have a family history of cancers linked to these syndromes, such as breast and ovarian
cancers, thyroid and ovarian cancer, and/or colorectal and endometrial (uterine) cancer,
you might want to ask your doctor about genetic counseling and testing. The American
Cancer Society recommends discussing genetic testing with a qualified cancer genetics
professional before any genetic testing is done. For more on this, see Genetics and
Cancer1.

Acquired genetic changes

Most mutations related to ovarian cancer are not inherited but instead occur during a
woman's life and are called acquired mutations. In some cancers, these types of
mutations leading to the development of cancer may result from radiation or cancer-

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causing chemicals, but there is no evidence for this in ovarian cancer. So far, studies
haven’t been able to specifically link any single chemical in the environment or in our
diets to mutations that cause ovarian cancer. The cause of most acquired mutations
remains unknown.

Most ovarian cancers have several acquired mutations. Research has suggested that
tests to identify acquired mutations in ovarian cancers, like the TP53 tumor suppressor
gene or the HER2 oncogene, can help predict a woman's prognosis. The role of these
tests is still not certain, and more research is needed.

Hyperlinks

1. www.cancer.org/cancer/cancer-causes/genetics.html

References

Cannistra SA, Gershenson DM, Recht A. Ch 76 - Ovarian cancer, fallopian tube

carcinoma, and peritoneal carcinoma. In: DeVita VT, Hellman S, Rosenberg SA,
eds. Cancer: Principles and Practice of Oncology. 10th ed. Philadelphia, PA: Lippincott
Williams & Wilkins; 2015.

Morgan M, Boyd J, Drapkin R, Seiden MV. Ch 89 – Cancers Arising in the Ovary. In:
Abeloff MD, Armitage JO, Lichter AS, Niederhuber JE, Kastan MB, McKenna WG,
eds. Clinical Oncology. 5th ed. Philadelphia, PA: Elsevier; 2014: 1592.

Last Medical Review: April 11, 2018 Last Revised: April 11, 2018

Can Ovarian Cancer Be Prevented?

Most women have one or more risk factors for ovarian cancer. But most of the common
factors only slightly increase your risk, so they only partly explain the frequency of the
disease. So far, what is known about risk factors has not translated into practical ways
to prevent most cases of ovarian cancer.

There are several ways you can reduce your risk of developing the most common type

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of ovarian cancer, epithelial ovarian cancer. Much less is known about ways to lower
the risk of developing germ cell and stromal tumors of the ovaries, so this information
does not apply to those types. It is important to realize that some of these strategies
lower your risk only slightly, while others lower it much more. Some strategies are easily
followed, and others require surgery. If you are concerned about your risk of ovarian
cancer, talk to your health care professionals. They can help you consider these ideas
as they apply to your own situation.

Avoiding certain risk factors

Some risk factors for ovarian cancer, like getting older or having a family history, cannot
be changed. But women might be able to lower their risk slightly by avoiding other risk
factors, for example, by staying at a healthy weight, or not taking hormone replacement
therapy after menopause. See Risk Factors for Ovarian Cancer to learn more.

Oral contraceptives

Using oral contraceptives (birth control pills) decreases the risk of developing ovarian
cancer for average risk women and BRCA mutation carriers , especially among women
who use them for several years. Women who used oral contraceptives for 5 or more
years have about a 50% lower risk of developing ovarian cancer compared with women
who never used oral contraceptives. Still, birth control pills do have some serious risks
and side effects such as slightly increasing breast cancer risk. Women considering
taking these drugs for any reason should first discuss the possible risks and benefits
with their doctor.

Gynecologic surgery

Both tubal ligation and hysterectomy may reduce the chance of developing certain types
of ovarian cancer, but experts agree that these operations should only be done for valid
medical reasons -- not for their effect on ovarian cancer risk.

If you are going to have a hysterectomy for a valid medical reason and you have a
strong family history of ovarian or breast cancer, you may want to consider having both
ovaries and fallopian tubes removed (called a bilateral salpingo-oophorectomy) as part
of that procedure.

Even if you don’t have an increased risk of ovarian cancer, some doctors recommend
that the ovaries be removed with the uterus if a woman has already gone through
menopause or is close to menopause. If you are older than 40 and you are going to

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have a hysterectomy, you should discuss the potential risks and benefits of having your
ovaries removed with your doctor.

Another option for average risk women who do not wish to have their ovaries removed
because they don’t want to lose ovarian function (and go through menopause early) is
to have just the fallopian tubes removed (a bilateral salpingectomy) along with the
uterus (a hysterectomy). They may choose to have their ovaries removed later. This has
not been studied as well as removing both the ovaries and fallopian tubes at the same
time, but there is enough information that it may be considered an option to reduce
ovarian cancer risk in average risk women.

Prevention strategies for women with a family history of ovarian

cancer or BRCA mutation

If your family history suggests that you (or a close relative) might have a syndrome
linked with a high risk of ovarian cancer, you might want to consider genetic counseling
and testing. During genetic counseling (by a genetic counselor or other health care
professional with training in genetic risk evaluation), your personal medical and family
history is reviewed. This can help predict whether you are likely to have one of the gene
mutations associated with an increased ovarian cancer risk.

The counselor will also discuss the benefits and potential drawbacks of genetic testing
with you. Genetic testing can help determine if you or members of your family carry
certain gene mutations that cause a high risk of ovarian cancer. Still, the results are not
always clear, and a genetic counselor can help you sort out what the results mean to
you.

For some women with a strong family history of ovarian cancer, knowing they do not
have a mutation that increases their ovarian cancer risk can be a great relief for them
and their children. Knowing that you do have such a mutation can be stressful, but
many women find this information very helpful in making important decisions about
certain prevention strategies for them and their children. See Genetics and Cancer1 to
learn more.

Using oral contraceptives is one way that high risk women (women with BRCA1 and
BRCA2 mutations) can reduce their risk of developing ovarian cancer. But birth control
pills can increase breast cancer risk in women with or without these mutations. This
increased risk appears highest while women are actively taking birth control pills but can
continue even after stopping them. Research is continuing to find out more about the
risks and benefits of oral contraceptives for women at high ovarian and breast cancer
risk.

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Tubal ligation may also effectively reduce the risk of ovarian cancer in women who have
BRCA1 or BRCA2 mutations. Usually this type of surgery is not done alone and is
typically done for reasons other than ovarian cancer prevention.

Sometimes a woman may want to consider having both ovaries and fallopian tubes
removed (called a bilateral salpingo-oophorectomy) to reduce her risk of ovarian cancer
before cancer is even suspected. If the ovaries are removed to prevent ovarian cancer,
the surgery is called risk-reducing or prophylactic. Generally, salpingo-oophorectomy
may be recommended for high-risk women after they have finished having children.
This operation lowers ovarian cancer risk a great deal but does not entirely eliminate it.
That’s because some women who have a high risk of ovarian cancer already have a
cancer at the time of surgery. These cancers can be so small that they are only found
when the ovaries and fallopian tubes are looked at in the lab after they are removed.
Also, women with BRCA1 or BRCA2 gene mutations have an increased risk of primary
peritoneal carcinoma. Although the risk is low, this cancer can still develop after the
ovaries and fallopian tubes are removed.

The risk of fallopian tube cancer is also increased in women with mutations in BRCA1 or
BRCA2. Sometimes early fallopian tube cancers are found unexpectedly when the
fallopian tubes are removed as a part of a risk-reducing surgery. In fact, some cancers
that were thought to be ovarian or primary peritoneal cancers may have actually started
in the fallopian tubes. That is why experts recommend that women at high risk of
ovarian cancer who are having their ovaries removed should have their fallopian tubes
completely removed as well (salpingo-oophorectomy).

Research has shown that premenopausal women who have BRCA gene mutations and
have had their ovaries removed reduce their risk of breast cancer2 as well as their risk
of ovarian cancer. The risk of ovarian cancer is reduced by 85% to 95%, and the risk of
breast cancer cut by 50% or more.

Some women who have a high risk of ovarian cancer due to BRCA gene mutations feel
that having their ovaries and fallopian tubes removed is not right for them. Often doctors
recommend that those women have screening tests to try to find ovarian cancer early.

Hyperlinks

1. www.cancer.org/cancer/cancer-causes/genetics.html
2. www.cancer.org/cancer/breast-cancer.html

References

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____________________________________________________________________________________

Brohet RM, Goldgar DE, Easton DF, et al. Oral contraceptives and breast cancer risk in
the international BRCA1/2 carrier cohort study: A report from EMBRACE, GENEPSO,
GEO-HEBON, and the IBCCS Collaborating Group. J Clin Oncol. 2007;25:3831-3836.

Cibula D, Zikan M, Dusek L, Majek O. Oral contraceptives and risk of ovarian and
breast cancers in BRCA mutation carriers: a meta-analysis. Expert Rev Anticancer
Ther. 2011;11(8):1197-1207.

Committee on the State of the Science in Ovarian Cancer Research; Board on Health
Care Services; Institute of Medicine; National Academies of Sciences, Engineering, and
Medicine. Ovarian Cancers: Evolving Paradigms in Research and Care. Washington
(DC): National Academies Press (US); 2016 Apr 25. 3, Prevention and Early Detection.
Available from: https://www.ncbi.nlm.nih.gov/books/NBK367614/

McLaughlin JR, et al; Hereditary Ovarian Cancer Clinical Study Group. Reproductive
risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control
study. Lancet Oncol. 2007; 8:26-34.

Moorman, Patricia G., et al. "Oral contraceptives and risk of ovarian cancer and breast
cancer among high-risk women: a systematic review and meta-analysis." J Clin Oncol
2013; 31 (33): 4188-98.

Morgan M, Boyd J, Drapkin R, Seiden MV. Ch 89 – Cancers Arising in the Ovary. In:
Abeloff MD, Armitage JO, Lichter AS, Niederhuber JE, Kastan MB, McKenna WG,
eds. Clinical Oncology. 5th ed. Philadelphia, PA: Elsevier; 2014: 1592.

Last Medical Review: April 11, 2018 Last Revised: April 11, 2018

Written by

The American Cancer Society medical and editorial content team

(www.cancer.org/cancer/acs-medical-content-and-news-staff.html)

Our team is made up of doctors and oncology certified nurses with deep knowledge of
cancer care as well as journalists, editors, and translators with extensive experience in
medical writing.

American Cancer Society medical information is copyrighted material. For reprint

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