SAFETY DATA SHEET

Isoprene Feedstock
Version 3.0 Revision Date 2019-04-17

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product information
Product Name : Isoprene Feedstock
Material : 1059202, 1059201, 1037432, 1015403

Use : Chemical intermediate

Company : Chevron Phillips Chemical Company LP

10001 Six Pines Drive
The Woodlands, TX 77380

Emergency telephone:

Health:
866.442.9628 (North America)
1.832.813.4984 (International)
Transport:
CHEMTREC 800.424.9300 or 703.527.3887(int'l)
Asia: CHEMWATCH (+612 9186 1132) China: 0532 8388 9090
EUROPE: BIG +32.14.584545 (phone) or +32.14583516 (telefax)
Mexico CHEMTREC 01-800-681-9531 (24 hours)
South America SOS-Cotec Inside Brazil: 0800.111.767 Outside Brazil: +55.19.3467.1600
Argentina: +(54)-1159839431

Responsible Department : Product Safety and Toxicology Group

E-mail address : [email protected]
Website : www.CPChem.com

SECTION 2: Hazards identification

Classification of the substance or mixture

This product has been classified in accordance with the hazard communication standard 29 CFR
1910.1200; the SDS and labels contain all the information as required by the standard.

Classification
: Flammable liquids, Category 1
Acute toxicity, Category 4, Oral
Skin irritation, Category 2
Eye irritation, Category 2A
Germ cell mutagenicity, Category 1B
Carcinogenicity, Category 1A
Reproductive toxicity, Category 2

SDS Number:100000013397 1/21

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Specific target organ systemic toxicity - single exposure,
Category 3, Central nervous system
Specific target organ systemic toxicity - repeated exposure,
Category 1, Blood
Specific target organ systemic toxicity - repeated exposure,
Category 2, Auditory organs, Liver, Kidney, Nervous system
Specific target organ systemic toxicity - repeated exposure,
Category 2, Inhalation, Auditory organs
Aspiration hazard, Category 1

Labeling

Symbol(s) :

Signal Word : Danger

Hazard Statements : H224: Extremely flammable liquid and vapor.

H302: Harmful if swallowed.
H304: May be fatal if swallowed and enters airways.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H336: May cause drowsiness or dizziness.
H340: May cause genetic defects.
H350: May cause cancer.
H361: Suspected of damaging fertility or the unborn child.
H372: Causes damage to organs (Blood, Auditory organs,
Liver, Kidney, Nervous system) through prolonged or repeated
exposure.
H373: May cause damage to organs (Auditory organs) through
prolonged or repeated exposure if inhaled.

Precautionary Statements : Prevention:

P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been
read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces.
No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ ventilating/ lighting/
equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P260 Do not breathe dust/fume/gas/mist/vapor/spray.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ protective clothing/ eye
protection/ face protection.
Response:
P301 + P310 IF SWALLOWED: Immediately call a POISON
CENTER/doctor.
P303 + P361 + P353 IF ON SKIN (or hair): Take off
immediately all contaminated clothing. Rinse skin with
water/shower.
P304 + P340 + P312 IF INHALED: Remove person to fresh

SDS Number:100000013397 2/21

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air and keep comfortable for breathing. Call a POISON
CENTER/doctor if you feel unwell.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with
water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing.
P308 + P313 IF exposed or concerned: Get medical advice/
attention.
P331 Do NOT induce vomiting.
P332 + P313 If skin irritation occurs: Get medical advice/
attention.
P337 + P313 If eye irritation persists: Get medical advice/
attention.
P362 Take off contaminated clothing and wash before reuse.
P370 + P378 In case of fire: Use dry sand, dry chemical or
alcohol-resistant foam to extinguish.
Storage:
P403 + P233 Store in a well-ventilated place. Keep container
tightly closed.
P403 + P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
Disposal:
P501 Dispose of contents/ container to an approved waste
disposal plant.

Carcinogenicity:
IARC Group 1: Carcinogenic to humans
Benzene 71-43-2
1,3-Butadiene 106-99-0
Group 2B: Possibly carcinogenic to humans
Isoprene 78-79-5
Ethylbenzene 100-41-4
NTP Known to be human carcinogen
Benzene 71-43-2
1,3-Butadiene 106-99-0
Reasonably anticipated to be a human carcinogen
Isoprene 78-79-5

SECTION 3: Composition/information on ingredients

Synonyms : C5 Amylene
C5 Diolefin Stream
Crude Isoprene

Molecular formula : UVCB

Component CAS-No. Weight %

Naphtha, (Petroleum), Light Steam- 68514-39-6 100
Cracked, Isoprene-Rich
Isopentane 78-78-4 0 - 60
n-Pentane 109-66-0 0 - 60
Isoprene 78-79-5 0 - 60
Cyclopentadiene 542-92-7 0 - 30

SDS Number:100000013397 3/21

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Benzene, dimethyl- 1330-20-7 0-5
Ethylbenzene 100-41-4 0-5
n-Butane 106-97-8 0-5
n-Heptane 142-82-5 0-5
n-hexane 110-54-3 0-5
Cyclopentane 287-92-3 0-5
Toluene 108-88-3 0-5
Benzene 71-43-2 0-5
1,3-Butadiene 106-99-0 0-5
Methylcyclopentane 96-37-7 0-5

SECTION 4: First aid measures

General advice : Move out of dangerous area. Show this material safety data
sheet to the doctor in attendance. Material may produce a
serious, potentially fatal pneumonia if swallowed or vomited.

If inhaled : Consult a physician after significant exposure. If unconscious,

place in recovery position and seek medical advice.

In case of skin contact : If skin irritation persists, call a physician. If on skin, rinse well
with water. If on clothes, remove clothes.

In case of eye contact : Immediately flush eye(s) with plenty of water. Remove contact
lenses. Protect unharmed eye. Keep eye wide open while
rinsing. If eye irritation persists, consult a specialist.

If swallowed : Keep respiratory tract clear. Never give anything by mouth to

an unconscious person. If symptoms persist, call a physician.
Take victim immediately to hospital.

SECTION 5: Firefighting measures

Flash point : -54 °C (-65 °F)

Method: Tag closed cup

Autoignition temperature : 220 °C (428 °F)

Suitable extinguishing : Alcohol-resistant foam. Carbon dioxide (CO2). Dry chemical.

media

Unsuitable extinguishing : High volume water jet.

media

Specific hazards during fire : Do not allow run-off from fire fighting to enter drains or water
fighting courses.

Special protective : Wear self-contained breathing apparatus for firefighting if

equipment for fire-fighters necessary.

Further information : Collect contaminated fire extinguishing water separately. This

must not be discharged into drains. Fire residues and
contaminated fire extinguishing water must be disposed of in
accordance with local regulations. For safety reasons in case
of fire, cans should be stored separately in closed
SDS Number:100000013397 4/21
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containments. Use a water spray to cool fully closed
containers.

Fire and explosion : Do not spray on an open flame or any other incandescent
protection material. Take necessary action to avoid static electricity
discharge (which might cause ignition of organic vapors). Use
only explosion-proof equipment. Keep away from open flames,
hot surfaces and sources of ignition.

Hazardous decomposition : Carbon oxides.

products

SECTION 6: Accidental release measures

Personal precautions : Use personal protective equipment. Ensure adequate

ventilation. Remove all sources of ignition. Evacuate
personnel to safe areas. Beware of vapors accumulating to
form explosive concentrations. Vapors can accumulate in low
areas.

Environmental precautions : Prevent product from entering drains. Prevent further leakage
or spillage if safe to do so. If the product contaminates rivers
and lakes or drains inform respective authorities.

Methods for cleaning up : Contain spillage, and then collect with non-combustible
absorbent material, (e.g. sand, earth, diatomaceous earth,
vermiculite) and place in container for disposal according to
local / national regulations (see section 13).

SECTION 7: Handling and storage

Handling

Advice on safe handling : Avoid formation of aerosol. Do not breathe vapors/dust. Avoid
exposure - obtain special instructions before use. Avoid
contact with skin and eyes. For personal protection see
section 8. Smoking, eating and drinking should be prohibited
in the application area. Take precautionary measures against
static discharges. Provide sufficient air exchange and/or
exhaust in work rooms. Container may be opened only under
exhaust ventilation hood. Open drum carefully as content may
be under pressure. Dispose of rinse water in accordance with
local and national regulations.

Advice on protection : Do not spray on an open flame or any other incandescent

against fire and explosion material. Take necessary action to avoid static electricity
discharge (which might cause ignition of organic vapors). Use
only explosion-proof equipment. Keep away from open flames,
hot surfaces and sources of ignition.

Storage

Requirements for storage : No smoking. Keep container tightly closed in a dry and well-
areas and containers ventilated place. Containers which are opened must be
carefully resealed and kept upright to prevent leakage.
Observe label precautions. Electrical installations / working

SDS Number:100000013397 5/21

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materials must comply with the technological safety standards.

Use : Chemical intermediate

SECTION 8: Exposure controls/personal protection

Ingredients with workplace control parameters

US
Components Basis Value Control parameters Note
Isopentane ACGIH TWA 1,000 ppm,
n-Pentane OSHA Z-1 TWA 1,000 ppm, 2,950 mg/m3 (b),
OSHA Z-1-A TWA 600 ppm, 1,800 mg/m3
OSHA Z-1-A STEL 750 ppm, 2,250 mg/m3
ACGIH TWA 1,000 ppm,
Isoprene US WEEL TWA 2 ppm,
Cyclopentadiene OSHA Z-1 TWA 75 ppm, 200 mg/m3 (b),
OSHA Z-1-A TWA 75 ppm, 200 mg/m3
ACGIH TWA 0.5 ppm, URT irr, LRT irr, eye irr,
ACGIH STEL 1 ppm,
Benzene, dimethyl- OSHA Z-1 TWA 100 ppm, 435 mg/m3 (b),
OSHA Z-1-A STEL 150 ppm, 655 mg/m3
OSHA Z-1-A TWA 100 ppm, 435 mg/m3
CNS impair, URT irr,
ACGIH TWA 100 ppm,
eye irr, BEI, A4,
CNS impair, URT irr,
ACGIH STEL 150 ppm,
eye irr, BEI, A4,
Ethylbenzene OSHA Z-1 TWA 100 ppm, 435 mg/m3 (b),
OSHA Z-1-A TWA 100 ppm, 435 mg/m3
OSHA Z-1-A STEL 125 ppm, 545 mg/m3
cochlear imp, kidney
ACGIH TWA 20 ppm, dam (nephropathy),
URT irr, BEI, A3,
n-Butane OSHA Z-1-A TWA 800 ppm, 1,900 mg/m3
ACGIH STEL 1,000 ppm, CNS impair, EX,
CNS impair, URT irr,
Methylcyclopentane ACGIH TWA 500 ppm,
eye irr,
CNS impair, URT irr,
ACGIH STEL 1,000 ppm,
eye irr,
OSHA Z-1-A TWA 500 ppm, 1,800 mg/m3
OSHA Z-1-A STEL 1,000 ppm, 3,600 mg/m3
n-Heptane OSHA Z-1 TWA 500 ppm, 2,000 mg/m3 (b),
OSHA Z-1-A TWA 400 ppm, 1,600 mg/m3
OSHA Z-1-A STEL 500 ppm, 2,000 mg/m3
ACGIH TWA 400 ppm, CNS impair, URT irr,
ACGIH STEL 500 ppm, CNS impair, URT irr,
CNS impair, eye irr,
n-hexane ACGIH TWA 50 ppm, peripheral neuropathy,
BEI, Skin,
OSHA Z-1 TWA 500 ppm, 1,800 mg/m3 (b),
OSHA Z-1-A TWA 50 ppm, 180 mg/m3
CNS impair, URT irr,
Cyclopentane ACGIH TWA 600 ppm,
eye irr, skin irr,
OSHA Z-1-A TWA 600 ppm, 1,720 mg/m3
visual impair, female
Toluene ACGIH TWA 20 ppm, repro, pregnancy loss,
BEI, A4,
OSHA Z-2 TWA 200 ppm,
OSHA Z-2 CEIL 300 ppm,
OSHA Z-2 Peak 500 ppm,
OSHA Z-1-A TWA 100 ppm, 375 mg/m3
OSHA Z-1-A STEL 150 ppm, 560 mg/m3
Benzene ACGIH TWA 0.5 ppm, leukemia, BEI, A1, Skin,
ACGIH STEL 2.5 ppm, leukemia, BEI, A1, Skin,
OSHA Z-1-A TWA 1 ppm,
OSHA Z-1-A CEIL 5 ppm,
OSHA Z-2 Peak 50 ppm, (a),
OSHA 29 CFR
TWA 1 ppm,
1910.1028(c)
OSHA 29 CFR
STEL 5 ppm,
1910.1028(c)
OSHA CARC PEL 1 ppm,
OSHA CARC STEL 5 ppm,
1,3-Butadiene ACGIH TWA 2 ppm, cancer, A2,
OSHA Z-1 TWA 1 ppm,
OSHA Z-1 STEL 5 ppm,
OSHA CARC PEL 1 ppm,

SDS Number:100000013397 6/21

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Version 3.0 Revision Date 2019-04-17
OSHA 29 CFR
TWA 1 ppm,
1910.1051(c)
OSHA CARC STEL 5 ppm,
OSHA 29 CFR
STEL 5 ppm,
1910.1051(c)
(a) This standard applies to the industry segments exempt from the 1 ppm 8-hour TWA and 5 ppm STEL of the benzene standard at
1910.1028.
(b) The value in mg/m3 is approximate.
A1 Confirmed human carcinogen
A2 Suspected human carcinogen
A3 Confirmed animal carcinogen with unknown relevance to humans
A4 Not classifiable as a human carcinogen
BEI Substances for which there is a Biological Exposure Index or Indices (see BEI® section)
cancer Cancer
CNS impair Central Nervous System impairment
cochlear imp Cochlear impair
EX Explosion hazard: the substance is a flammable asphyxiant or excursions above the TLV ® could approach 10% of the lower
explosive limit.
eye irr Eye irritation
female repro Female reproductive
kidney dam Kidney damage (nephropathy)
(nephropathy)
leukemia Leukemia
LRT irr Lower Respiratory Tract irritation
peripheral Peripheral neuropathy
neuropathy
pregnancy loss Pregnancy loss
Skin Danger of cutaneous absorption
skin irr Skin irritation
URT irr Upper Respiratory Tract irritation
visual impair Visual impairment

Hazardous components without workplace control parameters

Immediately Dangerous to Life or Health Concentrations (IDLH)

Substance name CAS-No. Control parameters Update

n-Pentane 109-66-0 Immediately Dangerous to Life or Health 1995-03-01
Concentration Value
1500 parts per million
Cyclopentadiene 542-92-7 Immediately Dangerous to Life or Health 1995-03-01
Concentration Value
750 parts per million
Benzene, dimethyl- 1330-20-7 Immediately Dangerous to Life or Health 1995-03-01
Concentration Value
900 parts per million
Ethylbenzene 100-41-4 Immediately Dangerous to Life or Health 1995-03-01
Concentration Value
800 parts per million
n-Heptane 142-82-5 Immediately Dangerous to Life or Health 1995-03-01
Concentration Value
750 parts per million
n-hexane 110-54-3 Immediately Dangerous to Life or Health 1995-03-01
Concentration Value
1100 parts per million
Toluene 108-88-3 Immediately Dangerous to Life or Health 1995-03-01
Concentration Value
500 parts per million
Benzene 71-43-2 Immediately Dangerous to Life or Health 1995-03-01
Concentration Value
500 parts per million
1,3-Butadiene 106-99-0 Immediately Dangerous to Life or Health 1995-03-01
Concentration Value
2000 parts per million

Biological exposure indices

US
Substance name CAS-No. Control parameters Sampling time Update

SDS Number:100000013397 7/21

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Benzene, dimethyl- 1330-20-7 Methylhippuric acids: 1.5 g/g End of shift (As 2013-03-01
creatinine (Urine) soon as possible
after exposure
ceases)
Ethylbenzene 100-41-4 Sum of mandelic acid and phenyl End of shift (As 2016-03-01
glyoxylic acid: 0.15 g/g creatinine soon as possible
(Urine) after exposure
ceases)
n-hexane 110-54-3 2,5-Hexanedione: 0.4 mg/l End of shift at 2007-01-01
(Urine) end of workweek
Toluene 108-88-3 Toluene: 0.02 mg/l (In blood) Prior to last shift 2010-03-01
of workweek
Toluene: 0.03 mg/l (Urine) End of shift (As 2010-03-01
soon as possible
after exposure
ceases)
o-Cresol: 0.3 mg/g Creatinine End of shift (As 2010-03-01
(Urine) soon as possible
after exposure
ceases)
Benzene 71-43-2 S-Phenylmercapturic acid: 25 End of shift (As 2010-03-01
µg/g creatinine (Urine) soon as possible
after exposure
ceases)
t,t-Muconic acid: 500 µg/g End of shift (As 2010-03-01
creatinine (Urine) soon as possible
after exposure
ceases)
1,3-Butadiene 106-99-0 1,2 Dihydroxy-4-(N-acetylcysteinyl)- End of shift (As 2010-03-01
butane: 2.5 mg/l (Urine) soon as possible
after exposure
ceases)
Mixture of N-1 and N- Not critical 2010-03-01
2(hydroxybutenyl)valine: 2.5
picomoles per gram Hemoglobin
(Hemoglobin (Hb) adducts in blood)
Engineering measures
Adequate ventilation to control airborned concentrations below the exposure guidelines/limits.
Consider the potential hazards of this material (see Section 2), applicable exposure limits, job
activities, and other substances in the work place when designing engineering controls and selecting
personal protective equipment. If engineering controls or work practices are not adequate to prevent
exposure to harmful levels of this material, the personal protective equipment listed below is
recommended. The user should read and understand all instructions and limitations supplied with
the equipment since protection is usually provided for a limited time or under certain circumstances.

Personal protective equipment

Respiratory protection : Wear a supplied-air NIOSH approved respirator unless

ventilation or other engineering controls are adequate to
maintain minimal oxygen content of 19.5% by volume under
normal atmospheric pressure. Wear a NIOSH approved
respirator that provides protection when working with this
material if exposure to harmful levels of airborne material may
occur, such as:. Air-Purifying Respirator for Organic Vapors.
Full-Face Air-Purifying Respirator for Organic Vapors, Dusts
and Mists. Use a positive pressure, air-supplying respirator if
there is potential for uncontrolled release, exposure levels are
not known, or other circumstances where air-purifying
respirators may not provide adequate protection.

Hand protection : The suitability for a specific workplace should be discussed

with the producers of the protective gloves. Please observe
the instructions regarding permeability and breakthrough time
which are provided by the supplier of the gloves. Also take into
consideration the specific local conditions under which the

SDS Number:100000013397 8/21

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product is used, such as the danger of cuts, abrasion, and the
contact time. Gloves should be discarded and replaced if there
is any indication of degradation or chemical breakthrough.

Eye protection : Eye wash bottle with pure water. Tightly fitting safety goggles.

Skin and body protection : Choose body protection in relation to its type, to the
concentration and amount of dangerous substances, and to the
specific work-place. Wear as appropriate:. Flame retardant
antistatic protective clothing. Workers should wear antistatic
footwear.

Hygiene measures : When using do not eat or drink. When using do not smoke.
Wash hands before breaks and at the end of workday.

SECTION 9: Physical and chemical properties

Information on basic physical and chemical properties

Appearance
Physical state : Liquid
Color : Colorless
Odor : distinct, hydrocarbon-like

Safety data
Flash point : -54 °C (-65 °F)
Method: Tag closed cup

Lower explosion limit : 1.5 %(V)

Upper explosion limit : 8.9 %(V)

Oxidizing properties : No

Autoignition temperature : 220 °C (428 °F)

Thermal decomposition : No data available

Molecular formula : UVCB

Molecular weight : Not applicable

pH : Not applicable

Freezing point : -147 °C (-233 °F)

Pour point No data available

Boiling point/boiling range : 33.9 °C (93.0 °F)

Vapor pressure : 400.00 MMHG

at 20 °C (68 °F)

Relative density : 0.66 - 0.69

at 15.6 °C (60.1 °F)
SDS Number:100000013397 9/21
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Water solubility : Insoluble

Partition coefficient: n- : No data available

octanol/water
Viscosity, kinematic : No data available

Relative vapor density : 2.4

(Air = 1.0)

Evaporation rate : No data available

SECTION 10: Stability and reactivity

Chemical stability : This material is considered stable under normal ambient and
anticipated storage and handling conditions of temperature
and pressure.

Possibility of hazardous reactions

Hazardous reactions : Hazardous reactions: Hazardous polymerization does not

occur.

Further information: No decomposition if stored and applied as

directed.

Hazardous reactions: Vapors may form explosive mixture with

air.

Conditions to avoid : Heat, flames and sparks.

Materials to avoid : May react with oxygen and strong oxidizing agents, such as
chlorates, nitrates, peroxides, etc.

Thermal decomposition : No data available

Hazardous decomposition : Carbon oxides

products

Other data : No decomposition if stored and applied as directed.

SECTION 11: Toxicological information

Isoprene Feedstock
Acute oral toxicity : LD50: 310.56 mg/kg
Species: Rat
Method: Acute toxicity estimate

Isoprene Feedstock
Acute inhalation toxicity : LC50: > 20 mg/l
Species: Rat
Test atmosphere: vapor

SDS Number:100000013397 10/21

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Method: Acute toxicity estimate

Isoprene Feedstock
Acute dermal toxicity : LD50 Dermal: > 2,000 mg/kg
Species: Rabbit
Method: Acute toxicity estimate

Isoprene Feedstock
Skin irritation : Irritating to skin.

May cause skin irritation in susceptible persons.

Isoprene Feedstock
Eye irritation : Irritating to eyes.

Vapors may cause irritation to the eyes, respiratory system

and the skin.

Isoprene Feedstock
Sensitization : Did not cause sensitization on laboratory animals.
Information refers to the main ingredient.

Isoprene Feedstock
Repeated dose toxicity : This information is not available.

Genotoxicity in vitro
Isopentane : Test Type: Ames test
Concentration: 1, 2, 5, 8, 10%
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative

Test Type: Ames test

Concentration: 1, 2, 5, 8, 10, 25, 50%
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: Information given is based on data obtained from
similar substances.

Test Type: Chromosome aberration test in vitro

Metabolic activation: with and without metabolic activation
Method: Mutagenicity (in vitro mammalian cytogenetic test)
Result: negative
Remarks: Information given is based on data obtained from
similar substances.

n-Pentane Test Type: Ames test

Metabolic activation: with and without metabolic activation
Result: negative

Test Type: Chromosome aberration test in vitro

Metabolic activation: with and without metabolic activation
Result: Ambiguous

Isoprene Test Type: Ames test

SDS Number:100000013397 11/21

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Result: negative

Test Type: Sister Chromatid Exchange Assay

Result: positive

Benzene, dimethyl- Test Type: Ames test

Result: negative

Test Type: Mouse lymphoma assay

Result: negative

Ethylbenzene Test Type: Ames test

Result: negative

Test Type: Unscheduled DNA synthesis assay

Result: negative

n-Butane Test Type: Ames test

Result: negative

n-Heptane Test Type: Ames test

Method: Mutagenicity (Escherichia coli - reverse mutation
assay)
Result: negative

Test Type: Mammalian cell gene mutation assay

Method: OECD Guideline 476
Result: negative

Test Type: Chromosome aberration test in vitro

Method: OECD Guideline 473
Result: negative

Test Type: Mitotic recombination

Result: negative

n-hexane Test Type: Ames test

Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative

Test Type: Mouse lymphoma assay

Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative

Test Type: Mouse lymphoma assay

Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: Positive results were obtained in some in vitro tests.

Cyclopentane Test Type: Modified Ames test

Concentration: 1250 microgram/plate
Metabolic activation: with and without metabolic activation
Method: see user defined free text
Result: negative
Remarks: In vitro tests did not show mutagenic effects

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Test Type: Mouse lymphoma assay
Concentration: 200 microgram/mililiter
Metabolic activation: with and without metabolic activation
Result: negative
Remarks: In vitro tests did not show mutagenic effects

Toluene Test Type: Ames test

Result: negative

Test Type: Sister Chromatid Exchange Assay

Result: negative

Test Type: Mouse lymphoma assay

Result: negative

Test Type: Cytogenetic assay

Result: negative

Benzene Test Type: Ames test

Result: negative

Test Type: Cytogenetic assay

Result: positive

Test Type: Mouse lymphoma assay

Result: positive

Test Type: Sister Chromatid Exchange Assay

Result: negative

1,3-Butadiene Test Type: Ames test

Metabolic activation: with and without metabolic activation
Result: Positive results were obtained in some in vitro tests.

Test Type: Chromosome aberration test in vitro

Test system: Chinese hamster cells
Method: OECD Guideline 473
Result: positive

Genotoxicity in vivo
Isopentane : Test Type: In vivo micronucleus test
Species: Rat
Cell type: Bone marrow
Route of Application: inhalation (vapor)
Method: Directive 67/548/EEC, Annex V, B.12.
Remarks: Information given is based on data obtained from
similar substances.

n-Pentane Test Type: Micronucleus test

Species: Rat
Cell type: Bone marrow
Result: negative

Isoprene Result: negative

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Test Type: Micronucleus test
Result: positive

Benzene, dimethyl- Test Type: Mouse micronucleus assay

Result: negative

Ethylbenzene Test Type: Mouse micronucleus assay

Species: Mouse
Result: negative

n-hexane Test Type: Dominant lethal assay

Species: Mouse
Dose: 100 and 400 ppm
Result: negative

Test Type: Cytogenetic assay

Species: Rat
Dose: 900, 3000, 9000 ppm
Result: negative

Cyclopentane Test Type: Micronucleus test

Species: Mouse
Dose: 28.7 mg/l
Result: negative

Toluene Test Type: Cytogenetic assay

Result: negative

Test Type: Mouse micronucleus assay

Result: negative

Benzene Test Type: Mouse micronucleus assay

Result: positive

1,3-Butadiene Test Type: Mouse micronucleus assay

Species: mice
Route of Application: inhalation (gas)
Exposure time: 6 h per day for 5 days
Dose: 50, 200, 500, 1300 ppm
Method: OECD Test Guideline 474
Result: positive

Test Type: Dominant lethal assay

Species: mice
Method: OECD Test Guideline 478
Result: Positive results were obtained in some in vivo tests.

Isoprene Feedstock
Carcinogenicity : Remarks: This information is not available.

Isoprene Feedstock
Reproductive toxicity : This information is not available.

Isoprene Feedstock
Developmental Toxicity : This information is not available.

SDS Number:100000013397 14/21

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Isoprene Feedstock
Version 3.0 Revision Date 2019-04-17
Isoprene Feedstock
Aspiration toxicity : May be fatal if swallowed and enters airways.
Substances known to cause human aspiration toxicity hazards
or to be regarded as if they cause human aspiration toxicity
hazard.
Toxicology Assessment

Isoprene Feedstock
CMR effects : Carcinogenicity:
May cause cancer.
Mutagenicity:
May cause genetic defects.
Teratogenicity:
Not available
Reproductive toxicity:
May damage the unborn child.

Isoprene Feedstock
Further information : Symptoms of overexposure may be headache, dizziness,
tiredness, nausea and vomiting. Concentrations substantially
above the TLV value may cause narcotic effects. Solvents
may degrease the skin.

SECTION 12: Ecological information

Ecotoxicity effects

Toxicity to fish : Toxic to fish.

Information given is based on data obtained from similar
substances.

Toxicity to daphnia and : Toxic to aquatic organisms.

other aquatic invertebrates Information given is based on data obtained from similar
substances.

Toxicity to algae : Toxic to algae.

Information given is based on data obtained from similar
substances.

Toxicity to fish (Chronic toxicity)

n-Heptane : NOELR: 1.284 mg/l

Exposure time: 28 d
Species: Oncorhynchus mykiss (rainbow trout)
Method: QSAR modeled data

Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity)

Ethylbenzene : NOEC: 1 mg/l

Exposure time: 7 d
SDS Number:100000013397 15/21
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Isoprene Feedstock
Version 3.0 Revision Date 2019-04-17
Species: Daphnia pulex (Water flea)
semi-static test
Analytical monitoring: yes

Biodegradability : Expected to be ultimately biodegradable

Elimination information (persistence and degradability)

Bioaccumulation : This material is not expected to bioaccumulate.

Results of PBT assessment : This mixture contains no substance considered to be

persistent, bioaccumulating and toxic (PBT).

Additional ecological : An environmental hazard cannot be excluded in the event of

information unprofessional handling or disposal., Toxic to aquatic life with
long lasting effects.

Ecotoxicology Assessment
Short-term (acute) aquatic : Toxic to aquatic life.
hazard
Long-term (chronic) aquatic : Toxic to aquatic life with long lasting effects.
hazard

SECTION 13: Disposal considerations

The information in this SDS pertains only to the product as shipped.

Use material for its intended purpose or recycle if possible. This material, if it must be discarded,
may meet the criteria of a hazardous waste as defined by US EPA under RCRA (40 CFR 261) or
other State and local regulations. Measurement of certain physical properties and analysis for
regulated components may be necessary to make a correct determination. If this material is
classified as a hazardous waste, federal law requires disposal at a licensed hazardous waste
disposal facility.

Product : The product should not be allowed to enter drains, water

courses or the soil. Do not contaminate ponds, waterways or
ditches with chemical or used container. Send to a licensed
waste management company.

Contaminated packaging : Empty remaining contents. Dispose of as unused product.

Do not re-use empty containers. Do not burn, or use a cutting
torch on, the empty drum.

SECTION 14: Transport information

The shipping descriptions shown here are for bulk shipments only, and may not apply to
shipments in non-bulk packages (see regulatory definition).

Consult the appropriate domestic or international mode-specific and quantity-specific Dangerous

Goods Regulations for additional shipping description requirements (e.g., technical name or names,
etc.) Therefore, the information shown here, may not always agree with the bill of lading shipping
description for the material. Flashpoints for the material may vary slightly between the SDS and the
bill of lading.

US DOT (UNITED STATES DEPARTMENT OF TRANSPORTATION)

UN3295, HYDROCARBONS, LIQUID, N.O.S., 3, I, MARINE POLLUTANT, (ISOPRENE), RQ

SDS Number:100000013397 16/21

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Version 3.0 Revision Date 2019-04-17
(BENZENE, 1,3-BUTADIENE)

IMO / IMDG (INTERNATIONAL MARITIME DANGEROUS GOODS)

UN3295, HYDROCARBONS, LIQUID, N.O.S., 3, I, (-54 °C), MARINE POLLUTANT, (NAPHTHA,
(PETROLEUM), LIGHT STEAM-CRACKED, ISOPRENE-RICH)

IATA (INTERNATIONAL AIR TRANSPORT ASSOCIATION)

UN3295, HYDROCARBONS, LIQUID, N.O.S., 3, I

ADR (AGREEMENT ON DANGEROUS GOODS BY ROAD (EUROPE))

UN3295, HYDROCARBONS, LIQUID, N.O.S., 3, I, (D/E), ENVIRONMENTALLY
HAZARDOUS, (NAPHTHA, (PETROLEUM), LIGHT STEAM-CRACKED, ISOPRENE-
RICH)

RID (REGULATIONS CONCERNING THE INTERNATIONAL TRANSPORT OF

DANGEROUS GOODS (EUROPE))
UN3295, HYDROCARBONS, LIQUID, N.O.S., 3, I, ENVIRONMENTALLY HAZARDOUS,
(NAPHTHA, (PETROLEUM), LIGHT STEAM-CRACKED, ISOPRENE-RICH)

ADN (EUROPEAN AGREEMENT CONCERNING THE INTERNATIONAL CARRIAGE

OF DANGEROUS GOODS BY INLAND WATERWAYS)
UN3295, HYDROCARBONS, LIQUID, N.O.S., 3, I, ENVIRONMENTALLY HAZARDOUS,
(NAPHTHA, (PETROLEUM), LIGHT STEAM-CRACKED, ISOPRENE-RICH)

Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

SECTION 15: Regulatory information

National legislation

SARA 311/312 Hazards : Flammable (gases, aerosols, liquids, or solids)

Acute toxicity (any route of exposure)
Skin corrosion or irritation
Serious eye damage or eye irritation
Germ cell mutagenicity
Carcinogenicity
Reproductive toxicity
Specific target organ toxicity (single or repeated exposure)
Aspiration hazard

EPCRA - EMERGENCY PLANNING COMMUNITY RIGHT - TO – KNOW

CERCLA Reportable : 167 lbs

Quantity
Isoprene

SDS Number:100000013397 17/21

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SARA 302 Reportable : This material does not contain any components with a SARA
Quantity 302 RQ.

SARA 302 Threshold : No chemicals in this material are subject to the reporting
Planning Quantity requirements of SARA Title III, Section 302.

SARA 304 Reportable : This material does not contain any components with a section
Quantity 304 EHS RQ.

SARA 313 Components : The following components are subject to reporting levels
established by SARA Title III, Section 313:

: Dicyclopentadiene - 77-73-6
Benzene, dimethyl- - 1330-20-7
Ethylbenzene - 100-41-4
n-hexane - 110-54-3
Toluene - 108-88-3
Benzene - 71-43-2
1,3-Butadiene - 106-99-0
Styrene - 100-42-5

Clean Air Act

Ozone-Depletion : This product neither contains, nor was manufactured with a Class I or
Potential Class II ODS as defined by the U.S. Clean Air Act Section 602 (40 CFR
82, Subpt. A, App.A + B).

The following chemical(s) are listed as HAP under the U.S. Clean Air Act, Section 12 (40 CFR 61):
: Ethylbenzene - 100-41-4
n-hexane - 110-54-3
Toluene - 108-88-3
Benzene - 71-43-2

The following chemical(s) are listed under the U.S. Clean Air Act Section 112(r) for Accidental
Release Prevention (40 CFR 68.130, Subpart F):
: Isopentane - 78-78-4
Isoprene - 78-79-5
n-Butane - 106-97-8
cis-2-Pentene - 627-20-3
trans-2-Pentene - 646-04-8
3-Methyl-1-Butene - 563-45-1
2-methyl-1-butene - 563-46-2

The following chemical(s) are listed under the U.S. Clean Air Act Section 111 SOCMI Intermediate or
Final VOC's (40 CFR 60.489):
: Isopentane - 78-78-4
Isoprene - 78-79-5
SDS Number:100000013397 18/21
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Version 3.0 Revision Date 2019-04-17
Benzene, dimethyl- - 1330-20-7
Ethylbenzene - 100-41-4
Toluene - 108-88-3
Benzene - 71-43-2

US State Regulations

Pennsylvania Right To Know

: Isopentane - 78-78-4
n-Pentane - 109-66-0
Isoprene - 78-79-5
Cyclopentadiene - 542-92-7
Benzene, dimethyl- - 1330-20-7
Ethylbenzene - 100-41-4
n-Butane - 106-97-8
n-Heptane - 142-82-5
n-hexane - 110-54-3
Cyclopentane - 287-92-3
Toluene - 108-88-3
Benzene - 71-43-2
1,3-Butadiene - 106-99-0
Methylcyclopentane - 96-37-7

California Prop. 65 : WARNING: This product can expose you to chemicals including
Components [listed below], which is [are] known to the State of California to
cause cancer. For more information go to
www.P65Warnings.ca.gov/food.

Isoprene 78-79-5

WARNING: This product can expose you to chemicals including

[listed below], which is [are] known to the State of California to
cause birth defects or other reproductive harm. For more
information go to www.P65Warnings.ca.gov.

Toluene 108-88-3

Notification status
Europe REACH : Not in compliance with the inventory
Switzerland CH INV : On the inventory, or in compliance with the inventory
United States of America (USA) : On the inventory, or in compliance with the inventory
TSCA
Canada NDSL : On the inventory, or in compliance with the inventory
Australia AICS : Not in compliance with the inventory
New Zealand NZIoC : Not in compliance with the inventory
Japan ENCS : On the inventory, or in compliance with the inventory
Korea KECI : On the inventory, or in compliance with the inventory

SDS Number:100000013397 19/21

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Version 3.0 Revision Date 2019-04-17
Philippines PICCS : Not in compliance with the inventory
China IECSC : Not in compliance with the inventory

SECTION 16: Other information

NFPA Classification : Health Hazard: 2

Fire Hazard: 4
Reactivity Hazard: 2
4
2 2

Further information
Legacy SDS Number : PE0052

Significant changes since the last version are highlighted in the margin. This version replaces all
previous versions.

The information in this SDS pertains only to the product as shipped.

The information provided in this Safety Data Sheet is correct to the best of our knowledge,
information and belief at the date of its publication. The information given is designed only as a
guidance for safe handling, use, processing, storage, transportation, disposal and release and is
not to be considered a warranty or quality specification. The information relates only to the
specific material designated and may not be valid for such material used in combination with any
other materials or in any process, unless specified in the text.

Key or legend to abbreviations and acronyms used in the safety data sheet
ACGIH American Conference of LD50 Lethal Dose 50%
Government Industrial Hygienists
AICS Australia, Inventory of Chemical LOAEL Lowest Observed Adverse Effect
Substances Level
DSL Canada, Domestic Substances NFPA National Fire Protection Agency
List
NDSL Canada, Non-Domestic NIOSH National Institute for Occupational
Substances List Safety & Health
CNS Central Nervous System NTP National Toxicology Program
CAS Chemical Abstract Service NZloC New Zealand Inventory of
Chemicals
EC50 Effective Concentration NOAEL No Observable Adverse Effect
Level
EC50 Effective Concentration 50% NOEC No Observed Effect Concentration
EGEST EOSCA Generic Exposure OSHA Occupational Safety & Health
Scenario Tool Administration
EOSCA European Oilfield Specialty PEL Permissible Exposure Limit
Chemicals Association
EINECS European Inventory of Existing PICCS Philippines Inventory of
Chemical Substances Commercial Chemical Substances
MAK Germany Maximum Concentration PRNT Presumed Not Toxic
Values
GHS Globally Harmonized System RCRA Resource Conservation Recovery
Act
>= Greater Than or Equal To STEL Short-term Exposure Limit
IC50 Inhibition Concentration 50% SARA Superfund Amendments and
Reauthorization Act.
IARC International Agency for Research TLV Threshold Limit Value
on Cancer
SDS Number:100000013397 20/21
 SAFETY DATA SHEET
Isoprene Feedstock
Version 3.0 Revision Date 2019-04-17
IECSC Inventory of Existing Chemical TWA Time Weighted Average
Substances in China
ENCS Japan, Inventory of Existing and TSCA Toxic Substance Control Act
New Chemical Substances
KECI Korea, Existing Chemical UVCB Unknown or Variable Composition,
Inventory Complex Reaction Products, and
Biological Materials
<= Less Than or Equal To WHMIS Workplace Hazardous Materials
Information System
LC50 Lethal Concentration 50%

SDS Number:100000013397 21/21