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Statistics Questions With Answers

1. The document provides examples of statistics questions and answers. The first question asks about the likelihood of abnormal lab values on a screening test with a 95% confidence interval for normal values (answer is 64%). The second asks about the likelihood a positive test indicates illness for a rare disease with a 100% sensitive and 95% specific test (answer is less than 2%). 2. The third question provides data on BRCA1 gene expression levels in breast cancer patients and normal individuals. It asks about the typical and variable expression levels between the groups. The cancer patients have a higher mean expression level of 2.5 compared to 1.2 for normal individuals, with larger standard deviation for cancer patients. 3. Additional analysis

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Julie V. Alegado
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60 views2 pages

Statistics Questions With Answers

1. The document provides examples of statistics questions and answers. The first question asks about the likelihood of abnormal lab values on a screening test with a 95% confidence interval for normal values (answer is 64%). The second asks about the likelihood a positive test indicates illness for a rare disease with a 100% sensitive and 95% specific test (answer is less than 2%). 2. The third question provides data on BRCA1 gene expression levels in breast cancer patients and normal individuals. It asks about the typical and variable expression levels between the groups. The cancer patients have a higher mean expression level of 2.5 compared to 1.2 for normal individuals, with larger standard deviation for cancer patients. 3. Additional analysis

Uploaded by

Julie V. Alegado
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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S tatistics column

Statistics questions with answers

Please consider and work through the following Breast cancer patients Normal individuals
questions. 2.34 1.31
1.72 0.99
1. You are screening normal and healthy GOOGLE 2.98 1.30
employees. Your screening test is a Chem 20. 1.70 1.48
Each test has a normal range representing the 2.04 1.35
95% confidence limits of normal values. What is 2.57 1.22
the likelihood that any given patient will have at 1.90 1.14
least 1 abnormal lab value on this test? 1.07 1.23
2.89 1.31
Answer 3.35 1.08
1- 0.9520 = 64% 1.60 2.00
4.26 0.50
2. You are screening young patients for an illness 1.99 1.51
that does not manifest until later in life. The illness 1.78 1.17
has no clinical signs or symptoms in the young but 2.56 1.43
can be identified by a laboratory test.  The prev- 4.57 1.15
alence of the illness in the population is 1/1000. 0.57 1.53
The test has a 100% sensitivity and a 95% spec- 1.66 0.80
ificity. What is the likelihood that a subject with a 2.00 1.85
positive test has the illness? 4.89 1.03
Answer 4.61 1.40

less than 2%
On average 1000 patients will include 1 with
What is the representative or typical BRAC1
the illness and 999 healthy patients. Since the
gene expression value for each group? Do the
test has 100% sensitivity, the 1 patient with the
two groups have similar amounts of variability?
illness generates 1 positive result. Since the test
What is the appropriate approach to describe the
has 95% specificity, the healthy subjects generate
data?
999 * 0.05 or slightly less than 50 positive results.
Out of 51 positive tests, 1 will have the illness or Answer
less than 2%.
Plot the data to check for potential outliers,
3. The BRAC1 gene expression values (normalized typos, and skewness of the data. For data with
read count) for a group of breast cancer patients symmetric distribution, mean and standard devi-
and a group of independent normal individuals ation can be used; otherwise, median and range
are presented in the following table. can be used.

The Southwest Respiratory and Critical Care Chronicles 2017;5(21):53–54 53


Statistics Questions With Answers

Q-Q plot can also be generalized for visualizing data


normality. The mean gene expression for the can-
cer patients and normal individuals are 2.5 and 1.2,
respectively. The corresponding standard deviations
are 1.2 and 0.33, respectively. A Bartlett’s test shows
that there is a significant difference in data variation
between the two groups (p<0.001), and a two sam-
ple t test shows that cancer patients have significant
higher expression of this gene than the normal indi-
viduals (p<0.001).
If you have questions or need assistance, please
email Gilbert Berdine at gilbert.berdine @ttuhsc.edu
or Shengping Yang at [email protected]

From the boxplot, we did not see any obvious


outliers, and the data do not seem to be skewed. A Submitted: 10/7/2017

54 The Southwest Respiratory and Critical Care Chronicles 2017;5(21):53–54

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