NHS

National Institute for

Health and Clinical Excellence

Quick reference guide

Antenatal care
Routine care for the healthy pregnant woman

Issue date: March 2008

June 2010
Recommendations on smoking in pregnancy have
been further developed in ‘How to stop smoking in
pregnancy and following childbirth’ (NICE public
health guidance 26). One recommendation on
page 24 of this document has been replaced.
For more information see
www.nice.org.uk/guidance/PH26

NICE clinical guideline 62 (partially updates and replaces NICE clinical guideline 6)
Developed by the National Collaborating Centre for Women’s and Children’s Health
About this booklet
This is a quick reference guide that summarises the recommendations NICE has made to the NHS in ‘Antenatal care:
routine care for the healthy pregnant woman’ (NICE clinical guideline 62). This guidance partially updates and replaces
NICE clinical guideline 6 (published October 2003).
In the update, the recommendations on antenatal information, gestational age assessment, vitamin D supplementation,
alcohol consumption, screening for haemoglobinopathies, screening for structural anomalies, screening for Down’s
syndrome, screening for chlamydia, gestational diabetes, pre-eclampsia, asymptomatic bacteriuria, placenta praevia,
preterm birth, and fetal growth and wellbeing, as well as the schedule of antenatal appointments, have changed. In
addition, some recommendations on smoking cessation and mental health have changed because NICE has produced
public health guidance on smoking cessation (NICE public health guidance 10) and the antenatal and postnatal mental
health clinical guideline (NICE clinical guideline 45). Following NICE protocol, we incorporated the relevant
recommendations verbatim into the guideline and marked them clearly. No other recommendations are affected.

Who should read this booklet?

This quick reference guide is for midwives, doctors and other staff who care for healthy pregnant women.

Who wrote the guideline?

The guideline was developed by the National Collaborating Centre for Women’s and Children’s Health, which is linked
with the Royal College of Obstetricians and Gynaecologists. The Collaborating Centre worked with a group of healthcare
professionals (including consultant obstetricians, GPs and midwives), user representatives, and technical staff, who
reviewed the evidence and drafted the recommendations. The recommendations were finalised after public consultation.
For more information on how NICE clinical guidelines are developed, go to www.nice.org.uk

Where can I get more information about the guideline?

The NICE website has the recommendations in full, reviews of the evidence they are based on, a summary of the
guideline for patients and carers, and tools to support implementation (see inside back cover for more details).
Contents
Woman-centred care 4

Key priorities for implementation 5

Women needing additional care 8

Antenatal information 10

Contents
Basic principles of antenatal care 12

Schedule of appointments 13

Antenatal interventions NOT routinely recommended 22

Lifestyle advice 23

Implementation tools 26

Further information 27

NICE clinical guidelines are recommendations about the treatment and care of people with specific diseases and
conditions in the NHS in England and Wales.
This guidance represents the view of the Institute, which was arrived at after careful consideration of the evidence
available. Healthcare professionals are expected to take it fully into account when exercising their clinical
judgement. The guidance does not, however, override the individual responsibility of healthcare professionals to
make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or
guardian or carer, and informed by the summary of product characteristics of any drugs they are considering.
 Woman-centred care
Women, their partners and their families should always be treated with kindness, respect and dignity.
The views, beliefs and values of the woman, her partner and her family in relation to her care and that of
her baby should be sought and respected at all times.
Women should have the opportunity to make informed decisions about their care and treatment, in
partnership with their healthcare professionals. If women do not have the capacity to make decisions,
healthcare professionals should follow the Department of Health guidelines – ‘Reference guide to consent
Woman-centred care

for examination or treatment’ (2001) (available from www.dh.gov.uk). Since April 2007 healthcare
professionals should also follow a code of practice accompanying the Mental Capacity Act (summary
available from www.publicguardian.gov.uk).
Good communication between healthcare professionals and women is essential. It should be supported
by evidence-based, written information tailored to the woman’s needs. Care and information should be
culturally appropriate. All information should also be accessible to women with additional needs such as
physical, sensory or learning disabilities, and to women who do not speak or read English.
Every opportunity should be taken to provide the woman and her partner or other relevant family
members with the information and support they need.

4 NICE clinical guideline 62 Quick reference guide

Key priorities for implementation
Antenatal information
● New Pregnant women should be offered information based on the current available evidence
together with support to enable them to make informed decisions about their care. This
information should include where they will be seen and who will undertake their care.

Key priorities for implementation

Lifestyle considerations
● New All women should be informed at the booking appointment about the importance for their
own and their baby’s health of maintaining adequate vitamin D stores during pregnancy and
whilst breastfeeding. In order to achieve this, women may choose to take 10 micrograms of
vitamin D per day, as found in the Healthy Start multivitamin supplement. Particular care should be
taken to enquire as to whether women at greatest risk are following advice to take this daily
supplement. These include:
– women of South Asian, African, Caribbean or Middle Eastern family origin
– women who have limited exposure to sunlight, such as women who are predominantly
housebound, or usually remain covered when outdoors
– women who eat a diet particularly low in vitamin D, such as women who consume no oily fish,
eggs, meat, vitamin D-fortified margarine or breakfast cereal
– women with a pre-pregnancy body mass index above 30 kg/m2.
continued

NICE clinical guideline 62 Quick reference guide 5

 Key priorities for implementation
Screening for haematological conditions
● New Screening for sickle cell diseases and thalassaemias should be offered to all women as early
as possible in pregnancy (ideally by 10 weeks). The type of screening depends upon the prevalence
and can be carried out in either primary or secondary care.
Key priorities for implementation

Screening for fetal anomalies

● New Participation in regional congenital anomaly registers and/or UK National Screening
Committee-approved audit systems is strongly recommended to facilitate the audit of
detection rates.
● New The ‘combined test’ (nuchal translucency, beta-human chorionic gonadotrophin,
pregnancy-associated plasma protein-A) should be offered to screen for Down’s syndrome
between 11 weeks 0 days and 13 weeks 6 days. For women who book later in pregnancy the
most clinically and cost-effective serum screening test (triple or quadruple test) should be offered
between 15 weeks 0 days and 20 weeks 0 days.

6 NICE clinical guideline 62 Quick reference guide

 Screening for clinical conditions
● New Screening for gestational diabetes using risk factors is recommended in a healthy
population. At the booking appointment, the following risk factors for gestational diabetes
should be determined:
– body mass index above 30 kg/m2

Key priorities for implementation

– previous macrosomic baby weighing 4.5 kg or above
– previous gestational diabetes (refer to ‘Diabetes in pregnancy’ [NICE clinical guideline 63],
available from www.nice.org.uk/CG063)
– family history of diabetes (first-degree relative with diabetes)
– family origin with a high prevalence of diabetes:
◆ South Asian (specifically women whose country of family origin is India, Pakistan or
Bangladesh)
◆ black Caribbean
◆ Middle Eastern (specifically women whose country of family origin is Saudi Arabia, United
Arab Emirates, Iraq, Jordan, Syria, Oman, Qatar, Kuwait, Lebanon or Egypt).
Women with any one of these risk factors should be offered testing for gestational diabetes (refer
to ‘Diabetes in pregnancy’ [NICE clinical guideline 63], available from www.nice.org.uk/CG063).

NICE clinical guideline 62 Quick reference guide 7

 Women needing additional care
The guideline makes recommendations on baseline clinical care for all pregnant women. Pregnant
women with the following conditions usually require additional care:
● cardiac disease, including hypertension ● use of recreational drugs such as heroin,
cocaine (including crack cocaine) and ecstasy
● renal disease
HIV or HBV infection
Women needing additional care

●
● endocrine disorders or diabetes
requiring insulin ● obesity (body mass index 30 kg/m2 or above)
or underweight (body mass index
● psychiatric disorders (being treated
below 18 kg/m2)
with medication)
● higher risk of developing complications, for
● haematological disorders
example, women aged 40 and older, women
● autoimmune disorders who smoke
● epilepsy requiring anticonvulsant drugs ● women who are particularly vulnerable (such
● malignant disease as teenagers) or who lack social support.
● severe asthma

8 NICE clinical guideline 62 Quick reference guide

 In addition, women who have experienced any of the following in previous pregnancies usually
require additional care:
● recurrent miscarriage (three or more) ● grand multiparity (parity four or more)
● preterm birth ● a stillbirth or neonatal death

Women needing additional care

● severe pre-eclampsia, HELLP syndrome ● a small-for-gestational-age infant
or eclampsia (below 5th centile)
● rhesus isoimmunisation or other significant ● a large-for-gestational-age infant
blood group antibodies (above 95th centile)
● uterine surgery including caesarean section, ● a baby weighing below 2.5 kg or
myomectomy or cone biopsy above 4.5 kg
● antenatal or postpartum haemorrhage on ● a baby with a congenital abnormality
two occasions (structural or chromosomal).
● puerperal psychosis

NICE clinical guideline 62 Quick reference guide 9

 Antenatal information
Give information that:
● is easily understood by all women, including women with additional needs such as physical, sensory or
learning disabilities, and women who do not speak or read English
● enables women to make informed decisions
Antenatal information

● is clear, consistent, balanced and accurate, and based on the current evidence
● is supported by written information and may also be provided in different formats.

Remember to:
● respect a woman’s decisions, even when her views are contrary to your own
● provide an opportunity for her to discuss concerns and ask questions
● make sure she understands the information
● give her enough time to make decisions
● explain details of antenatal tests and screening in a setting conducive to discussions (group setting or
one-to-one). This should happen before the booking appointment.

10 NICE clinical guideline 62 Quick reference guide

Information should cover:
● where the woman will be seen and who by
● the likely number, timing and content of antenatal appointments
● participant-led antenatal classes and breastfeeding workshops

Antenatal information
● the woman’s right to accept or decline a test.

The following pages contain details about information to give to pregnant women at specific times
during their pregnancy. This information can be supported by ‘The pregnancy book’, other relevant
resources such as UK National Screening Committee publications and the Midwives Information and
Resource Service information leaflets (www.infochoice.org).

NICE clinical guideline 62 Quick reference guide 11

 Basic principles of antenatal care
Midwives and GPs should care for women with an uncomplicated pregnancy, providing continuous care
throughout the pregnancy. Obstetricians and specialist teams should be involved where additional
care is needed.
Antenatal appointments should take place in a location that women can easily access. The location
should be appropriate to the needs of women and their community.
Basic principles of antenatal care

Maternity records should be structured, standardised, national maternity records, held by the woman.
In an uncomplicated pregnancy, there should be 10 appointments for nulliparous women and
7 appointments for parous women.
Each antenatal appointment should have a structure and a focus. Appointments early in pregnancy
should be longer to provide information and time for discussion about screening so that women can
make informed decisions.
If possible, incorporate routine tests into the appointments to minimise inconvenience to women.
Women should feel able to discuss sensitive issues and disclose problems. Be alert to the symptoms and
signs of domestic violence.

12 NICE clinical guideline 62 Quick reference guide

Schedule of appointments
First contact with a healthcare professional Give information
Give specific information on: (supported
● folic acid supplements by written
information
● food hygiene, including how to reduce the risk of a food-acquired infection
and antenatal
● lifestyle, including smoking cessation, recreational drug use and classes), with

Schedule of appointments
alcohol consumption an opportunity
● all antenatal screening, including risks, benefits and limitations of the to discuss
screening tests. issues and
ask questions.

Be alert to any
factors, clinical
and/or social,
that may affect
the health of
the woman
and baby.

For further information about lifestyle see pages 23–25.

NICE clinical guideline 62 Quick reference guide 13

 Give information Booking appointment (ideally by 10 weeks)
(supported Checks and tests
by written ● Identify women who may need additional care (see pages 8 and 9) and plan
information pattern of care for the pregnancy.
and antenatal
● Measure height and weight and calculate body mass index.
classes), with
an opportunity ● Measure blood pressure and test urine for proteinuria.
to discuss
Schedule of appointments

● Determine risk factors for pre-eclampsia and gestational diabetes (refer to

issues and ‘Diabetes in pregnancy’ [NICE clinical guideline 63], available from
ask questions. www.nice.org.uk/CG063).

Be alert to any ● Offer blood tests to check blood group and rhesus D status, and screening for
factors, clinical anaemia, haemoglobinopathies, red-cell alloantibodies, hepatitis B virus, HIV,
and/or social, rubella susceptibility and syphilis.
that may affect ● Offer screening for asymptomatic bacteriuria.
the health of ● Inform women younger than 25 years about the high prevalence of chlamydia
the woman infection in their age group, and give details of their local National Chlamydia
and baby. Screening Programme.
● Offer screening for Down’s syndrome.
● Offer early ultrasound scan for gestational age assessment and ultrasound
screening for structural anomalies.
● Identify women who have had genital mutilation (FGM).

14 NICE clinical guideline 62 Quick reference guide

● Ask about any past or present severe mental illness or psychiatric treatment. Give information
● Ask about mood to identify possible depression. (supported
by written
● Ask about the woman’s occupation to identify potential risks.
information
Give specific information on: and antenatal
● how the baby develops during pregnancy classes), with
● nutrition and diet, including vitamin D supplements
an opportunity
to discuss

Schedule of appointments
● exercise, including pelvic floor exercises issues and
● antenatal screening, including risks and benefits of the screening tests ask questions.
● the pregnancy care pathway Be alert to any
● planning place of birth (refer to ‘Intrapartum care’ [NICE clinical guideline 55], factors, clinical
available from www.nice.org.uk/CG055). and/or social,
● breastfeeding, including workshops that may affect
the health of
● participant-led antenatal classes the woman
● maternity benefits. and baby.

NICE clinical guideline 62 Quick reference guide 15

 Give information For women who choose to have screening, arrange as appropriate:
(supported ● blood tests (blood group, rhesus D status, screening for anaemia,

by written haemoglobinopathies, red-cell alloantibodies, hepatitis B virus, HIV, rubella

information susceptibility and syphilis), ideally before 10 weeks
and antenatal ● urine tests (proteinuria and asymptomatic bacteriuria)
classes), with
● ultrasound scan to determine gestational age using:
an opportunity
– crown–rump measurement between 10 weeks 0 days and 13 weeks 6 days
to discuss
Schedule of appointments

– head circumference if crown–rump length is above 84 mm

issues and
ask questions. ● Down’s syndrome screening using either:
– ‘combined test’ between 11 weeks 0 days and 13 weeks 6 days
Be alert to any – serum screening test (triple or quadruple test) between 15 weeks 0 days
factors, clinical and 20 weeks 0 days
and/or social, ● ultrasound screening for structural anomalies, normally between
that may affect 18 weeks 0 days and 20 weeks 6 days.
the health of
the woman
and baby.

16 NICE clinical guideline 62 Quick reference guide

16 weeks Give information
Checks and tests (supported
● Review, discuss and record the results of screening tests. by written
information
● Measure blood pressure and test urine for proteinuria.
and antenatal
● Investigate a haemoglobin level below 11 g/100 ml and consider classes), with
iron supplements. an opportunity
to discuss

Schedule of appointments
Give specific information on:
● the routine anomaly scan. issues and
ask questions.

Anomaly scan: 18 to 20 weeks Be alert to any

Checks and tests factors, clinical
● If the woman chooses, an ultrasound scan should be performed between and/or social,
18 weeks 0 days and 20 weeks 6 days to detect structural anomalies. that may affect
the health of
● For a woman whose placenta extends across the internal cervical os, offer
the woman
another scan at 32 weeks.
and baby.

NICE clinical guideline 62 Quick reference guide 17

 Give information 25 weeks – for nulliparous women
(supported Checks and tests
by written ● Measure blood pressure and test urine for proteinuria.
information
● Measure and plot symphysis–fundal height.
and antenatal
classes), with
28 weeks
an opportunity
Checks and tests
to discuss
Schedule of appointments

● Measure blood pressure and test urine for proteinuria.

issues and
ask questions. ● Offer a second screening for anaemia and atypical red-cell alloantibodies.
● Investigate a haemoglobin level below 10.5 g/100 ml and consider
Be alert to any
iron supplements.
factors, clinical
and/or social, ● Offer anti-D prophylaxis to women who are rhesus D-negative1.
that may affect ● Measure and plot symphysis–fundal height.
the health of
the woman
and baby.

1 The technology appraisal guidance ‘Guidance on the use of routine antenatal anti-D prophylaxis
for RhD-negative women’ (NICE technology appraisal 41) is being updated and is expected to be
published in June 2008.

18 NICE clinical guideline 62 Quick reference guide

31 weeks – for nulliparous women Give information
Checks and tests (supported
● Review, discuss and record the results of screening tests undertaken at 28 weeks. by written
information
● Measure blood pressure and test urine for proteinuria.
and antenatal
● Measure and plot symphysis–fundal height. classes), with
an opportunity
34 weeks to discuss

Schedule of appointments
Checks and tests issues and
● Review, discuss and record the results of screening tests undertaken at 28 weeks. ask questions.
● Measure blood pressure and test urine for proteinuria.
Be alert to any
● Offer a second dose of anti-D prophylaxis to women who are rhesus D-negative1. factors, clinical
● Measure and plot symphysis–fundal height. and/or social,
that may affect
Give specific information on:
the health of
● preparation for labour and birth, including the birth plan, recognising active
the woman
labour and coping with pain. and baby.

1 The technology appraisal guidance ‘Guidance on the use of routine antenatal anti-D prophylaxis
for RhD-negative women’ (NICE technology appraisal 41) is being updated and is expected to be
published in June 2008.

NICE clinical guideline 62 Quick reference guide 19

 Give information 36 weeks
(supported Checks and tests
by written ● Measure blood pressure and test urine for proteinuria.
information
● Measure and plot symphysis–fundal height.
and antenatal
classes), with ● Check the position of the baby. If breech, offer external cephalic version.
an opportunity Give specific information (at or before 36 weeks) on:
to discuss
Schedule of appointments

● breastfeeding: technique and good management practices, such as detailed in

issues and the UNICEF Baby Friendly Initiative (www.babyfriendly.org.uk)
ask questions.
● care of the new baby, vitamin K prophylaxis and newborn screening tests
Be alert to any ● postnatal self-care, awareness of ‘baby blues’ and postnatal depression.
factors, clinical
and/or social, 38 weeks
that may affect Checks and tests
the health of ● Measure blood pressure and test urine for proteinuria.
the woman
and baby. ● Measure and plot symphysis–fundal height.
Give specific information on:
● options for management of prolonged pregnancy2.

2 The clinical guideline ‘Induction of labour’ is being updated and is expected to be published in
June 2008.

20 NICE clinical guideline 62 Quick reference guide

40 weeks – for nulliparous women Give information
Checks and tests
(supported
● Measure blood pressure and test urine for proteinuria.
by written
information
● Measure and plot symphysis–fundal height. and antenatal
● Further discussion of management of prolonged pregnancy2. classes), with
an opportunity
41 weeks to discuss

Schedule of appointments
Checks and tests issues and
For women who have not given birth by 41 weeks: ask questions.
● offer a membrane sweep2 Be alert to any
● offer induction of labour2 factors, clinical
and/or social,
● measure blood pressure and test urine for proteinuria
that may affect
● measure and plot symphysis–fundal height. the health of
the woman
and baby.
From 42 weeks, offer women who decline induction of labour increased
monitoring (at least twice-weekly cardiotocography and ultrasound examination
of maximum amniotic pool depth).

2 The clinical guideline ‘Induction of labour’ is being updated and is expected to be published in
June 2008.

NICE clinical guideline 62 Quick reference guide 21

 Antenatal interventions NOT routinely recommended
● Repeated maternal weighing.
● Breast or pelvic examination.
● Iron or vitamin A supplements.
● Routine screening for chlamydia, cytomegalovirus, hepatitis C virus, group B streptococcus,
toxoplasmosis, bacterial vaginosis.
Antenatal interventions NOT routinely recommended

● Routine Doppler ultrasound in low-risk pregnancies.

● Ultrasound estimation of fetal size for suspected large-for-gestational-age unborn babies.
● Routine screening for preterm labour.
● Routine screening for cardiac anomalies using nuchal translucency.
● Gestational diabetes screening using fasting plasma glucose, random blood glucose, glucose challenge
test or urinalysis for glucose.
● Routine fetal-movement counting.
● Routine auscultation of the fetal heart.
● Routine antenatal electronic cardiotocography.
● Routine ultrasound scanning after 24 weeks.

22 NICE clinical guideline 62 Quick reference guide

Lifestyle advice
Work Reassure women that it is usually safe to continue working.
Ascertain a woman’s occupation to identify risk.
Refer to the Health and Safety Executive (www.hse.gov.uk) for more information.
Tell women about their maternity rights and benefits.

Nutritional Recommend supplementation with folic acid before conception and throughout the first

Lifestyle advice
supplements 12 weeks (400 micrograms per day).
Advise women of the importance of vitamin D intake during pregnancy and breastfeeding
(10 micrograms per day). Ensure women at risk of deficiency are following this advice.
Do not recommend routine iron supplementation.
Advise women of the risk of birth defects associated with vitamin A, and to avoid vitamin A
supplementation (above 700 micrograms) and liver products.

Avoiding infection Advise women how to reduce the risk of listeriosis and salmonella, and how to avoid
toxoplasmosis infection.

Medicines Prescribe as few medicines as possible, and only in circumstances where the benefit
outweighs the risk.
Advise women to use over-the-counter medicines as little as possible.

continued

NICE clinical guideline 62 Quick reference guide 23

 Lifestyle advice
Complementary Advise women that few complementary therapies have been proven as being safe and
therapies effective during pregnancy.

Exercise There is no risk associated with starting or continuing moderate exercise. However, sports
that may cause abdominal trauma, falls or excessive joint stress, and scuba diving, should
be avoided.
Lifestyle advice

Sexual intercourse Reassure women that intercourse is thought to be safe during pregnancy.

Alcohol Advise women planning a pregnancy to avoid alcohol in the first 3 months if possible.
If women choose to drink alcohol, advise them to drink no more than 1 to 2 UK units once
or twice a week (1 unit equals half a pint of ordinary strength lager or beer, or one shot
[25 ml] of spirits. One small [125 ml] glass of wine is equal to 1.5 UK units). At this low
level there is no evidence of harm.
Advise women to avoid getting drunk and to avoid binge drinking.

Smoking Discuss smoking status and give information about the risks of smoking during pregnancy.
Give information, advice and support on how to stop smoking throughout the pregnancy.
Give details of, and encourage women to use, NHS Stop Smoking Services and the NHS
Pregnancy Smoking Helpline (0800 169 9 169).
Discuss nicotine replacement therapy (NRT).
If women are unable to quit, encourage them to reduce smoking.

24 NICE clinical guideline 62 Quick reference guide

 Cannabis Discourage women from using cannabis.

Air travel Long-haul air travel is associated with an increased risk of venous thrombosis, although the
possibility of any additional risk in pregnancy is unclear.
In the general population, compression stockings are effective in reducing the risk.

Car travel Advise women that the seat belt should go ‘above and below the bump, not over it’.

Lifestyle advice
Travel abroad Advise women to discuss flying, vaccinations and travel insurance with their midwife
or doctor.

NICE clinical guideline 62 Quick reference guide 25

 Implementation tools
NICE has developed tools to help organisations ● Costing tools:
implement this guidance (listed below). – costing report to estimate the national savings
These are available on our website and costs associated with implementation
(www.nice.org.uk/CG062). – costing template to estimate the local costs
and savings involved.
● Slides highlighting key messages for local
discussion. ● Audit support for monitoring local practice.
Implementation tools

● Implementation advice on how to put the

guidance into practice and national initiatives
that support this locally.

26 NICE clinical guideline 62 Quick reference guide

Further information
Ordering information Related guidance
You can download the following documents from NICE has published clinical guidelines on
www.nice.org.uk/CG062 intrapartum care, postnatal care, caesarean
section, antenatal and postnatal mental health,
● A quick reference guide (this document) –
and diabetes in pregnancy; and public health
a summary of the recommendations for
guidance on maternal and child nutrition in

Further information
healthcare professionals.
low-income households and smoking cessation.
● The NICE guideline – all the recommendations. NICE is updating its guidance on induction of
● ‘Understanding NICE guidance’ – information labour and the use of routine antenatal anti-D
for patients and carers. prophylaxis for RhD-negative women.
● The full guideline – all the recommendations, Check our website for more information.
details of how they were developed, and
reviews of the evidence they were based on. Updating the guideline
This guideline will be updated as needed, and
For printed copies of the quick reference guide or
information about the progress of any update
‘Understanding NICE guidance’, phone NICE
will be posted on the NICE website
publications on 0845 003 7783 or email
(www.nice.org.uk/CG062).
[email protected] and quote:
● N1482 (quick reference guide)
● N1483 (‘Understanding NICE guidance’).

NICE clinical guideline 62 Quick reference guide 27

National Institute for
Health and Clinical Excellence
MidCity Place
71 High Holborn
London
WC1V 6NA

www.nice.org.uk

N1482 1P 150k Mar 08

© National Institute for Health and Clinical Excellence, 2008. All rights reserved. This
ISBN 1-84629-617-X material may be freely reproduced for educational and not-for-profit purposes. No
reproduction by or for commercial organisations, or for commercial purposes, is allowed
without the express written permission of the Institute.