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    Mosaicism PDF

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    Sidratul Muntaha Mullick
    Mosaicism is a condition where two or more chromosomal complements are present in the cells of an individual derived from a single zygote. It can occur due to errors in mitosis where cells end up with an extra or missing chromosome. This causes some cells to behave differently and can result in health issues or physical abnormalities depending on the level of mosaicism. Mosaicism is often confused with but different from chimerism which involves cells from multiple zygotes. Common causes include nondisjunction during cell division.

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    Mosaicism PDF

    Uploaded by

    Sidratul Muntaha Mullick
    292 views4 pages
    Mosaicism is a condition where two or more chromosomal complements are present in the cells of an individual derived from a single zygote. It can occur due to errors in mitosis where cells end up with an extra or missing chromosome. This causes some cells to behave differently and can result in health issues or physical abnormalities depending on the level of mosaicism. Mosaicism is often confused with but different from chimerism which involves cells from multiple zygotes. Common causes include nondisjunction during cell division.

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    MOSAICISM.pdf

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    Mosaicism is a condition where two or more chromosomal complements are present in the cells of an individual derived from a single zygote. It can occur due to errors in mitosis where cells end up with an extra or missing chromosome. This causes some cells to behave differently and can result in health issues or physical abnormalities depending on the level of mosaicism. Mosaicism is often confused with but different from chimerism which involves cells from multiple zygotes. Common causes include nondisjunction during cell division.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    292 views4 pages

    Mosaicism PDF

    Uploaded by

    Sidratul Muntaha Mullick
    Mosaicism is a condition where two or more chromosomal complements are present in the cells of an individual derived from a single zygote. It can occur due to errors in mitosis where cells end up with an extra or missing chromosome. This causes some cells to behave differently and can result in health issues or physical abnormalities depending on the level of mosaicism. Mosaicism is often confused with but different from chimerism which involves cells from multiple zygotes. Common causes include nondisjunction during cell division.

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    TOPIC :- MOSAICISM

    What is mosaicism? What is its cause?

    Mosaicism is a condition in which there is


    presence of two or more chromosomal
    complements found in the same tissue of
    an individual where cells derived from same
    genetic origin/zygotic genotype.
    This can occur in any type of cell and may
    cause health problems to the body.
    Mosaicism may also be present in any
    common individual, without any serious
    clinical issues, in the form of mole, different
    colours of iris, thin hair, patches of
    abnormal skin colour,spots on skin(as in
    ichthyosis with confetti),etc.

    Mosaicism may be caused by an error in


    mitosis. If there is an error in mitosis(like,
    non-disjunction), a cell doesn’t split evenly
    into 2 cells. The result is that some cells
    have the normal number of 46
    chromosomes, and other cells have more
    (47) or fewer (45) chromosomes.

    Mosaicism can arise when there is a


    mutation in early development so there can
    be group of cells that behave differently.
    This can happen at gene level or the whole
    chromosome.
    Mosaicism is often confused with
    chimerism. The difference lies in the fact
    that the former involves origin from a single
    zygote while the latter is for individuals
    originated from more than one zygote.

    Mechanism of Mosaic formation


    • Non disjunction
    • Anaphase lag
    • Premature centromere division
    Examples:-
    1. Germinal mosaicism- XXX
    syndrome, Turner syndrome, etc.

    2. Somatic mosaicism- Ring


    chromosome-14 syndrome, Mosaic
    down syndrome, trisomy 18 etc.

    When turner or down syndrome is present


    with mosaicism, of normal genotype
    pattern, intensity of disease manifestation
    is decreased and as a result, it is
    comparatively less fatal!

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