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Algorithm Attach2 PDF

This document provides an interpretation of clinical laboratory results from an HIV diagnostic testing algorithm. It outlines 7 scenarios (A-G) based on different combinations of test results from an HIV-1/2 antigen/antibody immunoassay, an HIV-1/HIV-2 antibody differentiation immunoassay, and an HIV-1 RNA assay. For each scenario it provides the test results and interpretation, including whether there is laboratory evidence of HIV infection and if provider case reporting is required.

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34 views1 page

Algorithm Attach2 PDF

This document provides an interpretation of clinical laboratory results from an HIV diagnostic testing algorithm. It outlines 7 scenarios (A-G) based on different combinations of test results from an HIV-1/2 antigen/antibody immunoassay, an HIV-1/HIV-2 antibody differentiation immunoassay, and an HIV-1 RNA assay. For each scenario it provides the test results and interpretation, including whether there is laboratory evidence of HIV infection and if provider case reporting is required.

Uploaded by

sahid
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Attachment 2

Interpreting Clinical Laboratory Results from the HIV Diagnostic Testing Algorithm

Test Method Test Result Interpretation

A 1. HIV-1/2 Ag/Ab combo immunoassay 1. Nonreactive Negative for HIV-1 antigen and HIV-1/HIV-2
antibodies. No laboratory evidence of HIV infection.

B 1. HIV-1/2 Ag/Ab combo immunoassay 1. Reactive Positive for HIV-1 antibodies. Laboratory evidence
2. HIV-1/HIV-2 antibody differentiation 2. HIV-1 Positive of HIV-1 infection is present.
immunoassay
Provider case reporting required*

C 1. HIV-1/2 Ag/Ab combo immunoassay 1. Reactive Positive for HIV-2 antibodies. Laboratory evidence
2. HIV-1/HIV-2 antibody differentiation 2. HIV-2 Positive of HIV-2 infection is present.
immunoassay
Provider case reporting required*

D 1. HIV-1/2 Ag/Ab combo immunoassay 1. Reactive HIV antibodies were not confirmed and HIV-1 RNA
2. HIV-1/HIV-2 antibody differentiation 2. Nonreactive or was not detected. No laboratory evidence of HIV-1
immunoassay Indeterminate infection is present. Further testing is recommended
3. HIV-1 RNA assay 3. Not detected if warranted by clinical evaluation or risk factors.

E 1. HIV-1/2 Ag/Ab combo immunoassay 1. Reactive Positive for HIV-1. Laboratory evidence of HIV acute
2. HIV-1/HIV-2 antibody differentiation 2. Nonreactive or HIV-1 infection is present.
immunoassay Indeterminate
3. HIV-1 RNA assay 3. Detected Provider case reporting required*

F 1. HIV-1/2 Ag/Ab combo immunoassay 1. Reactive Positive for HIV antibodies. Laboratory evidence of
2. HIV-1/HIV-2 antibody differentiation 2. HIV Positive HIV infection is present. HIV antibodies could not be
immunoassay (Undifferentiated) differentiated as HIV-1 or HIV-2. Additional testing
for HIV-1 RNA and HIV-2 RNA or DNA is warranted.

Provider case reporting required*

G 1. HIV-1/2 Ag/Ab combo immunoassay 1. Reactive HIV-1 antibodies were not confirmed and HIV-1
2. HIV-1/HIV-2 antibody differentiation 2. Nonreactive or RNA testing was not performed. Testing of this
immunoassay Indeterminate specimen is incomplete. Follow-up testing for
HIV antibodies and HIV-1 RNA is recommended
as soon as possible.

*Provider case reporting required: Under New York State public health law, medical providers are required to report to the NYSDOH
cases of HIV infection, HIV-related illness, AIDS and, for newly diagnosed cases, the names of all contacts known to the provide using
the NYS Medical Provider HIV/AIDS and Partner/Contact Report Form (PRF) (DOH-4189 revised 8/05) within 14 days of diagnosis.
Please contact the NYSDOH at (518) 474-4284 for additional information and reporting forms. In New York City, contact NYCDOHMH
at 212-442-3388.

September 5, 2013

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