Army Medical College Rawalpindi

Pharmacology Dept
2nd Term Test
2nd Year BDS Class Session 2016/2017

Total Marks: 90 Time allowed: 03 hrs

Pass Marks: 45 Test dated: 9-07-2018

Topics: CVS + Diuretics, Chemotherapy, Endo, Blood, GIT, Respiratory system

Misc: antihistamines, antiseptics & disinfectants in dentistry,
Drug Interaction & Adverse drug reactions.

Q.1. MCQs given on separate sheet. (20 Marks)

SAQs (60 Marks)

Q.1. A. Write down mechanism of action of Thiazide diuretics. (05 marks)

B. Classify anti-arrhythmic drugs. (05 marks)

Q.2. A. Enlist untoward actions of Tetracycline. (05 marks)

B. Describe mechanism of action of Chloroquine. (05 marks)

Q.3. A. Enumerate first line anti-tuberculosis drugs. (05 marks)

B. Enlist adverse effects of oral contraceptives. (05 marks)

Q.4. A. Enumerate therapeutic uses of corticosteroids. (05 marks)

B. Classify oral hypoglycaemic agents. (05 marks)

Q.5. A. Elucidate mechanism of action of Proton Pump Inhibitors. (05 marks)

B. Classify anti-coagulant drugs. (05 marks)

Q.6. A. Explain mechanism of action of Methylxanthines. (05 marks)

B. Write down untoward actions of Anti-Histamines. (05 marks)
 Roll No.__________
MCQs ( 20 marks)
1. Which one of the following antihypertensive drugs causes postural hypotension on initial
administration?
A. Atenolol.
B. Hydrochlorothiazide.
C. Metoprolol.
D. Prazosin.

2. A 45-year-old man was just started on therapy for hypertension and developed a persistent, dry
cough. Which one of the following agents is responsible for this side effect?
A. Enalapril.
B. Losartan.
C. Nifedipine.
D. Prazosin.

3. A 60-year-old man had a myocardial infarction. Which of the following should be used to prevent
life-threatening arrhythmias that can occur post–myocardial infarction in this patient?
A. Digoxin.
B. Flecainide.
C. Metoprolol.
D. Procainamide.

4. Which arrhythmia can be treated with lidocaine?

A. Paroxysmal supraventricular ventricular tachycardia.
B. Atrial fibrillation.
C. Atrial flutter.
D. Ventricular tachycardia.

5. Which one of the following statement best describes the action of ACE inhibitors on the failing
heart?
A. ACE inhibitors increase vascular resistance.
B. ACE inhibitors decrease cardiac output.
C. ACE inhibitors reduce preload.
D. ACE inhibitors increase aldosterone.

6. An elderly patient with a history of Chronic heart failure is brought to the emergency room with
difficulty breathing. Examination reveals that she has pulmonary edema. Which treatment is
indicated?
A. Acetazolamide.
B. Chlorthalidone.
C. Furosemide.
D. Hydrochlorothiazide.

7. A 55-year-old male with kidney stones has been placed on a diuretic to decrease calcium excretion.
However, after a few weeks, he develops an attack of gout. Which diuretic was he taking?
A. Furosemide.
B. Hydrochlorothiazide.
C. Spironolactone.
D. Triamterene.

8. Which one of the following diuretics is contraindicated in a patient with hyperkalaemia?

A. Acetazolamide.
B. Chlorthalidone.
C. Chlorothiazide.
D. Spironolactone.

9- Which one of the following exhibits post-antibiotic effect?

A. Aztreonam.
B. Gentamicin.
C. Penicillin G.
D. Vancomycin.
10. Which one of the following cephalosporins has activity against gram-negative anaerobic pathogens
like Bacteroides fragilis?
A. Cefazolin.
B. Cefepime.
C. Cefoxitin.
D. Ceftriaxone.

11. β-Lactam mechanism of action is dependent upon their structural resemblance with which one of the
following molecule?
A. Autolysin
B. N-acetylglucosamine
C. N-acetylmuramic acid
D. Transpeptidase

12. Which antimicrobial should be avoided in patients of liver disease:

A. Cephalexin
B. Cotrimoxazole
C. Doxycycline
D. Ethambutol

13. Which one of the following fluoroquinolone has enhanced activity against gram positive bacteria and
anaerobes
A. Ciprofloxacin
B. Moxifloxacin
C. Norfloxacin
D. Pefloxacin

14. ‘Orange discolouration’ of body secretions is the untoward reaction of which one of the following
first line anti tuberculosis drug?
A. Ethambutol
B. Isoniazid
C. Pyrazinamide
D. Rifampicin

15. The polyene anti-fungal drugs act by

A. Binding to ergosterol and creating micropores in fungal cell membrane
B. Disorienting microtubules in fungal cells
C. Inhibiting fungal cytochrome P450 enzyme
D. Inhibiting fungal DNA synthesis

16. Which one of the following antimalarial drugs is a radical curative in vivax malaria
A. Chloroquine
B. Mefloquine
C. Primaquine
D. Quinine

17. Which one of the following insulins is an ultra-short acting

A. Insulin aspart.
B. Insulin glargine.
C. NPH insulin.
D. Regular insulin.

18. Which of the following classes of oral diabetes drugs is paired most appropriately with its primary
mechanism of action?
A. DPP-4 inhibitor—inhibits breakdown of complex carbohydrates.
B. Glinide—increases insulin sensitivity.
C. Sulfonylurea—increases insulin secretion.
D. Thiazolidinedione—decreases hepatic gluconeogenesis

19. Which of the following statements is characteristic of metformin?

A. Metformin is inappropriate for initial management of type 2 diabetes.
B. Metformin decreases hepatic glucose production.
C. Metformin undergoes significant metabolism via the cytochrome P450 system.
D. Metformin should not be combined with sulfonylureas or insulin.
 Roll No.__________

20. Which of the following corticosteroids is most appropriate to administer to facilitate fetal lung
maturation?
A. Betamethasone.
B. Fludrocortisone.
C. Hydrocortisone.
D. Prednisone.
21. Carbimazole differs from propylthiouracil in that
A. It is dose to dose less potent
B. It has a shorter plasma half life
C. It does not produce an active metabolite
D. It does not inhibit peripheral conversion of thyroxine to triiodothyronine
22. Corticosteroids exert anti-inflammatory action by inhibiting one of the following enzymes
A. Cyclooxygenase-II
B. Lipoxygenase
C. Phospholipase-A2
D. Phosphodiesterase-4
23. Prednisone is converted to prednisolone in which one of the following organs?
A. Kidney
B. Liver
C. Lungs
D. Pancreas
24. Extrapyramidal symptoms (EPS) have been associated with which of the following drugs?
A. Aprepitant.
B. Loperamide.
C. Metoclopramide.
D. Omeprazole.
25. Which of the following drugs has been known to cause discoloration of the tongue?
A. Amoxicillin.
B. Bismuth compounds.
C. Lubiprostone.
D. Omeprazole.
26. Which one of the following medications inhibits the action of 5-lipoxygenase and consequently the
action of leukotriene B4 and the cysteinyl leukotrienes?
A. Cromolyn.
B. Montelukast.
C. Zafirlukast.
D. Zileuton.
27. Budesonide is a
A. Contraceptive
B. High ceiling diuretic
C. Inhaled corticosteroid for asthma
D. Nonsteroidal anti-inflammatory drug
28. Which one of the following is the first generation anti-Histamine drug?
A. Diphenhydramine.
B. Fexofenadine.
C. Levocetirizine.
D. Loratadine.
29. A patient is going on a deep sea fishing trip and is worried about motion sickness. Which of the
following would be the most appropriate?
A. Desloratadine
B. Dimenhydrinate
C. Doxylamine.
D. Fexofenadine
30. One effect that theophylline, nitroglycerin, salbutamol, and adrenaline have in common is
A. Bronchodilation
B. Direct stimulation of cardiac contractile force
C. Postural hypotension
D. Tachycardia
Key of MCQs

MCQs No. Key MCQs No. Key

1 D 16 C
2 B 17 A
3 C 18 C
4 D 19 B
5 C 20 A
6 C 21 D
7 D 22 C
8 D 23 B
9 B 24 C
10 C 25 B
11 D 26 D
12 C 27 C
13 B 28 A
14 D 29 B
15 A 30 D