MATERIAL SAFETY DATA SHEET

CHLOROFORM
Revision : 01 Date : 16.05.2017 MSDS Number : 058

Section 1 - Chemical P roduct and Company Identification

1.1 Product Name : CHLOROFORM

Synonyms : Trichloromethane, Methane, Formyl trichloride, Methyl trichloride
CAS No. : 67-66-3
HS Code : 2903 13 00
Molecular Weight : 119.38 g/mol
Chemical Formula : CHCl 3
Product Code : A 1022
B rand : SMART-LAB
1.2 Manuf acturer :PT.Smart-Lab Indonesia
Address :Taman TeknoBangunMultiguna Blok M/36,BSD Sektor XI Serpong,
Tangerang - Indonesia
Website :www.smartlab.co.id
Email :[email protected]
For inf ormation :Telp: +62-21- 7588 0205(Hunting) , fax:+62-21-7588 0198
1.3 Application : General Chemical reagent
Emergency Telephone: +62-21-7588 0205(Hunting)

Section 2 - Hazards Identification

2.1 Classif ication of the substance or mixture

Classif ication according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), H302
Acute toxicity, Inhalation (Category 3), H331
Skin irritation (Category 2), H315
Eye irritation (Category 2), H319
Carcinogenicity (Category 2), H351
Reproductive toxicity (Category 2), H361d
Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336
Specific target organ toxicity - repeated exposure (Category 1), H372

For the full text of the H-Statements mentioned in this Section, see Section 16

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008

P ictogram

Signal word Danger

Hazard statement(s)
H302 Harmful if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H331 Toxic if inhaled.
H336 May cause drowsiness or dizziness.

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H351 Suspected of causing cancer.

H361d Suspected of damaging the unborn child.
H372 Causes damage to organs through prolonged or repeated
exposure.

P recautionary statement(s)
P 261 Avoid breathing vapours.
P 281 Use personal protective equipment as required.
P 305 + P 351 + P 338 IF IN EYES: Rinse cautiously with water for several
minutes. Remove contact lenses, if present and easy to do.
Continue rinsing.
P 311 Call a P OISON CENTER /doctor.

Supplemental Hazard Statements none

2.3 Other hazards

This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (P BT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Section 3 - Composition, Information on Ingredients

3.1 Substances
Synonyms : TCM, Trichloromethane, Methane trichloride, Methyl trichloride
Formula : CHCl 3
Molecular weight : 119.38 g/mol
CAS-No. : 67-66-3
EC-No. : 200-663-8
Index-No. : 602-006-00-4

Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classif ication Concentration

Chloroform
Acute Tox. 4; Acute Tox. 3; Skin Irrit.
CAS-No. 67-66-3
2; Eye Irrit. 2; Carc. 2; Repr. 2; STOT
EC-No. 200-663-8 <=100 %
SE 3; STOT RE 1; H302, H331, H315,
Index-No. 602-006-00-4
H319, H351, H361d, H336, H372

For the full text of the H-Statements mentioned in this Section, see Section 16.

Section 4 - First Aid Measures

4.1 Description of f irst aid measures

G eneral advice
Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

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In case of eye contact

Flush eyes with water as a precaution.

If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and ef f ects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11

4.3 Indication of any immediate medical attention and special treatment needed
No data available

Section 5 - Firefighting Measures

5.1 Extinguishing media

Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising f rom the substance or mixture

Carbon oxides, Hydrogen chloride gas

5.3 Advice f or f iref ighters

Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further inf ormation

No data available.

Section 6 - Accidental Release Measures

6.1 Personal precautions, protective equipment and emergency procedures

Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate
personnel to safe areas. For personal protection see section 8.

6.2 Environmental precautions

P revent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.

6.3 Methods and materials f or containment and cleaning up

Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers
for disposal.

6.4 Ref erence to other sections

For disposal see section 13.

Section 7 - Handling and Storage

7.1 Precautions f or saf e handling

Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. For precautions see section 2.2.

7.2 Conditions f or saf e storage, including any incompatibilities

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Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Non-
combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

7.3 Specif ic end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

Section 8 - Exposure Controls, P ersonal P rotection

8.1 Control parameters

8.2 Exposure control
Appropriat engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
the product.

Personal protective equipment

Eye/f ace protection

Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal
technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good
laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC
and the standard EN 374 derived from it.

Full contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740, Size M)

Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740, Size M)

B ody Protection
Complete suit protecting against chemicals, The type of protective equipment must be
selected according to the concentration and amount of the dangerous substance at the specific
workplace.

Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face
respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator
cartridges as a backup to engineering controls. If the respirator is the sole means of
protection, use a full-face supplied air respirator. Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US) or CEN (EU).

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Control of environmental exposure

P revent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
the environment must be avoided.

Section 9 - P hysical and Chemical P roperties

9.1 Inf ormation on basic physical and chemical properties

Appearance Form: liquid, clear
Colour: colourless
Odour No data available
Odour Threshold No data available
pH neutral
Melting point/freezingpoint Melting point/range: -63 °C
Initial boiling point and boiling range 60.5 - 61.5 °C
Flash point No data available
Evaporation rate No data available
Flammability (solid, gas) No data available
Upper/lower flammability or Upper explosion limit: 7.1 %(V)
Lower explosion limit: 1.3 %(V)
explosive limits No data available
Vapour pressure 160.0 mmHg at 20.0 °C
Vapour density 3,73 - (Air = 1.0)
Relative density 1.492 g/mL at 25 °C
Water solubility No data available
P artition coefficient: noctanol/water log P ow: 1.97
Auto-ignition temperature 637.0 °C
Decomposition temperature No data available
Viscosity No data available
Explosive properties No data available
Oxidizing properties No data available

9.2 Other saf ety information

Surface tension 27.1 mN/m at 20.0 °C

Section 10 - Stability and Reactivity

10.1 Reactivity
No data available

10.2 Chemical stability

Stable under recommended storage conditions.
Contains the following stabiliser(s): (>=0.001 - <=0.015 %)

10.3 Possibility of hazardous reactions

No data available

10.4 Conditions to avoid

Heat, flames and sparks.

10.5 Incompatible materials

Strong oxidizing agents, Strong bases, Magnesium, Sodium/sodium oxides, Lithium

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10.6 Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides, Hydrogen chloride gas
Other decomposition products - No data available
In the event of fire: see section 5

Section 11 - Toxicological Information

11.1 Inf ormation on toxicological ef f ects

Acute toxicity
LD50 Oral - Rat - 908 mg/kg(Chloroform)
Remarks: Behavioral:Change in motor activity (specific assay).
Behavioral:Ataxia. Lungs, Thorax, or Respiration:Respiratory stimulation.
LOEC Inhalation - Rat - male - 6 h - 500 ppm(Chloroform)
LD50 Dermal - Rabbit - > 20,000 mg/kg(Chloroform)

Skin corrosion/irritation
Skin - Rabbit(Chloroform)
Result: Irritating to skin. - 24 h

Serious eye damage/eye irritation

Eyes - Rabbit(Chloroform)
Result: Irritating to eyes. - 24 h

Respiratory or skin sensitisation

Did not cause sensitisation on laboratory animals.(Chloroform)

G erm cell mutagenicity

Laboratory experiments have shown mutagenic effects.(Chloroform)

Carcinogenicity
The National Cancer Institute (NCI) has found clear evidence for carcinogenicity.
Limited evidence of a carcinogenic effect.(Chloroform)
IARC: 2B - Group 2B: P ossibly carcinogenic to humans (Chloroform)

Reproductive toxicity
Suspected of damaging the unborn child. Suspected human reproductive toxicant(Chloroform)

Specif ic target organ toxicity - single exposure

May cause drowsiness or dizziness.(Chloroform)

Specif ic target organ toxicity - repeated exposure

The substance or mixture is classified as specific target organ toxicant, repeated exposure,
category 1. - Liver, Kidney

Aspiration hazard
No data available

Additional Inf ormation

RTECS: FS9100000
Vomiting, Gastrointestinal disturbance, Exposure to and/or consumption of alcohol may increase toxic
effects.(Chloroform)

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Section 12 - Ecological Information

12.1 Toxicity
Toxicity to fish
LC50 - Leuciscus idus (Golden orfe) - 162 mg/l - 48 h(Chloroform)
LC100 - Leuciscus idus (Golden orfe) - 220 mg/l - 48 h(Chloroform)
LC50 - other fish - 97 mg/l - 96 h(Chloroform)
LC50 - Danio rerio (zebra fish) - 121 mg/l - 96 h(Chloroform)
NOEC - Oryzias latipes - 122 mg/l - 10 d(Chloroform)
NOEC - Oncorhynchus mykiss (rainbow trout) - 24 mg/l - 96 h(Chloroform)

Toxicity to daphnia and other aquatic invertebrates Immobilization

EC50 - Daphnia magna (Water flea) - 79.00 mg/l - 24 h(Chloroform) Immobilization
EC50 - Daphnia magna (Water flea) - 51.6 mg/l - 48 h(Chloroform)
NOEC - Daphnia magna (Water flea) - 120 mg/l - 11 d(Chloroform)

Toxicity to algae
EC50 - No information available. - 500.00 mg/l - 24 h(Chloroform)

12.2 Persistence and degradability

Biodegradability
aerobic - Exposure time 28 d(Chlorobenzene)
Result: 15 % - Not readily biodegradable.
(OECD Test Guideline 301F)

12.3 B ioaccumulative potential

Bioaccumulation
Lepomis macrochirus (Bluegill) - 14 d - 0.11 mg/l(Chloroform)
Bioconcentration factor (BCF): 6

12.4 Mobility in soil

No data available(Chloroform)

12.5 Results of PB T and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (P BT), or very persistent and very bioaccumulative (vP vB) at levels of 0.1% or higher.

12.6 Other adverse ef f ects

Harmful to aquatic life

Section 13 - Disposal Considerations

13.1 Waste treatment methods

Product
Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging
Dispose of as unused product.

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Section 14 - Transport Information

14.1 UN number
ADR/RID: 1888 IMDG: 1888 IATA 1888
14.2 UN proper shipping name
ADR/RID: CHLOROFORM
IMDG: CHLOROFORM
IATA: CHLOROFORM
14.3 Transport hazard class(es)
ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
14.4 Packaging group
ADR/RID:III IMDG:III IATA:III
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
Further inf ormation
No data available

Section 15 - Regulatory Information

15.1 Saf ety, health and environmental regulations/legislation specif ic f or the substance or mixture
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.2 Chemical saf ety assessment
For this product a chemical safety assessment was not carried out

Section 16 - Additional Information

Full text of H-Statements referred to under sections 2 and 3.

H302 Harmful if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H331 Toxic if inhaled.
H336 May cause drowsiness or dizziness.
H351 Suspected of causing cancer.
H361d Suspected of damaging the unborn child.
H372 Causes damage to organs through prolonged or repeated exposure..

HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 0
Reactivity: 0
P ersonal P rotection: h

National Fire Protection Association (U.S.A.):

Health: 2
Flammability: 0
Reactivity: 0

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Further information
The above information is believed to be correct but does not purport to be all inclusive and shall be used onlyas
a guide. The information in this document is based on the present state of our knowledge and is applicable to
the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties
of the product. PT. Smartlab Indonesia Corporation and its Affiliates shall not be held liable for any damage
resulting from handling or from contact with the above product. See www.sigmaaldrich.com and/or the reverse
side of invoice or packing slip for additional terms and conditions of sale.

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