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Compounding Solid Dosage Forms

The document discusses various types of solid dosage forms used for compounding medications, including tablets, capsules, lozenges, pastilles, dental cones, pills, granules and powders. It describes their composition, manufacturing process and intended uses.

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risda paujiah
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373 views28 pages

Compounding Solid Dosage Forms

The document discusses various types of solid dosage forms used for compounding medications, including tablets, capsules, lozenges, pastilles, dental cones, pills, granules and powders. It describes their composition, manufacturing process and intended uses.

Uploaded by

risda paujiah
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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COMPOUNDING

SOLID DOSAGE FORMS

Dina Rahmawanty, M.Farm.,Apt


Compounding means :
Preparation
Mixing
Assembling
Packaging
Labelling
…..Of Drug or Device
Tablet
• Hard, compressed medication in round, oval or square
shape
• Solid dosage form containing unit dose of one or more
medicament, prepared by mould method or compression
method
• The excipient include :
 Binders, glidants (flow aids) and lubricants to ensure
efficient tabletting
 Disintegrants to ensure that the tablet break up in the
digestive tract
 Sweeteners or flavours to mask the taste of bad-tasting
active ingridients
 Pigments to make uncoated tablets visually attractive
Coating tablet
A coating may be applied to :
1. Hide the taste of tablet’s components
2. Make the tablet smoother and easier to
swallow
3. Make it more resistant to the environment
4. Extending its shelf life
Buccal and Sublingual tablet
• Administered by placing them in the mouth,
either under the tongue(sublingual) or between
the gum ant the cheek(buccal)
• Dissolve rapidly and absorbed through the
mucous membranes of the mouth, where they
enter the bloodstream
• Avoid the acid and enzymatic environment of the
stomach and the drug metabolizing enzymes of
the liver
• Ex : vasodilators drugs, steroidal and hormones
drugs
Effervescent tablet
• Uncoated tablets, generally contain acid
substance (citric and tartaric acids) and
carbonates or bicarbonates
• React rapidly in the presence of water by
releasing carbon dioxide
• They are intended to be dissolved or
dispersed in water before use providing
• Very rapid tablet dispersion and
dissolution
• Pleasant tasting carbonated drink
Chewable tablet
• Tablets that chewed prior to swallowing
• Designed for administration to children,
adult
• Ex; vitamin products, etc
Capsule
• A medication in a gelatin container
• Two main types :
1.Hard-shelled capsules, used for dry,
powdered ingredients
2.Soft-shelled capsules, used for oils and for
active ingredients that are dissolved or
suspended in oil
Steps for hand-filling capsules
Using capsule-filling machine
Capsule size
Lozenge and Pastilles
LOZENGE PASTILLES
• Solid preparation consist • Designed to dissolve
of sugar and gum slowly in the mouth
• The latter giving strength • Softer than lozenges
and cohesiveness to the • Bases are either glycerol
lozenge and facilitating and gelatin, or acacia and
slow release of the sugar
medicament • Chewable gummy gel
• Used to medicate the lozenges
mouth and throat for the
slow administration of
indigestion or cough
remedies
Compounding gummy gel
lozenges
Compounding hand-rolled
lozenges
Dental cones
• A tablet form intended to be placed in the
empty socket following a tooth extraction,
for preventing the local multiplication of
pathogenic bacteria associated with tooth
extraction
• The cones may contain:
Antibiotic
Antiseptic
Pills
• Consist of spherical masses prepared
from one or more medicaments
incorporated with inert excipients
• Pills are now rarely used
Granules
• Consisting of solid, dry aggregates of powder
particles often supplied in single-dose sachets
• Irregular shape particle which are made to
improve flow property of powder
• Some granules are placed on the tongue and
swallowed with water, others are intended to be
dissolved in water before taking
• Effervescent granules evolve carbon dioxide
when added to water
Powder
• Bulk powders for external use
• Bulk oral powders
• Individual unit dose powders

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