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Reverse Laminar Air Flow: Technical Details

This document provides information on four types of cleanroom equipment: 1. A reverse laminar air flow unit that provides ISO Class 5 air flow using a three-stage filtration system. 2. A dynamic pass box that uses high chamber pressure and door interlocking to allow material transfer between areas of different sterility. 3. A static pass box that acts as a physical barrier between two equally sterile areas using door interlocking. 4. An open restricted air barrier with a HEPA-filtered acrylic or glass enclosure that provides ISO Class 5 air flow in the work area and includes glove port access.

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0% found this document useful (0 votes)
2K views17 pages

Reverse Laminar Air Flow: Technical Details

This document provides information on four types of cleanroom equipment: 1. A reverse laminar air flow unit that provides ISO Class 5 air flow using a three-stage filtration system. 2. A dynamic pass box that uses high chamber pressure and door interlocking to allow material transfer between areas of different sterility. 3. A static pass box that acts as a physical barrier between two equally sterile areas using door interlocking. 4. An open restricted air barrier with a HEPA-filtered acrylic or glass enclosure that provides ISO Class 5 air flow in the work area and includes glove port access.

Uploaded by

aboemadaldeen
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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1.

REVERSE LAMINAR AIR FLOW

Air Flow Diagram


Model: ≈ TrimAIR ≡
DESCRIPTION OF EQUIPMENT
Widely known as Sampling and Dispensing Booth, The REVERSE LAMINAR AIR FLOW UNIT is consisting of three
stage Filtration: Pre-filter, Intermediate Filter, HEPA Filter and Exhaust HEPA Filter.

The basic purpose of this equipment/ system is to provide ISO Class 5 (Class 100) Air flow in the workspace. Also,
about 80% air is recirculated in the planum and it passes though pre-filter, intermediate filter and supply HEPA filter
and again supplied in work space. Exhaust air is also passed through Exhaust HEPA. Hence RLAF provides Product,
Personnel and Environment safety.

TECHNICAL DETAILS
Air Handling: Motor Blower with Speed controller provided are statically and dynamically balanced, Supply of
sufficient capacity and static pressure is used to take care of airflow requirement for entire life of HEPA. Blower is
high performance, noise abated, light weighted.

Pressure Measurement: Differential Pressure Gauge :


0 - 25 mm: 1 No. to monitor pressure drop HEPA filter with respect to ambient.
0 - 10 mm: 2 Nos. to monitor pressure drop across 1st and 2nd Stage filtration with respect to ambient.
Illumination: Flush mounted LED Light
Electrical Control: Programmable Digital Graphic Display, with operation KEY for ON/OFF light & motor blower.

SPECIFICATIONS
 Maximum protection from airborne contaminants produced at the time of powder handling operations such as
charging, sampling, and dispensing
 MOC : SS 304/SS 316/SS 316 L or combination of both
 Down flow booth functions on a re-circulatory airflow principle
 At the base of the rear wall there is Pre filter to capture the airborne generated contaminants. Intake velocity at
pre filters increases to offer scavenging effect
 Continuous, clean, laminar down flow of Class 100 air supplied to work area in order to suppress
˃ Any dust clouds produced during open powder processing
˃ And eradicate and capture airborne particles from the operator's breathing zone
 EU 5 Pre filter (90-95 % Down to 5 µ)
 EU 14 - HEPA Filter Supply (99.999% down to 0.3 micron)
 EU 7 Intermediate Filter Supply (95% down to 3 micron)
 SS 304 Double walled Side Panels
 DOP Test port at upstream of HEPA filter
 Milky White Diffuser
 Audio / Visual alarm for blower tripping with Fault Acknowledgement & Reset Switch
 Warm Up/Clean Down Timer with Operation Hold Indicator & interlocking to put on LED lights only after clean
down time over

ACCESSORIES MADE AVAILABLE


 Sodium Vapour Lamps
 Photohelic Gauge with Audio / Visual Alarm in lieu of Magnehelic Gauge with High / Low Indicators
 Digital Pressure Gauge in lieu of Magnehelic Gauge
 On Line Velocity Indicator with Audio / Visual Alarm with High / Low Indicators
 Flame Proof Execution
 Double skin side panels with view windows.
 Front Anti-Static PVC Curtains (for warehouse applications)
 SS standalone table for keeping Weighing Balance.
 Safe change Bag In / Bag Out arrangement for filters
 SS 304 Worktable with due reinforcement

STANDARD SIZES
Model Hepa Filter Area (W x D) Work Area Dimension (W x D x H)

TrimAIR 4-2 1220 x 610 MM 1260 x 660

TrimAIR 3.5 1110 x 1110 MM 1065 x 1065

TrimAIR 4-4 1220 x 1220 MM 1280 x 1290

TrimAIR 5-5 1524 x 1524 MM 1585 x 1595

TrimAIR 6-4 1830 x 1220 MM 1890 x 1270

TrimAIR 6-5 1830 x 1524 MM 1890 x 1595


2. DYNAMIC PASS BOX
Model: ACTIVE

Air Flow Diagram


DESCRIPTION OF EQUIPMENT
DYNAMIC PASS BOX is a barrier between two areas with different sterility. It allows material transfer between area
with different sterility without cross contamination of air. To separate the areas Dynamic Pass Box uses High
Chamber pressure and techniques of door interlocking. Also, it is available in wide range of chamber sizes and
shapes like L-type and 3- way.

The Dynamic pass box is provided with Two stage filtration: Pre-filter, Fresh air filter, HEPA Filter. The Pre-filter, Final
Filter, Digital Gauge, Blower with Motor are installed inside the panel. Glass view panel on the doors are available to
have a vision on the material inside the chamber.

The basic purpose of this equipment/ system is to provide ISO Class 5 (Class 100) Air flow in the workspace. The units
are designed to deliver air in the Vertical – Recirculation system.

TECHNICAL DETAILS
Air Handling: Motor Blower with Speed controller provided are statically and dynamically balanced, Supply of
sufficient capacity and static pressure is used to take care of airflow requirement for entire life of HEPA. Blower is
high performance, noise abated, light weighted.

Pressure Measurement: Analog Differential Pressure Gauge: 0 - 25 mm: 1 No. to monitor pressure drop HEPA filter
with respect to ambient.
Electrical Control: Programmable Digital Graphic Display, with operation KEY for ON/OFF light & Motor blower.
Optional Accessories:
1. LED light
2. UV light
3. Digital Pressure Gauge
SPECIFICATIONS
 Two Stage filtration
 MOC : SS 304
 EU 5 Pre filter (90-95 % Down to 5 µ)

 EU14 - HEPA Filter Supply (99.999% down to 0.3 micron)


 Double walled flush glass view panels provided with doors
 SS 304 Handles and hinges
 Internal covings for easy cleaning
 Electro-magnetic Interlocking with Permanent magnet
 Indicator on either side
 Door Release Switch on either side
 DOP Test Port
 Audio / Visual alarm for blower tripping with Fault Acknowledgement & Reset Switch
 Plc base system

ACCESSORIES MADE AVAILABLE

 U. V. Light with inbuilt Hour Meter in digital display with interlocking arrangement that turns UV off when operator any opens door
 Support Stand for mounting the pass box with levelly lugs in the base.
 Flange for filling the gap between the pass box and the clean room wall
 Clean Down Timer with Operation Hold Indicator & interlocking to put on LED lights only after clean down time over
 LED light with interlocking arrangement to put off light when the doors are in closed position
 Door drop seal For base less / Floor mounted pass box

SMART SERIES

 EC Fans
 Night Mode
 Energy Efficient

STANDARD SIZES
Model Work Area Dimension (L x W x H)

ACTIVE 5-5-5 500 x 500 x 500 mm

ACTIVE 6-6-6 600 x 600 x 600 mm

ACTIVE 8-8-8 800 x 800 x 800 mm


3. STATIC PASS BOX
SAP Model:

Air Flow Diagram


DESCRIPTION OF EQUIPMENT
STATIC PASS BOX is a barrier between two areas with equal sterility. It allows material transfer between areas
equally sterile without cross contamination of air. To separate the areas Static Pass Box uses technique of door
interlocking. Also, it is available in wide range of chamber sizes and shapes like L-type and 3- way.

Glass view panel on the doors are available to have a vision on the material inside the chamber.
The basic purpose of this equipment/ system is to play role as a physical barrier between two areas.

TECHNICAL DETAILS
Electrical Control: Programmable Digital Graphic Display, with operation KEY for ON/OFF light & Motor blower.

Optional Accessories:
1. LED light
2. UV light
3. Digital Pressure Gauge.

Specifications :

 MOC SS 304
 Double Walled Construction
 Doors equipped with double walled flush glass view panels
 SS Handles and SS hinges
 Electro-magnetic Interlocking
 Indicator on either side
 Internal covings for easy cleaning
 Door Release Switch on either side

Accessories Made Available:

 Mechanical Interlocking
 Provision for ventilation with perforated grille
 U. V. Light with inbuilt Hour Meter in digital display with interlocking arrangement that turns UV off when operator any opens door
 Three wall construction for floor mounting
 Floor mounted construction with three side wall structure & Door Drop Seal
 Support stand for mounting the pass box
 LED light with interlocking arrangement to put off light when the doors are in closed

STANDARD SIZES
Model Work Area Dimension (L x W x H)

SAP 5-5-5 500 x 500 x 500 mm

SAP 6-6-6 600 x 600 x 600 mm

SAP 8-8-8 800 x 800 x 800 mm


4. ORAB – OPEN RESTRICTED AIR BARRIER

Model: ARIA
Air Flow Diagram

DESCRIPTION OF EQUIPMENT
ORABs we provide are with rigid Acrylic or Glass enclosure supplied with HEPA filtered ISO 5 classified laminar air in
work area. Provision of Glass doors or Glove port access for operator to handle material / equipment in the work
area. Gloves provided are available of wide range and specifications suitable to the user product along with both
domestic and International quality.

The ORABs is provided with Two stage filtration: Pre-filter and HEPA Filter. The Pre-filter, Final Filter, Digital Gauge,
Blower with Motor are installed inside the panel. The units are designed to deliver air in the Vertical axis.

TECHNICAL DETAILS
Air Handling: EC / AC Motor Blower with Speed controller provided are statically and dynamically balanced, Supply
of sufficient capacity and static pressure is used to take care of airflow requirement for entire life of HEPA. Blower is
high performance, noise abated, light weighted.

Pressure Measurement: Digital / Analog Differential Pressure Gauge: 0 - 25 mm: 1 No. to monitor pressure drop
HEPA filter with respect to ambient.

PLC With HMI: Programmable Digital Display, with touch pad for ON/OFF light & Motor blower.
5. LAMINAR AIR FLOW – STAND MOUNTED TYPE

Model: ≈ TrimAIR ≡
Air Flow Diagram
DESCRIPTION OF EQUIPMENT
The LAMINAR AIR FLOW UNIT mounted on SS stand structure to provide ISO 5 classified air on work table. High
pressure HEPA filtered air flows from Working area to outside in environment to ensure Product safety. It is widely
used for drug testing and material storage as well.

The LAF is provided with Two stage filtration: Pre-filter and HEPA Filter. The Pre-filter, Final Filter, Blower with
Motor are installed inside the panel.

TECHNICAL DETAILS
Air Handling: Motor Blower with Speed controller provided are statically and dynamically balanced, Supply of
sufficient capacity and static pressure is used to take care of airflow requirement for entire life of HEPA. Blower is
high performance, noise abated, light weighted.

Pressure Measurement: Analog Differential Pressure Gauge:


0 - 25 mm: 1 No. to monitor pressure drop HEPA filter with respect to ambient.
Electrical Control: Programmable Digital Graphic Display, with operation KEY for ON/OFF light & Motor blower.
Optional Accessories:
1. LED light
2. UV light
3. Digital Pressure Gauge.
4. PVC curtains at front
5. Acrylic Sash at front
6. Switch socket
7. GAS/ Air cock

STANDARD SIZES
Model DIMENSION OF HEPA

TRIM AIR – SM-4.2 4’ X 2’

TRIM AIR – SM-2.2 2’ X 2’

TRIM AIR – SM-3.2 3’ X 2’


6. LAMINAR AIR FLOW – CEILING SUSPENDED TYPE

Model: ≈ TrimAIR ≡
Air Flow Diagram

DESCRIPTION OF EQUIPMENT
The LAMINAR AIR FLOW UNIT suspended on the Ceiling provides ISO 5 classified air at the area below. HEPA filtered
laminar air flows to the area below the LAF to prevent contamination of sterilized products at Autoclave Outlet.

The LAF is provided with Two stage filtration: Pre-filter and HEPA Filter. The Pre-filter, Final Filter, Blower with
Motor are installed inside the panel.

TECHNICAL DETAILS
Air Handling: Motor Blower with Speed controller provided are statically and dynamically balanced, Supply of
sufficient capacity and static pressure is used to take care of airflow requirement for entire life of HEPA. Blower is
high performance, noise abated, light weighted.

Pressure Measurement: Analog Differential Pressure Gauge:


0 - 25 mm: 1 No. to monitor pressure drop HEPA filter with respect to ambient.
Electrical Control: Programmable Digital Graphic Display, with operation KEY for ON/OFF light & Motor blower.

Optional Accessories:
1. LED light
2. Digital Pressure Gauge.
3. PVC curtains on sides

Specifications:

 High product protection by provision of ISO Class 5 particle free work area
 Able enough to handle critical process
 Proven protection for the samples and processes
 The work area is continuously supplied with positive pressure HEPA filtered vertical air flow
 Vertical unidirectional airflow peed prevents contamination from operator and environment to work area.
 Laminarity of the flow handles cross contamination between the items in the working space.
 Made available in powder coated Mild Steel and SS 304 / SS 316/ SS 316L or a combination of both
 Two Stage filtration
 EU 5 Pre filter (90-95 % Down to 5 µ)

 EU14 - HEPA Filter Supply (99.999% down to 0.3 micron)


 SS work table with due reinforcement
 Glass side panels
 LED Lights with Milky White Diffuser
 On / Off Switch
 Warm up/Clean Down Timer with Operation HOLD indicator
 DOP Test Port

Accessories Made Available:

 Night Mode Operation


 U. V. Light with Hour Meter
 Velocity display with alarms (audible and visible)
 Filter blocked alarms (audible and visible)
 Explosion proof electrics for Flame-proof applications
 Audio / Visual alarm for blower tripping with Fault Acknowledgement & Reset Switch
 Photohelic Gauge with Audio / Visual Alarm in lieu of Magnehelic Gauge with High / Low Indicators
 On Line Velocity Indicator with Audio / Visual Alarm with High / Low Indicators

Suitable For :
For handling of non hazardous products :

 Sensible to dust
 Susceptible to contamination where operator protection not necessary

STANDARD SIZES
Model DIMENSION OF HEPA

TRIM AIR – CS-4.4 4’ X 2’

TRIM AIR – CS-2.2 2’ X 2’

TRIM AIR – CS-3.2 3’ X 2’


7. HORIZONTAL LAMINAR AIR FLOW
Model: ≈ TrimAIR ≡

Air Flow Diagram


DESCRIPTION OF EQUIPMENT
The HORIZONTAL LAMINAR AIR FLOW UNIT we provide supplies ISO 5 classifies laminar air horizontally from the
front side of work table. Clean air flows horizontally from work table to room which ensures Product safety. HLAF is
widely used in Microbiology.
The LAF is provided with Two stage filtration: Pre-filter and HEPA Filter. The Pre-filter, Final Filter, Blower with
Motor are installed inside the panel.
TECHNICAL DETAILS
Air Handling: Motor Blower with Speed controller provided are statically and dynamically balanced, Supply of
sufficient capacity and static pressure is used to take care of airflow requirement for entire life of HEPA. Blower is
high performance, noise abated, light weighted.

Pressure Measurement: Analog Differential Pressure Gauge:


0 - 25 mm: 1 No. to monitor pressure drop HEPA filter with respect to ambient.
Electrical Control: Programmable Digital Graphic Display, with operation KEY for ON/OFF light & Motor blower.
Optional Accessories:
1. LED light
2. Digital Pressure Gauge.
3. PVC curtains at three sides
Specifications :
 High product protection by provision of ISO Class 5 particle free work area
 Able enough to handle critical process
 Protection for the samples and processes
 The work area is incessantly supplied with positive pressure HEPA filtered horizontal air flow
 Horizontal unidirectional airflow peed prevents contamination from operator and environment to work area
 Laminarity of the flow handles cross contamination between the items in the working space
 Two Stage filtration
 Made available in powder coated Mild Steel and SS 304 / SS 316/ SS 316L or a combination of both
 EU 5 Pre filter (90-95 % Down to 5 µ)

 EU14 - HEPA Filter Supply (99.999% down to 0.3 micron)


 On / Off Switch for Motor
 SS 304 work table with due reinforcement
 Polycarbonate side panels
 LED Light with milky white diffuser (250 Lux)
 5/15 Amp single-phase switch socket for external equipment
 DOP Test Port

Suitable For :
For handling of non hazardous products :
 Sensible to dust
 Susceptible to contamination like :
 Injectable medicines
 Cell and tissue cultures
 Food sample preparation for sterility testing
 Sterile packaging
 I.V. pharmacy preparations
 Micromechanics
 Optics
 electronics

Options and Accessories :


A wide range of configurations to suit any containment application :
 Front doors (hinged/pneumatic cylinder)
 U. V. Light with Hour Meter
 Air / Gas Cock
 Night Mode Operation
 Filter blocked alarms (audible and visible)
 Velocity display with alarms (audible and visible)
 Explosion proof electrics for Flame-proof applications
 Clean Down Timer with Operation Hold Indicator & interlocking to put on LED lights only after clean down time over
 Audio / Visual alarm for blower tripping with Fault Acknowledgement & Reset Switch
 Foldable polycarbonate front door
 Photohelic Gauge with Audio / Visual Alarm in lieu of Minihelic Gauge with High / Low Indicators
 Digital Pressure Gauge in lieu of Minihelic Gauge

STANDARD SIZES
Model DIMENSION OF HEPA

TRIM AIR – HF-4.2 4’ X 2’

TRIM AIR – HF-3.2 3’ X 2’


8. BIOSAFETY CABINET – CLASS II A2

Model: AURA Gard


Air Flow Diagram
DESCRIPTION OF EQUIPMENT
Protect your Product, Personnel and surrounding Environment with Pious Biotech make AURA Gard A2 Biosafety
cabinet series. Reliable design, Aesthetic look, Human comfort and Ergonomics are the key feature of our design.

EU – 14 Supply and Exhaust HEPA Filters create ISO 5 atmosphere for Product nad for the environment.
Programmable HMI provides fool proof controlling of LED, UV and Blowers during the operations. Table is single
piece Stainless steel 304 grade with the perforations to let the contaminated air pass through it.

TECHNICAL DETAILS
Air Handling: Motor Blower with Speed controller provided are statically and dynamically balanced, Supply of
sufficient capacity and static pressure is used to take care of airflow requirement for entire life of HEPA. Blower is
high performance, noise abated, light weighted.

Pressure Measurement: Analog Differential Pressure Gauge:


0 - 25 mm: 1 No. to monitor pressure drop HEPA filter with respect to ambient.
0 - 10 mm : 1 Nos. to monitor pressure drop across Pre filter with respect to ambient.

Electrical Control: Programmable Digital Graphic Display, with operation KEY for ON/OFF light & Motor blower.

Door mechanism: Acrylic / Glass front door with Manual UP/Down.


Sensor Buzzer: If front door raises more than 6” then it will get.
Counter weight: To door open at UP/DWON position manually.
Specifications :

 Two Stage filtration


 Provided with HEPA-filter
 Lessens cross-contamination
 Free from contaminants
 Made available in powder coated Mild Steel, SS 304 / SS 316 / SS 316L or a combination of both.
 Class II cabinets designed as per level 1,2,3 biosafety levels
 EU 5 Pre filter (90-95 % Down to 5 µ)

 EU14 - HEPA Filter - Supply / Exhaust (99.999% down to 0.3 micron)


 Double walled flushed Glass Side Panels
 SS 304 work table with perforations at front and back side that can be removed for cleaning purpose
 1-piece fully openable sliding toughened glass front door with counterweight arrangement
 Sealed LED Lights provided with Milky White Diffuser
 ON/OFF Switches for motor & Lights
 Clean Down Timer with Operation HOLD indicator
 Alarm triggers in case front door is raised more than 8’’ (i.e. safe clear opening during operation)
 DOP Test Port
 5/15 Amp Switch Socket for external equipment
 SS 304 stands with leveling lugs
 SS 304 1 ft long elbow duct for exhaust
 PLC based Control System
 EC FAN

Accessories Made Available :

 Night Mode Operation


 Filter blocked alarms (audible and visible)
 Velocity display with alarms (audible and visible)
 Explosion proof electrics for Flame-proof applications
 Front doors with Glove arrangement
 Transfer hatch for material movement
 Safe change Bag in/Bag out arrangement for filters

STANDARD SIZES
Model Hepa Filter Area (L x W)

AURA Gard – 2.2 2’ X 2’

AURA Gard – 3.2 3’ X 2’

AURA Gard – 4.2 4’ X 2’


9. MOBILE LAMINAR AIR FLOW UNIT / MOBILE TROLLEY

Model: ≈ TrimAIR ≡

Air Flow Diagram


DESCRIPTION OF EQUIPMENT
The LAMINAR AIR FLOW UNIT mounted on SS stand structure with caster wheels to provide ISO 5 classified air on
work table. High pressure HEPA filtered air flows from working area to outside in environment to ensure Product
safety. With the provided UPS system it can continue working without Power supply hence used for material
transfer in various places due to its Dynamic characteristics.

The Mobile LAF is provided with two stage filtration: Pre-filter and HEPA Filter. The Pre-filter, Final Filter, Blower
with Motor are installed inside the panel. UPS and Fresh air Intake are provided in the base mounted above the
Caster wheels.
TECHNICAL DETAILS
Air Handling: Motor Blower with Speed controller provided are statically and dynamically balanced, Supply of
sufficient capacity and static pressure is used to take care of airflow requirement for entire life of HEPA. Blower is
high performance, noise abated, light weighted.

Pressure Measurement: Analog Differential Pressure Gauge:


0 - 25 mm: 1 No. to monitor pressure drop HEPA filter with respect to ambient.
Electrical Control: Programmable Digital Graphic Display, with operation KEY for ON/OFF light & Motor blower.
UPS: With battery backup of 1 hour.

Optional Accessories:
1. LED light
2. UV light
3. Digital Pressure Gauge.
4. PVC curtains at front
5. Acrylic doors at front
6. Switch socket

10. IVF WORKSTATION (IN VITRO FERTILISATION)


Model :

DESCRIPTION OF EQUIPMENT
IVF Workstation is a complete set of advanced features that helps embryologists in their daily work. It is Laminar Air
Flow Hood for gamete/Embryo manipulation during IVF and designed to keep culture dish at right temperature at all
times while observation and manipulation is carried out.

TECHNICAL DETAILS
Multi-Zone Heating System with Four Temperature Modes:
You have access to a high level of control over environmental conditions such as temperature and humidity. It has
the most advanced Multiple (9+1) independent zones with its own heating elements and sensors, ensuring no
crossover heating across zones. The Fertile safe also has four temperature modes that you can choose from: You can
turn on all zones, turn off the right zones, turn off the right and middle zones or all zones are turned off.

Accuracy: ± 0.2 °C

Uniformity: ± 0.2 °C.

Real-Time Surveillance System: Designed with a user-friendly platform, you have a real-time information of zone
performance and other work area parameters such as gas pressure and flow rate. Surveillance system with data
logging ensures proper system operation for maximum sample protection.

Optional Accessories:
1. LED light
2. Flexible Gas System
3. UV light
4. Digital Pressure Gauge.
5. Switch socket

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