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Nptel: Noc:Biomems and Microsystems - Video Course

This 8-week course covers topics related to BioMEMS and microsystems including introduction to microfabrication techniques, materials selection, sensor design, microfluidics, DNA and protein analysis, and lab-on-chip applications. Specific topics include introduction to silicon and polymer device fabrication, ion selective electrodes, DNA hybridization and sequencing, protein structure and charge, micromixers, microvalves, micropumps, etching, deposition, photolithography, and integrated gene analysis systems. The course is coordinated by Dr. Shantanu Bhattacharya from IIT Kanpur and is part of NPTEL, an online learning initiative by IISc and IITs funded by the Ministry of Human Resource Development in

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Debasis Roy
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50 views3 pages

Nptel: Noc:Biomems and Microsystems - Video Course

This 8-week course covers topics related to BioMEMS and microsystems including introduction to microfabrication techniques, materials selection, sensor design, microfluidics, DNA and protein analysis, and lab-on-chip applications. Specific topics include introduction to silicon and polymer device fabrication, ion selective electrodes, DNA hybridization and sequencing, protein structure and charge, micromixers, microvalves, micropumps, etching, deposition, photolithography, and integrated gene analysis systems. The course is coordinated by Dr. Shantanu Bhattacharya from IIT Kanpur and is part of NPTEL, an online learning initiative by IISc and IITs funded by the Ministry of Human Resource Development in

Uploaded by

Debasis Roy
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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NPTEL Syllabus

NOC:BioMEMS and
Microsystems - Video course

COURSE OUTLINE

This course covers topics on Introduction to BioMEMS and


microfluidics,Important materials for fabrication of BioMEMS
NPTEL
platforms,Design of ISE. Finding selectivity coefficient for a http://nptel.ac.in
mixed ion system.,Introduction to Cell biology, Basic structure of
DNA,Protein charging at different pH range, Amino acids,
protein polymerization, Transcription , Translation,Micromixers:
Design and mixing principales,Etching techniques, evaporation
Mechanical
and sputtering & Photolithography techniques. Engineering
COURSE DETAIL

Coordinators:
Week. Topics
No Dr. Shantanu Bhattacharya
Assistant ProfessorDepartment of
Mechanical EngineeringIIT Kanpur

1. Introduction to BioMEMS and microfluidics


Introduction to Bio nano technology,
Biosensors, fluidics.
Introduction to device fabrication (Silicon and
Polymers)
Introduction to device fabrication (Silicon and
Polymers) continued..
Sensors, Transduction and Performance
factors.
Sensors, Transduction and Performance
factors continued

2. Important materials for fabrication of BioMEMS


platforms
Introduction to silicon device fabrication
Some Fabrication Methods for soft materials
Transduction Methods. About cell potential and
SHEs
Cell reaction, Nernst equation, Construction of
Ion selective electrodes
Measurement and calibration of electrodes,
ion-solvent interaction
3. Design of ISE. Finding selectivity coefficient for
a mixed ion system.
ISE continued.. Gas sensing electrodes
Applications for biosensors in Diagnostics ,
Zeta potential and the model for electrode.
Flow between two fixed plates. Comparison
between plug like flow of electro-osmosis Vs
parabolic flow.
Electro-kinetic flow in silicon channels. Design
of electro-kinetic network.
Design of electro-kinetic network. Flow rate
calculations. Selection of good materials,
Streaming potential.

4. Introduction to Cell biology, Basic structure of


DNA
DNA hybridization, , DNA polymerization, PCR
Thermal cycle , Real Time PCR.PCR design
Electrophoresis, Gel and Capillary
electrophoresis, Agarose
DNA microarrays (concepts, and utility).
Affymetrix and Nanogen approaches in
realization of micro-arrays.
DNA sequencing (Sanger’s reaction). DNA
nano-pores. DNA detection using Mechanical
Cantilevers. Basics of Protein structure.

5. Protein charging at different pH range, Amino


acids, protein polymerization, Transcription ,
Translation
Antibody, Microencapsulation, Cyclic
voltametry
Microfluidics, Similarity of Streamlines,
Pathlines, Sreaklines and Timelines for a
steady flow
Stress tensor. Viscosity. Newtonian, non-
Newtonian fluids, Pseudoplastic, Dilatant,
Bingham Plastic materials, Thixotropic fluids.
Flow over infinite plates, laminar and turbulent
flow, Compressible and Incompressible flows
Flow over an infinite plate. Types of flows.
Types of Fluids. Kinematics of fluids

6. Micromixers: Design and mixing principales


Microvalves : Designing of pneumatic and
thermo pneumatic valves.
Hydrogel based valves. Electrochemical
valves.
Micropumps
Microelectronic-fabrication processes: Review
of basic fabrication processes for silicon
Introduction to microelectronic fabrication,
Optical lithography, photo-resists.

7. Etching techniques, evaporation and


sputtering.
Vacuum science and plasmas, Theory of
plasma
Review of basic fabrication processes for
polymers
Polymer materials for microsystems, Polymeric
micromachining technology.
Bulk and surface micro machining, Replication
technologies, laser machining,
micro-stereo lithography, micro-molding,
Assembly and packaging.

8. Photolithography techniques
Functionality of Polymer PDMS used in micro
technology
Additive techniques, Thermal oxidation
Single crystalline silicon, Subtractive technique.
Overview of Lab-on-chip technology/
biomedical and chemical sensors, specific
cases: Integrated gene analysis systems
Chip technology (Integrated analysis of
pathogenic bacteria), Electrochemical and
optical (labeled and unlabeled).

A joint venture by IISc and IITs, funded by MHRD, Govt of India http://nptel.ac.in

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