Nivolumab: Other Names: Opdivo®
Nivolumab: Other Names: Opdivo®
Nivolumab: Other Names: Opdivo®
Nivolumab
Bone marrow depression. This is a decrease in the number of white blood cells, red blood cells, and platelets. This may
raise your risk of infection, make you tired and weak (fatigue), and raise your risk of bleeding.
Tiredness and weakness
Joint, muscle and bone pain
Back pain
Loose bowel movements (diarrhea)
Nausea
Decreased appetite (decreased hunger)
Constipation (not able to move bowels)
Cough and trouble breathing
Upper respiratory infection
Fever
Rash and itching
Electrolyte changes. Your blood will be checked for electrolyte changes as needed.
Note: Each of the side effects above was reported in 20% or greater of patients treated with nivolumab. Not all possible side
effects are included above. Your side effects may be different or more severe if you receive nivolumab in combination with
other chemotherapy agents.
http://hillman.upmc.com/patients/community-support/education/chemotherapy-drugs/nivolumab 1/6
8/20/2018 Nivolumab (Other Names: Opdivo®) | UPMC Hillman Cancer Center
This drug works with your immune system and can cause inflammation in any of your organs and tissues and can change how
they work. This may put you at risk for developing serious medical problems which can very rarely be fatal.
Colitis. This is swelling (inflammation) in the colon - symptoms are loose bowel movements (diarrhea), stomach cramping, and
sometimes blood in the bowel movements
Inflammation (swelling) of the lungs which can very rarely be fatal - you may have a dry cough or trouble breathing.
This drug may affect some of your hormone glands (especially the thyroid, adrenals, pituitary and pancreas). Your hormone
levels will be checked as needed.
Blood sugar levels may change and you may develop diabetes. If you already have diabetes, changes may need to be made to
your diabetes medication.
Severe allergic skin reaction which can very rarely be fatal. You may develop blisters on your skin that are filled with fluid or a
severe red rash all over your body that may be painful.
Changes in your central nervous system can happen. The central nervous system is made up of your brain and spinal cord. You
could feel:
Extreme tiredness
Agitation
Confusion
Hallucinations (see or hear things that are not there)
Trouble understanding or speaking
Loss of control of your bowels or bladder
Eyesight changes
Numbness or lack of strength to your arms, legs, face, or body, and coma
If you start to have any of these symptoms let your doctor know right away.
While you are getting this drug in your vein (IV), you may have a reaction to the drug. Sometimes you may be given medication
to stop or lessen these side effects. Your nurse will check you closely for these signs:
http://hillman.upmc.com/patients/community-support/education/chemotherapy-drugs/nivolumab 2/6
8/20/2018 Nivolumab (Other Names: Opdivo®) | UPMC Hillman Cancer Center
Rash
Itching
Chest tightness
Chest pain
These reactions may happen after your infusion. If this happens, call 911 for emergency care.
Increased risk of complications, which may very rarely be fatal, in patients who will undergo a stem cell transplant after
receiving nivolumab.
Important Information
This drug may be present in the saliva, tears, sweat, urine, stool, vomit, semen, and vaginal secretions. Talk to your doctor
and/or your nurse about the necessary precautions to take during this time.
http://hillman.upmc.com/patients/community-support/education/chemotherapy-drugs/nivolumab 3/6
8/20/2018 Nivolumab (Other Names: Opdivo®) | UPMC Hillman Cancer Center
If you get a rash do not put anything on it unless your doctor or nurse says you may. Keep the area around the rash clean
and dry. Ask your doctor for medicine if your rash bothers you.
Infusion reactions may occur after your infusion. If this happens, call 911 for emergency care.
Tell your doctor and pharmacist about all the medicines and dietary supplements (vitamins, minerals, herbs and others) that
you are taking at this time. The safety and use of dietary supplements and alternative diets are often not known. Using these
might affect your cancer or interfere with your treatment. Until more is known, you should not use dietary supplements or
alternative diets without your cancer doctor's help.
Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:
http://hillman.upmc.com/patients/community-support/education/chemotherapy-drugs/nivolumab 4/6
8/20/2018 Nivolumab (Other Names: Opdivo®) | UPMC Hillman Cancer Center
Reproduction Warnings
Pregnancy warning: This drug can have harmful effects on the unborn baby. Women of child bearing potential should use
effective methods of birth control during your cancer treatment and for at least 5 months after treatment. Let your
doctor know right away if you think you may be pregnant.
Breastfeeding warning: It is not known if this drug passes into breast milk. For this reason, women should not breast feed
during treatment because this drug could enter the breast milk and cause harm to a breast feeding baby.
Fertility warning: Human fertility studies have not been done with this drug. Talk with your doctor or nurse if you plan to
have children. Ask for information on sperm or egg banking.
http://hillman.upmc.com/patients/community-support/education/chemotherapy-drugs/nivolumab 5/6
8/20/2018 Nivolumab (Other Names: Opdivo®) | UPMC Hillman Cancer Center
http://hillman.upmc.com/patients/community-support/education/chemotherapy-drugs/nivolumab 6/6