Diagnostic Report: Patient Name: Govinda Rajulu FH01.784161 0081SF006324
Diagnostic Report: Patient Name: Govinda Rajulu FH01.784161 0081SF006324
Diagnostic Report: Patient Name: Govinda Rajulu FH01.784161 0081SF006324
CLINICAL INFORMATION :
SEROLOGY
Interpretation(s)
WIDAL TEST, SERUM-WIDAL TEST, SERUM
The Widal agglutination test is used for diagnosing Enteric Fever. The term enteric fever includes typhoid fever caused by Salmonella typhi, Salmonella paratyphi A, B and C.
Though enteric fever is endemic in all parts of India, S.paratyphi C infections are uncommon and are not included in Widal testing.
Test Utility:
The Widal test measures the antibodies against the ''''''''''''''''H'''''''''''''''' (flagellar) & ''''''''''''''''O'''''''''''''''' (somatic) antigens of typhoid and paratyphoid(A & B) bacilli ,in the
patients sera. The test is performed in serially increasing dilutions.
- Diagnostic titre of Widal test varies highly between different geographical locations. It depends upon the baseline titre prevalent amongst the healthy individuals in that
geographical area, which in turn is influenced by endemicity of typhoid in that region.
- The titre of the Widal test will depend on the stage of the disease. Antibodies usually appear by the beginning of second week of infection. Hence blood taken earlier may
give a negative result. The titre increases steadily till the 3rd or 4th week after which it declines gradually.
- Cases treated early with antibiotics may show a poor antibody response.
- A single Widal test is of little clinical relevance due to the number of cross reacting infections,including malaria,tuberculosis, pneumonia, amoebiasis, rickettsial disease,
Rheumatoid arthritis, hepatitis B. A fourfold increase in the titer in paired sera in the course of the infection would be consistent with a typhoid infection.
- Persons who have suffered from enteric fever in the past may show agglutinins in moderate titre ,even when suffering from other unrelated illness. Such anamnestic
appearance may be differentitated by repeat testing after 7-10 days. Anamnestic response will show only a transient rise, while in enteric fever the rise will be sustained.
- TAB vaccinated patients may show a moderate rise in the titres against all three ‘H’, ‘AH’ & ‘BH’ antigens.
RAPID TYPHI IGM, SERUM/PLASMA EDTA/EDTA WB-RAPID TYPHI IgM
Typhoid fever is a bacterial infection caused by Salmonella serotypes including S.typhi, S.paratyphi A, S. paratyphi B and Salmonella sendai. The symptoms of the illness
include high fever, headache, abdominal pain, constipation and appearance of skin rashes. Accurate diagnosis of typhoid fever at an early stage is not only important for
etiological diagnosis but to identify and treat the potential carriers and prevent acute typhoid fever outbreaks. The conventional WIDAL test usually detects antibodies to
S.typhi in the patient serum from the second week of onset of the symptoms. Early rising antibodies to Lypopolysaccharides (LPS) O are predominantly IgM in nature.
Test Utility:
Detection of S.typhi specific IgM antibodies instead of IgG or both IgG and IgM (as measured by Widal test) serve as a rapid marker for recent infection.
Limitations:
A negative result does not rule out recent of current infection, as the positivity is influenced by the time elapsed from the onset of fever and immunocompetence of the
patient. However, if S.typhi infection is still suspected, retesting with second specimen obtained 5-7 days later is recommended.
**End Of Report**
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DIAGNOSTIC REPORT
CLINICAL INFORMATION :
1. It is presumed that the test sample belongs to the 5. The results of a laboratory test are dependent on
patient named or identified in the test requisition form. the quality of the sample as well as the assay
2. All Tests are performed and reported as per the technology.
turnaround time stated in the SRL Directory of services 6. Result delays could be because of uncontrolled
(DOS). circumstances. e.g. assay run failure.
3. SRL confirms that all tests have been performed or 7. Tests parameters marked by asterisks are excluded
assayed with highest quality standards, clinical safety & from the “scope" of NABL accredited tests. (If
technical integrity. laboratory is accredited).
4. A requested test might not be performed if: 8. Laboratory results should be correlated with clinical
a. Specimen received is insufficient or inappropriate information to determine Final diagnosis.
specimen quality is unsatisfactory 9. Test results are not valid for Medico- legal purposes.
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c. Request for testing is withdrawn by the ordering call at SRL customer care (Toll free: 1800-222-000).
doctor or patient Post proper investigation repeat analysis may be carried
d. There is a discrepancy between the label on the out.
specimen container and the name on the test
requisition form
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