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    Histological Variants:: Pathogenesis

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    Pravin Kumar
    This document summarizes information about ameloblastoma, a benign tumor that affects the jawbone. It defines ameloblastoma as a usually benign, intermittent tumor originating from dental tissue. The pathogenesis involves cell rests from tooth development. Clinically, it most commonly affects the mandible near the molars and presents as a central intraosseous lesion. Radiographically, it appears multilocular with septa extending into the radiolucent mass. Histologically, there are several variants described based on cell morphology and arrangements. Treatment involves thorough surgical removal via enucleation or more radical surgery.

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    Histological Variants:: Pathogenesis

    Uploaded by

    Pravin Kumar
    69 views2 pages
    This document summarizes information about ameloblastoma, a benign tumor that affects the jawbone. It defines ameloblastoma as a usually benign, intermittent tumor originating from dental tissue. The pathogenesis involves cell rests from tooth development. Clinically, it most commonly affects the mandible near the molars and presents as a central intraosseous lesion. Radiographically, it appears multilocular with septa extending into the radiolucent mass. Histologically, there are several variants described based on cell morphology and arrangements. Treatment involves thorough surgical removal via enucleation or more radical surgery.

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    This document summarizes information about ameloblastoma, a benign tumor that affects the jawbone. It defines ameloblastoma as a usually benign, intermittent tumor originating from dental tissue. The pathogenesis involves cell rests from tooth development. Clinically, it most commonly affects the mandible near the molars and presents as a central intraosseous lesion. Radiographically, it appears multilocular with septa extending into the radiolucent mass. Histologically, there are several variants described based on cell morphology and arrangements. Treatment involves thorough surgical removal via enucleation or more radical surgery.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    69 views2 pages

    Histological Variants:: Pathogenesis

    Uploaded by

    Pravin Kumar
    This document summarizes information about ameloblastoma, a benign tumor that affects the jawbone. It defines ameloblastoma as a usually benign, intermittent tumor originating from dental tissue. The pathogenesis involves cell rests from tooth development. Clinically, it most commonly affects the mandible near the molars and presents as a central intraosseous lesion. Radiographically, it appears multilocular with septa extending into the radiolucent mass. Histologically, there are several variants described based on cell morphology and arrangements. Treatment involves thorough surgical removal via enucleation or more radical surgery.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    AMELOBLASTOMA (Adamantinoma, Adamantoblastoma, Multilocular Cyst)

    Defined as ‘usually unicentric, nonfunctional, intermittent in growth, anatomically benign and clinically persistent’-Robinson

    PATHOGENESIS:

     Cell rest of the dental organ or remnants of Hertwig’s sheath


     Epithelium of odontogenic cysts – Dentigerous cyst & odontomas
     Disturbances of the developing enamel
     Basal cells of the surface epithelium

     CLINICAL PRESENTATION: RADIOGRAPHIC FEATURES :


    Mandible is most commonly affected
     Molar-angle-ramus area most common  Soap bubble appearance.
     Radiolucent area of multilocular type giving lesion Honey comb appearance.
     Located centrally or intra osseously.
     Compartmented appearance with septa of bones extending into radiolucent tumor mass.
     Impacted third molar can also be seen panoramic radiograph

    HISTOLOGICAL VARIANTS:

    PLEXIFORM AMELOBLASTOMA FOLLICULAR AMELOBLASTOMA: ACANTHOMATOUS AMELOBLASTOMA

     Cells are arranged in irregular mass  Peripheral layer of cuboidal or columnar cells.  Squamous metaplacia
     Network of interconnected strands of cells.  Nuclei are generally well polarized.  Keratin formation in central portion.
     Cystic degeneration of stroma common  Cyst formation common  Epithelial or keratin pearls may be observed.

    GRANULAR AMELOBLASTOMA BASAL CELL AMELOBLASTOMA DESMOPLASTIC AMELOBLASTOMA

     Stellate reticulum like cells.  Resemble to basal cell carcinoma of skin.  Appear hyaliized and hypocellular.
     Granular eosinophilic appearance.  Epithilial cells are more primitive and less  Strands and cords of epithelium stretched in
     Granules represent lysosomal aggregates with columnar. kite-tail like appearance.
    no cellular components

    TREATMENT: Enucleation with thorough bone curettage. & radical surgical approach.
    Submitted by: Pratibha Yadav, Supragya Raj, Neetu Pandey, Neha Srivastava, Nidhi Singh, Nishi Prasad, Pooja Pathak,
    Praveen Prabhakar, Pravin Kumar (2015-16)
    Teacher's incharge - Dr

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