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    Clinton 2003 Abstract

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    mohit jain
    The study compared four tumor markers (CA 15-3, CA 27.29, AFP, and CEA) for detecting breast cancer using samples from 554 patients and 200 healthy adults. CA 15-3 was found to have the highest diagnostic sensitivity at 63% while the other markers ranged from 22-39%. All markers showed similar diagnostic specificities from 80-88%.

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    Clinton 2003 Abstract

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    mohit jain
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    The study compared four tumor markers (CA 15-3, CA 27.29, AFP, and CEA) for detecting breast cancer using samples from 554 patients and 200 healthy adults. CA 15-3 was found to have the highest diagnostic sensitivity at 63% while the other markers ranged from 22-39%. All markers showed similar diagnostic specificities from 80-88%.

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    The study compared four tumor markers (CA 15-3, CA 27.29, AFP, and CEA) for detecting breast cancer using samples from 554 patients and 200 healthy adults. CA 15-3 was found to have the highest diagnostic sensitivity at 63% while the other markers ranged from 22-39%. All markers showed similar diagnostic specificities from 80-88%.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    18 views1 page

    Clinton 2003 Abstract

    Uploaded by

    mohit jain
    The study compared four tumor markers (CA 15-3, CA 27.29, AFP, and CEA) for detecting breast cancer using samples from 554 patients and 200 healthy adults. CA 15-3 was found to have the highest diagnostic sensitivity at 63% while the other markers ranged from 22-39%. All markers showed similar diagnostic specificities from 80-88%.

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    A comparative study of four serological tumor markers for the detection ... https://www.ncbi.nlm.nih.

    gov/pubmed/12724928

    Format: Abstract

    Biomed Sci Instrum. 2003;39:408-14.

    A comparative study of four serological tumor markers for the detection of breast cancer.
    Clinton SR1 , Beason KL, Bryant S, Johnson JT, Jackson M, Wilson C, Holifield K, Vincent C, Hall M.

    Author information

    Abstract
    Breast cancer is currently the third most common cause of cancer in the world. Circulating tumor antigens are often used as a
    minimally invasive tool for noting breast cancer progression. The objective of this study was to compare four tumor antigens (CA
    15-3, CA 27.29, alpha-fetoprotein [AFP], and carcinoembryonic antigen [CEA]) for their diagnostic efficacy in breast cancer
    patients. It was hypothesized that CA 15-3 would proved to be superior to CA 27.29, CEA, and AFP in assay performance. Tumor
    marker assays were performed according to the manufacturers' directions. Assays used in this study were CA 15-3 and CA 27.29
    (Fujirebio Diagnostics/Centocor Inc.), AFP (Abbott Inc.), and CEA (Hybritech Inc.). A total of 554 patient samples were obtained
    from an area hospital, plus 200 healthy adult samples which were used for the determination of normal reference intervals. The
    patients included patients with no disease (184), with non-malignant disease (11), with breast cancer (87), and with other types of
    cancer (272). Diagnostic percent sensitivities for each marker were: CA 15-3 (63%), CA 27.29 (39%), CEA (22%), and AFP (22%).
    Diagnostic specificities for each marker were comparable, ranging from 80-88%. Analytical parameters were evaluated for the
    assays and compared favorably. We concluded that CA 15-3 was the best tumor antigen for use as a diagnostic aid and monitoring
    agent.

    PMID: 12724928
    [Indexed for MEDLINE]

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