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Experiment 11, 12, 13 Classification Tests For Amines and Synthesis

This document provides information on the classification, properties, and synthesis of various organic compounds. It discusses amines and how to classify primary, secondary, and tertiary amines using the Hinsberg test. It also describes the synthesis of aspirin and methyl salicylate from salicylic acid. Tests for these compounds using ferric chloride and starch are also outlined. The document concludes with definitions of soap and detergent and compares their amphipathic nature, synthesis, and performance in hard water.

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Denise Yanci Demiar
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921 views19 pages

Experiment 11, 12, 13 Classification Tests For Amines and Synthesis

This document provides information on the classification, properties, and synthesis of various organic compounds. It discusses amines and how to classify primary, secondary, and tertiary amines using the Hinsberg test. It also describes the synthesis of aspirin and methyl salicylate from salicylic acid. Tests for these compounds using ferric chloride and starch are also outlined. The document concludes with definitions of soap and detergent and compares their amphipathic nature, synthesis, and performance in hard water.

Uploaded by

Denise Yanci Demiar
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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CLASSIFICATION

TEST FOR
AMINES
AMINES

R NH2 R1 NH
R2
R3
R1 N
R2
PROPERTIES OF AMINES
•  urine-like odor
•  Polar
•  Basic

HINSBERG TEST
•  differen2a2ng test for 10, 20 and 30 amines
•  Reagent: benzenesulfonyl chloride/NaOH

Cl
O
S
O
Soluble ppt
10 Amine
White ppt
10 or 20 Amine +NaOH (aq)

Amine benzenesulfonylchloride Insoluble ppt 20 Amine

No ppt
30 Amine
SYNTHESIS OF ASPIRIN AND
METHYL SALICILATE
ASPIRIN
•  Acetyl salicylic acid (ASA) O
•  Analgesic
•  An2pyre2c OH
•  Slightly soluble in water
O

O CH3
SYNTHESIS OF ASPIRIN

O O
O
OH H2SO4 OH
H3C O
+ + H2O
O
O
OH
CH3
O CH3
SYNTHESIS OF MEHYL SALICYLATE

O
O

OH H2SO4
+ H3C OH OH
+ H2O
OH
O
CH3
FERRIC CHLORIDE TEST
•  Complexa2on rxn of Fe3+
•  Fe3+ forms a complex with aspirin
STARCH TEST
•  Role of starch in pharmaceu2cal prepara2on:
–  Excipient: diluent or binder
•  Reagent: I2
•  Forma2on of iodo-starch complex: bluish-
black suspension
SYNTHESIS OF SOAP AND
DETERGENT
DEFINITION OF TERMS
Soap – sodium salt of faUy acid
Fa3y acid – long chain carboxylic acid
Detergent – sodium salt of long HC chain of
thioester

AMPHIPATIC NATURE OF SOAPS AND
DETERGENTS
SYNTHESIS OF SOAP

+ NaOH + H2O
Δ
SYNTHESIS OF DETERGENT

NaCl
+
BASIS OF SOAP DETERGENT
COMPARISON
Structure Na+ salt of faUy acid Na+ salt of thioester
Ac2vity in dis2lled Forma2on of suds Forma2on of suds
water
Ac2vity in Hard Minimal to no suds No effect suds
Water Forma2on of scums forma2on
Test for Glycerol Burnt fat odor No burnt fat odor
TEST FOR GLYCEROL
(ACROLEIN TEST)
•  Dehydra2on reac2on

KHSO4
+ 2H2O
THANK YOU!

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