Chapter-

Endocrine System
Despite the huge variety of hormones, there are really only two mechanisms by which hormones
trigger changes in cells.

1. Water equilibrium. The endocrine system controls water equilibrium by regulating

the solute concentration of the blood.
2. Growth, metabolism, and tissue maturation. The endocrine system controls the
growth of many tissues, like the bone and muscle, and the degree of metabolism of
various tissues, which aids in the maintenance of the normal body temperature and
normal mental functions. Maturation of tissues, which appears in the development of
adult features and adult behavior, are also determined by the endocrine system.
3. Heart rate and blood pressure management. The endocrine system assists in
managing the heart rate and blood pressure and aids in preparing the body for physical
motion.
4. Immune system control. The endocrine system helps regulate the production and
functions of immune cells.
5. Reproductive function controls. The endocrine system regulates the development
and the functions of the reproductive systems in males and females.
6. Uterine contractions and milk release. The endocrine system controls uterine
contractions throughout the delivery of the newborn and stimulates milk release from
the breasts in lactating females.
7. Ion management. The endocrine system regulates Na+, K+, and Ca2+ concentrations
in the blood.
8. Blood glucose regulator. The endocrine system controls blood glucose levels and
other nutrient levels in the blood.
9. Direct gene activation. Being lipid-soluble molecules, the steroid hormones can
diffuse through plasma membranes of their target cells; once inside, the steroid
hormone enters the nucleus and binds to a specific receptor protein there; then, the
hormone-receptor complex binds to specific sites on the cell’s DNA, activating certain
genes to transcribe messenger RNA; the mRNA then is translated in the cytoplasm,
resulting in the synthesis of new proteins.
 10. Second messenger system. Water-soluble, nonsteroidal hormones-protein, and
peptide hormones- are unable to enter the target cells, so instead, they bind to
receptors situated on the target cell’s plasma membrane and utilize a second
messenger system..
Hypothalamus
The major endocrine organs of the body include the pituitary, thyroid, parathyroid, adrenal,
pineal and thymus glands, the pancreas, and the gonads.

 Hypothalamus. The hypothalamus, which is part of the nervous system, is also

considered as a major endocrine organ because it produces several hormones. It is an
important autonomic nervous system and endocrine control center of the brain located
inferior to the thalamus.
 Mixed functions. Although the function of some hormone-producing glands is purely
endocrine, the function of others (pancreas and gonads) is mixed- both endocrine and
exocrine.

Pituitary Gland
The pituitary gland is approximately the size of a pea.

 Location. The pituitary gland hangs by a stalk from the inferior surface of
the hypothalamus of the brain, where it is snugly surrounded by the “Turk’s saddle”
of the sphenoid bone.
 Lobes. It has two functional lobes- the anterior pituitary (glandular tissue) and the
posterior pituitary (nervous tissue).

Hormones of the Anterior Pituitary

There are several hormones of the anterior pituitary hormones that affect many body organs.

 Growth hormone (GH). Growth hormone is a general metabolic hormone, however,

its major effects are directed to the growth of skeletal muscles and long bones of the
body; it is a protein-sparing and anabolic hormone that causes amino acids to be built
into proteins and stimulates most target cells to grow in size and divide.
  Prolactin (PRL). Prolactin is a protein hormone structurally similar to growth
hormone; its only known target in humans is the breast because, after childbirth, it
stimulates and maintains milk production by the mother’s breast.
 Adrenocorticotropic hormone (ACTH). ACTH regulates the endocrine activity of
the cortex portion of the adrenal gland.
 Thyroid-stimulating hormone (TSH). TSH, also called thyrotropin hormone
influences the growth and activity of the thyroid gland.
 Gonadotropic hormones. The gonadotropic hormones regulate the hormonal activity
of gonads (ovaries and testes).
 Follicles-stimulating hormone (FSH). FSH stimulates follicle development in the
ovaries; as the follicles mature, they produce estrogen and eggs that are readied for
ovulation; in men, FSH stimulates sperm development by the testes.
 Luteinizing hormone (LH). LH triggers ovulation of an egg from the ovary and
causes the ruptured follicle to produce progesterone and some estrogen; in men, LH
stimulates testosterone production by the interstitial cells of the testes.

Hormones of the Posterior Pituitary

The posterior pituitary is not an endocrine gland in the strict sense because it does not make the
peptide hormones it releases, but it simply acts as a storage area for hormones made by
hypothalamic neurons.

 Oxytocin. Oxytocin is released in significant amount only during childbirth and in

nursing women; it stimulates powerful contractions of the
uterine muscle during labor, during sexual relations, and during breastfeeding and also
causes milk ejection (let-down reflex) in a nursing woman.
 Antidiuretic hormone (ADH). ADH causes the kidneys to reabsorb more water from
the forming of urine; as a result, urine volume decreases and blood volume increases;
in larger amounts, ADH also increases blood pressure by causing constriction of the
arterioles, so it is sometimes referred to as vasopressin.
Thyroid Gland

The thyroid gland is a hormone-producing gland that is familiar to most people primarily
because many obese individuals blame their overweight condition on their “glands” (thyroid).

 Location. The thyroid gland is located at the base of the throat, just inferior to the
Adam’s apple, where it is easily palpated during a physical examination.
 Lobes. It is a fairly large gland consisting of two lobes joined by a central mass,
or isthmus.
 Composition. Internally, the thyroid gland is composed of hollow structures
called follicles, which store a sticky colloidal material.
 Types of thyroid hormones. Thyroid hormone often referred to as the body’s major
metabolic hormone, is actually two active, iodine-containing hormones, thyroxine or
T4, and triiodothyronine or T3.
 Thyroxine. Thyroxine is the major hormone secreted by the thyroid follicles.
 Triiodothyronine. Most triiodothyronine is formed at the target tissues by conversion
of the thyroxine to triiodothyronine.
 Function. Thyroid hormone controls the rate at which glucose is “burned” oxidized,
and converted to body heat and chemical energy; it is also important for normal tissue
growth and development.
 Calcitonin. Calcitonin decreases blood calcium levels by causing calcium to be
deposited in the bones; calcitonin is made by the so-called parafollicular cells found
in the connective tissues between the follicles.

Parathyroid Glands
The parathyroid glands are mostly tiny masses of glandular tissue.

 Location. The parathyroid glands are located on the posterior surface of the thyroid
gland.
 Parathormone. The parathyroids secrete parathyroid hormone (PTH) or
parathormone, which is the most important regulator of calcium ion homeostasis of
the blood; PTH is a hypercalcemic hormone (that is, it acts to increase blood levels
 of calcium), whereas calcitonin is a hypocalcemic hormone.; PTH also stimulates the
kidneys and intestines to absorb more calcium.
Adrenal Glands

Although the adrenal gland looks like a single organ, it is structurally and functionally two
endocrine organs in one.
Hormones of the Adrenal Cortex
The adrenal cortex produces three major groups of steroid hormones, which are collectively
called corticosteroids– mineralocorticoids, glucocorticoids, and sex hormones.

 Mineralocorticoids. The mineralocorticoids, primarily aldosterone, are produced by

the outermost adrenal cortex cell layer; mineralocorticoids are important in regulating
the mineral (or salt) content of the blood, particularly the concentrations
of sodium and potassium ions and they also help in regulating the water and
electrolyte balance in the body.
 Renin. Renin, am enzyme produced by the kidneys when the blood pressure drops,
also cause the release of aldosterone by triggering a series of reactions that
form angiotensin II, a potent stimulator of aldosterone release.
 Atrial natriuretic peptide (ANP). ANP prevents aldosterone release, its goal being
to reduce blood volume and blood pressure.
 Glucocorticoids. The middle cortical layer mainly produces glucocorticoids, which
include cortisone and cortisol; glucocorticoids promote normal cell metabolism and
help the body to resist long-term stressors, primarily by increasing blood glucose
levels, thus it is said to be a hyperglycemic hormone; it also reduce pain and
inflammation by inhibiting some pain-causing molecules called prostaglandins.
 Sex hormones. Both male and female sex hormones are produced by the adrenal
cortex throughout life in relatively small amounts; although the bulk of sex hormones
produced by the innermost cortex layer are androgens (male sex hormones),
some estrogens (female sex hormones), are also formed.
Hormones of the Adrenal Medulla
The adrenal medulla, like the posterior pituitary, develops from a knot of nervous tissue.
  Catecholamines. When the medulla is stimulated by sympathetic nervous
systemneurons, its cells release two similar hormones, epinephrine, also
called adrenaline, and norepinephrine (noradrenaline), into the bloodstream;
collectively, these hormones are referred to as catecholamines.
 Function. Basically, the Catecholamines increase heart rate, blood pressure, and
blood glucose levels and dilate the small passageways of the lungs; the
catecholamines of the adrenal medulla prepare the body to cope with a brief or short-
term stressful situation and cause the so-called alarm stage of the stress response.
Pancreatic Islets
The pancreas, located close to the stomach in the abdominal cavity, is a mixed gland.

 Islets of Langerhans.The islets of Langerhans also called pancreatic islets, are little
masses of hormone-producing tissue that are scattered among the enzyme-producing
acinar tissue of the pancreas.
 Hormones. Two important hormones produced by the islet cells
are insulin and glucagon.
 Islet cells. Islet cells act as fuel sensors, secreting insulin and glucagon appropriately
during fed and fasting states.
 Beta cells. High levels of glucose in the blood stimulate the release of insulin from the
beta cells of the islets.
 Alpha cells. Glucagon‘s release by the alpha cells of the islets is stimulated by low
blood glucose levels.
 Insulin. Insulin acts on just about all the body cells and increases their ability to
transport glucose across their plasma membranes; because insulin sweeps glucose out
of the blood, its effect is said to be hypoglycemic.
 Glucagon. Glucagon acts as an antagonist of insulin; that is, it helps to regulate blood
glucose levels but in a way opposite that of insulin; its action is
basically hyperglycemic and its primary target organ is the liver, which it stimulates
to break down stored glycogen into glucose and release the glucose into the blood.

Pineal Gland
The pineal gland, also called the pineal body, is a small cone-shaped gland.
  Location. The pineal gland hangs from the roof of the third ventricle of the brain.
 Melatonin. Melatonin is the only hormone that appears to be secreted in substantial
amounts by the pineal gland; the levels of melatonin rise and fall during the course of
the day and night; peak levels occur at night and make us drowsy as melatonin is
believed to be the “sleep trigger” that plays an important role in establishing the
body’s day-night cycle.
Thymus Gland
The thymus gland is large in infants and children and decreases in size throughout adulthood.
 Location. The thymus gland is located in the upper thorax, posterior to the sternum.
 Thymosin. The thymus produces a hormone called thymosin and others that appear to
be essential for normal development of a special group of white blood cells (T-
lymphocytes, or T cells) and the immune response.

Gonads
Main Article: Female Reproductive System and Male Reproductive System
The female and male gonads produce sex hormones that are identical to those produced by
adrenal cortex cells; the major difference are the source and relative amount produced.

Hormones of the Ovaries

The female gonads or ovaries are a pair of almond-sized organs.

 Location. The female gonads are located in the pelvic cavity.

 Steroid hormones. Besides producing female sex cells, ovaries produce two groups
of steroid hormones, estrogen, and progesterone.
 Estrogen. Alone, the estrogens are responsible for the development of sex
characteristics in women at puberty; acting with progesterone, estrogens promote
breast development and cyclic changes in the uterine lining (menstrual cycle).
 Progesterone. Progesterone acts with estrogen to bring about the menstrual cycle;
during pregnancy, it quiets the muscles of the uterus so that an implanted embryo will
not be aborted and helps prepare breast tissue for lactation.

Hormones of the Testes

The testes of the male are paired oval organs in a sac.
  Location. The testes are suspended in a sac, the scrotum, outside the pelvic cavity.
 Male sex hormones. In addition to male sex cells, or sperm, the testes also produce
male sex hormones, or androgens, of which testosterone is the most important.
 Testosterone. At puberty, testosterone promotes the growth and maturation of the
reproductive system organs to prepare the young man for reproduction; it also causes
the male’s secondary sex characteristics to appear and stimulates male sex
drive; Testosterone is also necessary for the continuous production of sperm.
Other Hormone-Producing Tissues and Organs
Besides the major endocrine organs, pockets of hormone-producing cells are found in fatty tissue
and in the walls of the small intestine, stomach, kidneys, and heart- organs whose chief functions
have little to do with hormone production.
Placenta
The placenta is a remarkable organ formed temporarily in the uterus of pregnant women.

 Function. In addition to its roles as the respiratory, excretory, and

nutrition deliverysystems for the fetus, it also produces several proteins and steroid
hormones that help to maintain the pregnancy and pave the way for delivery of the
baby.
 Human chorionic gonadotropin. During very early pregnancy, a hormone called
human chorionic gonadotropin (hCG) is produced by the developing embryo and then
by the fetal part of the placenta; hCG stimulates the ovaries to continue
producing estrogenand progesterone so that the lining of the uterus is not sloughed off
in the menses.
 Human placental lactogen (hPL). hPL works cooperatively
with estrogen and progesterone in preparing the breasts for lactation.
 Relaxin. Relaxin, another placental hormone, causes the mother’s pelvic ligaments
and the pubic symphysis to relax and become more flexible, which eases birth
passage.

Physiology of the Endocrine System

Although hormones have widespread effects, the major processes they control are reproduction,
growth, and development; mobilizing the body’s defenses against stressors; maintaining
electrolyte, water, and nutrient balance of the blood; and regulating cellular metabolism and
energy balance.
The Chemistry of Hormones
The key to the incredible power of the endocrine glands is the hormones they produce and
secrete.

 Hormones. Hormones may be defined as chemical substances that are secreted by

endocrine cells into the extracellular fluids and regulate the metabolic activity of other
cells in the body.
 Classification. Although many different hormones are produced, nearly all of them
can be classified chemically as either amino acid-based molecules (including
proteins, peptides, and amines) or steroids.
 Steroid hormones. Steroid hormones (made from cholesterol) include the sex
hormones made by the gonads and hormones produced by the adrenal cortex.
 Amino acid-based hormones. All the others are nonsteroidal amino acid derivatives.

Mechanisms of Hormone Action

Although the blood-borne hormones circulate to all the organs of the body, a given hormone
affects only certain tissue cells or organs.

 Target cells. For a target cell to respond to the hormone, specific protein receptors
must be present on its plasma membrane or in its interior to which that hormone can
attach; only when this binding occurs can the hormone influence the workings of
cells.
 Function of hormones. The hormones bring about their effects on, the body cells
primarily by altering cellular activity- that is, by increasing or decreasing the rate of a
normal, or usual, metabolic process rather than stimulating a new one.
 Changes in hormone binding. The precise changes that follow hormone binding
depend on the specific hormone and the target cell type, but typically one or more of
the following occurs:

1. Changes in plasma membrane permeability or electrical state.

2. Synthesis of protein or certain regulatory molecules (such as enzymes) in the cell.’
 3. Activation or inactivation of enzymes.
4. Stimulation of mitosis.
5. Promotion of secretory activity.

Control of Hormone Release

What prompts the endocrine glands to release or not release their hormones?

 Negative feedback mechanisms. Negative feedback mechanisms are the chief means
of regulating blood levels of nearly all hormones.
 Endocrine gland stimuli. The stimuli that activate the endocrine organs fall into
three major categories- hormonal, humoral, and neural.
 Hormonal stimuli. The most common stimulus is a hormonal stimulus, in which the
endocrine organs are prodded into action by other hormones; for example,
hypothalamic hormones stimulate the anterior pituitary gland to secrete its hormones,
and many anterior pituitary hormones stimulate other endocrine organs to release their
hormones into the blood.
 Humoral stimuli. Changing blood levels of certain ions and nutrients may also
stimulate hormone release, and this is referred to as humoral stimuli; for example, the
release of parathyroid hormone (PTH) by cells of the parathyroid glands is prompted
by decreasing blood calcium levels.
 Neural stimuli. In isolated cases, nerve fibers stimulate hormone release, and the
target cells are said to respond to neural stimuli; a classic example is
sympathetic nervous system stimulation of the adrenal medulla to
release norepinephrine and epinephrine during periods of stress.