Clasificarea Epilepsiilor
Clasificarea Epilepsiilor
Clasificarea Epilepsiilor
synchronous neuronal activity in the brain. A seizure does not necessarily mean that a person
has epilepsy. Seizures fall broadly into two main groups: focal and generalized, although these
categories may not be suitable to describe all seizures.
GENERALIZED SEIZURE
A generalized seizure is conceptualized as originating at some point within, and rapidly engaging,
bilaterally distributed networks. Such bilateral networks can include cortical and subcortical
structures, but do not necessarily include the entire cortex. Although individual seizure onsets can
appear localized, the location and lateralization are not consistent from one seizure to another.
Generalized seizures can be asymmetric.
Generalized convulsive seizures are typically bilateral and symmetric although variants with
asymmetry including head and eye deviation can be seen. A tonic clonic seizure is a seizure
consisting of a tonic and a clonic phase, typically in this order, however variations such as clonic-
tonic-clonic are also seen. A clonic seizure is a seizure involving bilaterally rhythmic jerking and
may occur alone or in combination with tonic activity where there is bilaterally increased tone of
the limbs typically lasting seconds to a minute. The jerking in a clonic seizure is more sustained
and rhythmic than seen in a myoclonic seizure
EEG Ictal
With generalized convulsive seizures, the ictal EEG is often obscured by artifact. Generalized fast
rhythmic spikes are seen in the tonic stage. Bursts of spikes and after-coming slow waves are
synchronous with clonic jerks. A postictal period of irregular slow activity follows. Although
individual seizure onsets can appear localized, the location and lateralization are not consistent
from one seizure to another.
Differential diagnosis
Non-epileptic seizures
Syncope with anoxic seizure
Focal seizure evolving to bilateral convulsion
Related conditions
ABSENCE – TYPICAL
A typical absence seizure is a generalized seizure with abrupt onset and offset of altered
awareness which can vary in severity (see specific syndromes). Memory for events during the
seizures is usually impaired although there may be some retained awareness particularly for
adolescents. Clonic movements of eyelids, head, eyebrows, chin, perioral or other facial parts
may occur, most typically at 3Hz. Myoclonus of limbs can rarely occur. Oral and manual
automatisms are common and there may be perseveration of behaviors occurring prior to seizure
onset. Absence seizures were previously known as 'petit mal' seizures. Absence status
epilepticus can occur.
CAUTION Individual absence seizure longer than 45 seconds or with a post-ictal phase
consider focal seizure.
CAUTION Onset of absence seizures < 4 years consider glucose transporter disorders
EEGIctal
Differential diagnosis
Absence with eyelid myoclonia: repetitive, rhythmic, fast >4 Hz jerks of the eyelids, with
upward deviation of the eyeballs and with head extension; often very frequent and provoked
by photic stimulation.
Myoclonic absence: 3 Hz myoclonic jerks of upper limbs with tonic abduction.
Atypical absence: more prolonged subtle altered awareness often seen in individuals with
intellectual disability.
Focal seizures with dyscognitive features
Daydreaming / inattention
Related syndromes
TONIC
A generalized tonic seizure involves bilaterally increased tone of the limbs typically lasting
seconds to a minute. They often occur out of sleep and in runs of varying intensity of tonic
stiffening. The individual is unaware during these events. At the beginning of tonic seizures with
more intense stiffening, individuals may make an expiratory sound. More severe and prolonged
tonic seizures may have a vibratory component which may be confused with clonic jerking. Tonic
seizures often occur in individuals with intellectual impairment.
CAUTION Although asymmetry can occur in a generalized tonic seizure, if consistent focal
features are seen from seizure to seizure consider focal seizure involving the frontal lobe.
NOTE Tonic seizures are one type of seizure that can result in a "drop attack" (also known as
astatic seizure), other causes of drop attacks include myoclonic (especially in younger children),
atonic and myoclonic-atonic seizures.
Ictal
Tonic seizures show diffuse or generalized accelerating low amplitude paroxysmal fast activity,
which is often bilateral and predominates in the anterior and vertex regions.
Tonic seizure, on EEG accompanied by electrodecrement and paroxysmal fast frequencies.
CAUTION Consistent focality of spikes or maximal amplitude of ictal rhythm consider focal
seizure.
Differential diagnosis
Epileptic spasms: the motor contraction is often shorter in duration (<2 seconds), epileptic
spasms often occur in a series.
Focal seizure - supplementary sensorimotor cortex of frontal lobe
Syncope
Non epileptic seizures
Related sindr
Lennox-Gastaut syndrome
Epilepsy with myoclonic-atonic seizures
ATONIC
An atonic seizure involves sudden loss or diminution of muscle tone without apparent preceding
myoclonic or tonic features. Atonic seizures are very brief (<2 seconds) and may involve the
head, trunk or limbs. Atonic seizures often occur in individuals with intellectual impairment.
NOTE Atonic seizures are one type of seizure that can result in a "drop attack" (also known as an
astatic seizure), other causes of drop attacks include myoclonic (especially in younger children),
tonic and myoclonic-atonic seizures.
Ictal
Generalized spike-and-wave is typical, with atonia at the time of the slow wave.
Myoclonic-atonic seizure: the myoclonic component may be missed without careful review of
video
Syncope
Focal seizure with atonic motor features
Related syndr
MYOCLONIC
A myoclonic seizure is a single or series of jerks (brief muscle contractions). Each jerk is
typically milliseconds in duration. Myoclonic status epilepticus is characterized by ongoing (> 30
minutes) irregular jerking, often with partially retained awareness.
NOTE Myoclonic seizures are one type of seizure that can result in a "drop attack" (also known as
astatic seizure), other causes of drop attacks include tonic, atonic and myoclonic-atonic seizures.
Ictal
The myoclonic jerk correlates with a generalized spike-and-wave or polyspike-and-wave
Differential dg
Related syndr
NEGATIVE MYOCLONUS
A negative myoclonic seizure is a seizure with brief cessation of background muscle tone,
lasting less than 500 milliseconds. The resulting movement produced can have two components,
an initial loss of posture caused by the negative myoclonus, and a subsequent voluntary,
compensatory movement to restore posture. Negative myoclonic seizures may occur in isolation
or in a series.
Ictal
Negative myoclonus is seen in association with the spike of a spike or spike-and-wave discharge
on EEG.
Differential dg
Related syndr
MYOCLONIC-ATONIC
NOTE Myoclonic-atonic seizures are one type of seizure that can result in a "drop attack" (also
known as astatic seizure), other causes of drop attacks include myoclonic (especially in younger
children), tonic and atonic seizures.
Ictal
The myoclonic component is associated with a generalized spike or polyspike. The atonic
component is associated with the aftergoing high voltage slow wave.
CAUTION Focal discharges are not seen consider structural brain abnormality.
Differential dg
Atonic seizure
Tonic seizure
Typical absence: with myoclonic or atonic components
Related syndr
Focal seizures can be described by their semiology (features). The features that occur may
reflect the regional networks involved in the seizure origin or propagation, often enabling these
areas of the brain to be identified. Some features allow identification of the hemisphere involved,
others allow identification of the discrete area of the brain (for example a lobe) that is involved. In
this section of EpilepsyDiagnosis.org, features of focal seizures are presented as well as the
collection of features that may allow the seizure onset or network to be lateralized to a
hemisphere and/or discretely localized to a lobe or a more localized area of the brain.
AURA
Auras are subjective and may be sensory or experiential. They reflect the initial seizure
discharge. An aura may be an isolated phenomenon or progress to a focal seizure with objective
features (with or without altered awareness) or to a bilateral convulsion. An aura is also known as
a "warning".
Sensory aura
A sensory aura involves a sensation without an objective clinical sign. Sensory aura include the
following types:
Experiential aura
An experiential aura involves affective, mnemonic (memory) or perceptual subjective phenomena
including depersonalization and hallucinatory events; these may appear alone or in combination.
Experiential aura include the following types:
Affective aura are characterized by phenomena such as fear, depression, joy and anger.
Mnemonic aura are characterized by memory phenomena such as feelings of familiarity
(déjà vu) and unfamiliarity (jamais vu).
Hallucinatory aura are characterized by imagined complex sensory phenomena that may
involve visual (e.g. formed images), auditory (e.g. hearing voices) or other sensory
modalities, without change in awareness. The sensory phenomena may be accompanied by
associated emotion or interpretation e.g. may be experienced as persecutory.
Illusory aura are characterized by an alteration of actual perception involving visual,
auditory, somatosensory, olfactory, and/or gustatory phenomena, without change in
awareness.
MOTOR
A motor feature involves motor activity and may consist of an increase (positive) or decrease
(negative) in muscle contraction. Motor features may be elementary or complex.
Elementary motor
An elementary motor feature involves a stereotyped contraction of a muscle or group of
muscles. Such motor features may be predominantly convulsive Convulsive: rhythmic jerking
(clonic activity), may occur alone or in combination with tonic activity. (e.g. hemiclonic
Hemiclonic: rhythmic jerking (clonic activity) involving only one side of the body),
myoclonicMyoclonic: a single or short cluster of brief muscle contractions (jerks). Each jerk is
typically milliseconds in duration., tonicTonic: increased muscle tone, usually lasting for seconds
to minutes., epileptic spasmEpileptic spasm: sudden flexion, extension or mixed flexion-
extension of proximal and truncal muscles, lasting 1-2 seconds, typically occurs in a series,
versiveVersive: sustained, forced conjugate ocular, cephalic, and/or truncal rotation or lateral
deviation from the midline. or dystonicDystonic: sustained contractions of both agonist and
antagonist muscles producing athetoid or twisting movements, may produce abnormal postures..
Complex motor
A complex motor feature involves complex movement patterns. Three types are recognized:
A hypermotor feature involves proximal limb or axial muscles, producing irregular large
amplitude ballistic movements, such as pedaling, pelvic thrusting, jumping, thrashing and/or
rocking movements.
A negative motor feature is characterized by reduced motor activity.
o A negative myoclonic feature involves an interruption in normal tonic muscle activity for
500 milliseconds or less, without evidence of preceding myoclonus Myoclonic: a single or
short cluster of brief muscle contractions (jerks). Each jerk is typically milliseconds in
duration..
o An atonic feature involves sudden loss or diminution of muscle tone without apparent
preceding myoclonic or tonic activity. This lasts >500 milliseconds but < 2 seconds. It
may involve the head, trunk, jaw, or limb musculature
o A hypomotor feature involves a decrease in amplitude and/or rate or arrest of ongoing
motor activity.
An automatism is a coordinated, repetitive motor activity usually occurring when cognition is
impaired and for which the subject is usually amnesic afterward. This often resembles a
voluntary movement and may consist of an inappropriate continuation of pre-ictal motor
activity. Automatisms include:
o Oroalimentary: lip smacking, lip pursing, chewing, swallowing, clicking.
o Manual or pedal: bilateral or unilateral distal or proximal movements, including fumbling,
tapping, manipulating movements of hands or feet.
o Gestural: often unilateral, fumbling or exploratory movements with the hand intended to
lend emotional tone to communication.
o Gelastic: bursts of laughter or giggling, usually without appropriate affective tone and
described as 'mirthless'. This is characteristic of seizures arising in the hypothalamus, but
can occur in seizures arising in the frontal or temporal lobes.
o Vocal: single or repetitive sounds such as shrieks or grunts
o Verbal: single or repetitive words, phrases or brief sentences.
o Dacrystic: outbursts of crying.
AUTONOMIC
CAUTION Ictal asystole of sufficient duration (> 5 seconds) to cause reduced brain perfusion may
result in loss of body tone, stiffening and/or convulsive movements.
DYSCOGNITIVE
HEMISPHERIC LATERALIZATION
Specific focal seizure features are useful in lateralizing the seizure onset or network to one
hemisphere. Such features can be informative when EEG recordings are not helpful.
Features that suggest lateralization of the seizure are outlined below. These features provide
strong evidence for lateralization, but it should be noted that occasionally they can be falsely
lateralizing.
Unilateral ictal clonic activity or ictal dystonia suggests lateralization of the seizure to the
contralateral hemisphere.
Early forced head version suggests lateralization to the hemisphere contralateral to the
direction of the head version i.e. if the head turns to the right, the seizure onset is in the left
hemisphere.
Ictal speech lateralizes to the non-dominant hemisphere.
Ictal aphasia lateralizes to the dominant hemisphere.
Postictal dysphasia lateralizes to the dominant hemisphere.
Preserved awareness during ictal automatisms lateralizes to the non-dominant hemisphere.
Post-ictal nose-wiping lateralizes to the hemisphere ipsilateral to the hand used for nose-
wiping.
Unilateral eye-blinking lateralizes to the hemisphere ipsilateral to the eye-blinking.
Ictal vomiting lateralizes to the non-dominant hemisphere
FRONTAL
Overview
The frontal lobe is the largest lobe and gives rise to seizures with distinctive features depending
on the area of the frontal lobe involved. Motor features are prominent and range from hypermotor
thrashing attacks with pelvic thrusting and bipedal automatisms to asymmetric tonic posturing.
Frontal lobe seizures may begin with a brief aura, even when seizures occur from sleep. Seizures
are typically brief, and can have prominent vocalization, bizarre behavior, urinary incontinence,
and head and eye deviation. Frontal lobe seizures may be exclusively nocturnal and often cluster.
The ictal EEG may not show ictal patterns or may be obscured by movement artifact.
CAUTION Nocturnal frontal lobe seizures can be mistaken for parasomnias, however:
Frontal lobe seizures are usually brief events (< 2 minutes), with stereotyped features seen
from seizure to seizure and preserved awareness. Parasomnias are usually longer in
duration (> 10 minutes), have variable features from event to event and are characterized
by a confusional state with the patient having no memory of the event afterwards.
In parasomnias, clustering is rare and the common non-REM parasomnias typically occur
1-2 hours after falling asleep, in the first cycle of deep slow wave sleep. Nocturnal frontal
lobe seizures typically occur throughout the night, and more frequently within half an hour
of falling asleep or awakening.
CAUTION Frontal lobe seizures may be mis-diagnosed as non-epileptic seizures as there may be
bilateral motor phenomena with preserved awareness, and the ictal EEG can be normal.
Seizures are characterized by localized convulsive, tonic or myoclonic activity. They may
exhibit features of a Jacksonian march where unilateral convulsive movements start in one
muscle group and spread systematically to adjacent groups reflecting the spread of ictal
activity through the motor cortex according to the homunculus. There may be sensory
features alone such as unilateral tingling, or in combination with motor features. Negative
motor features such as atonic features may also occur.
Seizures are characterized by an abrupt onset and offset of asymmetric tonic posturing,
lasting 10-40 seconds with minimal postictal confusion. Asymmetric posturing of the upper
limbs occurs, with extension of the upper limb contralateral to the hemisphere of seizure
onset and flexion of the ipsilateral upper limb. Loud vocalization or speech arrest can occur at
seizure onset. The head and eyes are often turned to the side contralateral to the hemisphere
of seizure onset. There may be a somatosensory aura.
CAUTION The supplementary sensorimotor area is highly connected to other brain regions
and asymmetric posturing may be seen in seizures from other regions through rapid spread
to the supplementary sensorimotor area.
3. Orbitofrontal cortex
4. Frontopolar cortex
In the dominant hemisphere, a seizure occurring in or near Broca's area can result in aphasia
or dysphasia in a patient who is otherwise awake and responsive. Motor features occur, most
commonly tonic features, and are accompanied by contralateral head and eye version.
'Forced thinking' or 'forced acts' may be described.
6. Cingulate cortex
7. Fronto-parietal operculum
Seizures are characterized by facial (mouth and tongue) clonic movements (which may be
unilateral), laryngeal symptoms, articulation difficulty, swallowing or chewing movements and
hyper-salivation. Sensory (e.g. epigastric) and experiential (e.g. fear) aura and autonomic
(urogenital, gastrointestinal, cardiovascular or respiratory) features are common. Gustatory
hallucinations are particularly common.
NOTE the terms fronto-parietal opercular, centrotemporal, sylvian and rolandic seizures are
synonymous, referring to seizures involving the region around the central sulcus, particularly
in the lower central sulcus.
There are large areas of mesial and inferior frontal cortex that are not sampled by scalp EEG.
The interictal EEG is frequently normal if the etiology of the epilepsy is a structural brain
abnormality in these areas. Even with repeated EEGs, epileptiform discharges may only be seen
in up to 70% of such patients. In these patients, discharges are typically midline or bi-frontal.
Ictal
Ictal EEG in frontal lobe seizures may be difficult to interpret. Seizures often involve hypermotor
activity, which causes the EEG to be obscured by muscle artifact. Ictal EEG can demonstrate a
localized ictal rhythm in lateral frontal lobe seizures with localized repetitive discharges. Ictal EEG
in mesial frontal lobe seizures can often appear as a generalized EEG change, if an EEG change
is present. These bilateral discharges often have an amplitude asymmetry, representing
secondary bilateral synchrony rather than true generalized seizure onset, and may be preceded
by generalized suppression of the EEG. Ictal EEG may also be characterized by diffuse or
localized low voltage fast rhythms.
CAUTION False localization may occur, especially to the ipsilateral temporal lobe. Interpretation of
seizure features in conjunction with ictal EEG is important in this situation.
Differential dg
Related syndr
Autosomal dominant nocturnal frontal lobe epilepsy
Childhood epilepsy with centrotemporal spikes
Familial focal epilepsy with variable foci
TEMPORAL
Overview
Temporal lobe seizures are characterized by behavioral arrest with loss of awareness
(dyscognitive features). Automatisms are common and include oro-alimentary and/or gestural
automatisms. Seizures often commence with an aura which can be experiential such as fear or
déjà vu. Epigastric and auditory aura also occur. Autonomic features are common including pallor
and palpitations. Postictal confusion typically occurs.
Specific features suggest seizure onset in the dominant or non-dominant temporal lobe (see
hemispheric lateralization). Ictal speech, spitting, vomiting, drinking, urge to urinate and
automatisms with preserved consciousness suggest seizure onset in the non-dominant temporal
lobe. Postictal speech disturbance suggests a dominant temporal lobe seizure. Upper limb
dystonia is a useful lateralizing feature, lateralizing the seizure to the contralateral hemisphere.
Conversely, manual automatisms usually occur on the ipsilateral side.
In infants, temporal seizures may be subtle and manifest with pallor, apnoea and behavioral
arrest. There may be earlier and more marked motor manifestations including tonic events and
epileptic spasms, which may reflect different patterns of spread in the developing brain.
CAUTION Temporal focal dyscognitive seizures can have similar features to frontal seizures,
however dyscognitive seizures of temporal origin tend to have a slower onset and progression,
and postictal confusion is more pronounced.
CAUTION Temporal focal dyscognitive seizures need to be distinguished from absence seizures.
While both may have automatisms, temporal lobe seizures are typically longer (> 30 seconds),
associated with pallor, and followed by postictal confusion.
Subtypes of temporal lobe seizures
Seizures that arise in the mesial temporal lobe may be characterized by distinctive auras
such as a rising epigastric sensation or abdominal discomfort and experiential features such
as déjà vu, jamais vu and fear. Unpleasant olfactory and gustatory auras may also occur.
Auras may occur in isolation or may be followed by the onset of behavioral arrest with slowly
progressive impairment of awareness and oro-alimentary (chewing, lip-smacking, swallowing,
tongue movements) and manual automatisms. Autonomic phenomena (pallor, flushing,
tachycardia) are common. Upper limb automatisms may be unilateral and may lateralize the
seizure to the ipsilateral hemisphere. Unilateral pupillary dilatation can occur, and can also
lateralize the seizure to the ipsilateral hemisphere. Contralateral upper limb dystonia may
develop and head and eye version to the contralateral side can occur. Whilst seizures tend to
have a longer duration than for lateral temporal lobe seizures, evolution to a bilateral
convulsion is uncommon.
Lateral temporal lobe seizures may have an initial aura with auditory, complex visual,
illusionary or vertiginous features. The auditory aura is usually a basic sound such as buzzing
or ringing (rather than formed speech). If the aura is heard in only one ear it suggests the
seizure is in the contralateral hemisphere. In comparison to mesial temporal lobe seizures,
seizures are of shorter duration, and the onset of altered awareness is an earlier feature (the
initial aura is not as prolonged). Lateral temporal lobe seizures may spread and motor
features such as contralateral upper limb dystonia, facial twitching or grimacing, and head
and eye version may occur. Evolution to a bilateral convulsion is more common than in
mesial temporal lobe seizures.
EEG abnormalities (spike-and-wave or sharp slow waves) are seen in an anterior temporal
distribution in mesial temporal lobe structural brain abnormality. Focal slow and/or temporal
intermittent rhythmic delta activity (TIRDA) can be seen in around half of patients with mesial
temporal structural brain abnormality. EEG abnormalities may be seen in a mid-temporal or
posterior temporal distribution in lateral temporal lobe structural brain abnormalities.
Ictal
Seizures in mesial temporal lobe structural brain abnormality are characterized by rhythmic theta
(or less commonly spike) activity in the anterior temporal EEG leads (F7, T3; F8, T4). The EEG
change may follow the clinical seizure onset. Focal post-ictal slow activity occurs in about 70% of
such seizures and if present is consistent with side of seizure onset in 90% of seizures.
Seizures in lateral temporal lobe structural brain abnormality are characterized by mid- to
posterior temporal ictal rhythms (rhythmic theta or spike activity seen at T3, T5; T4, T6), with a
broad field. The ictal rhythmic activity may be less stable in frequency and amplitude than in
mesial temporal seizures, bi-temporal spread occurs more often (in up to 20%) and more rapidly.
Differential dg
Related syndromes
Related etiologies
Hippocampal sclerosis
PARIETAL
Overview
Seizures with ictal onset in the parietal lobe may be difficult to diagnose, especially in children,
because of the subjective nature of these seizures. Positive and/or negative sensory features
occur. Typically paraesthesia is reported but disorientation, complex visual hallucinations,
vertiginous and visual illusions and disturbance of body image (somatic illusion) can occur.
Receptive language impairment can occur with dominant hemisphere involvement. Ipsilateral or
contralateral rotatory body movements can occur. There is often involvement of other lobes as
the seizure spreads.
Subtypes of parietal lobe seizures
Seizures present with contralateral (or rarely ipsilateral or bilateral) sensory aura, most
commonly paraesthesias with tingling and/or numbness. There may be prickling, tickling,
crawling or electric-shock sensations in the affected body part. The sensory abnormality may
spread sequentially along a body part as the seizure spreads on the cortex according to the
sensory homunculus (Jacksonian march), when this occurs motor activity in the affected body
part commonly follows. Less common sensory aura include pain and thermal perceptions
(such as sensations of burning or cold).
Seizures may be characterized by body image distortions with feelings of movement (e.g.
floating) or altered posture (e.g. twisting movement) in a stationary limb. Somatic illusions
such as feeling of a body part being enlarged (macrosomatognosia), shrunken
(microsomatognosia) or absent (asomatognosia), or elongated (hyperschematica) or
shortened (hyposchematica) may also occur. Distal body parts and the tongue are more
commonly affected.
4. Parieto-occipital junction
Visual illusions including macropsia (objects in a section of the visual field appear larger) or
micropsia (objects appear smaller) may occur. Versive eye movements (typically
contralateral) or epileptic nystagmus may be seen. If nystagmus is seen, this is typically with
the fast component to the side contralateral to the hemisphere of seizure onset with the slow
component returning to the ipsilateral side. Eye movements typically occur with retained
awareness, and may be accompanied by head or trunk version. Complex visual
hallucinations may occur.
5. Paracentral lobule
7. Fronto-parietal operculum
Seizures are characterized by facial (mouth and tongue) clonic movements (which may be
unilateral), laryngeal symptoms, articulation difficulty, swallowing or chewing movements and
hyper-salivation. Sensory (e.g. epigastric), experiential (e.g. fear) and autonomic (urogenital,
gastrointestinal, cardiovascular or respiratory) features are common. Gustatory hallucinations
are particularly common.
NOTE the terms fronto-parietal opercular, centrotemporal, sylvian and rolandic seizures are
synonymous, referring to seizures involving the region around the central sulcus, particularly
in the lower central sulcus.
For some patients, EEG abnormality and ictal events may be precipitated by sensory stimulation
e.g. movement or touch of a body part.
EEG abnormalities (spike-and-wave or sharp slow waves) may be seen in a posterior distribution
in lateral parietal lobe brain abnormalities. The EEG may be normal in structural brain
abnormalities affecting mesial parietal areas.
Ictal
Surface ictal EEG in parietal lobe seizures can be unhelpful, the ictal EEG may be normal in up to
80% of seizures, or there may be lateralized slow activity. Central parietal rhythmic spike or
spike-and-wave is occasionally seen. The EEG patterns may instead reflect the seizure spread,
which may be to the temporal or frontal lobes or bilaterally. Seizures arising in mesial parietal
areas are often associated with secondary bilateral synchrony.
Differential dg
Non-epileptic seizures
Migraine with visual aura
Psychiatric disorders
Related disorders
OCCIPITAL
Overview
Seizures arising in the occipital lobe are characterized by visual aura that are subjective leading
to difficulty in diagnosis in young children. Oculomotor features may also occur such as forced
eye closure, eyelid fluttering, eye deviation and nystagmus. There is often involvement of other
lobes as the seizure spreads.
Sub-locations
Seizures in this area result in elemental visual auras, these may be positive phenomena
(typically multi-colored shapes such as circles, flashes), or negative phenomena such as loss
of a part of a visual field or blindness (amaurosis). Bilateral loss of vision may occur and this
may be in the form of a black-out or a white-out. More complex formed visual images are not
seen in seizures arising in this area. The visual aura is seen in the contralateral visual field to
the hemisphere of seizure onset. If positive visual phenomena occur in a part of the visual
field, the person may be seen to look in that direction during the seizure. It can be helpful to
ask a young child to draw what they see during their seizure. Visual aura are usually brief (<
2 minutes) which can assist in distinguishing them from migraine aura (5-15 minutes).
2. Extra-striate cortex
Seizures in this area are associated with more complex formed visual hallucinations such as
pictures of people, animals or scenes.
3. Parieto-occipital junction
Epileptic nystagmus may be seen. If nystagmus is seen, this is typically with the fast
component to the side contralateral to the hemisphere of seizure onset and the slow
component returning to the ipsilateral side. Eye movements typically occur with retained
awareness, and may be accompanied by head or trunk version. There may also be eyelid
flutter or forced eyelid closure.
Occipital seizures arising in this area tend to spread to the temporal lobe producing
dyscognitive features.
Occipital seizures arising in this area can spread to the parietal lobe, fronto-parietal
operculum or frontal lobes. Atonic motor features can occur if the seizure spreads rapidly to
frontal regions.
In some syndromes/etiologies, photic stimulation and/or eye closure may enhance EEG
abnormalities.
In occipital structural brain abnormality, background posterior dominant alpha rhythms and photic
driving responses may be asymmetric in amplitude; the interictal EEG may or may not show
interictal epileptiform abnormality (spike-and-wave or sharp slow waves).
Ictal
In occipital structural brain abnormality, the ictal EEG can be unhelpful and may vary with seizure
spread, which may be to the temporal or frontal lobes or bilaterally. A localized (lobar) or
lateralized (hemispheric) ictal rhythm may not be present in up to 20% of patients. Generalized
epileptiform abnormalities are common and may exhibit bilateral asynchrony. Ictal rhythms when
present may be characterized by occipital paroxysmal fast activity or rhythmic spike activity,
which may be preceded by brief attenuation of the EEG.
Differential
Non-epileptic seizures
Migraine with visual aura
Psychiatric disorders
Related syndromes
Panayiotopoulos syndrome
Childhood occipital epilepsy (Gastaut type)
Photosensitive occipital lobe epilepsy
Familial focal epilepsy with variable foci
Related etiologies
Celiac disease, epilepsy and cerebral calcification syndrome (check anti-gliadin antibodies)
FOCAL/GENERALIZED
For everyday purposes seizures are broadly categorized as either generalized or focal, these
terms can be used where appropriate but there are seizures that cannot be categorized in this
manner. Seizure types that may be focal or generalized are presented in this section
EPILEPTIC SPASMS
CAUTION Epileptic spasms usually occur in a series (several in a cluster) if singular, consider
other seizure types
As a general rule, EEG abnormality may be first evident / enhanced in sleep and on wakening.
Ictal
Epileptic spasms are most commonly accompanied by a high voltage generalized sharp or slow
wave followed by low amplitude fast activity and generalized voltage attenuation. This EEG
pattern may be seen in sleep with or without clinical seizures seen.
Differential syndr
Tonic seizures
Myoclonic seizures
Atonic seizures
Gastro-intestinal conditions e.g. colic, Sandifer syndrome
Hypnogogic jerks
Self-gratification
Related syndromes
West syndrome
Early myoclonic encephalopathy
Ohtahara syndrome
Lennox-Gastaut syndrome
Structural brain abnormalities
Related etiologies