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Igm Igg Iga Ige Igd: Μ Γ Α Ε Δ None None None

The document summarizes the key properties of the five major classes of antibodies (immunoglobulins): IgM, IgG, IgA, IgE, and IgD. IgM is a pentamer found mainly in blood and lymph. IgG is the most abundant antibody found primarily in blood and lymph. IgA is a dimer found mainly in secretions. IgE binds to mast cells and basophils and plays a crucial role in allergic reactions. IgD is a monomer found on B cell surfaces.

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elene nikoleishvili
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114 views2 pages

Igm Igg Iga Ige Igd: Μ Γ Α Ε Δ None None None

The document summarizes the key properties of the five major classes of antibodies (immunoglobulins): IgM, IgG, IgA, IgE, and IgD. IgM is a pentamer found mainly in blood and lymph. IgG is the most abundant antibody found primarily in blood and lymph. IgA is a dimer found mainly in secretions. IgE binds to mast cells and basophils and plays a crucial role in allergic reactions. IgD is a monomer found on B cell surfaces.

Uploaded by

elene nikoleishvili
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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IgM IgG IgA IgE IgD

PENTAMER MONOMER DIMER MONOMER MONOMER

Heavy chains μ γ α ε δ
Subtypes None IgG 1-4 IgA1-2 none none
(H chain) γ1 γ2 γ3 γ4 α1 α2
Number of
antigen binding 10 2 4 2 2
sites
Serum 1.5 13.5 3.5 0.05 3
concentration
location Blood Blood(80%) Secretions(tears, Bound to mast and B cell surface
Lymph Lymph saliva, mucus,milk basophil cells Blood
B cell surface intestine intestine) throughout body Lymph
Blood blood
lymph
Sensitizes mast
cells and
_ _ _ +++ _
basophils
Placenta -_ + _ _ _
transfer
Hypersensitivit Type II Type II Type I
y types Type II typeIII
notes  Can activate  Can activate  Level  crucial role  It acts in
complement complement decreases in allergic conjunction
system. system during stress reactions. It with IgM as
 Primary immune  Secondary  provides binds to mast an antigen
response immune localized cells, and receptor
 It’s subunits are response protection of when
held together by  Most mucous triggered by
a glycoprotein abundant of membranes the presence
called j-chain the  neutralize of antigen
(joining chain circulating viruses and causes
antibodies. bacteria as histamine
 first antibody
they enter the release and
class to be
body. hence
secreted by
inflammation
plasma cells
and other
after initial
common
exposure to any
allergic
antigen
symptoms.
 causes
agglutination and
lysis of microbes

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