Journal of Traditional and Complementary Medicine Vo1. 3, No. 2, pp.

 82-87
Copyright © 2013 Committee on Chinese Medicine and Pharmacy, Taiwan This is an open access article under the CC BY-NC-ND license.

Herbal Treatment for Osteoporosis: A Current Review

Ping‑Chung Leung1, Wing-Sum Siu2,3

1
Jockey Club Centre for Osteoporosis Care and Control, The Chinese University of Hong Kong, Shatin, Hong Kong.
2
Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
3
State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, Hong Kong.

ABSTRACT

Osteoporosis is an aging problem. The declining bone mineral density (BMD) enhances the chances of fractures during minor falls.
Effective pharmaceuticals are available for a rapid improvement of BMD. However, hormonal treatment gives serious complications,
and bisphosphonates may lead to odd fractures of long bones, resulting from excessive rigidity of the cortical components. Many
medicinal herbs used in Traditional Chinese Medicine, known as kidney tonics, have been tested for their effects on bone metabolism in
the laboratory and clinically. Three of these, viz. Herba epimedii (淫羊藿, Yín Yáng Huò), Fructus ligustri lucidi (女貞子, Nǚ Zhēn Zi),
and Fructus psoraleae (補骨脂, Bǔ Gǔ Zhī) were chosen to form a herbal formula, ELP. ELP was tested on in vitro platforms and was
shown to have both osteoblastic and anti‑osteoclastic action. ELP tested on ovariectomized rats also showed BMD protection. ELP
was then put on a placebo‑controlled randomized clinical trial. BMD protection was obvious among those women with the onset of
menopause beyond 10 years (P < 0.05). A general protective trend was observed among all women under trial (P > 0.05). Although a
thorough literature review on the herbal treatment effects did not give convincing answers to the use of Chinese herbs in osteoporosis,
our study supports more research and trials in this area, while we are looking for safe and effective agents to keep the bone metabolism
in a balanced state.

Key words: Bone mineral density, Herbal treatment, Osteoporosis

breakdown are kept at a harmonized speed, so that there is good

INTRODUCTION
balance between the two mechanisms that are kept at a dynamic
state. The balance is affected most commonly when the breakdown
Bone is the most rigid tissue in the human body. Yet, it is the
mechanism supersedes the restoration process and the causes
most dynamic and ever‑changing tissue apart from blood. From
behind could be aging, nutritional, disuse, vitamin D deficiency
birth until around age 20 years, the bone grows and stores up its
(no sunlight), and disease conditions. Given good health, good
calcium reserve. At the same time and under all circumstances, nutrition, and freedom from major diseases, aging becomes the
every bone unit is undergoing continuous changes of breakdown most unquestionable cause of bone loss.[1]
and restoration. These rapid, continuous changes are required for There are many ways to assess the physiological state of bone in
the control of calcium metabolism and to maintain the healthy the living individual, including clinical tests, imaging, and biochemi‑
state of the bone. Special cells called osteoblasts are responsible cal tests, of which imaging to detect the bone mineral density (BMD)
for the build‑up of the bone unit, while other special cells called has become the most accepted simple and reliable investigation.[2]
osteoclasts are responsible for the breakdown. Build‑up and There have been many studies on the BMD of patients of

Correspondence to:
Dr. Ping‑Chung Leung, 5/F, School of Public Health Building, Prince of Wales Hospital, Shatin, Hong Kong. Tel: 8522252 8868; Fax: 8522632 5441.
E‑mail: [email protected]
DOI: 10.4103/2225-4110.110407
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different ages, and it has been confirmed that BMD declines with sharp and severe, under which circumstance, effective restoration
aging, and for women, menopause is accompanied with a rapid is preferred. However, when the BMD is only starting to decline,
drop of BMD. When the sudden drop of BMD associated with there is a doubtful necessity of bringing it up quickly and artificially
menopause became solidly known, explorations on the preven‑ using drug treatment. It might be more favorable just to maintain
tion of the drop started. Exercises and nutritional considerations the bone mineral contents and prevent any uncontrolled decline.
could well be effective means to prevent the decline in BMD and Food supplements, therefore, could be a valuable offer.
to maintain a balance. Nevertheless, clinicians and their clients are The intention of this review is to explore the biological effects
not satisfied with a slow maintenance. They want an immediate of the herbs used to maintain bone health, and then study the
rise of BMD. Starting with hormonal replacement which appears reported results of clinical treatment. Our own experience in the
logical because menopause is associated with a decline in female search for effective herbal treatment for the maintenance of bone
hormones, other pharmaceutical agents have come to market with health will be finally described.
increasing efficacy on BMD promotion.[3]
There are incidents of bone fractures at the vulnerable PHYTOTHERAPY FOR OSTEOPOROSIS AS
weight‑bearing sites, particularly during accidents, when the bones REVEALED FROM CHINESE LITERATURE
have become weak because of low BMD (osteopenia and osteo‑
porosis). The increased risks of fracture when the bone becomes Laboratory studies
osteoporotic appear logical since the weak bone is certainly less Natural herbs have been widely used in clinical practice in
resistant to stress and bending forces. All aging people have great China and other countries since ancient times. Certain natural herbs
fear against fractures. The fear thus becomes transferred to a fear have potential effects in promoting gonadal function and fracture
about osteoporosis. The transfer of fear could have been logical healing, and therefore are suitable items for current research to
but might not be fair because there must be many other risk factors counteract and prevent postmenopausal osteoporosis.
leading to fractures, apart from a low BMD. Other risk factors In China, bone health is considered closely related to kidney
are the accident itself and the factors leading to the accident such function. Thus, “kidney deficiency” (腎虛, Shèn Xū) is consid‑
as dementia, frailty, neurological symptoms, visual problems, ered the root of all pathologies related to bones and joints, which
medications, etc., led pharmaceuticals companies on an active include arthritis and osteoporosis. Treatment accordingly follows
pursuit for BMD raising drugs agents to artificially raise the BMD. the principle of strengthening the kidney function when the bones
Osteoporosis has become a major health issue worldwide. It is and joints are considered “weak”.[10]
defined as a condition characterized by low BMD and micro‑archi‑ Of the many herbs reported to be useful for kidney strength‑
tectural deterioration of bone tissues leading to enhanced bone fra‑ ening, around 30 are popular and 6-8 are most frequently used.
gility and a consequent increase in fracture risk.[4] Postmenopausal They are: Herba epimedii (淫羊藿 Yín Yáng Huò), Fructus
osteoporosis typically affects women within 10-15 years after psoraleae (補骨脂 Bǔ Gǔ Zhī), Radix rehmanniae (生地黃
menopause. It is complicated with fractures occurring at sites that Shēng Dì Huáng), Rhizoma drynariae (骨碎補 Gǔ Suì Bǔ), Herba
contain relatively large amounts of cancellous bone. The prevalence cistanches (肉蓯蓉 Ròu Cōng Róng), and Cortex eucommaie
of osteoporotic fracture is extremely high. In the United States, for (杜仲 Dù Zhòng).
women at 50 years of age, the lifetime risk is 17.5% for the hip No matter how many biologically active chemical components
fracture, 16% for vertebral fracture, and 16% for Colles’ fracture. are contained in the herbs and how complex their mechanisms of
Approximately 50% of 70‑year‑old women or 40% women after action could be, the phytoestrogens in the herbal preparations, viz.
the menopause experience one or more fractures.[5,6] certain flavones, isoflavones, flavanones, flavonols, coumestans,
In China, epidemiological studies have shown that the inci‑ and lignans, could be playing an important role in the amelioration
dence of osteoporosis in the population over 40 years of age is of postmenopausal bone loss.[11‑13] The effects of phytoestrogens
16.1%, over 60 years of age is 22.6%, and over 80 years of age, have been reported in both laboratory studies and clinical trials.
it is as high as 50%. Osteoporosis in the spine not only leads of Studies in ovariectomized rats have suggested that the known
fractures, but would also produce pain and back deformities, which phytoestrogens such as coumestrol, genistein, and daidzein can
seriously affect the patients’ quality of life.[7] reduce bone loss.[14,15]
Estrogen plays an important role in coordinating the activities Phytochemical analyses have revealed that the six most com‑
of the bone‑forming osteoblasts and bone‑resorbing osteoclasts in monly used herbs just quoted contain more specific components
bone homeostasis. Ovarian hormonal deficiency is one of the most such as icariin in H. epimedii (淫羊藿 Yín Yáng Huò) and iso‑
important factors leading to postmenopausal osteoporosis, which has psoralen in F. psoraleae (補骨脂 Bǔ Gǔ Zhī). These effective
made hormonal replacement therapy popular in the early days for the components have estrogen‑like effects and may become new
prevention of bone loss in postmenopausal women. However, treat‑ phytoestrogens for future research.[15]
ment with estrogen has well‑known side effects such as breast sore‑
ness and nausea, and in the long‑term, may lead to increased risk of Clinical studies
breast and uterine cancer development and also venous thrombosis.[8,9] Xu, et al. reported in 2008 that 63 randomized control tri‑
Subsequently, when other therapeutic measures are developed als (RCTs) were conducted in China in which postmenopausal
to correct the deteriorating BMD, the direction is one of quick bone loss was treated with oral administration of herbs. Only 14
correction. This concept is acceptable when the loss of BMD is of the trials met the criteria of RCT. Treatment duration of the

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included trials ranged from 1 to 6 months. In 11 out of the 14

RESULTS
trials, the treatment groups were treated with patent herbal for‑
mulae. There were obvious defects in the design of the clinical
In the in vitro studies, ELP significantly increased the prolifera‑
trials. Firstly, the use of blinding and stratified randomization
tion of UMR‑106 cells in a dose‑dependent manner from 50 to 400
according to age and length of menopause were not employed.
µg/ml [Figure 1]. For MSCs, ELP stimulated the osteogenic differ‑
Secondly, the small sample sizes in some of the trials were a matter
entiation as indicated by the increase of bone markers such as alka‑
of concern. Thirdly, prior drug history was not stated explicitly.
line phosphatase (ALP) activity and matrix calcium mineralization.
Fourthly, reporting BMD change as mean differences with as‑
ELP elevated the ALP activity significantly at concentrations of
sociated standard deviations was not sufficient for data analysis.
50 and 100 µg/ml [Figure 2a]. The amount of mineralization also
The authors compared the results of herbal treatment with those
increased significantly with ELP [Figure 2b]. In regards to bone
of hormonal treatment and reported that the prevention of bone
resorption, ELP significantly inhibited osteoclast formation from
loss at the classical regions of lumbar and femoral regions was
RAW 264.7 cells upon receptor activation of nuclear factor‑kappa
about the same, and that adverse effects like uterine bleeding and
B ligand induction on the 4th day of treatment, at a concentration of
breast pain were not objectively described. These studies could be
80 and 160 µg/ml. The difference between treated and untreated
further criticized because of short treatment durations.[16]
cultures of osteoclasts reached statistical significance (P ≤ 0.05).
The experimental data, therefore, illustrated that the formula ELP
STUDIES DONE IN HONG KONG had positive effects on bone metabolism through a double process
of osteoblastic promotion and osteoclastic inhibition.
Our laboratory is aware of the importance of osteoporosis
In the ovariectomized, and calcium deficiency‑induced osteopo‑
related to aging. We are of the view that osteoporosis, though
rotic model, after 11 weeks of ELP treatment, it was demonstrated
contributing toward the risks of bone fractures, might not be the
that there was preservation of BMD at the proximal femur in a
major culprit. Hence, clinicians’ concern might not be a rapid
dose‑dependent manner with a preference for higher dosages. No
boosting of the BMD, but a long‑term maintenance of the bone
significant increase in uterine weight was observed in the ELP
quality. In this regard, highly effective therapeutic agents that
treated rats. In addition, the microarray data of kidney tissues re‑
artificially suppress osteoclastic activities might not be the best
vealed that ELP was able to down‑regulate the expression of phase
choice for bone health, unless the BMD has reached a dangerously
II drug metabolizing enzymes, similar to the effects of estrogens.[19]
low level. This consideration might appear particularly logical
when potent osteoclast antagonists, viz. the bisphosphonates, are Clinical studies
showing incidents of adverse effects like odd fractures and cardiac The design of the clinical trial was of randomized, dou‑
complications when taken for a long duration.[17,18] ble‑blind, and placebo‑controlled nature. Proper ethical approval
We selected three herbs classically used for “kidney insuf‑ was obtained before starting the clinical trial and proper consent
ficiency,” for our laboratory and clinical studies. was given by the clients.
Laboratory studies The inclusion criteria were: Women who experienced menopause
The herbs used were H. epimedii (淫羊藿 Yín Yáng Huò), for at least 1 year, with their lumbar spine BMD lower than 0.891 g/cm2,
Fructus ligustri lucidi (女貞子 Nǚ Zhēn Zi), and F. psoraleae which indicated osteopenia. Those suffering from serious concomitant
(補骨脂 Bǔ Gǔ Zhī) – ELP. They were mixed in the ratio 10:8:2,
and were boiled, extracted, and prepared in a powder form.
ELP were first tested in the laboratory to establish the sci‑
entific evidence of their bone supportive activities. The known
active compounds of the three herbs, ELP, are listed in Table 1.
The anabolic effects of ELP on bone formation were evalu‑
ated using cultured rat osteoblast‑like osteosarcoma cell line
UMR‑106 and rat mesenchymal stem cells (MSCs). To test for
bone resorption, RAW 264.7 cell line was used to investigate
the inhibition of osteoclast formations. A dosing effect with
several concentrations (1 g/day, 0.5 g/day, and 0.175 g/day)
was tested in ovariectomized, and calcium deficiency‑induced
osteoporotic rats.[19]

Table 1. Known active compounds of ELP

Herbs Known active compound Figure 1. Effect of ELP water extract on the cell viability of osteoblast‑like
Herba epimedii Icariin UMR‑106 cells for 3 days at different concentrations. Data are the means
Fructus ligustri lucidi Salidroside (SEM; error bars) from three independent experiments in triplicate.
*P  <  0.05; **P  <  0.01 for difference in percentage of live cells from
Fructus psoraleae Psoralen, isopsoralen
respective baseline culture without treatment

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Figure 2a. Dose effect of ELP on the ALP activity in rat MSCs on day 7 Figure 2b. Dose effect of ELP on the matrix mineralization in rat MSCs
on day 7 (***P < 0.001)

ing a Hologic type 4500 DEXA machine. Secondary end points

included peripheral quantitative computed tomography (pQCT)
measurements of the distal tibia and an analysis of the physical
components of the quality of life (SF‑36 questionnaire). Only the
four physical domains relevant to bone and joint problems were
evaluated. Among the 150 subjects, 79 subjects (41 in the ELP
group and 38 in the placebo group) received pQCT examination.
Adverse events (AEs) were carefully monitored and checking
for biochemical functions of the liver and kidney was done for all
clients before and after treatment. The resulting data were analyzed
using to the ITT principles.

RESULTS

In the ELP group, 75 subjects completed the 12‑month clinical

study; 74 subjects in the placebo group completed the 12‑month
Figure 3. Flowchart for inclusion of patients
study: The mean drug compliance rates were 73.7% and 81.2% in
the ELP and placebo groups, respectively. There were no statistical
diseases and were maintained on complicated medications, and those differences between the two groups.
suffering from psychiatric or addiction disorders were excluded. Both ELP and placebo groups showed a decrease in spine BMD
Two hundred and twenty‑eight patients from volunteers in com‑ over the 12‑months treatment period (−0.31% in the ELP group
munity centers in Hong Kong were screened and 78 were found and −0.39% in the placebo group). However, the spine BMD of
unsuitable. A total of 150 subjects were considered adequate for the ELP group was increased by 0.69% in subjects with more than
this study basing on the assumption that at least 1% difference in 10 years duration of menopause. In contrast, the placebo group of
BMD could be observed between the treatment and placebo groups the same stratum decreased by 0.61% (P = 0.067).
with 90% power, if the standard deviation of BMD measurements The hip BMD of the ELP group remained unchanged
was 3.6%. over 12‑month treatment, whereas the placebo group decreased
The subjects enrolled were randomized to either ELP (75 cas‑ by 0.22%. In the subjects with more than 10 years duration of
es) or placebo (75 cases) group. In the ELP group, the mean menopause, the hip BMD increased by 0.21%, compared with a
age of subjects was 58.4 ± 3.6 years, the mean time since last decrease of 0.52% in the placebo group [Table 2].
menses was 8.1  ±  4.4 years, and the mean age of menopause After 12 months of treatment with the herbal preparation, the
onset was 50.4 ± 3.8 years, whereas in the control group, they distal tibia pQCT decreased by 2.43% in the ELP group compared
were 58.4  ±  3.8 years, 8.4  ±  4.7 years, and 50.0  ±  4.2 years, with 3.67% in the placebo group (P = 0.052). The tibia (T33%)
respectively. There were no significant differences between the strength–strain index (SSI) was increased by 1.94% in the ELP
ELP and placebo groups in demographic and baseline BMD group compared with 0.33% in the placebo group (P  =  0.047)
characteristics. The intention‑to‑treat (ITT) approach was ad‑ [Table 3].[20]
opted [Figure 3].
The primary outcome was the BMD of the lumbar spine Comparison of QOL
assessed at baseline and 6 and 12 months after treatment, us‑ SF‑36 questionnaire showed remarkable improvement in

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Table 2. Comparison of BMD changes

Item ELP (75 cases) Placebo (74 cases) P value
Spine
Baseline (g/cm2) 0.7994±0.1089 0.7949±0.1011 0.794
Change from
baseline (%)
Month 6 −0.01 0.35
Month 12 −0.31 −0.39
Menopausal
duration >10 years
Month 6 0.13 0.18
Month 12 0.69 −0.61 0.067
Hip
Baseline (g/cm2) 0.7573±0.0736 0.7592±0.0904 0.885
Change from
baseline (%)
Month 6 0.19 0.44 Figure 4. Changes in the four subscales of the SF‑36 after 12 months
of treatment
Month 12 0.03 −0.22
Menopausal
duration >10 years described. However, syndromes with low back pain, back deformi‑
Month 6 0.63 0.30 ties, loosening teeth, etc., which appear in classical records, could
Month 12 0.21 −0.52 0.159 be the manifestations of osteoporosis. Chinese herbs have been
BMD: bone mineral density widely used in orthopedic practice and many of their therapeutic
effects on skeletal problems and fractures have been reported.[21‑23]
Table 3. Annual changes of BMD at different anatomic sites measured In our study, we have selected three common herbs from the pool of
by pQCT (%) Chinese medicine, which are known to be good for bone health, to
Group Case BMD of BMD of Tibia form a cocktail. The three herbs have been used both as a traditional
distal radius distal tibia (T33%) SSI drug and as food items for “kidney strengthening” in soup making
Total Cortical Total Trabecular for normal meals. The safety of these herbs has been proven in our
ELP 41 6.65 3.57 −2.43 6.15 1.94 clinical trial, as no significant adverse effects are demonstrated.
Placebo 38 2.03 −0.28 −3.67 12.17 0.33 The best results were shown among the group of clients
P value 0.724 0.322 0.052 0.525 0.047 who had experienced menopause for over 10 years. This group
BMD: bone mineral density; SSI: strength strain index; pQCT: peripheral of patients when treated with ELP for 12 months showed better
quantitative computed tomography results than the placebo group. Other women with shorter periods
of menopause also showed a better trend of bone preservation
physical function and physical role in the ELP group compared which, however, was statistically insignificant. If BMD represents
with the baseline, but failed to reach dominance over the placebo the standard changes in the bone density, pQCT which assesses
group [Figure 4]. AEs were insignificant. the distal tibia is more sensitive to early influences and less potent
effects. In our clinical trial, the supportive effects of ELP on the
DISCUSSION distal tibia were shown and statistical significance was reached.
Although there are many reports in China endorsing the
Traditional Chinese Medicine is built on the principle of main‑ therapeutic value of various herbs originally used as “kidney
taining physiological harmony. Since specific pathological changes tonics” against “kidney deficiencies,” the claims have not been
are unknown to the ancient experts, Chinese medicine aims, not based on reliable clinical trials. Since ELP is not aiming at any
specific target of bone metabolism, its efficacy would be inferior
at specific targets, but at the maintenance of normal “internal bal‑
to target‑oriented pharmaceuticals. A longer period of observa‑
ance.” The well‑known theory of “yin and yang” is a philosophical
tion and a larger sample size might be mandatory for a proper
expression of excess and deficiency which need to be balanced. In
biostatistical revelation of the results of treatment. ELP might be
the case of osteoporosis prevention, when Chinese herbs are used,
considered capable of providing additional support on top of the
the rationale would be one of balanced bone formation and bone essential needs against osteoporosis, like vitamin D and calcium.
resorption. On a cellular level, it would be a balance between os‑ Herbal treatments in Chinese medicine are well known to be work‑
teoblastic construction and osteoclastic destruction. The expected ing slowly and non‑specifically. Although the mechanism of action
responses would be a steady BMD, and not a rapidly increasing one. of the three herbs in EPL has been shown in our laboratory to be
However, when we design a protocol for an osteoporosis preven‑ both pro‑osteogenic and anti‑resorptive, more explorations on
tion trial using Chinese herbs, the end point would best follow the the mode of action of the herbs need to be done. We also need to
current trend which relies on the BMD levels. know whether the support on the BMD is through a cellular level,
In Traditional Chinese Medicine, osteoporosis has not been or indirectly via an increased absorption or decreased excretion

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