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Povidone

This document describes several formulations for povidone-iodine solutions and gels. It provides the ingredients and manufacturing process for each formulation. It also details the properties and stability results of each formulation, such as viscosity, pH and percentage of available iodine over time and under different storage conditions. The formulations are for various applications including general solutions, teat dips, mastitis creams and gels.

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Elizabeth Walsh
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192 views2 pages

Povidone

This document describes several formulations for povidone-iodine solutions and gels. It provides the ingredients and manufacturing process for each formulation. It also details the properties and stability results of each formulation, such as viscosity, pH and percentage of available iodine over time and under different storage conditions. The formulations are for various applications including general solutions, teat dips, mastitis creams and gels.

Uploaded by

Elizabeth Walsh
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
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Povidone-Iodine Solution

(10%), I
1. Formulations
No. 1 No. 2
PVP-Iodine 30/06 (BASF) .............................10.0 g 10.0 g
Lutrol F 127 [1] ...................................................– 0.3 g
Lutrol E 400 [1] ...................................................– 0.5 g
Citric acid 0.1 molar solution ........................43.6 g 43.2 g
Na2HPO4 · 12H2O 0.2 molar solution ..........46.4 g 46.0 g
2. Manufacturing
Dissolve the PVP-Iodine (and Lutrol F 127) in the mixture of the buffer
solutions (and Lutrol E 400).
3. Properties of the solutions
Brown clear solutions having a low viscosity and pH of about 4.5.
4. Chemical stability
Formulation No. 1 (20–25 °C, 1 year)
0 Month 6 Months 12 Months
Available iodine 100% 100% 96%
pH 4.4 4.1 4.4
Formulation No. 2 (52 °C, 14 days)
Loss of available iodine 6.3%
BASF Pharma

Povidone-Iodine Solution
(10%), II
1. Formulation
I. PVP-Iodine 30/06 (BASF) ......................10.00 g
II. Texapon K 12 (Henkel) ............................0.03 g
III. Sodium biphosphate (Na2HPO4) .............0.14 g
Sodium citrate........................................0.03 g
Sodium hydroxyde solution, 1 molar ........2.08 g
Glycerol .................................................1.00 g
Water...................................................86.42 g
2. Manufacturing
Dissolve Texapon K 12 (II) in solution III and add slowly PVP-Iodine to the
well stirred solution.
3. Properties of the solution
Brown transparent liquid having a pH of 4.5.
4. Chemical stability
After production After 14 days/52 °C
pH ...............................................4.5 3.5
Available iodine .......................1.08% 1.03%
Loss of iodine ..................................– 4.6%
BASF

Povidone-Iodine Teat-Dip Solution


for Cattles (3%)
1. Formulation
PVP-Iodine 30/06 (BASF) ........................3.00 g
Glycerol .................................................8.00 g
Glacial acetic acid ..................................0.80 g
Sodium hydroxide solution, 50%.............0.35 g
Water ..............................................ad 100.0 g
2. Manufacturing
Mix all liquid components and dissolve PVP-Iodine.
3. Properties of the solution
Brown transparent liquid having a pH of 4.3.
4. Chemical

Povidone-Iodine Mastitis Cream for Cattles


(10%)
1. Formulation
I. PVP-Iodine 30/06 (BASF) ...........................10 g
II. Liquid paraffin ...........................................10 g
Vaseline ....................................................10 g
Cetylstearyl alcohol.................................5 – 8 g
Cremophor A 6 [1].......................................2 g
Cremophor A 25 [1] .....................................2 g
III. Propylene glycol Pharma [1].........................5 g
Water .................................................53 – 56 g
2. Manufacturing
Dissolve PVP-Iodine I in the solvents III. Mix the components II by
heating, stir the solution I/III in the molten mixture II and cool by stirring.
3. Stability (52 °C, 14 days)
The cream is physically stable and shows no loss of iodine.
BASF

Povidone-Iodine Gels
(10%)
1. Formulations
No. 1 No. 2
I. PVP-Iodine 30/06 (BASF) ........................10.0 g 10.0 g
Sodium chloride .............................................– 1.0 g
II. Lutrol F 127 [1] .......................................20.0 g 20.0 g
III. Sodium hydroxide solution, 1 molar.................– 7.9 g
IV. Water.....................................................70.0 g 61.1 g
2. Manufacturing
Dissolve the solids (I) in water (IV), cool to about 6 °C, dissolve Lutrol F
127 (II) and adjust the pH value with the sodium hydroxide solution (III).
Maintain cool until all air bubbles escaped.
3. Properties of the gels
No. 1 No. 2
Viscosity 61,000 mPa · s 54,000 mPa · s
(Brookfield, 23 °C)
pH value (20 % in water) 2.2 4.6
4. Stability (14 days, 52 °C)
No. 1 No. 2
Viscosity 58,000 mPa · s 45,000 mPa · s
(Brookfield, 23 °C)
pH value (20 % in water) 1.9 2.7
Loss of available iodine 10.2% 8.0%
BASF Fine

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