Acquired Immuno-Deficiency Syndrome (AIDS) : Savitha R S JSSCP, Mysore
Acquired Immuno-Deficiency Syndrome (AIDS) : Savitha R S JSSCP, Mysore
Acquired Immuno-Deficiency Syndrome (AIDS) : Savitha R S JSSCP, Mysore
Syndrome (AIDS)
Savitha R S
JSSCP, Mysore
Introduction
Profound Immunosuppression
Retrovirus
Properties of HIV
Types of HIV
Structure of HIV
Routes of Transmission
• Sexual contact. Homosexual and bisexual males (50%) and heterosexual males
and females.
i.
Intravenous drug abusers (sharing needles and syringes)
ii.
Hemophiliacs who have received large amounts of factor VIII concentrates
from pooled blood concentrates from multiple donors
iii.
Recipients of blood and blood products who have received multiple
transfusions of whole blood or components like platelets and plasma.
Pathogenesis
Sequence of Events - 1
Sequence of Events - 2
Sequence of Events - 3
Cytopathic effects
Effects on Monocytes/
Macrophages
Do not directly invade nerve cells but affects their health and
function.
Neurological manifestations
Major signs
Minor signs
Fever, Weight loss (> 10% body weight), chronic diarrhea lasting more
than one month.
Opportunistic infections
Enzyme Immmunoassays
Western Blot
Detects antibodies to
specific HIV antigens on
cellulose strip
Indirect Tests
Lymphopenia
Specific Tests
Questions?
1. HIV – 1
2. HIV – 2
3. HIV – 3
4. HIV - 4
1. ELISA
According to WHO,
diagnosis of AIDS requires
presence of