BIOGRAPHICAL SKETCH

Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED
FOUR PAGES.

NAME POSITION TITLE

Silverstein, Jonathan Charles Associate Professor,Surgery,Radiology,The College
eRA COMMONS USER NAME Associate Director, Computation Institute
JCSilverstein University of Chicago and Argonne National Lab
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
DEGREE
INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY
(if applicable)
University of Illinois at Urbana-Champaign BS 1983-1986 Microbiology
Washington University Medical School, St. Louis MD 1986-1990 Medicine/Surgery
Washington University Informatics Lab, St. Louis 1990-1991 Informatics
Rush-Presbyterian-St. Luke’s, Chicago 1991-1996 Surgery Residency
Harvard School of Public Health, Boston MS 1996-1998 Clinical Epidemiology

A. Positions and Honors.

Positions and Employment

1996-2001 Assistant Professor, Dept. of Surgery, University of Illinois at Chicago (UIC)
1996-2001 Assistant Professor, School of Biomedical and Health Information Sciences, UIC
1997-1999 Adjunct Appointment, Graduate School of Library and Information Science, UI-Urbana
1998-2001 Co-Director, UIC Virtual Reality in Medicine Laboratory (VRMedLab)
1999,2000-01 Adjunct Appointments, Dept. of Bioengineering and Dept. of Radiology, UIC
2001-2007 Assistant Professor, Department of Surgery, The University of Chicago (UC)
2001-2008 Director, Center for Clinical Information, The University of Chicago Hospitals
2002- Scientific Director, Chicago Biomedical Consortium
2003- Senior Fellow, Computation Institute of University of Chicago and Argonne Natl. Lab. (CI)
2006- Associate Director, Computation Institute (CI)
2007- Associate Professor, Departments of Surgery, Radiology, and the Collegiate Division
Biological Sciences Division, University of Chicago

Selected Experience and Professional Memberships (excludes teaching, Hospital committees, panels)
1989- Member, Americal Medical Informatics Association (AMIA)
1995- Member, American Medical Association, Illinois State Medical Society and Chicago Medical
1997- Certified, American Board of Surgery
1997-2001 Physician advisor to Cerner Corporation for Physician Order Entry
1997-2003 Creator and Manager web-based Resident Case Log system (used by 5 universities)
1998- Member, Association for Academic Surgery, Illinois Surgical, and Chicago Surgical
1998, 2002 Special Emphasis Panel Reviewer for National Library of Medicine, NIH
1999- Fellow, American College of Surgeons and Member, Association for Surgical Education
1999-2001 Creator and Manager UIC Division of General Surgery clinical database
2000-2006 Member, Regents Committee on Informatics, American College of Surgeons
2002-2006 Member, Biomedical Library and Informatics Review Committee, NLM/NIH
2003-2009 Member, Association of Medical Directors of Information Systems
2003-2006 Member (Chair FY06), Board of Computing Activities and Services, University of Chicago
2003 Reviewer, NASA Peer Review Services
2003- Executive Committee, Computation Institute of The Univ. of Chicago and Argonne Natl. Lab.
2004-2009 Reviewer, Artificial Intel in Med, Future Gen Comp Sys, Clinical Anatomy, JBI, IJCARS, JAMIA,
PLOS Medicine, MedNet, AMIA Symposium
2004-2008 Director, Biomedical Informatics Core, University of Chicago Biological Sciences Division
2006- Member, Board of Scientific Counselors, Lister Hill Center, National Library of Medicine/NIH
2007 Member, AMIA Symposium Scientific Program Committee
2007 Member, NIH Roadmap National Centers for Biomedical Computing Program Review
2007- Fellow, American College of Medical Informatics

Selected Honors
1996 Resident Teacher of the Year, Department of Surgery, Rush-Presbyterian-St. Luke's
1999 Jerry and Thelma Stergios Award for Excellence in Basic Science, UIC Dept. of Surgery
2001 Class Act Award, University of Illinois at Chicago Medical Center
2002 Most Outstanding Faculty Poster Presentation, Charles B. Huggins Research Conference, The
University of Chicago Department of Surgery
2004,2005 Top Five Poster Prize, Midwest Clinical Conference of Chicago Medical Society
2006 Finalist, CityLIGHTS Award, Illinois I.T. Association (ITA)

B. Selected peer-reviewed publications (in chronological order).

1. Cousins SB, Silverstein JC, Frisse ME. Query Networks for Medical Information Retrieval - Assigning
Probabilistic Relationships. In: Miller, RA, editor. Proc. 14th Ann. Symp. on Computer Applications in
Medical Care; 1990 Nov 4-7; Wash., DC. Los Alimitos (CA): IEEE Computer Society Press 1990;:800-4.
2. Millikan KW, Silverstein J, Hart V, Blair K, Bines S, Roberts J, Doolas A. A 15-Year Review of
Esophagectomy for Carcinoma of the Esophagus and Cardia. Arch Surg 1995 Jun;130(6):617-24.
3. Millikan KW, Silverstein JC, Timmerman G, Economou SG. Fractionated Irradiation of the Regenerated
Rat Liver. J Surg Res 1995 Aug;59(2):229-35.
4. Silverstein JC, Staren E, Velasco J. Thermal Bile Duct Protection During Liver Cryoablation. J Surg Oncol
1997 Feb;64(2):163-4.
5. Silverstein J, Rubenstein J, Millman A, Panko W. Web-Based Segmentation and Display of 3-Dimensional
Radiologic Image Data. Stud Health Technol Inform 1998;50:53-9.
6. Silverstein JC, Wavak E, Millikan KW. A Prospective Experience with Selective Cholangiography. Am Surg
1998 Jul; 64(7):654-8; discussion 658-9.
7. Panko W, Silverstein JC, Lincoln T. Technologies for extracting the full value from electronic patient
records. Proc Hawaii International Conf on System Sci; IEEE Computer Society Jan 1999.
8. Rubenstein J, Silverstein J, Panko W. Limitations of Distributed Segmentation of 3-Dimensional Radiologic
Image Data. Stud Health Technol Inform. 1999; 62:308-14.
9. Silverstein JC, Shenoy A, Rice CL. Web-based entry, validation, and reporting of resident operative
experience. Current Surgery 1999 March/April;56(3):161-4.
10. Millikan KW, Deziel D, Silverstein JC, Kanjo T, Christein J, Doolas A, Prinz R. Prognostic factors
associated with resectable adenocarcinoma of the head of the pancreas. Am Surg 1999 Jul;65(7):618-24.
11. Pearl RK, Evenhouse R, Rasmussen M, Dech F, Silverstein JC, Prokasy S, Panko WB. The Virtual Pelvic
Floor, a Tele-Immersive Educational Environment. Proc AMIA Symp 1999 Nov 6;:345-348
12. Ai Z, Gupta BK, Rasmussen M, Lin YJ, Dech F, Panko W, Silverstein JC. Simulation Of Eye Diseases in a
Virtual Environment. Proc Hawaii International Conf on System Sci; IEEE Computer Society Jan 2000.
13. Ai Z, Dech F, Rasmussen M, Silverstein JC. Radiological Tele-Immersion for Next Generation Networks.
Stud Health Technol Inform 2000;65:4-9.
14. Dech F, Ai Z, Silverstein JC. Manipulation of Volumetric Patient Data in a Distributed Virtual Reality
Environment. Stud Health Technol Inform 2001; 81:119-25.
15. Chhadia A, Dech F, Ai Z, Silverstein JC Autocolorization of Three-Dimensional Radiological Data. Stud
Health Technol Inform. 2001; 81:90-96.
16. Silverstein JC, Dech F, Ai Z. Biomedical Tele-Immersion for Next Generation Systems. Federal Large
Scale Networking Workshop. Mar 2001.
17. Ai Z, Dech F, Silverstein JC, Rasmussen M. Tele-Immersive Medical Education Environment. Stud Health
Technol Inform. 2002; 85:24-30.
18. Silverstein JC, Chhadia A, Dech F. Visualization of conserved structures by fusing highly variable
datasets. Stud Health Technol Inform 2002; 85:494-500.
19. Dech F, Silverstein JC. Rigorous Exploration of Medical Data in Collaborative Virtual Reality Applications.
IEEE Computer Society Proc. of 6th Annual Conf. on Information Visualisation. 2002;:32-38.
20. Silverstein JC, Dech F, Edison M, Jurek P, Helton WS, Espat NJ. Virtual Reality: Immersive Hepatic
Surgery Educational Environment (IHSEE). Surgery. 2002 Aug;132(2):274-7.
21. Dobson HD, Pearl RK, Orsay CP, Rasmussen M, Evenhouse R, Ai Z, Blew G, Dech F, Edison MI,
Silverstein JC, Abcarian H. Virtual Reality: new method of teaching anorectal and pelvic floor anatomy. Dis
Colon Rectum 2003 Mar;46(3):349-52.
22. Silverstein JC, Dech F, Kouchoukos PL. Enhancing Radiological Volumes with Symbolic Anatomy Using
Image Fusion and Collaborative Virtual Reality. Stud Health Technol Inform 2004; 98:347-52.
23. Silverstein JC, Tsirline V, Dech F, Kouchoukos P, Jurek P. Automated Renderer for Visible Human and
Volumetric Scan Segmentations. Stud Health Technol Inform 2005; 111:473-6.
24. Silverstein JC, Dech F, Binns J, Jones D, Papka ME, Stevens R. Distributed Collaborative Radiological
Visualization using Access Grid. Stud Health Technol Inform 2005; 111:477-81.
25. Silverstein JC, Dech F. Precisely Exploring Medical Models and Volumes in Collaborative Virtual Reality.
Presence (MIT Press) Feb 2005; 14(1):47-59.
26. Binns J, Dech F, McCrory M, Papka ME, Silverstein JC, Stevens R. Developing a Distributed Collaborative
Radiological Visualization Application. Stud Health Technol Inform 2005;112:70-9.
27. Silverstein JC, Ehrenfeld JM, Croft D, Dech F, Small S, Cook S. Tele-Immersion: Preferred Infrastructure
for Anatomy Instruction. Journal of Computing in Higher Education Fall 2005; 18(1):80-93.
28. Silverstein JC, Amine M, Dech F, Jurek P, Pires I, Tsirline V, Walsh C. Web-based viewer for systematic
combination of anatomy and nomenclature. Stud Health Technol Inform. 2006;119:518-22.
29. Silverstein JC, Selkov E, Salud L, Pugh C. Developing Performance Criteria for the e-Pelvis Simulator
Using Visual Analysis. Stud Health Technol Inform. 2007;125:436-8.
30. Silverstein JC, Walsh C, Dech F, Olsen E, Papka ME, Parsad N, Stevens R. Immersive Virtual
Anatomy Course Using a Cluster of Volume Visualization Machines and Passive Stereo. Stud Health
Technol Inform. 2007;125:439-44.
31. Erberich SG, Silverstein JC, Chervenak A, Schuler R, Nelson M, Kesselman C. Globus MEDICUS –
Federation of DICOM Medical Imaging Devices into Healthcare Grids. Stud Health Technol Inform.
2007;126:269-278.
32. Erberich SG, Silverstein JC, Chervenak A, Schuler R, Nelson M, Kesselman C. Globus MEDICUS –
Protected Health Information in Medical Imaging Grids. Proceedings of the 21st International Congress and
Exhibition of Computer Assisted Radiology and Surgery Conference (CARS) 2007, Springer-Verlag.
33. Silverstein JC, Walsh C, Dech F, Olsen E, Papka ME, Parsad N, Stevens R. Multi-Parallel Open
Technology to Enable Collaborative Volume Visualization: How to Create Global Immersive Virtual
Anatomy Classrooms. Stud Health Technol Inform. 2008;132:463-8.
34. Silverstein JC, Parsad NM, Tsirline V. Automatic perceptual color map generation for realistic volume
visualization. J Biomed Inform. 2008;41(6):927–935.
35. Savel TG, Silverstein JC, Hall K, Lenert L. In Response to: What is a Grid? J Am Med Inform Assoc.
2008;15(5):705-6.
36. Xiaoming Wang, Lili Liu, James Fackenthal, Shelly Cummings, Maggie Cook, Kisha Hope, Jonathan
Silverstein, Olufunmilayo I Olopade. Translational Integrity and Continuity: Personalized Biomedical
Data Integration. J Biomed Inform. 2008 Aug 12 [Epub ahead of print].
37. Roach PB, Roggin KK, Selkov Jr, E, Posner MC, Silverstein JC. The Use of a Novel, Web-based
Educational Platform Facilitates Intraoperative Training in a Surgical Oncology Fellowship Program. Ann
Surg Onc. 2009;16(5):1100-07.
38. Yang Shen, Jonathan C. Silverstein, Steven Roth. In hospital complications and mortality after elective
spinal fusion surgery in the United States: A study of the Nationwide Inpatient Sample from 2001 to
2005. Journal of Neurosurgical Anesthesiology 2009;21(1):21-30..
39. Roach, Paul B.; Silverstein, JC. Training fellows and core competency: "Making quality certain". Journal
of Surgical Oncology. 2009;99(2):83-4.
40. Bernstam EV, Hersh WR, Johnson SB, Chute CG, Nguyen H, Sim I, Nahm M, Weiner M, Miller P,
DiLaura RP, Overcash M, Lehmann HP, Eichmann D, Athey BD, Scheuermann RH, Anderson N,
Starren JB, Harris PA, Smith JW, Barbour E, Silverstein JC, Krusch DA, Nagarajan R and Becich MJ.
Synergies and Distinctions between Computational Disciplines in Biomedical Research: Perspective
from the Clinical and Translational Science Award Programs. Acad Med [In Press].

C. Research Support
Ongoing Research Support
Searle Funds of The Chicago Community Trust (Chicago Biomedical Consortium) 6/1/2009 – 5/30/2011
Innovative Cryo-STEM for Element-Specific Imaging of Cells and Tissues
Role: PI (O’Halloran, Dravid, and Silverstein, PIs)

1U24RR025736-01 (PI – Carl Kesselman, USC) 12/15/2008 – 11/30/2013

NIH/National Center for Research Resources
Biomedical Informatics Research Network Coordinating Center (BIRN-CC)
Role: Co-PI

University of Chicago (PI - Vigneswaran) 07/01/2008 - 07/01/2009

University of Chicago Provost’s Academic Technology Innovation Program
Collaboratory for Surgical and Perioperative Innovation (CSPI)
Role: Investigator

St. John’s Hospital, L.A./USC University of Chicago Sub-award (PI – Ian Foster) 7/1/2008 – 7/1/2009
Center for Health Informatics (CHI)
Role: Co-PI

1UL1RR024999-01 (PI - Julian Solway) 09/17/2007 – 05/31/2012

NIH/National Center for Research Resources
Re-Engineering Translational Research at The University of Chicago (CTSA)
Role: Director, Biomedical Informatics Component

Chicago Biomedical Consortium (CBC) (Morimoto, Silverstein, and Russell are PIs) 01/2006 – 12/2010
Searle Funds of the Chicago Community Trust
Chicago Biomedical Consortium
Role: PI

Completed Research Support (last three years only)

N01 LM-3-3508 Silverstein (PI) 09/30/2003-08/31/2007
NIH/NLM
Advanced Biomedical Collaboration Testbed in Surgery, Anesthesia, Radiology and Emergency Medicine
Role: PI

N01 - Stevens (PI) 07/2004 – 07/2009

NIH/NIAID
National Microbial Pathogen Data Resource Center
Role: Investigator

P50 CA125183 (PI - Olopade) 11/1/2006 - 10/31/2011

NCI/NIH
SPORE in Breast Cancer
Role: Co-Director, Analytic and Informatics Core

UChicago Graduate Medical Education Committee - Roach (Oncology Fellow is PI) 7/1/2006 – 6/30/2008
Quality-Based Surgical Education: Surgical Training and Assessment Tool (STAT)
Role: Faculty PI

Joint Theory Institute of Argonne National Laboratory and University of Chicago 7/1/2007 – 7/1/2008
Mathematics for Systems Biology
Role: PI (Maltsev and Silverstein, PIs)