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Mycobacterium Tuberculosis Streptococcus Pyogenes and Francisella Tularensis Escherichia Coli Salmonella

MR1-restricted T cells (MR1Ts) recognize and defend against various microbial pathogens through recognition of ligands presented on the MR1 protein. Using mass spectrometry, the researchers identified a diverse array of ligands presented by MR1 from Escherichia coli and Mycobacterium smegmatis, demonstrating that the MR1 ligandome is broader than previously thought. These MR1 ligands can be distinguished by MR1Ts with different T cell receptor usage, showing that MR1 acts as an immune sensor of microbial molecules.

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29 views1 page

Mycobacterium Tuberculosis Streptococcus Pyogenes and Francisella Tularensis Escherichia Coli Salmonella

MR1-restricted T cells (MR1Ts) recognize and defend against various microbial pathogens through recognition of ligands presented on the MR1 protein. Using mass spectrometry, the researchers identified a diverse array of ligands presented by MR1 from Escherichia coli and Mycobacterium smegmatis, demonstrating that the MR1 ligandome is broader than previously thought. These MR1 ligands can be distinguished by MR1Ts with different T cell receptor usage, showing that MR1 acts as an immune sensor of microbial molecules.

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MR1-restricted T cells (MR1Ts) are a T cell subset that recognize and mediate host defense

to a broad array of microbial pathogens, including respiratory pathogens


(e.g., Mycobacterium tuberculosis, Streptococcus pyogenes, and Francisella tularensis) and
enteric pathogens (e.g., Escherichia coli and Salmonella species). Mucosal-associated
invariant T (MAIT) cells, a subset of MR1Ts, were historically defined by the use of a semi-
invariant T cell receptor (TCR) and recognition of small molecules derived from the riboflavin
biosynthesis pathway presented on MR1. We used mass spectrometry to identify the
repertoire of ligands presented by MR1 from the microbes E. coli and Mycobacterium
smegmatis. We found that the MR1 ligandome is unexpectedly broad, revealing functionally
distinct ligands derived from E. coliand M. smegmatis. The identification, synthesis, and
functional analysis of mycobacterial ligands reveal that MR1T ligands can be distinguished
by MR1Ts with diverse TCR usage. These data demonstrate that MR1 can serve as an
immune sensor of the microbial ligandome.

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