Alprazolam

The Drug Enforcement Administration's Special Testing and Research Laboratory

generated this monograph using structurally confirmed reference material.

H3C N
N
N

Cl N

1. GENERAL INFORMATION

IUPAC Name: 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

CAS#: 28981-97-7

Synonyms: Xanax

Source: DEA Reference Material Collection

Appearance: White powder

UVmax(nm): Not Determined

2. CHEMICAL AND PHYSICAL DATA

2.1 CHEMICAL DATA

Form Chemical Formula Molecular Weight Melting Point (oC)

Base C17H13ClN4 308 224-230

Latest Revision: 7/14/14 SWGDRUG.org/monographs.htm Page 1 of 5

 Alprazolam
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.

3. QUALITATIVE DATA

3.1 NUCLEAR MAGNETIC RESONANCE

Sample Preparation: Dilute analyte to ~23 mg/mL inCD3OD containing TMS for 0 ppm reference and
dimethylsulfone as quantitative internal standard.

Instrument: 400 MHz NMR spectrometer

Parameters: Spectral width: at least containing -3 ppm through 13 ppm
Pulse angle: 90o
Delay between pulses: 45 seconds
1
H NMR Alprazolam Lot I0G195, CD3OD, 400MHz
Dimethylsulfone

10

4
CD3OD
3 CD3OD

2
TMS
1

0
26 1 1 3

8 7 6 5 4 3 2 1 0

0 1 1 3
2 6
5.30 5.25 4.275 4.225 2.70 2.65
7.8 7.7 7.6 7.5 7.4

Latest Revision: 7/14/14 SWGDRUG.org/monographs.htm Page 2 of 5

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and Research Laboratory generated this monograph using
ed reference material. Alprazolam

3.3 INFRARED SPECTROSCOPY (FTIR)

an Parameters: Insrument:
f background scans: 32 Resolution:
Number
4 cm-1of scans:
FTIR 32
with diamond ATR attachment (3 bounce)

72
999
779
463

1165 1207
658

64
1323
1311
1298
850 933

1539
1612

56
582
550
528

1487
1425

48
820 831

40
698

3500 3000 2500 2000 1500 Wavenumber (cm-1)

72
850

999
933

1323
1311
1298
1207
1165
1103
1038

64
687
658

779
463

744

1612
1539
1487
1425

56
582
550
528

48
820 831

40
698

Latest Revision: 7/14/14 1500 1400 1300 1200 1100 1000 900 800 700 Wavenumber (cm-1)
SWGDRUG.org/monographs.htm
17001600 Page 4 of 5
 Alprazolam
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.

4. ADDITIONAL RESOURCES

Forendex
http://forendex.southernforensic.org/index.php/detail/index/248

http://en.wikipedia.org/wiki/Alprazolam Wikipedia

Latest Revision: 7/14/14 SWGDRUG.org/monographs.htm Page 5 of 5