BAB IV

HASIL DAN PEMBAHASAN

IV.1 HASIL PENGAMATAN

IV.1.1 TABEL DATA PARACETAMOL

NO BOBOT TIKUS JUMLAH (MENIT)

(GRAM)
15 30 45 60
1 175 2 KALI 6 KALI 5 KALI 8 KALI
2 141 2 KALI 5 KALI 5 KALI 3 KALI
3 161 3 KALI 13 KALI 7 KALI 8 KALI
4 151 7 KALI 6 KALI 3 KALI 1 KALI
5 146 6 KALI 7 KALI 3 KALI 3 KALI
6 149 7 KALI 5 KALI 4 KALI 3 KALI
7 124 6 KALI 5 KALI 3 KALI 2 KALI
8 124 5 KALI 5 KALI 4 KALI 1 KALI
9 158 4 KALI 7 KALI 5 KALI 5 KALI
10 134 9 KALI 6 KALI 5 KALI 3 KALI
11 145 8 KALI 6 KALI 5 KALI 3 KALI
JML 146,2 5,37 KALI 6,45 KALI 4,95 KALI 3,63 KALI

 Analisis data (Suspensi paracetamol 500 mg/kg BB)

KD = dosis pada manusia x fk
= 500 mg/70 kg BB x 0.018
= 9 mg/200 gr BB
Stok = KD x BB max Tikus
= 9 mg/200 gr BB x 175 gr / 0.5 x 5 ml
= 3,15 mg/ml
Vp (175 gr ) = KD x BB tikus / stok
= 9 mg/200 gr BB x 175 gr / 3,15 mg/ml
= 3,15 ml
Vp (141 gr) = KD x BB tikus / stok
= 9 mg/200 gr BB x 141 gr / 3,15 mg/ml
= 2,53 ml
Vp (161 gr) = KD x BB tikus / stok
 = 9 mg/200 gr BB x 161 gr / 3,15 mg/ml
= 2,3 ml
Vp (151 gr) = KD x BB tikus / stok
= 9 mg/200 gr BB x 151 gr / 3,15 mg/ml
= 2,71 ml
Vp (146 gr) = KD x BB tikus / stok
= 9 mg/200 gr BB x 146 gr / 3,15 mg/ml
= 2,62 ml
Vp (149 gr) = KD x BB tikus / stok
= 9 mg/200 gr BB x 149 gr / 3,15mg/ml
= 2,68 ml
Vp (124 gr) = KD x BB tikus / stok
= 9 mg/200 gr BB x 124 gr / 3,15 mg/ml
= 2,23 ml
Vp (124 gr) = KD x BB tikus / stok
= 9 mg/200 gr BB x 124 gr / 3,15 mg/ml
= 2,23 ml
Vp (158 gr) = KD x BB tikus / stok
= 9 mg/200 gr BB x 158 gr / 3,15 mg/ml
= 2,25 ml
Vp (134 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 134 gr / 3,15 mg/ml
= 2,07 ml
 Analisis data (IP asam asetat 25 mg/70 kg BB)
KD = dosis pada manusia x fk
= 25 mg x 0.018
= 0.45 mg/200 gr BB
Stok = KD x BB max Tikus
= 0.45 mg/200 gr BB x 167 gr / 0.5 x 5 ml
= 0.15 mg/ml
Vp (175 gr ) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 175 gr / 0.15 mg/ml
= 2,62 ml
Vp (141 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 141 gr / 0.15 mg/ml
= 2,11 ml
Vp (161 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 161 gr / 0.15 mg/ml
= 2,41 ml
Vp (151 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 151 gr / 0.15 mg/ml
= 2,26 ml
Vp (146 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 146 gr / 0.15 mg/ml
= 2,19 ml
Vp (149 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 149 gr / 0.15 mg/ml
= 2,23 ml
Vp (124 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 124 gr / 0.15 mg/ml
= 1,86 ml
Vp (124 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 124 gr / 0.15 mg/ml
= 1.86 ml
Vp (158 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 158 gr / 0.15 mg/ml
= 2,57 ml
Vp (134 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 134 gr / 0.15 mg/ml
= 2,01 ml
Vp (145 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 145 gr / 0.15 mg/ml
= 2,17 ml
IV.1.2 TABEL DATA IBUPROFEN

NO BOBOT TIKUS JUMLAH (MENIT)

(GRAM)
15 30 45 60
1 126 4 KALI 9 KALI 14 KALI 13 KALI
2 123 5 KALI 1 KALI 12 KALI 6 KALI
3 131 6 KALI 18 KALI 8 KALI 1 KALI
4 139 8 KALI 10 KALI 9 KALI 7 KALI
5 116 18 KALI 24 KALI 20 KALI 12 KALI
6 103.5 5 KALI 5 KALI 5 KALI 10 KALI
7 131 18 KALI 11 KALI 16 KALI 10 KALI
8 103.5 4 KALI 4 KALI 1 KALI 5 KALI
9 101 4 KALI 19 KALI 5 KALI 2 KALI
10 167 21 KALI 5 KALI 3 KALI 11 KALI
11 118 9 KALI 8 KALI 10 KALI 8 KALI
JML 123 9.27 KALI 10.36 KALI 9.36 KALI 7.54 KALI

 Analisis data (Suspensi ibuprofen 500 mg/kg BB)

KD = dosis pada manusia x fk
= 100 mg x 0.018
= 1,8 mg/200 gr BB
Stok = KD x BB max Tikus
= 1,8 mg/200 gr BB x 167 gr / 0.5 x 5 ml
= 0.6 mg/ml
Vp (126 gr ) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 126 gr / 0.6 mg/ml
= 1.9 ml
Vp (123 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 123 gr / 0.6 mg/ml
= 1.8 ml
Vp (131 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 131 gr / 0.6 mg/ml
= 2 ml
Vp (139 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 139 gr / 0.6 mg/ml
 = 2.1 ml
Vp (116 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 116 gr / 0.6 mg/ml
= 1.7 ml
Vp (103.5 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 103.5 gr / 0.6 mg/ml
= 1.6 ml
Vp (131 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 131 gr / 0.6 mg/ml
= 2 ml
Vp (103.5 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 103.5 gr / 0.6 mg/ml
= 1.6 ml
Vp (101 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 101 gr / 0.6 mg/ml
= 1.5 ml
Vp (167 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 167 gr / 0.6 mg/ml
= 1.8 ml
 Analisis data (IP asam asetat 25 mg/70 kg BB)
KD = dosis pada manusia x fk
= 25 mg x 0.018
= 0.45 mg/200 gr BB
Stok = KD x BB max Tikus
= 0.45 mg/200 gr BB x 167 gr / 0.5 x 5 ml
= 0.15 mg/ml
Vp (126 gr ) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 126 gr / 0.15 mg/ml
= 1.9 ml
Vp (123 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 123 gr / 0.15 mg/ml
= 1.2 ml
Vp (131 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 131 gr / 0.15 mg/ml
= 2 ml
Vp (139 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 139 gr / 0.15 mg/ml
= 2.1 ml
Vp (116 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 116 gr / 0.15 mg/ml
= 1.7 ml
Vp (103.5 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 103.5 gr / 0.15 mg/ml
= 1.6 ml
Vp (131 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 131 gr / 0.15 mg/ml
= 2 ml
Vp (103.5 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 103.5 gr / 0.15 mg/ml
= 1.6 ml
Vp (101 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 101 gr / 0.15 mg/ml
= 1.5 ml
Vp (167 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 167 gr / 0.15 mg/ml
= 1.8 ml