Visual Field Testing: From One

Medical Student to Another

Joy N. Carroll and Chris A. Johnson, Ph.D.
August 22, 2013

Introduction: Components of Vision

Vision is a combination of distinct measurable functions: visual acuity, color vision, vernier
(alignment) acuity, the perception of movement and change in luminous intensity (flicker) or
differences in luminous intensity (contrast). Visual acuity is the ability to determine fine detail and
distinguish one object from another. Acuity is tested with vision charts of letters or images.
Changes in luminous intensity are perceived as flicker, and the difference in luminous intensity
from one object to another is perceived as contrast [1]. The visual field encompasses the entire
region of space seen while gaze is directed at any central object. This tutorial explains visual field
testing.

The Visual Field

Under normal daylight (photopic) conditions, the smallest or least intense visible objects are only
seen in the central region of the visual field. In the periphery, objects must be larger or more
intense to be identified. A normal visual field extends approximately 100° temporally (laterally),
60° nasally, 60° superiorly, and 70° inferiorly [2]. A physiologic scotoma (a blind spot) exists at
15° temporally where the optic nerve leaves the eye. Definitive location varies slightly on an
individual basis. The average blind spot is 7.5° in diameter, vertically centered 1.5° below the
horizontal meridian [3]. See figure 1. For dim night lighting (scotopic) conditions, the mid
periphery is the most sensitive region of the visual field.

Figure 1: Physiologic scotoma. The scotoma is the area of increased pixilation, indicating decreased visual
acuity.
Anatomy & Physiology
The visual field corresponds to the topographic arrangement of photoreceptors in the eye. When
photons of light are absorbed by the photoreceptor cells of the retina, a cis-trans isomerization of
11-cis chromophore begins the phototransduction cascade, resulting in hyperpolarization of
bipolar and horizontal cells, and ultimately activation of ganglion cells, which form the nerve fiber
layer [4]. The nerve fibers travel to the optic nerve head, where the optic nerve originates. At the
optic nerve head (also known as the optic disc), there are no photoreceptors, only nerve fibers.
This region corresponds to the physiologic scotoma.
The highest density of cone (photopic) photoreceptors is located in the macula. The ganglion cell
axons which ultimately join to form the optic nerve travel horizontally as the papillomacular
bundle from the macula to the temporal aspect of the optic disc. The nerve fibers respect the
median raphe along the horizontal meridian. The ganglion cells originating temporal to the
macula must also travel to the optic disc without crossing the median raphe. To do so they must
arc around the papillomacular bundle, forming the appropriately named arcuate fibers. Ganglion
cells originating in the areas of the retina nasal to the disc do not have to arc around the
macula. They are therefore oriented radially, making a fairly straight path to the optic nerve.
Visual field defects resulting from ganglion cell loss, such as those from glaucoma, correspond to
these anatomical patterns.

Figure 2: Ganglion Cell Pathways

It is important to note that visual field coordinates are the opposite of retinal coordinates. Light
entering the eye from the temporal visual field is detected by photoreceptors on the nasal side of
the retina and light entering from the nasal visual field is detected by the temporal
photoreceptors. Similarly, light from the superior visual field is absorbed in the inferior retina and
vice versa. Therefore, a patient with injury to the ganglion cells in the temporal retina would be
predicted to have a nasal visual field defect.

Figure 3: Light Paths to the Retina. Light originating superior to the eye is detected by the inferior retina. Light
originating temporal to the eye is detected by the nasal aspect of the retina.
History
Recognition of the visual field extends back more than 2,000 years to the time of Hippocrates,
who recognized a hemianopsia [5]. Visual fields are frequently evaluated by simply covering one
eye and asking the patient to look straight ahead while using peripheral vision to identify an
object, or the number of fingers shown by the examiner. The field is often tested at only four
locations, which is sensitive only for large field defects. This method of testing is referred to
as confrontation visual field evaluation.
Quantification of visual fields was developed during the nineteenth century. Jannik Bjerrum
began mapping visual fields by asking patients to identify whether a white object on the end of a
black stick, in front of a black screen, was seen. Several targets of varying sizes on the wand
were tested, effectively mapping the variation in size required for vision in different areas of the
field. This method of testing, known as the tangent screen, only measures the central 30° of the
visual field [5].
The Amsler grid is another tool for measuring the central visual field occupied by the macula
(approximately 8 degrees in diameter). The test consists of a card with horizontal and vertical
black lines intersecting on a white background, held at a distance of 25 cm or 40 cm. While fixing
gaze on a point in the center of the grid, areas that are blurry, absent, or distorted are identified
by the patient. Central vision corresponds with the macula, hence the use of Amsler grids to
follow macular pathology clinically [5].

Figure 4: Amsler grid

Kinetic and Static Perimetry

A method of testing the complete visual field was developed by Hans Goldmann. His bowl-
shaped perimeter uses bright light as targets superimposed on a white background. Targets may
vary in size, luminance, and color. Goldmann perimetry requires trained perimetrists to measure
and draw the visual field. Challenges include cost and inter-perimetrist variability [5]. In practice,
Goldmann perimetry is a form of kinetic perimetry: a stimulus is moved from beyond the edge of
the visual field into the field. The location at which the stimulus is first seen marks the outer
perimeter of the visual field for the size of the stimulus tested.
Automated perimetry was developed in the 1970s. As the name suggests, automated perimetry
maps a visual field with the aid of a computer. The Octopus perimeter, the Humphrey Field
Analyzer, and Humphrey Matrix are a few of the available automated perimeters. Although the
Octopus can perform a modified kinetic perimetry, most automated perimetry is
static: stationary stimuli, varying in size and intensity, are presented in specific locations within
the visual field [6].

Humphrey Visual Field Test

Several basic conditions must be met for a successful map of the visual field to be produced by
any method. The individual must be able to maintain a constant gaze toward a fixed location for
several minutes. Each eye is tested separately while the opposite eye is covered with a
patch. Refractive correction must be made with a test lens. Spectacles must not be worn
because they can cause false defects in the visual field due to their shape [6]. In addition,
correction must be made for presbyopia, to reduce accommodative strain. Standard adjustments
for presbyopia are available based on age alone. To correct an astigmatism >0.75 diopters, a
cylindrical lens must be used. If the eyelid or lashes obstruct the visual axis, the lid may be
taped to the forehead to lift it out of the way.
During Humphrey Visual Field (HVF) testing, the patient places his head in the chinrest and fixes
his gaze toward a central fixation point in a large, white bowl. As stated above, this test is an
example of static perimetry. It assesses the ability to see a non-mobile stimulus which remains
for a brief moment (200 ms) in the visual field. When the patient sees a presented stimulus, he
presses the button on a handheld remote control. Different locations within a given region of the
visual field are tested until the threshold, or the stimulus intensity seen 50% of the time, is seen
at each test location.
Stimuli vary in size and luminous intensity. Goldmann size III (about ½ degree in diameter) is
generally used, but Goldmann size V (approximately 2 degrees in diameter) is available for
patients with decreased visual acuity (< 20/200) or other visual impairment. Goldmann sizes I, II,
and III are rarely used clinically. The luminous intensity of the stimuli can be varied over a range
of 0.08 to 10,000 apostilbs (asb). It is reported in decibels (dB) of attenuation, or dimming,
extending from 0 dB (the brightest, unattenuated stimulus) to 51 dB (the dimmest, maximally
attenuated stimulus). If the patient is unable to see even the brightest, unattenuated stimlulus, it
is reported as <0 dB.
The Swedish Interactive Thresholding Algorithm (SITA) is frequently used. SITA is a forecasting
procedure that uses Bayesian statistical properties that is similar to the methods used for
providing weather information and predictions. SITA allows for more rapid analysis than would be
possible without forecasting. By taking into account a user's results in nearby locations, stimuli
that are unlikely to be seen, or extremely likely to be seen are not tested exhaustively. Instead
the stimuli that are likely near threshold are tested.

Figure 5: Humphrey Visual Field Analyzer

Reading the Humphrey Visual Field Printout
All of the information provided on the visual field printout is important. Patient identity information
and the specific test and stimulus size are located near the top of the analysis. It is important to
verify that the patient's birthdate was properly entered as an error will result in comparisons with
normals in the wrong age group.
Beneath the patient's name is a statement giving information about the testing parameters, such
as "Central 24-2 Threshold Test." The first statement, "Central 24" indicates that the central 24
degrees of visual field were analyzed. The next number indicates how the grid of points is
aligned to the visual axis. The number "1" indicates that the middle points are overlying the
horizontal and vertical meridians. The number "2" indicates that the grid of points straddles
these meridians. This is the setting most commonly used, as it is easier to assess whether visual
field defects respect the horizontal or vertical midline.
Next on the report are the reliability indices, including fixation losses, false positives, and false
negatives. Fixation losses occur when the patient reports seeing a stimulus that is presented in
the predicted area of the physiologic blind spot. False positives occur when a patient presses
the button when no stimulus is presented. Eager-to-please participants sometimes struggle with
high false positive rates (i.e., they are "trigger happy"). False positives can often be corrected by
providing a simple statement that many stimuli will not be seen even with normal vision. False
negatives occur when a patient fails to see a significantly brighter stimulus at a location than was
previously seen. False negatives are usually the result of attention lapses or fatigue and are
difficult to correct.
The visual threshold is the intensity of stimulus seen 50% of the time at each location. The
threshold values of each tested point are listed in decibels in the sensitivity plot. Higher numbers
mean the patient was able to see a more attenuated light, and thus has more sensitive vision at
that location. To the right of the numerical sensitivity plot is the grayscale map. This map
presents sensitivity across the patient's visual field with lighter regions indicating higher
sensitivity and darker regions reflecting lower sensitivity. The sensitivities are not compared to
any normative database. Therefore the map may draw attention to an irregularity within a field,
but may minimize field loss if loss is more homogenous across the field. Caution should be used
as it can be misleading based on where the machine chooses to make the cutoff between the
different shades of gray. The raw threshold data should always be assessed in conjunction with
the grayscale representation.
The numerical total deviation map compares the patient's visual sensitivity to an average normal
individual of the same age. It is useful to compare with age-matched normal thresholds as
sensitivity normally decreases gradually with age. Positive values represent areas of the field
where the patient can see dimmer stimuli than the average individual of that age. Negative
values represent decreased sensitivity from normal.
The numerical pattern deviation map shows discrepancies within a patient's visual field by
correcting for generalized decreases in visual sensitivity. It is useful to show localized areas of
sensitivity loss hidden within a field that is diffusely depressed. For example, a person with dense
cataracts may have decreased threshold across the entire visual field and this may obscure more
focal losses due to coexisting disorders like glaucoma. Rather than comparing the patient's
threshold values with a normative database, the pattern deviation analysis finds the patient's 7th
most sensitive (85th percentile) non-edge point and gives it a value of zero [6]. Each other test
location is then compared with this value to correct for any generalized depression. It has been
demonstrated that this method is the best for separating widespread or diffuse loss from
localized loss.
The bottom-most probability plots are grayscale versions of the total deviation and pattern
deviation maps. These maps may be useful to visually represent the statistical significance of the
total and pattern deviation calculations. The grayscale maps should only be interpreted in
conjunction with the numerical maps to avoid extrapolations.
On the right side of the printout are several useful numbers. The glaucoma hemifield test (GHT)
compares groups of corresponding points above and below the horizontal meridian to assess for
significant difference which may be consistent with glaucoma. Mean deviation (MD) is the mean
deviation in the patient's results compared to those expected from the age-matched normative
database. This calculation weighs center points more highly than peripheral points. Pattern
standard deviation (PSD) is a depiction of focal defects. It is determined by comparing the
differences between adjacent points. Higher values represent more focal losses, while lower
values can represent either no loss or diffuse loss. Short-term fluctuations (SF) are a calculation
portraying the variability between repeated measurements of the same test location. High SF
decreases the reliability of the test. Corrected pattern standard deviation (CPSD) corrects the
PSD for the SF. If there is high variability when testing the same point (high SF), PSD is given
less weight due to decreased predictive value, and CPSD will therefore appear lower than PSD.
Along the bottom of the HVF printout is a gaze tracker. The patient's pupil is monitored during
testing, and each time the pupil moves (representing a loss of fixation or head alignment), an
upstroke is recorded. Losses of fixation decrease the accuracy of visual field testing because
abnormalities will not correspond with the expected anatomic region of the retina and some may
be missed entirely. When the gaze tracker loses view of the pupil (representing a blink or droopy
upper eyelid), a downstroke is recorded. Pupillary obstruction can also decrease the accuracy of
results.

Figure 6: HVF 24-2. Courtesy Michael Wall, M.D.

Goldmann Visual Field Testing
Goldmann visual field (GVF) perimetry is not as widely available as HVF because it requires
skilled perimetrists who manually map the visual field without the aid of a computer algorithm.
Light is projected into a white bowl with a standardized background light intensity. The projected
light forms a fairly circular stimulus. Six stimulus sizes are available, ranging from 0.0625
mm2 (about 6 minutes of arc diameter) to 64 mm2 (about 2 degrees in diameter) when viewed at
30 cm, which is the standard distance between the patient's eye and the stimulus on the
background. The overall field mapping technique used is a form of kinetic perimetry, where a
stimulus is moved into the field of vision. When the patient sees the stimulus, he indicates so with
a low-tech method. At the University of Iowa a washer is given to the patient, with instructions to
tap the table with the washer whenever the stimulus is seen. The perimetrist then makes a mark
at the point where the stimulus was seen. To account for reaction time, a good perimetrist
consistently adjusts the location of the mark. At the conclusion of the tests, the marks are
connected by lines to form smooth boundaries of the visual field, or isopters. Areas of decreased
sensitivity (scotomata) are mapped by an opposite process, beginning at the center of the area of
loss and moving the target outward in at least 8 directions (different clock hours). The different
colors used represent stimuli of different sizes and luminous intensities.

Figure 7: Goldmann Perimeter

Goldmann Visual Field Interpretation

The final result of a GVF is a diagram similar to a topographic map. An analogy commonly used
to conceptualize these diagrams is the "island of vision." In this analogy, the visual field is an
island with a central peak and the altitude correlates with the visual sensitivity in a given location.
In this analogy, physiologic blind spot is represented by a pit or a well in the island. The isopters
are named with three characters: a Roman numeral, an Arabic number, and a letter. The Roman
numeral indicates the Goldmann size of the stimulus. The Arabic number and letter indicate the
attenuation of the light. The combination "4e" is used when there is no attenuation. For each
Arabic number less than "4," the light is attenuated by 5 dB. For each letter earlier in the
alphabet than "e," the light is attenuated by 1 dB. Within the confines of an isopter, the patient is
able to see a light of this size and intensity. Scotomata are represented by areas shaded with a
solid color. The color represents the depth of the scotoma, or the dimmest, smallest stimulus the
patient is unable to see in that area. For example, in the image below, the physiologic blind spot
is shaded orange like the I2e isopter. This suggests the patient is unable to see the I2e stimulus
in the area but was able to see the dimmer I4e stimulus.

Figure 8: Goldmann Visual Field. Courtesy Chris A. Johnson, Ph.D.

Glaucomatous Visual Field Defects

Loss of optic nerve axons in glaucoma eventually results in visual field defects, but the defects
may not be evident until a considerable percentage of axons are lost. After that point in disease
progression, further progression can be followed with serial visual field measurements. The
visual field defects associated with glaucoma are not specific for the disease. For example, a
generalized depression of the entire field is a change associated not only with glaucoma, but
could also be the result of a cataract. Additional examples of glaucomatous changes include but
are not limited to focal depression, focal or generalized contraction of the visual field, and blind
spot baring (reduced sensitivity directly around the optic nerve head) [7].
Scotomata are islands of reduced sensitivity within the visual field surrounded by areas of better
vision. Islands shaped like commas are named Seidel scotomata. Islands that arc in the shape of
the arcuate fibers are Bjerrum or arcuate scotomata. Those that affect the center of vision are
central scotomata and those that are located around the central ten degrees of the visual field
are paracentral scotomas. If a defect is located in the nasal field and extends ten degrees along
the horizontal meridian in a single isopter, or 5 degrees in multiple isopters, it is known as a nasal
step.
End stage glaucoma can result in a superior or inferior hemifield defect, or even loss of all vision
other than a central or temporal island of vision. Visual acuity (which is a measure of central
vision) may remain 20/20, but the peripheral field of vision may be severely reduced.

Patterns of Visual Field Loss [7,8,9]

Damage to visual mechanisms along various portions of the visual pathways from the optics and
photoreceptors up to the visual centers of the brain will produce different shapes and patterns of
visual field loss. To assist you in being able to properly interpret visual fields, a table indicating
the classic patterns of visual field loss associated with damage to different visual structures is
presented, along with a simple "cookbook" for interpreting visual fields is presented at the end of
this report. Please keep in mind that the steps of the "cookbook" should be performed in the
order specified without shortcuts.

Patterns Visual Field Loss Classic Location of Defect

Generalized decrease in sensitivity Media opacity (cornea, lens, or vitreous),

decreased attention

Constriction of the visual field Retina, optic nerve, small pupils

Ring scotoma Retina degeneration

Central scotoma Macula or optic nerve

Cecocentral scotoma Papillomacular nerve bundle or nearby retina in

region between the macula and optic nerve
head

Arcuate scotoma Arcuate retina ganglion cell nerve fiber bundles

or retinal vasculature

Temporal wedge Nasal retina radial fibers entering the optic

nerve

Blind spot enlargement Optic nerve

Multiple scattered defects Retina

Hemifields respecting the horizontal meridian Retina ganglion cell nerve fiber bundles or less
commonly retinal vasculature

Hemifields respecting the vertical meridian Optic chiasm or posterior visual pathways

Bitemporal Optic chiasm

Homonymous Optic chiasm or optic radiations

Horizontal tongue Lateral geniculate body

Congruous bilateral defects Nearer to the optic chiasm

Incongruous bilateral defects Nearer to the posterior visual cortex

"Pie in the sky" Temporal lobe

"Pie on the floor" Parietal lobe

"Punched out" defects Occipital lobe

Figure 9: Common visual field defects. A: Constriction of the visual field, B: Ring scotoma, C: Central
scotoma, D: Cecocentral scotoma, E: Arcuate scotoma, F: Temporal wedge, G: Blind spot enlargement, H:
Multiple scattered defects, I: Hemifields respecting the horizontal meridian, J: Hemifields respecting the vertical
meridian, K: Homonymous, L: Bitemporal, N: Incongruous bilateral defects, O: Congruous bilateral defects, P:
"Pie in the sky", Q: "Pie on the floor", R: "Punched out" defects
The Visual Field Interpretation Cookbook [8,9]
*These guidelines must be followed in this order for the most accurate results.

1. Look for signs of unreliable fields: Are there many false positives (> 15% using SITA), or
losses of fixation (> 33%)? Is there a lens rim artifact or uncorrected ptosis? If the fields
appear reliable, continue to step 2.
2. Look at the sensitivity map to determine whether the field is within normal limits. If the
fields are within normal limits, there is no further analysis. If one or both of the eyes
exhibit abnormal fields, continue to step 3.
3. Is the visual field damage present in one or both eyes? If only one eye is affected, the
damage is located in front of the optic chiasm (i.e. the cornea, vitreous, retina, or optic
nerve of only one eye). Damage in the visual fields of both eyes could be due to damage
at the level of the optic chiasm and beyond, or due to separate damage in the visual
pathways of each eye anterior to the chiasm.
4. Locate the region of the visual field deficit. Refer to the patterns of visual field defects
chart to determine the likely region of damage to the visual pathway.
5. Identify the shape of the visual field defect. Refer to the chart to determine the likely
region of damage to the visual pathway.
6. Compare these visual fields with each of the patient's previous visual field tests to identify
progression of visual field loss. Do not take a shortcut by comparing these fields to only
the most recent visual field, as this may be misleading. Generally six or more visual field
tests are necessary to evaluate disease progression. Consider the findings in the context
of the physical exam findings and the results of other tests and imaging.
7. If there is uncertainty, consult with colleagues.

Online Resources
 EyeWiki by The American Academy of Ophthalmology
 Imaging and Perimetry Society

References
1. Anderson DR. Standard Perimetry. Ophthalmol Clin N Am 2003;16: 205-212. [PMID:
12809158]
2. Ramulu P. Standard Automated Perimetry. 2012. [Cited 2013 May 29]; Available
from http://eyewiki.aao.org/Standard_Automated_Perimetry
3. Armaly MF. The size and location of the normal blind spot. Arch Ophthalmol. 1969; 81(2):192-
201. [PMID: 5764683]
4. Palczewsk K. Chemistry and Biology of Vision. The Journal of Biological Chemistry 2012;
287(3): 1612-1619. [PMID: 22074921]
5. Johnson CA, Wall M, Thompson HS. A history of perimetry and visual field testing. Optom Vis
Sci. 2011 Jan;88(1):E8-15. [PMID: 21131878]
6. Sample PA, Dannheim F, Artes P, Dietzsch J, Henson D, Johnson CA, Ng M, Schiefer U,
Wall M. Imaging and Perimetry Society Standards and Guidelines. Optom Vis Sci 2011;88:4-
7. [PMID: 21099442]
7. Alward, WL. (1999) Perimetry. In: WL Alward, Glaucoma: The Requisites, 1e (pp. 56-102).
Mosby.
8. Johnson CA. Detecting functional changes in the patient's vision – Visual Field Analysis.
Schacknow and Samples, The Glaucoma Book, Wilmington, PA: Springer, 2010, Chapter 23,
p. 229-264.
9. Johnson CA, Wall M. The Visual Field. Chapter 35 in Adler's Physiology of the Eye, 11th ed
(Levin, Nilsson, Ver Hoeve, Wu, Kaufman and Alm, eds), 2011, pp 655-676.
Suggested citation format
Carroll JN, Johnson CA. Visual Field Testing: From One Medical Student to Another.
EyeRounds.org. August 21, 2013; available from http://EyeRounds.org/tutorials/VF-testing/
last updated: 2/14/2018

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