WHAT IS A THEORY OF AGING?

Theories of aging can be divided into two categories: those that answer the question “Why
do we age?” and those that address the question “How do we age?” Only a few broad,
overarching theories attempt to explain why we and nearly all living organisms age. These
theories compete with each other, making it unlikely that more than one of them could be
true. Over time, some theories have fallen out of favor as others have become more widely
accepted. Other theories, more properly called hypotheses, are smaller in scope and
address the question, “How do we age?” They attempt to explain the mechanisms that
affect how we and other species age, and it is likely that a number of them are
simultaneously true. Testing these hypotheses is the current pursuit of most ag ing -
research. Identification of the mechanisms that affect aging could lead to interventions
that slow or alter aging. Recent research implies that there may be a limited number of
these mechanisms, giving scientists hope that their efforts may one day le ad to strategies
that could help us lead longer, healthier lives.

Biological Ageing

Most people will live to experience ageing. Age-related deterioration is affecting an ever-
growing number of people. Although the process is unavoidable, if we better under stand
the process, as a physiotherapist, it is important to understand that we might be able to
positively influence aspects that maintain or engender better health and wellness as a
person ages, treating and ameliorating symptoms of common conditions asso ciated with
ageing.

In the past, maximum life span (the maximum biological limit of life in an ideal
environment) was not thought to be subject to change with the process of ageing
considered non-adaptive, and subject to genetic traits. In the early 1900’s, a series of
flawed experiments by researcher Alexis Carrel demonstrated that in an optimal
environment, cells of higher organisms (chickens) were able to divide continually, leading
people to believe our cells to potentially possess immortal properties. In the 1960’s
Leonard Hayflick disproved this theory by identifying a maximal number of divisions a
human cell could undergo in culture (known as the Hayflick limit), which set our maximal
life span at around 115 years. Life span is the key to the intrinsic biological causes of
ageing, as these factors ensure an individual’s survival to a certain point until biological
ageing eventually causes death.

There are many theories about the mechanisms of age related changes, and they are
mutually exclusive, no one theory is sufficiently able to explain the process of ageing, and
they often contradict one another.
Modern biological theories of ageing in humans currently fall into two main categories:
programmed and damage or error theories.
The programmed theories imply that ageing follows a biological timetable (regulated by
changes in gene expression that affect the systems responsible for maintenance, repair and
defense responses), and the damage or error theories emphasise environmental assaults to
living organisms that induce cumulative damage at various levels as the cause of ageing [1] .

These two categories of theory [2] are also referred to as non-programmed ageing theories
based on evolutionary concepts (where ageing is considered the result of an organism’s
inability to better combat natural deteriorative processes), and programmed ageing
theories (which consider ageing to ultimately be the result of a biological mechanism or
programme that purposely causes or allows deterioration and death in order to obtain a
direct evolutionary benefit achieved by limiting lifespan beyond a species -specific
optimum lifespan (Figure 1).

Figure 1: Evolutionary cost/ benefit of additional lifespan vs. age.

Curve 1: Modern non-programmed aging theories – The evolutionary value of further life
and reproduction is effectively zero beyond some species-specific age.

Curve 2: Modern programmed aging theories – There is an evolutionary cost associated

with surviving beyond a species-specific age.

Curve 3: Medawar’s concept – The evolutionary value of survival and reproduction

declines with age following a species-specific age [3] .
Goldsmith's review of modern programmed (adaptive) theories of biological ageing
investigates how organisms have evolved mechanisms that purposely limit their lifespans
in order to obtain an evolutionary benefit.
In his review of the modern theories of ageing, Jin [1] highlights three sub-categories of the
programmed theory, and four sub-categories of the damage or error theory, and also
relates some to how these might be observed in ageing populations.

 The programmed theory:

1) Programmed Longevity, which considers ageing to be the result of a sequential

switching on and off of certain genes, with senescence being defined as the time when
age-associated deficits are manifested.
2) Endocrine Theory, where biological clocks act through hormones to control the pace of
ageing.
3) Immunological Theory, which states that the immune system is programmed to decline
over time, leading to an increased vulnerability to infectious disease and thus ageing and
death.

 The damage or error theory include:

1) Wear and tear theory, where vital parts in our cells and tissues wear out resulting in
ageing.
2) Rate of living theory, that supports the theory that the greater an organism's rate of
oxygen basal, metabolism, the shorter its life span
3) Cross-linking theory, according to which an accumulation of cross-linked proteins
damages cells and tissues, slowing down bodily processes and thus result in ageing.
4) Free radicals theory, which proposes that superoxide and other free rad icals cause
damage to the macromolecular components of the cell, giving rise to accumulated damage
causing cells, and eventually organs, to stop functioning.
Trindade et al [4] provide a different viewpoint again, stating that to understand the
evolution of ageing, we have to understand the environment-dependent balance between
the advantages and disadvantages of extended lifespan in the process of spreading genes.
These researchers have developed a fitness-based framework in which they categorise
existing theories into four basic types: secondary (beneficial), maladaptive (neutral),
assisted death (detrimental), and senemorphic aging (varying between beneficial to
detrimental).

Some of the more commonly discussed theories and their relation to ageing are
summarised below:
1. Disengagement Theory

 Refers to an inevitable process in which many of the relationships between a person

and other members of society are severed & those remaining are altered in quality.
 Withdrawal may be initiated by the aging person or by society, and may be partial
or total.
 It was observed that older people are less involved with life than they were as
younger adults.
 As people age they experience greater distance from society & they d evelop new
types of relationships with society.
 In America there is evidence that society forces withdrawal on older people
whether or not they want it.
 Some suggest that this theory does not consider the large number of older people
who do not withdraw from society.
 This theory is recognized as the 1st formal theory that attempted to explain the
process of growing older.

2. Activity Theory

 Is another theory that describes the psychosocial aging process.

 Activity theory emphasizes the importance of ongoing social activity.
 This theory suggests that a person's self-concept is related to the roles held by that
person i.e. retiring may not be so harmful if the person actively maintains other
roles, such as familial roles, recreational roles, volunteer & commu nity roles.
 To maintain a positive sense of self the person must substitute new roles for those
that are lost because of age. And studies show that the type of activity does matter,
just as it does with younger people.

3. The Neuroendocrine Theory

First proposed by Professor Vladimir Dilman and Ward Dean MD, this theory elaborates
on wear and tear by focusing on the neuroendocrine system. This system is a complicated
network of biochemicals that govern the release of hormones which are altered by the
walnut sized gland called the hypothalamus located in the brain.
The hypothalamus controls various chain-reactions to instruct other organs and glands to
release their hormones etc. The hypothalamus also responds to the body hormone levels as
a guide to the overall hormonal activity. But as we grow older the hypothalamus loses it
precision regulatory ability and the receptors which uptake individual hormones become
less sensitive to them. Accordingly, as we age the secretion of many hormones declines
and their effectiveness (compared unit to unit) is also reduced due to the receptors down -
grading
4. The Free Radical Theory

 This now very famous theory of aging was developed by Denham Harman MD at
the University of Nebraska in 1956. The term free radical describes any molecule
that has a free electron, and this property makes it react with healthy molecules in a
destructive way.
 Because the free radical molecule has an extra electron it creates an extra negative
charge. This unbalanced energy makes the free radical bind itself to another
balanced molecule as it tries to steal electrons. In so doing, the balanced molecule
becomes unbalanced and thus a free radical itself.
 It is known that diet, lifestyle, drugs (e.g. tobacco and alcohol) and radiation etc.,
are all accelerators of free radical production within the body.

5. The Membrane Theory of Aging

The membrane theory of aging was first described by Professor Imre Zs. -Nagy of
Debrechen University, Hungary. According to this theory it is the age-related changes of
the cells ability to transfer chemicals, heat and electrical processes that impair it.
As we grow older the cell membrane becomes less lipid (less watery and more solid). This
impedes its efficiency to conduct normal function and in particular there is a toxic
accumulation

6. The Mitochondrial Decline Theory

The mitochondria are the power producing organelles found in every cell of every organ.
Their primary job is to create Adenosine Triphosphate (ATP) and they do so in the various
energy cycles that involve nutrients such as Acetyl-L-Carnitine, CoQ10 (Idebenone),
NADH and some B vitamins etc.

Enhancement and protection of the mitochondria is an essential part of preventing and

slowing aging. Enhancement can be achieved with the above mention nutrients, as well as
ATP supplements themselves

7. The Cross-Linking Theory

The Cross-Linking Theory of Aging is also referred to as the Glycosylation Theory of

Aging. In this theory it is the binding of glucose (simple sugars) to protein, (a process that
occurs under the presence of oxygen) that causes various problems.
Once this binding has occurred the protein becomes impaired and is unable to perform as
efficiently. Living a longer life is going to lead to the increased possibility of oxygen
meeting glucose and protein and known cross-linking disorders include senile cataract and
the appearance of tough, leathery and yellow skin.