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Multiple Choice Questions - in A Test /exam Each Worth 1 Mark

This document provides a tutorial covering basic concepts in therapeutics including: 1. Multiple choice questions about drug targets, affinity, antagonists, and the processes of distribution, metabolism, absorption, and excretion. 2. Short answer questions about how the response to a partial agonist differs from a full agonist and matching types of changes in drug response like tachyphylaxis and downregulation to their mechanisms. 3. An application question about "hexamethonium man" asking where the drug he was prescribed acts, why he had the symptoms described, and what more targeted treatment he would receive today.

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44 views2 pages

Multiple Choice Questions - in A Test /exam Each Worth 1 Mark

This document provides a tutorial covering basic concepts in therapeutics including: 1. Multiple choice questions about drug targets, affinity, antagonists, and the processes of distribution, metabolism, absorption, and excretion. 2. Short answer questions about how the response to a partial agonist differs from a full agonist and matching types of changes in drug response like tachyphylaxis and downregulation to their mechanisms. 3. An application question about "hexamethonium man" asking where the drug he was prescribed acts, why he had the symptoms described, and what more targeted treatment he would receive today.

Uploaded by

ThiênHiếu
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Essential Understanding of Disease and Treatment

Tutorial Questions, Week 3, 12th – 16th March 2018


Basic Concepts in Therapeutics

This tutorial covers lecture content from week 2, lectures 3 and 4. Please attempt the questions
before attending the session.

Multiple Choice Questions – in a test /exam each worth 1 mark

1. With regard to drug targets within the body, which is the best answer?
a. carriers: regulate protein concentrations & bioactive products
b. enzymes: move nutrients & waste in and out of cells
c. ion channels: move small ions, eg sodium and potassium, in and out of cells
d. receptors: recognise only drugs to change cellular response
e. receptors: are grouped into families on the basis of the ligands that bind to them

2. The degree to which a drug binds to a receptor is an indication of:


a. affinity
b. safety
c. selectivity
d. efficacy
e. toxicity

3. An antagonist has the following pharmacological properties:


a. potency
b. efficacy
c. affinity
d. can only bind competitively to a receptor
e. they can not block the response to an agonist

4. Our bodies influence drug response; which is the best answer related to these processes?
a. Distribution: is the irreversible loss of unchanged drug from the body
b. Metabolism: occurs mainly in the kidney
c. Metabolism: converts water-soluble drugs into fat-soluble compounds
d. Absorption: can be a passive or active process
e. Excretion: is the reversible transfer of a drug from one location to another
Short answer questions – marks in brackets indicative of test / exam question mark allocation

5. In comparison to full agonists, how does the response to a partial agonist differ? (2 marks)

6. Changes in function or expression of receptors can lead to changes in drug response. Match each
type of change with the mechanisms causing the change: (4 marks)
Term:
a. Tachyphylaxis
b. Downregulation
c. Desensitisation
d. Upregulation

Description:
1. Change in receptor location
2. Change in messenger system or receptor status
3. Decrease in receptor number
4. Increase in receptor number

Application question – From lecture 4


• Look up “hexamethonium man”

• Why is he taking this drug?
• Where does it act?
• Why does he have the symptoms described?
• What would he be prescribed today that would be a more targeted treatment?
Explain why, with reference to the ANS.

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