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Buspirone

Buspirone is approved to treat anxiety disorders in the short- and long-term in the US and Australia, and short-term in the UK. It has a delayed onset of action, taking 2-4 weeks for full effectiveness. Studies show it is as effective as benzodiazepines for generalized anxiety disorder. There is some evidence it may also help social phobia and depression when combined with SSRIs. While not FDA-approved for it, research shows buspirone can effectively augment SSRIs to treat clinical depression. It has also shown promise in treating cerebellar ataxia, hypoactive sexual desire disorder in women, attention deficit hyperactivity disorder, and irritability in dementia patients.

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Kim Patrick Guevarra
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160 views1 page

Buspirone

Buspirone is approved to treat anxiety disorders in the short- and long-term in the US and Australia, and short-term in the UK. It has a delayed onset of action, taking 2-4 weeks for full effectiveness. Studies show it is as effective as benzodiazepines for generalized anxiety disorder. There is some evidence it may also help social phobia and depression when combined with SSRIs. While not FDA-approved for it, research shows buspirone can effectively augment SSRIs to treat clinical depression. It has also shown promise in treating cerebellar ataxia, hypoactive sexual desire disorder in women, attention deficit hyperactivity disorder, and irritability in dementia patients.

Uploaded by

Kim Patrick Guevarra
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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Effects of Buspirone

Anxiety

Buspirone is approved in the United States by the Food and Drug Administration (FDA) for the short- or
long-term treatment of anxiety disorders or can also be used for the short-term relief of the symptoms of
anxiety Likewise in Australia, buspirone is licensed for the treatment of anxiety disorders. In the United
Kingdom, buspirone is indicated only for the short-term treatment of anxiety.

Buspirone has no immediate anxiolytic effects, and hence has a delayed onset of action; its full clinical
effectiveness may require 2 to 4 weeks to manifest. The drug has been shown to be similarly effective in
the treatment of GAD to benzodiazepines including diazepam, alprazolam, lorazepam,
and clorazepate. Buspirone is not known to be effective in the treatment of other anxiety
disorders besides GAD, although there is some limited evidence that it may be useful in the treatment
of social phobia as an adjunct to selective serotonin reuptake inhibitors (SSRIs).

Depression

Although not approved for this indication, studies such as STAR*D have shown buspirone to be an
effective augmentation agent alongside treatment with selective serotonin reuptake inhibitors (SSRIs)
for clinical depression and is also used to counter the sexual dysfunction (anorgasmia and erectile
dysfunction) associated with SSRIs. The drug has also been found to be effective in the treatment of
depression as a standalone drug.

Other uses

Cerebellar ataxia

There is evidence that buspirone may be used to treat Cerebellar ataxia.

Sexual dysfunction

There is some evidence that buspirone on its own may be useful in the treatment of hypoactive sexual
desire disorder (HSDD) in women.

ADHD

Several clinical trials, most randomized double-blind trials (and in one buspirone was used as an adjunct
to atomoxetine) and one open-label, have been conducted to evaluate the utility of buspirone in the
treatment of attention deficit hyperactivity disorder (ADHD), with mostly positive results.

Miscellaneous

Buspirone may be useful in the management of irritability, agitation, and aggression in older patients
with dementia and in pediatrics, although further research is necessary to more clearly establish its
effectiveness.

Buspirone is not effective as a treatment for benzodiazepine withdrawal, barbiturate withdrawal,


or alcohol withdrawal/delirium tremens.

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