Metrorrhagia (metro = womb, -rrhagia = excessive flow[1]) is uterine bleeding at irregular
intervals, particularly between the expected menstrual periods.[2]
In some women, menstrual spotting between periods occurs as a normal and harmless part
of ovulation. Some women experience acute mid-cycle abdominal pain around the time of
ovulation (sometimes referred to by the German term for this phenomenon, mittelschmerz). This
may also occur at the same time as menstrual spotting. The term breakthrough bleeding or
breakthrough spotting is usually used for women using hormonal contraceptives, such
as IUDs or oral contraceptives, in which it refers to bleeding or spotting between any expected
withdrawal bleedings, or bleeding or spotting at any time if none is expected. If spotting continues
beyond the first three cycles of oral contraceptive use, a woman should have her prescription
changed to a pill containing either more estrogen or more progesterone.[3]
Besides the aforementioned physiologic forms, metrorrhagia may also represent abnormal
uterine bleeding and be a sign of an underlying disorder, such as hormone
imbalance, endometriosis, uterine fibroids, uterine cancer, or vaginal cancer.
If the bleeding is repeated and heavy, it can cause significant iron-deficiency anemia.