MATERIAL SAFETY DATA SHEET

Cat# 1878-500, -1000, Glibenclamide MSDS DATE: Mar 27, 2012

SECTION 1: PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME: Glibenclamide

PRODUCT CODES: Cat# 1878-500, -1000

MANUFACTURER: BioVision, Inc.

ADDRESS: 155 S. Milpitas Boulevard, Milpitas, CA 95035

EMERGENCY PHONE: 858-373-8066

CHEMTREC PHONE:
OTHER CALLS: 408-493-1800
FAX PHONE: 408-493-1801

SECTION 2: COMPOSITION/INFORMATION ON INGREDIENTS

Component Description Volume Safety Information

1878-500: 500 mg
Glibenclamide Solid See below
1878-1000: 1 g

SECTION 3: HAZARDS IDENTIFICATION

Product Name/Chemical Name CAS Number EC-No. MW Chemical Formula

Glibenclamide 10238-21-8 233-570-6 494.0 C23H28ClN3O5S

Glibenclamide:
OSHA Hazards: Target organ effect
Target Organs: Pancreas, Gastrointestinal tract
GHS Classification: Not a dangerous substance according to GHS
GHS Label elements, including precautionary statements
Pictogram: none
Signal word: none
Hazard statement(s): none
Precautionary statement(s): none
HMIS Classification
Health hazard: 0
Chronic health hazard: *
Flammability: 0
Physical hazards: 0
NFPA Rating
Health Hazard: 0
Fire: 0
Reactivity Hazard: 0
Potential Health Effects
Inhalation: May be harmful if inhaled. May cause respiratory tract irritation.
Skin: May be harmful if absorbed through skin. May cause skin irritation.
Eyes: May cause eye irritation.
Ingestion: May be harmful if swallowed.

SECTION 4: FIRST AID MEASURES

General advice: Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled: If breathed in, move person into fresh air. If not breathing, give artificial respiration.
In case of skin contact: Wash off with soap and plenty of water.
In case of eye contact: Flush eyes with water as precaution.
If swallowed: Never give anything by mouth to an unconscious person. Rinse mouth with water.

5: FIRE-FIGHTING MEASURES

Condition of flammability: Not flammable or combustible.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special protective equipment for fire-fighters: Wear self-contained breathing apparatus for firefighting if necessary.
Hazardous combustion products: Hazardous combustion products formed under fire conditions not data available.

SECTION 6: ACCIDENTAL RELEASE MEASURES

Personal precautions: Avoid dust formation. Avoid breathing vapors, mist, gas, or dust. Ensure adequate ventilation.
Environmental precautions: Do not let product enter drains.
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MATERIAL SAFETY DATA SHEET
Cat# 1878-500, -1000, Glibenclamide MSDS DATE: Mar 27, 2012
Methods for cleaning up: Sweep up and shovel. Keep in suitable, closed containers for disposal.

SECTION 7: HANDLING AND STORAGE

Precautions for safe handling

Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection.
Conditions for safe storage
Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: 2-8C

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION

Contains no substances with occupational exposure limit values.

Personal protective equipment
Respiratory protection
Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1
(EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as
NIOSH (US) or CEN (EU).
Hand protection
For prolonged or repeated contact use protective gloves.
Eye protection
Safety glasses.
Skin and body protection
Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-
place.
Hygiene measures
General industrial hygiene practice.

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

Property Glibenclamide
Appearance: White to off-white solid
pH: No data available
Water Solubility: No data available
Other Solubility: DMSO (100 mM), EtOH (5 mM)
Specific Gravity (g/ml): No data available
Boiling Point (C): No data available
Melting Point (C): 173-175 oC (343-347 oF)
Flash Point (C): No data available
Ignition Temperature (C): No data available
Density No data available

SECTION 10: STABILITY AND REACTIVITY

Property Glibenclamide
Chemical stability Stable under recommended storage conditions
Conditions to avoid: No data available
Materials to avoid: Strong oxidizing agents
Hazardous decomposition products: Carbon oxides, nitrogen oxides, sulfur oxides,
hydrogen chloride gas

SECTION 11: TOXICOLOGICAL INFORMATION

Glibenclamide:
Acute toxicity: LD50 Oral rat >20,000 mg/kg
Skin corrosion/irritation: no data available
Serious eye damage/eye irritation: no data available
Respiratory or skin sensitization: no data available
Germ cell mutagenicity: no data available
Carcinogenicity:
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or
confirmed human carcinogen by IARC.
ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential
carcinogen by ACGIH.
NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated
carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential
carcinogen by OSHA.
Reproductive toxicity: Developmental toxicity rat subcutaneous Effects on embryo or fetus: fetal death.

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MATERIAL SAFETY DATA SHEET
Cat# 1878-500, -1000, Glibenclamide MSDS DATE: Mar 27, 2012
Developmental toxicity rat subcutaneous Specific developmental abnormalities: eye, ear.
Reproductive toxicity rat Intraperitoneal Effects on newborn: viability index (e.g. # alive at day 4 per # born alive).
Teratogenicity: no data available
Aspiration hazard: no data available
Potential Health Effects
Inhalation: May be harmful if inhaled. May cause respiratory tract irritation.
Skin: May be harmful if absorbed through skin. May cause skin irritation.
Eyes: May cause eye irritation.
Ingestion: May be harmful if swallowed.
Signs and Symptoms of Exposure: Exposure may cause hypoglycemia, gastrointestinal disturbance, central nervous system depression,
blood disorders, and/or circulatory collapse. To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Synergistic effects: no data available
Additional information: RTECS: YS4725200

SECTION 12: ECOLOGICAL INFORMATION

Glibenclamide:
Persistence and degradability: no data available
Toxicity: no data available
Bioaccumulative potential: no data available
Mobility in soil: no data available
PBT and vPvB assessment: no data available
Other adverse effects: no data available

SECTION 13: DISPOSAL CONSIDERATIONS

Product: Observe all federal, state, and local environmental regulations.

Contaminated packaging: Dispose of as unused product.

SECTION 14: TRANSPORT INFORMATION

Glibenclamide:
DOT (US): Not dangerous goods.
IMDG: Not dangerous goods.
IATA: Not dangerous goods.

SECTION 15: REGULATORY INFORMATION

Glibenclamide:
OSHA Hazards: Target organ effect
DSL Status: All components of this product are on the Canadian DSL list.
SARA 302 Components: SARA 302: No chemical in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components: SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the
threshold (De Minimis) reporting levels established by SARA Title II, Section 313.
SARA 311/312 Hazards: Chronic Health Hazard
Massachusetts Right To Know Components: No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know Components: Glibenclamide, CAS-No. 10238-21-8
New Jersey Right To Know Components: Glibenclamide, CAS-No. 10238-21-8
California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or
any other reproductive harm.

EU regulations
Component Risk Phrases Safety Phrases
Glibenclamide -- S24/25

SECTION 16: OTHER INFORMATION

DISCLAIMER:
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in
this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It
does not represent any guarantee of the properties of the product. BioVision, Inc., shall not be held liable for any damage resulting from
handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.

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