ANAESTHESIA FOR VENTRICULO-

PERITONEAL SHUNT INSERTION

ANAESTHESIA TUTORIAL OF THE WEEK 121

8TH DECEMBER 2008

Dr R Sunderland Specialist Registrar

Dr S Mallory Consultant
Anaesthetic Department, Great Ormond Street Hospital for Children, London, UK
Correspondence to [email protected]

SELF-ASSESSMENT QUESTIONS

Before reading the tutorial consider the following questions and discuss them with your
colleagues

1. What are the symptoms and signs of raised intracranial pressure?

2. What are the causes of hydrocephalus in children?
3. What mechanisms regulate cerebral blood flow?
4. What is the relationship between intracranial pressure and cerebral perfusion
pressure and how can we manipulate this therapeutically?
5. What additional considerations are there if the patient is a neonate?

INTRODUCTION

This article aims to look at anaesthetic techniques which can be employed for the
insertion of ventriculoperitoneal (VP) shunts. It will also address the basic principles of
neurophysiology which are required to treat patients with raised intracranial pressure.
Prior to shunting being introduced as a treatment for hydrocephalus in the 1940s, those
children affected had a poor prognosis. Only 20% of those who did not receive surgery
reached adulthood and 50% of the survivors were brain damaged. The development of
valved and then silicone shunt systems have dramatically improved the outlook for these
patients.

INTRACRANIAL PRESSURE (ICP) AND CEREBRAL PERFUSION

PRESSURE (CPP)

Successful management of patients undergoing VP shunt insertion is dependent on

understanding the relationship between ICP and CPP and how this is affected by any
disease process, anaesthetic agents and surgery.
The cranial contents consist of brain tissue (80%), blood (10%) and cerebrospinal fluid
(10%). The volume of the cranial vault is fixed once the sutures of the skull have become
fused, normally by 2 years of age. However, in the neonate, even though the volume of
the vault can expand if the increase in intracranial contents occurs gradually, such as in
congenital hydrocephalus, this accommodation has a maximum limit which once
exceeded will lead to an increase in ICP. Any changes in the volume of the individual
cranial contents can lead to an alteration in ICP and this has both pathological and
therapeutic implications.

Cerebral blood flow (CBF) determines cerebral blood volume and is higher in children
compared to adults (100 vs 50 ml/100g/min). It is coupled to the metabolic demands of
the normal brain and regulated via oxygen requirement, PaCO2 and intracerebral acidosis.
Autoregulation allows for a relatively constant blood flow across a wide range of arterial
pressures which can be as low as 40 mmHg in small children. This mechanism is not
available to premature neonates or during some pathological processes (e.g. infection)
where the relationship between CBF and arterial pressure is more linear. Reducing
PaCO2 causes vasoconstriction of the cerebral vessels, reducing CBF and hence blood
volume and ICP but at the expense of oxygen delivery. Therefore hyperventilation should
only be used as a short-term measure when ICP is dangerously high, prior to more
definitive treatment.

Cerebrospinal fluid (CSF) is continuously produced by the choroid plexus, and after
circulating through the ventricles is absorbed at the arachnoid villi. In children the rate of
production of CSF is 0.2-0.4 ml/min with around 250 ml produced and absorbed per day
and at any given time around 70 mls is present in the head. Any interruption to normal
flow, increased production or decreased reabsorption of CSF can manifest itself as
hydrocephalus which may lead to raised ICP. The classical distinction between
obstructive and communicating hydrocephalus is less useful clinically as the cause of
reduced absorption of CSF in communicating hydrocephalus is usually functional
obstruction at the arachnoid villi (e.g. by blood or protein).

Brain tissue, the largest component of the cranial contents, may be pathologically
enlarged by the presence of a space occupying lesion which if of insidious onset may lead
to a gradual increase in ICP.

Cerebral perfusion pressure is defined as the difference between the mean arterial
pressure (MAP) and the sum of intracranial pressure and the central venous pressure
(CVP).

CPP = MAP (ICP + CVP)

The normal range of ICP in neonates is 2-4 mmHg (7-15 mmHg in adults). Increased ICP
gives rise to such symptoms and signs as: vomiting, irritability, drowsiness, bulging
fontanelle (if still present), increasing head circumference, downward gaze of the eyes
(setting sun sign), Cushings response (hypertension and bradycardia). At ICP >
20mmHg focal ischaemia occurs and at >50 mmHg global ischaemia occurs if CPP
remains constant (this is the reason MAP is raised therapeutically with the use of
vasoconstrictors in some cases of raised ICP). Long term increases in ICP can impair
neurological development, whilst in the acute setting, high ICP can cause distortion and
displacement of the cerebral contents through the foramen magnum - coning - leading
to coma, respiratory arrest and death. Most anaesthetic agents cause a reduction in MAP
but this potentially deleterious effect is usually offset by the corresponding reduction in
the cerebral metabolic demand for oxygen (CMRO2).

THE INDICATIONS FOR SHUNTING

There are several causes of hydrocephalus which may necessitate the insertion of a VP
shunt (see Box 1). VP shunts are therefore required for a wide range of patients from
newborns to older children with the potential for a number of co-morbidities. The shunt
provides a route for the CSF to drain and decreases ICP. The proximal end is placed in
the ventricle and the distal end at a site where the CSF can be absorbed (most commonly
peritoneum but atria and pleura are also used). The complications associated with VP
shunts include blockage, infection and over drainage, all of which may necessitate
revision surgery.

Endoscopic third ventriculostomy (ETV) is an alternative treatment for hydrocephalus in

carefully selected patients. A neuroendoscope is used to make a hole in the floor of the
third ventricle to facilitate CSF drainage. The technique was originally developed in the
1900s but was abandoned due to severe complications, most likely attributable to poor
anaesthesia and surgical equipment. Developments in optics, image processing and
improvements in anaesthesia have enabled ETV to be used safely with comparable results
to VP shunts as Warf et al have demonstrated in their series from Mbale, Uganda. ETV
has the benefit of avoiding the long-term complications of VP shunts and the attendant
costs of follow up and revision surgery, which has enormous implications for developing
countries with limited resources.

The incidence of infantile hydrocephalus is estimated at 3-5 cases per 1000 live births.
The peak ages of presentation include the first weeks of life, 4-8 years and early
adulthood. An estimated 750,000 people have hydrocephalus, approximately 160 000
ventriculoperitoneal shunts are inserted worldwide each year, with over 56 600 children
under 18 years thought to have a shunt in place. Depending on the indication for VP
shunt insertion, the procedure may be urgent or an emergency with additional attendant
risks (full-stomach, abnormal electrolytes, hypovolaemia, precipitously high ICP).
Table 1: Causes of hydrocephalus

Congenital : Acquired :
Myelomeningocele Infection
Stenosis of the cerebral aqueduct Intraventricular haemorrhage
Arnold-Chiari malformation Tumour
Arachnoid cysts Trauma
Vascular malformations Nutritional deficiencies
Idiopathic

PREOPERATIVE ASSESSMENT

The preoperative visit is an essential component of any anaesthetic technique. This

should include the standard anaesthetic history of problems with previous anaesthetics,
family history of reactions to anaesthesia, past medical history, current medication (e.g.
anticonvulsants, acetazolamide,furosemide), allergies and last oral intake. Particular
attention should be paid to the possibility of co-morbidities including problems with the
cardiovascular (e.g. congenital cardiac disease) and respiratory systems (e.g.
bronchopulmonary dysplasia, kyphoscoliosis, recurrent respiratory infections secondary
to neurological dysfunction).

Examination should include assessment of the airway, cardiorespiratory and neurological

systems, which in cases of raised ICP may demonstrate reduced level of consciousness
(LOC) and therefore increased risk of pulmonary aspiration. Volume status should be
determined as prolonged vomiting and dehydration may necessitate intravenous fluid
preoperatively.

Blood results should be reviewed to ascertain the level of haemoglobin and clotting
function so that appropriate blood products can be ordered as indicated. Urea and
electrolytes should be checked if medical problems or drug treatment suggest that they
may be abnormal and require attention perioperatively.

The preoperative visit is an opportunity to apply topical anaesthesia over a suitable vein if
intravenous induction is planned. Sedative premedication should be considered carefully
as it may exacerbate or mask signs of neurological dysfunction conversely, an anxious
combative patient may have a detrimental rise in ICP during induction. The patient
should be carefully monitored whilst awaiting surgery for signs of neurological
deterioration as this can occur rapidly. If the preoperative assessment reveals a patient
with multiple co-morbidities, such as an ex-premature infant with chronic lung disease,
the need for additional respiratory support in the postoperative period should be
considered and organised in advance.
PREPARATION, EQUIPMENT AND MONITORING

Prior to induction all anaesthetic equipment and drugs should be checked to ensure they
are available and in good working order. This should include a means of delivering
oxygen and volatile anaesthetic agent, suction, a tilting trolley and monitoring.
Equipment such as facemasks, oropharyngeal airways, tracheal tubes and laryngoscopes
should be available in a range of sizes appropriate for the patient. A weight appropriate
breathing circuit should be checked for correct configuration and patency. Standard
monitoring should include pulse oximetry, electrocardiogram, non-invasive blood-
pressure, oxygen concentration, and capnography.

INDUCTION OF ANAESTHESIA

The method of induction is determined by the circumstances of the case and the
preference of the patient and the anaesthetist.

Intravenous induction allows for rapid control of the airway in emergency situations if
the patient is not fasted and if no difficulties with the airway have been anticipated. This
may be achieved using a suitable induction agent in a carefully titrated sleep dose.
(proprofol 2-4 mg/kg, thiopentone 3-5 mg/kg) Hypotension should be avoided because of
the risk of decreasing CPP in the face of raised ICP. Ketamine should not be used as it
can increase ICP. Muscle relaxation can be achieved with the use of a neuromuscular
blocking agent (NMB). Suxamethonium can be used if the risk of aspiration outweighs
the problems of transient increases in ICP, otherwise non-depolarising NMB are
preferable.

Gaseous induction is an acceptable alternative with a non-irritant volatile anaesthetic

agent such as sevoflurane or halothane. A rapid gaseous induction is preferable to
prolonged attempts at cannulation in a distressed and unwell child. Once anaesthetized,
intravenous access should be established quickly to allow the use of a NMB to facilitate
control of the airway. Hypercarbia should be avoided as it causes cerebral vasodilation
and may worsen raised ICP especially in combination with laryngoscopy and airway
manipulation. The airway should be secured by intubation of the trachea with an
appropriate sized tracheal tube. This should be a reinforced (armoured) tube if available
but a standard tube can be used providing this information is communicated to the
surgeon, as the tube will be more likely to kink during positioning. The tube should be
firmly secured with waterproof tape and dressing and the eyes should be padded and
taped.

The patient should be positioned to allow good access for the surgeon and to avoid any
undue pressure on vulnerable areas. Consideration should be given to optimizing venous
drainage to increase CPP, reduce venous bleeding and improve the surgical field. The
core temperature of the patient should be monitored (rectal or oesophageal) and warming
devices (e.g. warm air blankets) used as required to maintain normothermia.
MAINTENANCE OF ANAESTHESIA

Anaesthesia can be maintained with a volatile agent and a mixture of oxygen and air. The
aim is to maintain CPP until the raised ICP is relieved by positioning of the VP shunt. To
do this hypotension should be avoided and minute ventilation controlled to maintain
normocarbia (end tidal CO2 4-4.5 kPa) to optimise CPP and avoid increases in ICP.
Positive end-expiratory pressure (PEEP) should be minimised to avoid venous congestion
in the head but may be used if there are difficulties in maintaining oxygenation.

The most stimulating parts of the surgery include the initial incision and tunnelling under
the skin. A short acting opioid, such as fentanyl (1-3 mcg/kg) or remifentanil (1 mcg/kg),
or increased depth of anaesthesia, can be used to attenuate the increase in heart rate and
ICP. Post-operative analgesia can be provided by a combination of infiltration of local
anaesthetic such as bupivicaine 0.25% (0.5-0.75 ml/kg) and paracetamol (15 mg/kg)
either intravenous or per rectum. High doses of long acting opioids should be avoided
because of potential detrimental effects on conscious level.

POSTOPERATIVE MANAGEMENT

At the end of the procedure neuromuscular blockade can be antagonized using

neostigmine (50 mcg/kg) combined with an anticholinergic (e.g. atropine 25 mcg/kg).
Most patients can be extubated once awake, avoiding hypercarbia, and with a technique
which minimizes the risk of aspiration (lateral or sitting). Analgesia can be achieved with
a combination of paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) if not
contra-indicated with additional oral opioid for breakthrough pain. The patient should be
monitored in a suitable environment by those familiar with paediatric neurosurgical cases
and able to carry out regular neurological observations.

THE NEONATAL PATIENT

A reasonable proportion of patients requiring VP shunt insertion are neonates (8% in a

series from California). Neonates are physiologically immature and so present additional
considerations for the anaesthetist. Many of these patients are premature, with a low birth
weight, with congenital hydrocephalus needing urgent surgical treatment in the first days
of life. This group are more likely to have complications with their VP shunts and so
return more frequently for further surgery to correct these problems.

Preoperative assessment should look for problems associated with neonates and
prematurity such as anaemia, coagulopathy, jaundice, respiratory disease and congenital
cardiac problems. Additional investigations such as an echocardiogram may therefore be
indicated. Blood and any other required products should be readily available prior to
surgery.
Gaseous induction of anaesthesia with sevoflurane provides good cardiovascular stability.
Neonates are a more technically challenging group of patients and particular attention
must be paid to securing tracheal tubes and intravenous cannulae as endobronchial
intubation and extravasation are commonly encountered problems. Congenital
hydrocephalus may have distorted the anatomy of the skull which can make management
of the airway more difficult. Often a pillow placed under the body of the neonate can
facilitate laryngoscopy. The use of a naso-gastric tube is an important component of
managing the neonatal airway and ventilation. Handling should be careful and minimal to
reduce the risks of complications (e.g. pneumothoraces).

Neonates have a high surface area to volume ratio and so lose heat quickly and their
mechanisms for maintaining thermal homeostasis are poorly developed. Core temperature
must be recorded and active measures taken to maintain body heat. These include,
increasing the ambient temperature, warm air blankets, overhead heaters, heat-moisture
exchangers to warm inspired gases, warming intravenous fluids and covering of exposed
areas.

Drug metabolism is different in neonates with an immature liver but a relatively higher
volume of distribution. Paracetamol, local anaesthetics, volatile anaesthetic agents and
opioids are all used in relatively lower doses. Careful attention must be paid to fluid
balance as renal function is also immature in the neonate. An infusion of 10% glucose
may be required to maintain blood glucose within the normal range but hypo and
hyperglycaemia should be avoided. Regular monitoring of blood glucose and electrolytes
allows for adjustment of fluid regimens as required.

Postoperatively some neonates will require further respiratory support (especially pre-
term infants with bronchopulmonary dysplasia). Patients that can be extubated will need
apnoea monitoring for 24-hour hours postoperatively in addition to regular neurological
observations.

CONCLUSION

Anaesthesia for the insertion of VP shunts requires an understanding of neurophysiology

and the relationship between ICP and CPP in both normal and disease states and
preparation to provide anaesthesia across the entire paediatric age range from premature
neonates to post pubertal children. The application of sound basic anaesthetic principles
will allow for the safe conduct of surgery in this varied and challenging population of
children.

ANSWERS TO SELF-ASSESSMENT

1. Symptoms and signs include headache, vomiting, irritability, drowsiness, bulging

fontanelle, increasing head circumference, downward gaze of the eyes, and later
 Cushings response (hypertension and bradycardia), coma and reduced respiratory
rate.
2. Any process that either increases production, reduces absorption or interferes with
circulation of CSF, see box 1.
3. CBF is regulated via oxygen requirement, PaCO2, intracerebral acidosis and hormonal
influences and is coupled to metabolic demand. Autoregulation keeps blood flow
constant over a range of pressures. (See also TOTW Cerebral Blood Flow and
Intracranial Pressure Parts 1 and 2)
4. See equation in text. We can increase CPP by either increasing MAP (with fluids,
vasoconstrictors or inotropes) or by reducing ICP (hyperventilation, mannitol,
sedation and analgesia) and reducing CVP (head up position, head midline, avoiding
obstruction of venous drainage of neck with central lines or tight endotracheal tapes)
5. See explanation in text (and also TOTW Neonatal Anaesthesia 1: physiology)

REFERENCES AND FURTHER READING

Paediatric and Neonatal Anaesthesia: Anaesthesia in a Nutshell 2004 Black A and

McKewan A, Butterworth Hinemann.

Neuroanaesthesia: Anaesthesia in a Nutshell 2002 Dinsmore J and Hall G, Butterworth

Hinemann

Wu Y et al. Ventriculoperitoneal Shunt Complications in California: 1990 TO 2000.

Neurosurgery 2007, 61:557563 www.neurosurgery-online.com

Warf B, Hydrocephalus in Uganda: the predominance of infectious origin and primary

management with endoscopic third ventriculostomy. J Neurosurg 2005, 102:115
http://www.ifglobal.org/uploads/documents/articleBenWarf_ETV%20(JNP).pdf

Engelhard HH, Hydrocephalus eMedicine 2007

http://www.emedicine.com/med/TOPIC2884.HTM

Kramer LC, Management of Spina Bifida, Hydrocephalus and Shunts eMedicine 2007
http://www.emedicine.com/ped/TOPIC2976.HTM

Mohammed IS, Neonatology Considerations for the Pediatric Surgeon 2006

http://www.emedicine.com/ped/TOPIC2982.HTM

Hill L, Cerebral Blood Flow and Intracranial Pressure. Parts 1 and 2 Tutorial of the week.
www.worldanaesthesia.org

Walker I and Wouters K, Neonatal Anaesthesia 1: physiology. Tutorial of the week.

www.worldanaesthesia.org