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Nstemi Patho

This document summarizes the pathophysiology of atherosclerosis and myocardial infarction. It outlines modifiable risk factors like diet, hypertension, obesity, and smoking and non-modifiable factors like age, family history, and gender. It then describes the process where endothelial injury allows lipids to accumulate in the arterial wall, forming plaques that can rupture and cause clots, restricting blood flow. Restricted blood flow leads to ischemia, cell damage, and eventually cell death, causing a myocardial infarction. It notes signs and symptoms and diagnostic lab results of myocardial infarction.

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1K views2 pages

Nstemi Patho

This document summarizes the pathophysiology of atherosclerosis and myocardial infarction. It outlines modifiable risk factors like diet, hypertension, obesity, and smoking and non-modifiable factors like age, family history, and gender. It then describes the process where endothelial injury allows lipids to accumulate in the arterial wall, forming plaques that can rupture and cause clots, restricting blood flow. Restricted blood flow leads to ischemia, cell damage, and eventually cell death, causing a myocardial infarction. It notes signs and symptoms and diagnostic lab results of myocardial infarction.

Uploaded by

Sheana Tmpl
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
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PATHOPHYSIOLOGY

MODIFIABLE FACTORS: Non- Modifiable FACTORS:


- Diet ( High fatty foods) Age: 78
- Hypertension
- Obesity Family History: DM, HPN, CVA
- Sedentary lifestyle Gender: Male
- Cigarette smoking
- stress

Endothelial lining of arteries are injured

Permeability to lipoproteins Platelets, WBC & Fibrin converge


at the injured site

Lipoproteins accumulated in the


intima of arterial wall

Macrophages infiltrate the area to


ingest lipids and die

Formation of dead fatty core

Formation of fibrous cap over dead


fatty core (plaque)

Plaque protrudes in lumen of the vessel

Plaque ruptures & causes thrombus formation


(Platelet aggregation + fibrin)

Occlusion of an artery

Narrowed blood vessel


obstructs/impedes blood flow

Myocardial perfusion/
Blood flow to myocardium
Oxygen supply

Myocardial Ischemia
Angina
s/s: chest pain
radiating to left arm
Partially Ischemic Cells Totally Ischemic Cells

Inadequate supply of Accumulation of Accumulation of No supply of O2 and


O2 and nutrients waste products waste products nutrients

Anaerobic Inflammatory No ATP


ATP production Mediators
Metabolism Causes: Noncontractile

Accumulation of Hypocontractile
lactate Loss of cell membrane
integrity
Inhibition of Inhibition of Ion
Glycolysis pumps

Cell Rupture
Altered cell
membrane
integrity

Ion Leak

Myocyte death/ Necrosis

Lab results Myocardial Infarction S/S: Dizziness


K: 3.4mmol/L Diaphoresis
WBC: 15.5 x 109 /L N/V
Creatinine: 1.39 mg/dL SOB
Blood Uric Acid: 9.29 mg/dL Unrelieved Chest
CXR: Cardiomegaly Pain
Enzymes level: Elevated Non-ST 07/20/1
Elevation MI ST Elevation MI
(NSTEMI) (STEMI)

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