Scribd Logo
Upload

Welcome to Scribd!

  • 31 views

    Chronic Periodontitis

    Uploaded by

    rahul sharma
    Chronic periodontitis is an inflammatory disease caused by bacteria that destroys the tissues supporting teeth. If left untreated, it can lead to tooth loss. Following initial treatment, lifelong maintenance including cleanings and monitoring is needed to prevent further progression. This study monitored 41 patients and found that levels of Porphyromonas gingivalis and Treponema denticola bacteria in plaque samples could predict which sites would experience periodontal disease progression within 3 months, allowing for targeted preventive therapy.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd

    Chronic Periodontitis

    Uploaded by

    rahul sharma
    31 views1 page
    Chronic periodontitis is an inflammatory disease caused by bacteria that destroys the tissues supporting teeth. If left untreated, it can lead to tooth loss. Following initial treatment, lifelong maintenance including cleanings and monitoring is needed to prevent further progression. This study monitored 41 patients and found that levels of Porphyromonas gingivalis and Treponema denticola bacteria in plaque samples could predict which sites would experience periodontal disease progression within 3 months, allowing for targeted preventive therapy.

    Original Description:

    PERIO

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Chronic periodontitis is an inflammatory disease caused by bacteria that destroys the tissues supporting teeth. If left untreated, it can lead to tooth loss. Following initial treatment, lifelong maintenance including cleanings and monitoring is needed to prevent further progression. This study monitored 41 patients and found that levels of Porphyromonas gingivalis and Treponema denticola bacteria in plaque samples could predict which sites would experience periodontal disease progression within 3 months, allowing for targeted preventive therapy.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    31 views1 page

    Chronic Periodontitis

    Uploaded by

    rahul sharma
    Chronic periodontitis is an inflammatory disease caused by bacteria that destroys the tissues supporting teeth. If left untreated, it can lead to tooth loss. Following initial treatment, lifelong maintenance including cleanings and monitoring is needed to prevent further progression. This study monitored 41 patients and found that levels of Porphyromonas gingivalis and Treponema denticola bacteria in plaque samples could predict which sites would experience periodontal disease progression within 3 months, allowing for targeted preventive therapy.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 1

    Chronic periodontitis is an inflammatory

    disease of the supporting tissues of the


    teeth associated with bacteria. It results in
    localized or generalized destruction of the
    supporting tissues of the teeth; the periodontal
    ligament, bone, and soft tissues
    (30). The disease if left untreated, can
    ultimately lead to tooth loss. Following
    diagnosis and initial treatment, a lifelong
    maintenance program involving regular
    examinations coupled with scaling, root
    planing, and oral hygiene instruction is
    necessary to monitor and attempt to
    prevent further disease progression. The
    maintenance therapy is generally non-specific
    and does not target active or at-risk
    sites. It is costly, time-consuming, can be
    unpleasant, and has been shown to result
    in both soft and hard tissue losses as the
    result of trauma (4, 8, 56). Chronic
    periodontitis affects approximately 35%
    of the population worldwide (1, 55), and
    poses a significant public-health challenge
    because it has also been suggested to be a
    Oral Microbiology Immunology 2009: 24: 469477
    Printed in Singapore. All rights reserved
    _ 2009 John Wiley & Sons A/S

    Progression of chronic
    periodontitis can be predicted by
    the levels of Porphyromonas
    gingivalis and Treponema
    denticola in subgingival plaque
    Byrne SJ, Dashper SG, Darby IB, Adams GG, Hoffmann B, Reynolds EC. Progression of
    chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and
    Treponema denticola in subgingival plaque.
    Oral Microbiol Immunol 2009: 24: 469477. _ 2009 John Wiley & Sons A/S.
    Introduction: Chronic periodontitis is an inflammatory disease of the supporting tissues
    of the teeth associated with bacteria. Diagnosis is achieved retrospectively by clinical
    observation of attachment loss. Predicting disease progression would allow for targeted
    preventive therapy. The aim of this study was to monitor disease progression in patients
    on a maintenance program and determine the levels of specific bacteria in subgingival
    plaque samples and then examine the ability of the clinical parameters of disease and
    levels of specific bacteria in the plaque samples to predict disease progression.
    Methods: During a 12-month longitudinal study of 41 subjects, 25 sites in 21 subjects
    experienced disease progression indicated by at least 2 mm of clinical attachment loss.
    Real-time polymerase chain reaction was used to determine the levels of Porphyromonas
    gingivalis, Treponema denticola, Tannerella forsythia, Fusobacterium nucleatum, and
    Prevotella intermedia in subgingival plaque samples.
    Results: No clinical parameters were able to predict periodontal disease progression. In
    sites undergoing imminent periodontal disease progression within the next 3 months,
    significant partial correlations were found between P. gingivalis and T. forsythia
    (r = 0.55, P < 0.001) and T. denticola and T. forsythia (r = 0.43, P = 0.04). The odds of
    a site undergoing imminent periodontal disease progression increased with increasing
    levels of P. gingivalis and T. denticola.
    Conclusion: Monitoring the proportions of P. gingivalis and T. denticola in subgingival
    plaque has the potential to help identify sites at significant risk for progression of
    periodontitis, which would assist in the targeted treatment of disease.
    S. J. Byrne, S. G. Dashper, I. B. Darby,
    G. G. Adams, B. Hoffmann,
    E. C. Reynolds
    Cooperative Research Centre for Oral Health
    Science, Melbourne Dental School and the
    Bio21 Institute of Molecular Science and
    Biotechnology, The University of Melbourne,
    Melbourne, Vic., Australia
    Key words: bacterial pathogens; biomarkers;
    chronic periodontitis; clinical study;
    real-time PCR
    Eric C. Reynolds, Centre for Oral Health
    Science, Melbourne Dental School, Faculty
    of Medicine, Dentistry and Health Sciences,
    The University of Melbourne, 720 Swanston
    Street, Melbourne, Vic. 3010, Australia
    Tel.: +61 3 9341 1547;
    fax: +61 3 9341 1596;
    e-mail: [email protected]
    Accepted for publication June 25, 2009

    You might also like