The Semantic Web in Action
The Semantic Web in Action
KEY CONCEPTS
Corporate applications are well under way,
A wide variety of online
Semantic Web applications are and consumer uses are emerging
emerging, from Vodafone Live!s
mobile phone service to Boeings
S
system for coordinating the work
of vendors. ix years ago in this magazine, Tim Ber- that would make this vision come true: a com-
ners-Lee, James Hendler and Ora Las- mon language for representing data that could
Scientic researchers are devel-
sila unveiled a nascent vision of the be understood by all kinds of software agents;
oping some of the most advanced
Semantic Web: a highly interconnected network ontologies sets of statements that translate
applications, including a system
that pinpoints genetic causes of of data that could be easily accessed and under- information from disparate databases into
heart disease and another system stood by any desktop or handheld machine. common terms; and rules that allow software
that reveals the early stages of in- They painted a future of intelligent software agents to reason about the information de-
uenza outbreaks. agents that would head out on the World Wide scribed in those terms. The data format, ontol-
Web and automatically book ights and hotels ogies and reasoning software would operate
Companies and universities,
working through the World Wide for our trips, update our medical records and like one big application on the World Wide
Web Consortium, are developing give us a single, customized answer to a partic- Web, analyzing all the raw data stored in online
standards that are making the Se- ular question without our having to search for databases as well as all the data about the text,
SLIM FILMS
mantic Web more accessible and information or pore through results. images, video and communications the Web
easy to use. The Editors They also presented the young technologies contained. Like the Web itself, the Semantic
Web would grow in a grassroots fashion, only Web to enhance business-to-business interac-
this time aided by working groups within the tions and to build the hidden data-processing
World Wide Web Consortium, which helps to structures, or back ends, behind new consumer
advance the global medium. services. And like an iceberg, the tip of this
Since then skeptics have said the Semantic large body of work is emerging in direct con- semantic web
Web would be too difcult for people to under- sumer applications, too. [si-man-tik web]
stand or exploit. Not so. The enabling technol- noun
ogies have come of age. A vibrant community Just below the Surface A set of formats and lan-
of early adopters has agreed on standards that The Semantic Web is not different from the guages that nd and ana-
have steadily made the Semantic Web practical World Wide Web. It is an enhancement that gives lyze data on the World
to use. Large companies have major projects the Web far greater utility. It comes to life when Wide Web, allowing con-
sumers and businesses to
under way that will greatly improve the ef- people immersed in a certain eld or vocation,
understand all kinds of use-
ciencies of in-house operations and of scientic whether it be genetic research or hip-hop music, ful online information.
research. Other rms are using the Semantic agree on common schemes for representing
w w w. S c i A m . c o m SCIENTIFIC AMERICAN 91
20 07 SCIENTIFIC AMERIC AN, INC.
[CONSUMER APPLICATIONS]
information they care about. As more groups
LUCY READING-IKKANDA ( illustration); AGILE KNOWLEDGE ENGINEERING AND SEMANTIC WEB ( screen shot); COURTESY OF APPLE, INC. ( laptop)
pan has already released the Semantic Web
4 languages and technologies needed to cross
such boundaries, and large companies are ex-
ploiting them. For example, British Telecom has
built a prototype online service to help its many
vendors more effectively develop new products
together. Boeing is exploring the technologies
to more efciently integrate the work of part-
ners involved in airplane design. Chevron is ex-
perimenting with ways to manage the life cycle
of power plants and oil reneries. MITRE Cor-
1
poration is applying Semantic Web tool kits to
help the U.S. military interpret rules of engage-
ment for convoy movements. The U.K.s nation-
2 al mapping agency, Ordnance Survey, uses the
Semantic Web internally to more accurately and
inexpensively generate geographic maps.
3
Other companies are improving the back-end
4 operations of consumer services. Vodafone
Live!, a multimedia portal for accessing ring
tones, games and mobile applications, is built on
Semantic Web formats that enable subscribers
to download content to their phones
much faster than before. Harpers
Magazine has harnessed semantic
w w w. S c i A m . c o m SCIENTIFIC AMERICAN 93
20 07 SCIENTIFIC AMERIC AN, INC.
Personalized The challenge, of course, is to somehow meld
a bewildering array of data sets: all sorts of his-
four or ve databases for each one, trying to dis-
cern which genes (or the proteins they encode)
medicine will toric and current medical records about each have features most likely to affect the biology of
become person and all sorts of scientic reports on a
number of drugs, drug tests, potential side ef-
the disorder a painstaking task. In the end, in-
vestigators often cannot afford the hours, and
possible only fects and outcomes for other patients. Tradi- the work falters.
when semantics tional database tools cannot handle the com-
plexity, and manual attempts to combine the
The Cincinnati team, which includes a Se-
mantic Web consultant, began by downloading
makes medical databases would be prohibitively expensive. into a workstation the databases that held rele-
databases Just maintaining the data is difcult: each time
new scientic knowledge is incorporated into
vant information but from different origins and
in incompatible formats. These databases in-
smarter and one data source, others linked to it must be re- cluded Gene Ontology (containing data on genes
easier to use. integrated, one by one.
A research team at Cincinnati Childrens
and gene products), MeSH (focused on diseases
and symptoms), Entrez Gene (gene-centered in-
Hospital Medical Center is leveraging semantic formation) and OMIM (human genes and ge-
capabilities to nd the underlying genetic causes netic disorders). The investigators translated the
of cardiovascular diseases. Traditionally, re- formats into RDF and stored the information in
searchers would search for genes that behave a Semantic Web database. They then used Pro-
differently in normal and diseased tissues, as- tg and Jena, freely available Semantic Web
suming that these genes could somehow be in- software from Stanford University and HP Labs,
volved in causing the pathology. This exercise respectively, to integrate the knowledge.
could yield tens or hundreds of suspect genes. The researchers then prioritized the hun-
Researchers would then have to pore through dreds of genes that might be involved with car-
CHANDRA GUDIVADA, ANIL JEGGA, ERIC BARDES, SCOTT TABAR AND BRUCE ARONOW Cincinnati Childrens Hospital Medical Center (screen shot); COURTESY OF APPLE, INC. (monitor)
diac function by applying a ranking algorithm
[ANALYZING DATABASES] somewhat similar to the one Google uses to
rank Web pages of search results. They found
Which Genes Cause Heart Disease? candidate genes that could potentially play a
causative role in dilated cardiomyopathy, a
Hundreds of genes could potentially contribute to heart disease. Researchers at
weakening of the hearts pumping ability. The
Cincinnati Childrens Hospital Medical Center are using Semantic Web tools to nd
team instructed the software to evaluate the
the most likely culprits by analyzing numerous online databases and scientic refer-
ranking information, as well as the genes rela-
ences (left, on screen), revealing possible causative connections (right, on screen).
For example, they have pinpointed suspect genes related to a chromosomal region tions to the characteristics and symptoms of the
linked to dilated cardiomyopathy, a weakening of the hearts pumping ability. condition and similar diseases. The software
identied four genes with a strong connection
to a chromosomal region implicated in dilated
cardiomyopathy. The researchers are now in-
vestigating the effects of these genes mutations
as possible targets for new therapeutic treat-
ments. They are also applying the semantic sys-
tem to other cardiovascular diseases and expect
to realize the same dramatic improvement in ef-
ciency. The system could also be readily ap-
plied to other disease families.
Similarly, senior scientists at Eli Lilly are ap-
plying Semantic Web technologies to devise a
complete picture of the most likely drug targets
for a given disease. Semantic tools are allowing
them to compile numerous incompatible biolog-
ical descriptions into one unied le, greatly ex-
pediting the search for the next breakthrough
drug. Pzer is using Semantic Web technologies
to mesh data sets about protein-protein interac-
tion to reveal obscure correlations that could
help identify promising medications. Research-
ers there are convinced that these technologies
w w w. S c i A m . c o m SCIENTIFIC AMERICAN 95
20 07 SCIENTIFIC AMERIC AN, INC.
If two three days faster than before. The CDC is now
helping local health departments nationwide to
Health and Human Services epidemiologists in
the eld. SAPPHIRE succeeded in identifying
databases implement similar systems, replacing tedious, gastrointestinal, respiratory and conjunctivitis
joined by the inconsistent and decades-old paper schemes.
The nimbleness of Semantic Web technolo-
outbreaks in survivors of the disaster much
sooner than would have been possible before.
Semantic Web gies allows SAPPHIRE to operate effectively in SAPPHIREs exibility showcases an impor-
have different other contexts as well. When Hurricane Katrina
evacuees poured into Houstons shelters, public
tant lesson about Semantic Web systems: once
they are congured for a general problem in this
privacy criteria, health ofcials quickly became concerned about case, public health reporting they can quickly
the software the possible spread of disease. Within eight
hours after the shelters were opened, personnel
be adapted to a variety of situations within that
eld. Indeed, the CDC would like to roll out a
will have to at the University of Texas Health Science Center single, integrated, SAPPHIRE-style illness alert
honor both configured SAPPHIRE to help. They armed
public health ofcials with small handheld com-
system nationwide.
SAPPHIRE succeeds because it can unify in-
sets of rules. puters loaded with health questionnaires. The formation from many places, which can then be
responses from evacuees were then uploaded to used for different goals. This same attribute is fu-
the system, which integrated them with data eling FOAFs grassroots growth. By using an
from the shelters emergency clinics and surveil- agreed-on Semantic Web vocabulary, the FOAF
lance reports from Houston Department of system nds common interests among friends
COURTESY OF THE CENTER FOR BIOSECURITY AND PUBLIC HEALTH INFORMATICS RESEARCH, UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON ( screen shot) ; COURTESY OF DELL, INC. ( laptop)
and acquaintances, even if they do not belong to
[UNIFYING INFORMATION] the same social-networking sites such as MySpace
or Facebook. FOAF enthusiasts are also now de-
Is a Flu Outbreak Under Way? veloping semantic trust networks white lists of
trusted senders as a way to ght e-mail spam.
Public health ofcials take longer than they would like to recognize new disease out-
breaks, because they must manually compare disparate reports in incompatible for-
mats from many hospitals and doctors ofces. Researchers at the University of Texas
Crossing Boundaries
The success of SAPPHIRE and other applica-
Health Science Center have built a Semantic Web system that quickly and automatical-
ly tracks and analyzes these online data across the Houston area. It presents ofcials tions has prompted calls for more Semantic
with clear trends, such as the incidence of u symptoms across different age groups Web integration in health care. The Food and
over time (center, on screen); a sharp rise would indicate early signs of outbreaks. Drug Administration and the National Insti-
tutes of Health have both recently declared that
a shift toward research into translating data
across boundaries is necessary for improving
the drug development and delivery process.
The same work will enhance the traditional
computerized clinical decision support (CDS)
systems that medical professionals use knowl-
edge bases that contain the latest wisdom on
therapeutic treatments. Each hospital, physi-
cians network and insurance company has had
to custom-design its own system, and all of
them are struggling mightily to stay current.
Every time an advance is made about diagnoses,
clinical procedures or drug safetywhich is of-
ten administrators must rework their systems.
The personnel time required is usually far great-
er than most of these organizations can afford.
Furthermore, because the custom systems are
frequently incompatible, making industry-wide
insights or deciphering best practices is slow
and cumbersome. What is more, we are
investigating Semantic Web technol-
ogies because traditional approach-
es for data integration, knowledge
management and decision support
tion within Wikipedias seven million articles. house and make them an offer. Grand visions
w3.org/topic/SemanticWebTools
This project will allow Web surfers to perform rarely progress exactly as planned, but the Se-
detailed searches of Wikipedias content that are mantic Web is indeed emerging and is making Related blogs and RSS feeds can be
impossible today, such as, Find me all the lms online information more useful than ever. g accessed at http://planetrdf.com
w w w. S c i A m . c o m SCIENTIFIC AMERICAN 97
20 07 SCIENTIFIC AMERIC AN, INC.