Advice Sheet Adrenaline

1
The Flight/ Fight Response in Chronic Pain

Dr Giresh Kanji (MbCHb, PGDip MusMed, FRNZCGP, PGDip BusInfo, FAFMM, MMgt)
Musculoskeletal Pain Specialist
Southern Cross Hospital
90 Hanson St, Newtown, Wellington.
[email protected]
www.southerncrosspain.co.nz
Introduction
Adrenaline is a "fight or flight" hormone, and plays a central role in the short-term
stress reaction. It is designed to protect individuals against threatening situations or in
emergencies. In evolutionary terms this hormone helped the survival of the fittest
animals. Prior to modern civilization human beings were busy hunting for food and
avoiding being eaten by predators. When faced with a tiger the release of adrenaline
helps the body to cope with the physical demands of fighting the tiger or running from
the tiger. The intense physical act of running away or fighting burned up the extra
adrenaline produced and stopped the effects of adrenaline on the body.
As humans have become city dwellers the need to run from threat or hunt for food is
decreased. In modern society pain, psychological stress, viral illness, alcohol,
caffeine, bad memories and perceived threat release adrenaline. The release of
adrenaline can also be subconscious due to memories. Bad experiences (post
traumatic stress disorder) can lead to release of adrenaline without conscious control.
When people are dreaming or having nightmares adrenaline can be released.
The significant problem with releasing adrenaline for pain or stress is that the body
cannot fight or take flight from these conditions as they are internal. Adrenaline is
not burnt up and sensitizes the body and brain to cause significant distress. Adrenaline
exerts its effect on the body by attaching to adrenaline receptors throughout the body.
Often medications target these receptors including headache medications and blood
pressure medications.
Effects of sympathetic nervous system activation
When the body reacts to signals of threat the sympathetic nervous system creates
several changes in the body preparing the body to fight or take flight (run from
danger) including:
The force of contraction and heart rate increase. Blood pressure is raised.
Palpitations or awareness of heart beat may result.
Suppression of stomach and intestinal action. Digestion is not important to

fight or run so is suppressed.
Blood flow changes to increase blood to muscles and the brain to enhance the
fight flight response. The skin blood flow decreases and may result in cold
hands, cold feet and increased hair loss as scalp blood flow decreases.
2
Glucose and fats are released into the blood stream ready to provide for the
increased physical effort that may be required during the fight/flight response.
The release of glucose in the blood stream can aggravate diabetes. The release
of fats, glucose into the blood stream as well as a raised blood pressure can all
contribute to the risk of heart disease.
Increased alertness results from sympathetic activation. If faced with a threat

such as a tiger then being alert is beneficial to fight or run. If there is no tiger
or physical threat increased alertness and anxiety leads to disturbed sleep as
the body is alert to deal with a perceived threat. It is as though one is sleeping
with a tiger in the bed. Ongoing anxiety can lead to lowered mood
(depression).
The pathways of the sympathetic nervous system

The hypothalamus (a centre in the brain) sends nerve impulses to the spinal cord that
sends signals to the adrenal gland, a small gland that sits above the kidney. The
sympathetic nerves weave through the adrenal gland and signal the release of
adrenaline.
Figure 1 The pathways of the sympathetic nervous system
Physical Threat (Tiger)

Pain
Stress
Illness
Memory
Poor Sleep
Alcohol
Caffeine
Adrenal Glands
Kidney
Secretion adrenaline and cortisol

into blood stream
Fight Flight response activated

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Sensitisation
Adrenaline is produced for vigorous physical activity to either run or fight. When
running or fighting the adrenaline is used up. When the fight flight response is
activated for pain, stress, flu illness or alcohol there is no vigorous physical activity
that follows. The excess adrenaline then stays in the brain pathways and causes
sensitization of adrenaline pathways in the brain.
Normally nerves work in relays. At the relay (synapse) there are chemical messengers
(adrenaline among others) that are released across the gap to activate the next nerve.
Figure two shows normal transmission with the electricity traveling in nerve D being
similar to A. Figure 3 shows the effect of sensitization of nerves with increases in
nerve synapses that allow increased adrenaline to cross the synapse and increase the
electricity (increasing the strength of transmission) in nerve D.
Cortisol
Cortisol is a stress hormone released by the adrenal gland that has a daily variation,
with the highest levels present in the early morning, and the lowest levels present
around midnight (Figure 2). In conditions of long term stress, pain or infection the
release of cortisol may burnout so the high levels in the morning are similar to the low
levels at night (figure 3). Low levels of cortisol cause fatigue. After long periods of
stress or chronic pain the low cortisol in the morning makes you feel tired like at
night. Cortisol also increases the bodys sensitivity to adrenaline and can aggravate
symptoms of the fight flight response.
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Figure 3 Normal Cortisol Pattern
Cortisol
level
Morning Bedtime
Figure 4 Cortisol Burnout Pattern
Cortisol
level
Morning Bedtime
The Sympathetic Nervous System

The sympathetic nervous system arises from between the ribs at back of the rib cage
and supplies all the blood vessels, sweat glands and the muscles that help hairs stand
on end throughout the body. The sympathetic fibers from the first rib space generally
pass up into the head, fibers from the second and their rib space into the neck, fibers
from the third to the sixth into the chest, fibers from the seventh to eleventh into the
abdomen and fibers from the last few spaces into the back and legs. There is however
significant overlap in the segments. Treatment directed to the rib spaces helps chronic
pain.
Treatment
Reducing adrenaline in the circulation will help the distress and insomnia patients
suffer from chronic pain. Adrenaline can either be consumed or production can be
reduced.
Exercise
If exercise is to be used it should be short bursts of high intensity exercise such as
walking up stairs for short intervals interspersed with rest. This would recreate the
type of exercise that helps burn adrenaline (running or fighting the tiger). Intervals of
5
30 seconds intense exercise with rest periods of a few minutes may help burn
adrenaline. While recreational walking helps with relaxation it is very unlikely to help
decrease pain or help with significant anxiety symptoms.
Sweating
Sweating helps diminish the chemicals that produce adrenaline in the body. The deep
relaxation felt after a sauna is likely to be linked to the depletion of adrenaline as well
as other affects from the heat. Attending a sauna upto three times a week initially and
then reducing to once a week after symptoms have subsided should be sufficient. A
hot bath will produce the same effect but is less effective and required to be
performed approximately five times per week.
Initially for those not use to attending a sauna acclimatizsing slowly is recommended.
After five to ten minutes leave the sauna, have a warm shower then reduce the
temperature to cold. This will help stop any headaches due to the increased heat in the
sauna causing vasodilatation of vessels.
Meditation
Deep relaxation or meditation is likely to reduce the production of adrenaline. In one
large study 20 minutes meditation per day helped reduce headaches by 95%. Any
relaxation therapy may help if performed 20 minutes daily. Meditation however
seems to have the most evidence. Although there is evidence for meditation it is
difficulty to perform as the brain is often irritable and will not keep still. The hot baths
or saunas will decrease adrenaline sensitivity in the brain and body.
Injections/deep tissue massage or acupuncture

Initially injections of anesthetic and saline have been performed over the past three
years to learn the above information. However the treatment does not require
injections although these are available for people if required. Once the adrenaline
sensitivity is decreased then the muscle tender regions need to be treated.
Figure 5 The sympathetic (adrenaline nerves) enter the spinal cord between the ribs.

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1

The Flight/ Fight Response in Chronic Pain

Effects of sympathetic nervous system activation

Suppression of stomach and intestinal action. Digestion is not important to

Increased alertness results from sympathetic activation. If faced with a threat

The pathways of the sympathetic nervous system

Figure 1 The pathways of the sympathetic nervous system

Physical Threat (Tiger)

Secretion adrenaline and cortisol

Fight Flight response activated

Figure 3 Normal Cortisol Pattern

Figure 4 Cortisol Burnout Pattern

The Sympathetic Nervous System

Injections/deep tissue massage or acupuncture

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