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A Biological Inverter

An inverter in biology functions like an inverter in electronics by producing the opposite output from its input. It uses a control protein that is produced from the inverter's input DNA sequence. This control protein then binds to the output's polymerase landing pad, blocking transcription from occurring. When the input is inactive, no control protein is produced so the landing pad is clear and transcription can proceed from the output. This allows the inverter to function by producing the opposite transcriptional output compared to its input.

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Kethavath Sakrunaik K
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56 views1 page

A Biological Inverter

An inverter in biology functions like an inverter in electronics by producing the opposite output from its input. It uses a control protein that is produced from the inverter's input DNA sequence. This control protein then binds to the output's polymerase landing pad, blocking transcription from occurring. When the input is inactive, no control protein is produced so the landing pad is clear and transcription can proceed from the output. This allows the inverter to function by producing the opposite transcriptional output compared to its input.

Uploaded by

Kethavath Sakrunaik K
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOC, PDF, TXT or read online on Scribd
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Inverter

Example:
1. Repressor gene in conjunction with a repressible promoter. One condition causes
the gene to be made and then its promoter.

Example of a device multiple parts with a higher level function


Inverters are currently protein specific, the newest idea to standardize the parts would be
through a measurement much like current in an electrical circuit, PoPS, Polymerase per
second.

A BIOLOGICAL INVERTER

A) A polymerase molecule transcribes the DNA strand starting with the inverter's input
and ending with a sequence that tells the polymerase to stop transcribing. The result: a
control protein.

B) The control protein binds to a "landing pad" for polymerase near the inverter's output,
blocking other polymerase molecules from latching on and transcribing DNA.

A) With no polymerase at the input, the landing pad is clear. A free-floating polymerase
molecule latches on.

B) The polymerase, now latched on, begins transcribing at the inverter's output and
continues down the DNA strand.

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